How much do paid clinical trials in Chicago pay?

Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.

Is compensation for clinical trials taxable?

In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.

What is the difference between a research center and a hospital study in Chicago?

Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.

How often do new paid studies open in Chicago?

Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Chicago.

Can I be in more than one clinical trial at a time?

Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Chicago typically complete one or two studies per year.

Paid Clinical Trials Chicago, IL — 2443 Studies Recruiting (Oct 2026)

A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy

Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications Phase 3 Interventional 115 participants sought

Ann & Robert H. Lurie Children's Hospital of Chicago (Adults and Pediatrics) — Chicago, Illinois (2.1 mi) · Sponsor: Pierre Fabre Medicament

See eligibility & contact on ClinicalTrials.gov (NCT03394365)

Combining MyoCI With Memory Reactivation to Improve Motor Recovery After Stroke

Stroke N/A Interventional 70 participants sought

Northwestern University — Chicago, Illinois (2.1 mi) · Sponsor: Northwestern University

See eligibility & contact on ClinicalTrials.gov (NCT04312269)

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

High Grade Glioma, Diffuse Intrinsic Pontine Glioma Phase 2 Interventional 120 participants sought

Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois (2.1 mi) · Sponsor: Nationwide Children's Hospital

See eligibility & contact on ClinicalTrials.gov (NCT05096481)

Study of Navtemadlin as Maintenance Therapy in TP53WT Advanced or Recurrent Endometrial Cancer

Endometrial Cancer Phase 2, Phase 3 Interventional 268 participants sought

Dr. Sudarshan K. Sharma, Ltd. — Hinsdale, Illinois (13.1 mi) · Sponsor: Kartos Therapeutics, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT05797831)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought

Lurie Children's Hospital-Chicago — Chicago, Illinois (2.1 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT06124157)

Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections

Gonorrhea, Chlamydia Phase 4 Interventional 760 participants sought

University Illinois Chicago — Chicago, Illinois (2.1 mi) · Sponsor: Westat

See eligibility & contact on ClinicalTrials.gov (NCT06738407)

Validation and Scaling of Screening Program for Undiagnosed Myasthenia Gravis-Social Media Campaign Paired With a Self-moderated Assessment

Myasthenia Gravis, Neuromuscular Disease N/A Observational 1,000 participants sought

ZS Associates — Evanston, Illinois (14.1 mi) · Sponsor: ZS Associates

See eligibility & contact on ClinicalTrials.gov (NCT06866483)

A Study to Learn About Salanersen's (BIIB115) Effects on Movement and Its Safety When Given Before Symptoms Appear in Babies With Genetically Diagnosed Spinal Muscular Atrophy (SMA)

Muscular Atrophy, Spinal Phase 3 Interventional 30 participants sought

Ann and Robert H Lurie Childrens Hospital of Chicago — Chicago, Illinois (2.1 mi) · Sponsor: Biogen

See eligibility & contact on ClinicalTrials.gov (NCT07221669)

GATEWAY: Safety Evaluation of the MiniMed™ NMX8-AID System in Children and Adults Living With Diabetes

Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus N/A Interventional 400 participants sought

Northwestern University — Chicago, Illinois (2.1 mi) · Sponsor: Medtronic MiniMed, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT07228117)

A Study to Evaluate Adverse Events, Change in Disease Activity, Tolerability, and How Intravenous ABBV-438 Moves Through the Body in Adult Participants With Multiple Myeloma (MM)

Multiple Myeloma Phase 1 Interventional 127 participants sought

University of Chicago Medical Center /ID# 278863 — Chicago, Illinois (2.1 mi) · Sponsor: AbbVie

See eligibility & contact on ClinicalTrials.gov (NCT07409246)

Intralesional Gardasil-9 for the Treatment of Recalcitrant Warts

Warts, Verruca (Warts) Phase 2 Interventional 55 participants sought

Rush University Medical Center — Chicago, Illinois (2.1 mi) · Sponsor: Rush University Medical Center

See eligibility & contact on ClinicalTrials.gov (NCT07806617)

One-Time DNA Study for Vasculitis

Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Giant Cell Arteritis N/A Observational 1,000 participants sought

Northwestern University — Chicago, Illinois (2.1 mi) · Sponsor: University of Pennsylvania

See eligibility & contact on ClinicalTrials.gov (NCT01241305)

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

Lymphoma, Non-Hodgkin, Multiple Myeloma Phase 2 Interventional 4,200 participants sought

Cancer Treatment Centers of America-Chicago — Chicago, Illinois (2.1 mi) · Sponsor: American Society of Clinical Oncology

See eligibility & contact on ClinicalTrials.gov (NCT02693535)

CLOZAPINE Response in Biotype-1

Schizophrenia, Schizoaffective Disorder Phase 4 Interventional 524 participants sought

University of Chicago — Chicago, Illinois (2.1 mi) · Sponsor: University of Texas Southwestern Medical Center

See eligibility & contact on ClinicalTrials.gov (NCT04580134)

A Study of Enzalutamide Plus the Glucocorticoid Receptor Antagonist Relacorilant Versus Placebo for Patients With High-risk Localized Prostate Cancer

Prostate Cancer, Prostate Adenocarcinoma Phase 2 Interventional 90 participants sought

University of Chicago Comprehensive Cancer Center — Chicago, Illinois (2.1 mi) · Sponsor: University of Chicago

See eligibility & contact on ClinicalTrials.gov (NCT05726292)

