Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/IL/Naperville
Updated September 2026 from ClinicalTrials.gov

Paid Clinical Trials in Naperville, IL

Studies commonly pay $75 to $4,500 per completed study

2,351 clinical trials are currently recruiting participants within 30 miles of Naperville. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

2,351studies recruiting
9+research centers nearby
6condition categories
Live from the NIH registry

Studies recruiting near Naperville right now

Top 25 of 2,351 recruiting studies, sorted by proximity — each links to its official registry page

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

High Grade Glioma, Diffuse Intrinsic Pontine Glioma Phase 2 Interventional 120 participants sought
Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois (27.5 mi) · Sponsor: Nationwide Children's Hospital
See eligibility & contact on ClinicalTrials.gov (NCT05096481)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Advocate Children's Hospital-Oak Lawn — Oak Lawn, Illinois (21.2 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Lymphoma, Large B-Cell, Diffuse Phase 2 Interventional 594 participants sought
University of Chicago Medical Center ( Site 0126) — Chicago, Illinois (27.5 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06890884)

GATEWAY: Safety Evaluation of the MiniMed™ NMX8-AID System in Children and Adults Living With Diabetes

Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus N/A Interventional 400 participants sought
Northwestern University — Chicago, Illinois (27.5 mi) · Sponsor: Medtronic MiniMed, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07228117)

One-Time DNA Study for Vasculitis

Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Giant Cell Arteritis N/A Observational 1,000 participants sought
Northwestern University — Chicago, Illinois (27.5 mi) · Sponsor: University of Pennsylvania
See eligibility & contact on ClinicalTrials.gov (NCT01241305)

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

Lymphoma, Non-Hodgkin, Multiple Myeloma Phase 2 Interventional 4,200 participants sought
Cancer Treatment Centers of America-Chicago — Chicago, Illinois (27.5 mi) · Sponsor: American Society of Clinical Oncology
See eligibility & contact on ClinicalTrials.gov (NCT02693535)

A Study of Enzalutamide Plus the Glucocorticoid Receptor Antagonist Relacorilant Versus Placebo for Patients With High-risk Localized Prostate Cancer

Prostate Cancer, Prostate Adenocarcinoma Phase 2 Interventional 90 participants sought
University of Chicago Comprehensive Cancer Center — Chicago, Illinois (27.5 mi) · Sponsor: University of Chicago
See eligibility & contact on ClinicalTrials.gov (NCT05726292)

Understanding How Powered Componentry Impacts K2-Level Transfemoral Amputee Gait

Amputation, Amputation, Traumatic N/A Interventional 20 participants sought
Shirley Ryan AbilityLab — Chicago, Illinois (27.5 mi) · Sponsor: Shirley Ryan AbilityLab
See eligibility & contact on ClinicalTrials.gov (NCT06433648)

APPROVE Trial: Evaluating a Prescription Digital Therapeutic for Treatment of OAB in Women

Overactive Bladder (OAB), Urinary Urgency N/A Interventional 596 participants sought
University of Chicago — Chicago, Illinois (27.5 mi) · Sponsor: Medstar Health Research Institute
See eligibility & contact on ClinicalTrials.gov (NCT06797245)

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)

Ulcerative Colitis Phase 2 Interventional 224 participants sought
University of Chicago Medical Center — Chicago, Illinois (27.5 mi) · Sponsor: Genentech, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06979336)

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

PIK3CA Mutation, HER2- Negative Breast Cancer Phase 3 Interventional 540 participants sought
Rush University Medical Center — Chicago, Illinois (27.5 mi) · Sponsor: Relay Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06982521)

Implementing a Decision Support Tool to Prevent Community-Acquired Pressure Injury in Spinal Cord Injury (SCI) in the Spinal Cord Injury Clinic

Spinal Cord Injury, Pressure Injury N/A Interventional 808 participants sought
Edward Hines Jr. VA Hospital, Hines, IL — Hines, Illinois (18.3 mi) · Sponsor: VA Office of Research and Development
See eligibility & contact on ClinicalTrials.gov (NCT06529094)

BMS-986489 (Atigotatug + Nivolumab) vs Durvalumab in Limited-stage Small-cell Lung Cancer (TIGOS-LS)

Limited Stage Small Cell Lung Cancer Phase 2 Interventional 250 participants sought
Illinois Cancer Specialists — Arlington Heights, Illinois (25.4 mi) · Sponsor: SCRI Development Innovations, LLC
See eligibility & contact on ClinicalTrials.gov (NCT06773910)

Waveform Capnography Compared to Colorimetric Carbon Dioxide Detection During Tracheal Intubation of Critically Ill Adults

