Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/IL/Chicago
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Chicago, IL

Studies commonly pay $75 to $4,500 per completed study

2,448 clinical trials are currently recruiting participants within 30 miles of Chicago. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

2,448studies recruiting
9+research centers nearby
7condition categories
Live from the NIH registry

Studies recruiting near Chicago right now

Top 25 of 2,448 recruiting studies, sorted by proximity — each links to its official registry page

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

High Grade Glioma, Diffuse Intrinsic Pontine Glioma Phase 2 Interventional 120 participants sought
Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois (2.1 mi) · Sponsor: Nationwide Children's Hospital
See eligibility & contact on ClinicalTrials.gov (NCT05096481)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Lurie Children's Hospital-Chicago — Chicago, Illinois (2.1 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Lymphoma, Large B-Cell, Diffuse Phase 2 Interventional 594 participants sought
University of Chicago Medical Center ( Site 0126) — Chicago, Illinois (2.1 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06890884)

GATEWAY: Safety Evaluation of the MiniMed™ NMX8-AID System in Children and Adults Living With Diabetes

Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus N/A Interventional 400 participants sought
Northwestern University — Chicago, Illinois (2.1 mi) · Sponsor: Medtronic MiniMed, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07228117)

A Study of Enzalutamide Plus the Glucocorticoid Receptor Antagonist Relacorilant Versus Placebo for Patients With High-risk Localized Prostate Cancer

Prostate Cancer, Prostate Adenocarcinoma Phase 2 Interventional 90 participants sought
University of Chicago Comprehensive Cancer Center — Chicago, Illinois (2.1 mi) · Sponsor: University of Chicago
See eligibility & contact on ClinicalTrials.gov (NCT05726292)

Understanding How Powered Componentry Impacts K2-Level Transfemoral Amputee Gait

Amputation, Amputation, Traumatic N/A Interventional 20 participants sought
Shirley Ryan AbilityLab — Chicago, Illinois (2.1 mi) · Sponsor: Shirley Ryan AbilityLab
See eligibility & contact on ClinicalTrials.gov (NCT06433648)

APPROVE Trial: Evaluating a Prescription Digital Therapeutic for Treatment of OAB in Women

Overactive Bladder (OAB), Urinary Urgency N/A Interventional 596 participants sought
University of Chicago — Chicago, Illinois (2.1 mi) · Sponsor: Medstar Health Research Institute
See eligibility & contact on ClinicalTrials.gov (NCT06797245)

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

PIK3CA Mutation, HER2- Negative Breast Cancer Phase 3 Interventional 540 participants sought
Rush University Medical Center — Chicago, Illinois (2.1 mi) · Sponsor: Relay Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06982521)

Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design

Fibromyalgia Phase 3 Interventional 620 participants sought
Clinical Research Site — Chicago, Illinois (2.1 mi) · Sponsor: Axsome Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07398417)

Waveform Capnography Compared to Colorimetric Carbon Dioxide Detection During Tracheal Intubation of Critically Ill Adults

Acute Respiratory Failure N/A Observational 2,092 participants sought
Rush University Medical Center — Chicago, Illinois (2.1 mi) · Sponsor: Brian Driver
See eligibility & contact on ClinicalTrials.gov (NCT06934876)

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Endometrial Cancer Phase 3 Interventional 600 participants sought
Research Site — Evanston, Illinois (14.1 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06989112)

Moon and Sun Brothers: A Community Prevention Intervention (Hermanos de Luna y Sol)

Help-Seeking Behavior, Pre-exposure Prophylaxis Use N/A Interventional 360 participants sought
Chicago Queer Latine Collaborative — Chicago, Illinois (2.1 mi) · Sponsor: San Francisco State University
See eligibility & contact on ClinicalTrials.gov (NCT07475702)

A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression

Depressive Disorder, Treatment-Resistant Phase 3 Interventional 348 participants sought
Psychiatric Medicine Associates LLC — Skokie, Illinois (13.7 mi) · Sponsor: Janssen Research & Development, LLC
See eligibility & contact on ClinicalTrials.gov (NCT07716098)

Study Evaluating the Safety and Efficacy of Neffy or Intramuscular Adrenalin in Patients With Allergic Reactions After Oral Food Challenge or Allergen Immunotherapy

Allergic Reactions Phase 4 Interventional 600 participants sought
Endeavor Health — Glenview, Illinois (16.9 mi) · Sponsor: ARS Pharmaceuticals, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06834165)

Medical Management With Endovascular Thrombectomy Versus Medical Management Alone in Patients Presenting Beyond 24 Hours of Last Known Well