APPROVE Trial: Evaluating a Prescription Digital Therapeutic for Treatment of OAB in Women

Overactive Bladder (OAB), Urinary Urgency N/A Interventional 596 participants sought

University of Chicago — Chicago, Illinois (2.1 mi) · Sponsor: Medstar Health Research Institute

See eligibility & contact on ClinicalTrials.gov (NCT06797245)

Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC

Prostate Cancer Phase 3 Interventional 940 participants sought

Northwestern University — Chicago, Illinois (2.1 mi) · Sponsor: Novartis Pharmaceuticals

See eligibility & contact on ClinicalTrials.gov (NCT06855277)

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

PIK3CA Mutation, HER2- Negative Breast Cancer Phase 3 Interventional 540 participants sought

Rush University Medical Center — Chicago, Illinois (2.1 mi) · Sponsor: Relay Therapeutics, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT06982521)

Horizon Two: HR NDMM (MMRC-100)

High Risk Newly Diagnosed Multiple Myeloma Phase 2 Interventional 300 participants sought

UChicago Medicine — Chicago, Illinois (2.1 mi) · Sponsor: Multiple Myeloma Research Consortium

See eligibility & contact on ClinicalTrials.gov (NCT07053436)

A Study of Brenipatide in Participants With Alcohol Use Disorder

Alcohol Use Disorder Phase 3 Interventional 1,100 participants sought

Re:Cognition Health - Chicago — Chicago, Illinois (2.1 mi) · Sponsor: Eli Lilly and Company

See eligibility & contact on ClinicalTrials.gov (NCT07219953)

PRImary Care Strategies for Weight Management (PRISM) Study

Obesity N/A Interventional 214 participants sought

Rush University Medical Center — Chicago, Illinois (2.1 mi) · Sponsor: Rush University Medical Center

See eligibility & contact on ClinicalTrials.gov (NCT07288294)

Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design

Fibromyalgia Phase 3 Interventional 620 participants sought

Clinical Research Site — Chicago, Illinois (2.1 mi) · Sponsor: Axsome Therapeutics, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT07398417)

Nicotinamide Adenine Dinucleotide Responses to a Nutritional Supplement

Healthy Adult N/A Interventional 34 participants sought

Biofortis Clinical Research — Addison, Illinois (16.9 mi) · Sponsor: Shaklee Corporation

See eligibility & contact on ClinicalTrials.gov (NCT07428889)

Phase 2 Study to Assess the Safety and Efficacy of ANG003

Exocrine Pancreatic Insufficiency (EPI), Cystic Fibrosis (CF) Phase 2 Interventional 113 participants sought

The Cystic Fibrosis Institute — Glenview, Illinois (16.9 mi) · Sponsor: Anagram Therapeutics, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT07450547)

Clinical Decision Support Tool in PARDS Pilot Study

Ventilation Therapy; Complications, Ventilator-Induced Lung Injury N/A Interventional 180 participants sought

Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois (2.1 mi) · Sponsor: Children's Hospital Los Angeles

See eligibility & contact on ClinicalTrials.gov (NCT04068012)

Paid Clinical Trials in Chicago, IL

Studies recruiting near Chicago right now

A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy

Combining MyoCI With Memory Reactivation to Improve Motor Recovery After Stroke

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

Study of Navtemadlin as Maintenance Therapy in TP53WT Advanced or Recurrent Endometrial Cancer

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections

Validation and Scaling of Screening Program for Undiagnosed Myasthenia Gravis-Social Media Campaign Paired With a Self-moderated Assessment

A Study to Learn About Salanersen's (BIIB115) Effects on Movement and Its Safety When Given Before Symptoms Appear in Babies With Genetically Diagnosed Spinal Muscular Atrophy (SMA)

GATEWAY: Safety Evaluation of the MiniMed™ NMX8-AID System in Children and Adults Living With Diabetes

A Study to Evaluate Adverse Events, Change in Disease Activity, Tolerability, and How Intravenous ABBV-438 Moves Through the Body in Adult Participants With Multiple Myeloma (MM)

Intralesional Gardasil-9 for the Treatment of Recalcitrant Warts

One-Time DNA Study for Vasculitis

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

CLOZAPINE Response in Biotype-1

A Study of Enzalutamide Plus the Glucocorticoid Receptor Antagonist Relacorilant Versus Placebo for Patients With High-risk Localized Prostate Cancer

APPROVE Trial: Evaluating a Prescription Digital Therapeutic for Treatment of OAB in Women

Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

Horizon Two: HR NDMM (MMRC-100)

A Study of Brenipatide in Participants With Alcohol Use Disorder

PRImary Care Strategies for Weight Management (PRISM) Study

Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design

Nicotinamide Adenine Dinucleotide Responses to a Nutritional Supplement

Phase 2 Study to Assess the Safety and Efficacy of ANG003

Clinical Decision Support Tool in PARDS Pilot Study

Studies you may be able to join near Chicago

See which clinical studies you may qualify for

Top-rated research centers in Chicago

Chicago Clinical Research Institute, Inc.

Cedar Crosse Research Center

Next Innovative Clinical Research

All of Us Research Program at University of Illinois

DM Clinical Research—Chicago

Atlantia Clinical Trials USA

Flourish Research - Chicago (Andersonville)

Institute for Health Research & Policy

Robert H. Lurie Medical Research Center

Clinical trials in Chicago: what's recruiting

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Paid clinical trials near Chicago

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