Acute Respiratory Failure N/A Observational 2,092 participants sought
Rush University Medical Center — Chicago, Illinois (27.5 mi) · Sponsor: Brian Driver
See eligibility & contact on ClinicalTrials.gov (NCT06934876)

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Endometrial Cancer Phase 3 Interventional 600 participants sought
Research Site — Arlington Heights, Illinois (25.4 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06989112)

Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

Urothelial Cancer, Bladder Cancer Phase 2, Phase 3 Interventional 630 participants sought
Research Site — Niles, Illinois (26.4 mi) · Sponsor: Daiichi Sankyo
See eligibility & contact on ClinicalTrials.gov (NCT07129993)

A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression

Depressive Disorder, Treatment-Resistant Phase 3 Interventional 348 participants sought
Psychiatric Medicine Associates LLC — Skokie, Illinois (29.7 mi) · Sponsor: Janssen Research & Development, LLC
See eligibility & contact on ClinicalTrials.gov (NCT07716098)
Actively enrolling

Studies you may be able to join near Naperville

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research studies for chronic kidney disease

This research platform is enrolling Black and African American adults in eligible areas who have been diagnosed with chronic kidney disease. Compensation may be available. The study team confirms eligibility before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Naperville

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Bioluminux Clinical Research Illinois

Brom Medical Center, 720 Brom Dr Ste 205, Naperville, IL 60540
(331) 401-5117

Endeavor Health Linden Oaks Hospital

★ 2.5 (257 reviews)
852 S West St, Naperville, IL 60540
(847) 432-5464
"If I could give them zero stars I would! Don’t send your alcoholic loved ones here they load them up on prescription pills and send them home with a …"
— Rose, 1★

Midwest Cardiovascular Institute

★ 4.8
10 W Martin Ave Ste 200, Naperville, IL 60540
(630) 600-0700
"PA Sonal was kind, informative, and thorough. She listened to me, answered my questions, created an acceptable plan. She was genuinely interested …"
— Lee Ann Olson, 5★

DM Clinical Research—Chicago

★ 4.3
1111 Superior St #306, Melrose Park, IL 60160
(708) 616-1313
"INCREDIBLE PPL ACROSS THE BOARD......A FEEL GOOD EXPERIENCE IN MELROSE PARK ON SUPERIOR.......I JUST COMPLETED MY COVID PROGRAM MAY 12 2026 . THIS…"
— Warren Roesner, 5★

AMR Clinical

★ 4.4
2001 Midwest Rd Ste 305, Oak Brook, IL 60523
(630) 491-1900
"I've been coming to the AMR clinic for about 3 yrs and the staff and doctors are amazing. I especially want to thank Laura, she always go above and b…"
— Jennifer Henderson, 5★

Avicenna Clinical Research

★ 4.9
9912 SW Hwy, Oak Lawn, IL 60453
(708) 575-5535
"Joy Jibunoh was very professional and knowledgeable!! Showed great patience when asking questions with clarity!"
— tony torres, 5★

Lemah Creek Clinical Research

17W715 Butterfield Rd E, Oakbrook Terrace, IL 60181
(708) 274-1577

Biofortis Research

★ 4.6
800A S Rohlwing Rd, Addison, IL 60101
(630) 617-2000
"Amazing staff, always helpful,<br><br>And Plenty of free parking!"
— DJ HVargas, 5★

Fox Valley Clinical Research Center

1320 N Highland Ave Ste A, Aurora, IL 60506
(630) 723-3487

Clinical trials in Naperville: what's recruiting

The Naperville area currently has 2,351 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Naperville, the most active research areas are:

  • Cancer & Oncology10 studies
  • Heart & Vascular2 studies
  • Brain & Mental Health2 studies
  • Immune & Skin2 studies
  • Diabetes & Metabolism1 studies

Every listing shows the study phase, the recruiting site and its distance from Naperville, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Naperville

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Naperville participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Are clinical trials in Naperville safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Naperville, IL?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
How often do new paid studies open in Naperville?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Naperville.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Naperville typically complete one or two studies per year.

Paid clinical trials near Naperville

Other metros within reach

Aurora, IL614 Joliet, IL514 Chicago, IL2,437 Round Lake Beach, IL466 Rockford, IL110 Milwaukee, WI698 Champaign, IL168 Peoria, IL219

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Naperville Chronic Kidney Disease (HealthMatch) in Naperville Bladder Issues Due To Spinal Cord Injury in Naperville All conditions

More of IL

Chicago2,437 Aurora614 Joliet514 Round Lake Beach466 Peoria219 Springfield181 Champaign168 Rockford110

New paid studies open every week

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