More than six million adults in the United States live with heart failure — a diagnosis that means the heart is not pumping as well as it should, not that it has stopped. It is one of the most heavily researched conditions in medicine, because current treatments manage the condition rather than reverse it, and that gap is exactly what investigational therapies are trying to close.
A study is currently enrolling US adults who have been diagnosed with heart failure. It runs from a limited number of investigator sites, which makes geography the first filter: this page covers who the study is looking for, what screening involves, and which metros are within reach of an active site.
Who the study is looking for
The headline criterion is a physician diagnosis of heart failure. Suspecting a heart problem, or having been told your blood pressure is high, is not the same thing — screening will ask for the diagnosis, and the study team verifies it against your medical records before anything else happens.
Heart failure is not one uniform condition, and protocols in this area typically care about the details behind the diagnosis:
- Ejection fraction — whether your heart failure is the reduced-EF kind (HFrEF) or the preserved-EF kind (HFpEF); different studies target each;
- How recently things have changed — a recent hospitalization, heart attack or procedure can matter in either direction depending on the protocol;
- Current medications — study treatments are generally evaluated on top of standard care, not instead of it.
Which of these applies to the currently enrolling study is established on the screening call, not on the form. If you have a heart failure diagnosis, the honest summary is: you are the population this study is recruiting from, and the details get worked out with the coordinator.
Why location decides this one
Like a number of studies we list, this one runs from a small set of investigator sites rather than nationwide — currently clustered around the Washington DC area, the North Carolina Research Triangle, Cincinnati, eastern Nebraska, and Denver. Participation means travelling to a site for visits, so being within reach of one is a hard requirement no medical criterion can override.
The metros listed further down are the ones inside the paid recruitment zone — roughly a 30-mile radius around each site. If you are outside them, this particular study is not available to you, and it is better to know that before filling in a form than after three screening steps.
Heart research overall is anything but narrow, though: cardiovascular studies appear in nearly every large metro we track. Our per-city pages list every study recruiting within 30 miles, straight from the NIH registry, and heart and vascular research is one of the most active categories on almost all of them.
What screening involves
Screening runs in the usual stages: a short online form checks the headline criteria, a coordinator calls to go through your cardiac history and medications, and an in-person screening visit follows if it still looks like a fit — typically with bloodwork, an ECG, and often an echocardiogram to measure ejection fraction.
Two things worth knowing going in. First, never adjust or stop your current heart medication to qualify for a study — no legitimate protocol asks you to do that on your own, and any change happens under the study physician's supervision if it happens at all. Second, screening failure is common in cardiology studies because measurements have to land inside a defined window; being screened out says nothing about how well managed your condition is.
Screening is free at every stage. Compensation for time and travel is set by each study's protocol, reviewed by an ethics board, and disclosed in writing before you enroll — across US research generally, payments run from $75 to $4,500 per completed study depending on visit count and procedures.
Want to know when a paid study opens near you?Join the free email alert — we watch the NIH registry weekly so you don't have to.
Get trial alerts The terms you will see on listings
Cardiology listings lean on abbreviations that are worth being able to parse before a screening call:
- Ejection fraction (EF) — the percentage of blood the left ventricle pumps out with each beat; the single most-used number in heart failure research.
- HFrEF / HFpEF — heart failure with reduced (roughly 40 % or less) or preserved ejection fraction. Half the research targets each, so knowing yours narrows the field immediately.
- NYHA class — the I-to-IV scale describing how much symptoms limit daily activity; protocols often specify a range.
- Cardiomyopathy — disease of the heart muscle itself, one of the underlying causes of heart failure and a research area in its own right.
Your most recent echocardiogram report contains most of these numbers. Having it to hand makes the screening call substantially shorter.