Acute Ischemic Stroke N/A Interventional 408 participants sought
University of Chicago — Chicago, Illinois (2.1 mi) · Sponsor: Amrou Sarraj
See eligibility & contact on ClinicalTrials.gov (NCT07115940)

Assessing the Effects of Corn and Avocado Oils on the Cardiometabolic Risk Factor Profile

Hypercholesterolemia N/A Interventional 54 participants sought
Biofortis Clinical Research — Addison, Illinois (16.9 mi) · Sponsor: Midwest Center for Metabolic and Cardiovascular Research
See eligibility & contact on ClinicalTrials.gov (NCT07514663)
Actively enrolling

Studies you may be able to join near Chicago

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research studies for chronic kidney disease

This research platform is enrolling Black and African American adults in eligible areas who have been diagnosed with chronic kidney disease. Compensation may be available. The study team confirms eligibility before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Chicago

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Chicago Clinical Research Institute, Inc.

★ 5.0
611 W Roosevelt Rd, Chicago, IL 60607
(312) 823-6800

Cedar Crosse Research Center

★ 3.0
800 S Wells St Ste M-15, Chicago, IL 60607
(312) 431-6780
"A total waste of time I received a $10 amazon gift and reimbursed for travel $5 and didn't get selected for the study. 🙁"
— Ed White, 1★

Next Innovative Clinical Research

★ 5.0
Behind Chase Bank, 337 E 35th St, Chicago, IL 60616
(773) 825-3370
"This company was truly life-changing for my battle with fibroids. Their clinical trial helped ease both my pain and stress and helped me learn about …"
— Destiny Green, 5★

All of Us Research Program at University of Illinois

★ 5.0
Clinical Sciences Building, 840 S Wood St Ste 148, Chicago, IL 60612
(312) 996-2778

DM Clinical Research—Chicago

★ 4.3
1111 Superior St #306, Melrose Park, IL 60160
(708) 616-1313
"INCREDIBLE PPL ACROSS THE BOARD......A FEEL GOOD EXPERIENCE IN MELROSE PARK ON SUPERIOR.......I JUST COMPLETED MY COVID PROGRAM MAY 12 2026 . THIS…"
— Warren Roesner, 5★

Atlantia Clinical Trials USA

★ 5.0
142 E Ontario St #1200, Chicago, IL 60611
(312) 535-9440
"Caitlin is an absolute Rockstar...compassionate , welcoming, skilled and knowledgeable. She made my first experience with a clinical trial so excitin…"
— ZLS, 5★

Flourish Research - Chicago (Andersonville)

★ 3.7
5149 N Ashland Ave, Chicago, IL 60640
(312) 931-8883
"Wonderful experience, super friendly and professional staff.<br>Lucia has followed up and answered all questions, and everyone along the way has been…"
— Kaitlyn Santoro, 5★

Institute for Health Research & Policy

★ 5.0
1747 W Roosevelt Rd, Chicago, IL 60608
(312) 996-7222

Robert H. Lurie Medical Research Center

★ 4.9
303 E Superior St, Chicago, IL 60611
(312) 908-5250
"Very new & modern! Great large lecture halls & some good food spots as well. Lots of places to study with great sunlight."
— David Parkinson, 5★

Clinical trials in Chicago: what's recruiting

The Chicago area currently has 2,448 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Chicago, the most active research areas are:

  • Cancer & Oncology6 studies
  • Heart & Vascular2 studies
  • Diabetes & Metabolism1 studies
  • Immune & Skin1 studies
  • Lungs & Breathing1 studies

Every listing shows the study phase, the recruiting site and its distance from Chicago, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Chicago

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Chicago participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Chicago pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
What is the difference between a research center and a hospital study in Chicago?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Chicago?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Chicago.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Chicago typically complete one or two studies per year.

Paid clinical trials near Chicago

Other metros within reach

Naperville, IL2,362 Joliet, IL514 Aurora, IL614 Round Lake Beach, IL472 Milwaukee, WI694 South Bend, IN110 Rockford, IL113 Lafayette, IN37

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Chicago Chronic Kidney Disease (HealthMatch) in Chicago Bladder Issues Due To Spinal Cord Injury in Chicago All conditions

More of IL

Naperville2,362 Aurora614 Joliet514 Round Lake Beach472 Peoria219 Springfield188 Champaign169 Rockford113

New paid studies open every week

Get an email when a new clinical trial starts recruiting within 30 miles of your ZIP code. No spam — only real studies from the NIH registry.

By subscribing you agree to receive study alert emails. Unsubscribe anytime in one click.

Get free trial alerts