Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only

Home/IL/Springfield

Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Springfield, IL

Studies commonly pay $75 to $4,500 per completed study

188 clinical trials are currently recruiting participants within 30 miles of Springfield. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

188studies recruiting

3+research centers nearby

5condition categories

Live from the NIH registry

Studies recruiting near Springfield right now

Top 25 of 188 recruiting studies, sorted by proximity — each links to its official registry page

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

Smoldering Plasma Cell Myeloma Phase 3 Interventional 288 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: ECOG-ACRIN Cancer Research Group

See eligibility & contact on ClinicalTrials.gov (NCT03937635)

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm Phase 2 Interventional 2,000 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT05564390)

Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction, Concentric Hypertrophy N/A Interventional 105 participants sought

Prairie Education and Research Cooperative-St. John's — Springfield, Illinois (2.2 mi) · Sponsor: Medtronic Cardiac Rhythm and Heart Failure

See eligibility & contact on ClinicalTrials.gov (NCT05839730)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT06124157)

Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8 Phase 3 Interventional 356 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: NRG Oncology

See eligibility & contact on ClinicalTrials.gov (NCT06958328)

LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis

Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate Phase 2 Interventional 1,431 participants sought

Springfield Clinic - First — Springfield, Illinois (2.2 mi) · Sponsor: Eli Lilly and Company

See eligibility & contact on ClinicalTrials.gov (NCT07415044)

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 189 participants sought

Central Illinois Hematology Oncology Center — Springfield, Illinois (2.2 mi) · Sponsor: ECOG-ACRIN Cancer Research Group

See eligibility & contact on ClinicalTrials.gov (NCT02734537)

Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

Malignant Female Reproductive System Neoplasm, Malignant Solid Neoplasm Phase 2 Interventional 70 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT06126276)

Collection of Research Data and Samples From Patients Who Experience Immunotherapy Side Effects

Malignancy N/A Observational 240 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: Alliance for Clinical Trials in Oncology

See eligibility & contact on ClinicalTrials.gov (NCT04242095)

Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment

Plasma Cell Myeloma Phase 3 Interventional 510 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: SWOG Cancer Research Network

See eligibility & contact on ClinicalTrials.gov (NCT05561387)

High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

Head and Neck Squamous Cell Carcinoma, Stage I Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8 Phase 3 Interventional 228 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: Alliance for Clinical Trials in Oncology

See eligibility & contact on ClinicalTrials.gov (NCT06992427)

Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

Classic Follicular Lymphoma, Follicular Lymphoma With Unusual Cytological Features Phase 3 Interventional 600 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT06337318)

A Phase 2b Clinical Trial of YN001 in Adults With Coronary Atherosclerosis

Atherosclerosis, Coronary Artery Disease Phase 2 Interventional 456 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: Beijing Inno Medicine Co., Ltd.

See eligibility & contact on ClinicalTrials.gov (NCT07521007)

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8 Phase 3 Interventional 1,209 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: NRG Oncology

See eligibility & contact on ClinicalTrials.gov (NCT05946213)

A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

Anaplastic Kidney Wilms Tumor, Recurrent Kidney Wilms Tumor Phase 2 Interventional 256 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: Children's Oncology Group

See eligibility & contact on ClinicalTrials.gov (NCT04322318)

A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

High Grade Osteosarcoma, Localized Osteosarcoma Phase 2, Phase 3 Interventional 1,122 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT05691478)

Efficacy of Simbrinza and Rocklatan vs Cosopt and Latanoprost

Open Angle Glaucoma Phase 4 Interventional 70 participants sought

Prairie Eye Center — Springfield, Illinois (2.2 mi) · Sponsor: Prairie Eye Center

See eligibility & contact on ClinicalTrials.gov (NCT06883123)

Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors

Colorectal Cancer Stage II, Colorectal Cancer Stage III Phase 3 Interventional 1,057 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: SWOG Cancer Research Network

See eligibility & contact on ClinicalTrials.gov (NCT07018869)

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

Atherosclerotic Cardiovascular Disease, Overweight Phase 3 Interventional 12,800 participants sought

Prarie Education and Research — Springfield, Illinois (2.2 mi) · Sponsor: Amgen

See eligibility & contact on ClinicalTrials.gov (NCT07037433)

Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

Advanced Endometrial Carcinoma, Recurrent Endometrial Carcinoma Phase 3 Interventional 255 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT07198074)

Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma

Lymphoplasmacytic Lymphoma, Waldenstrom Macroglobulinemia Phase 2 Interventional 92 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT04840602)

A Study to Test the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures

Stereotypical Prolonged Seizures Phase 3 Interventional 350 participants sought

Ep0162 50375 — Springfield, Illinois (2.2 mi) · Sponsor: UCB Biopharma SRL

See eligibility & contact on ClinicalTrials.gov (NCT05077904)

Nephroureterectomy With and Without Lymph Node Dissection for Upper Tract Urothelial Cell Carcinoma

Urothelial Carcinoma N/A Interventional 94 participants sought

Southern Illinois University — Springfield, Illinois (2.2 mi) · Sponsor: Case Comprehensive Cancer Center

See eligibility & contact on ClinicalTrials.gov (NCT06262516)

THRIVE- THerapeutic IntravasculaR Ultrasound (TIVUS™) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension

Hypertension N/A Interventional 261 participants sought

St. John's Prairie Heart — Springfield, Illinois (2.2 mi) · Sponsor: SoniVie Inc.

See eligibility & contact on ClinicalTrials.gov (NCT06559891)

Rural Illinois Lung Cancer Screening Initiative

Lung Cancer N/A Observational 10,000 participants sought

Sowmy Thuppal — Springfield, Illinois (2.2 mi) · Sponsor: Southern Illinois University

See eligibility & contact on ClinicalTrials.gov (NCT06084078)

Actively enrolling

Studies you may be able to join near Springfield

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Google-rated

Top-rated research centers in Springfield

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Behavioral Health Center of Illinois

★ 4.0 (15 reviews)

1220 S 7th St, Springfield, IL 62703

(217) 679-5379

Website

"Started off as a 4 star review. After going here for a while to see Brittany it was a mutual decision there wasn't much point to keep going. Brittany…"

— Brett R, 1★

SIU Medicine Smith Alzheimer's Center

★ 5.0

751 N Rutledge St Rm 3100, Springfield, IL 62702

(217) 545-8000

Website

"The activity day at Duncan Park was a wonderful way to engage everyone. The live music was a nice touch as it really encouraged dancing and singing …"

— Daren Perrero, 5★

SIU Medicine Simmons Cancer Institute

★ 4.4

315 W Carpenter St, Springfield, IL 62702

(217) 545-8000

Website

Clinical trials in Springfield: what's recruiting

The Springfield area currently has 188 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Springfield, the most active research areas are:

Cancer & Oncology17 studies
Heart & Vascular3 studies
Immune & Skin1 studies
Liver & Kidney1 studies
Diabetes & Metabolism1 studies

Every listing shows the study phase, the recruiting site and its distance from Springfield, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Springfield

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Springfield participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Springfield pay?

Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.

Do I need to be sick to join a clinical trial in Springfield?

No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.

How do I join a study in Springfield, IL?

Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.

How often do new paid studies open in Springfield?

Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Springfield.

Can I be in more than one clinical trial at a time?

Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Springfield typically complete one or two studies per year.

Paid clinical trials near Springfield

Other metros within reach

Peoria, IL219 St. Louis, MO1,490 Champaign, IL169 Davenport, IA41 Joliet, IL514 Aurora, IL614 Naperville, IL2,362 Rockford, IL113

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Springfield Bladder Issues Due To Spinal Cord Injury in Springfield All conditions

More of IL

Chicago2,448 Naperville2,362 Aurora614 Joliet514 Round Lake Beach472 Peoria219 Champaign169 Rockford113

New paid studies open every week

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