Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only

Home/IL/Springfield

Updated October 2026 from ClinicalTrials.gov

Paid Clinical Trials in Springfield, IL

Studies commonly pay $75 to $4,500 per completed study

188 clinical trials are currently recruiting participants within 30 miles of Springfield. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

188studies recruiting

3+research centers nearby

4condition categories

Live from the NIH registry

Studies recruiting near Springfield right now

Top 25 of 188 recruiting studies, sorted by proximity — each links to its official registry page

Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction, Concentric Hypertrophy N/A Interventional 105 participants sought

Prairie Education and Research Cooperative-St. John's — Springfield, Illinois (2.2 mi) · Sponsor: Medtronic Cardiac Rhythm and Heart Failure

See eligibility & contact on ClinicalTrials.gov (NCT05839730)

Oral Iron Supplementation on Alternate vs. Consecutive Days for Iron Deficiency Anemia in Pregnancy

Iron-deficiency Anemia (IDA), Pregnancy Phase 4 Interventional 120 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: Southern Illinois University

See eligibility & contact on ClinicalTrials.gov (NCT06492512)

RENAISSANCE 2: SPN-817 Phase 2, Double-Blind, Placebo-Controlled Study in Adults With Focal Onset Seizures

Focal Onset Seizures Phase 2 Interventional 216 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: Supernus Pharmaceuticals, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT06798896)

Efficacy and Safety of 186 mcg of OPN-375 Nasal Spray Twice a Day (BID) in Adolescents With Chronic Rhinosinusitis Without Nasal Polyps

Chronic Rhinosinusitis Without Nasal Polyps Phase 3 Interventional 84 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: Optinose US Inc.

See eligibility & contact on ClinicalTrials.gov (NCT06850805)

LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis

Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate Phase 2 Interventional 1,431 participants sought

Springfield Clinic - First — Springfield, Illinois (2.2 mi) · Sponsor: Eli Lilly and Company

See eligibility & contact on ClinicalTrials.gov (NCT07415044)

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

Biochemically Recurrent Prostate Carcinoma, Metastatic Prostate Carcinoma Phase 3 Interventional 804 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: ECOG-ACRIN Cancer Research Group

See eligibility & contact on ClinicalTrials.gov (NCT04423211)

Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

Metastatic Clear Cell Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma Phase 3 Interventional 364 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: SWOG Cancer Research Network

See eligibility & contact on ClinicalTrials.gov (NCT04510597)

Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early Stage Non-small Cell Lung Cancer From Returning, AASI-NSCLC Trial

Lung Non-Small Cell Carcinoma Phase 3 Interventional 336 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT07388524)

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

Low Grade Astrocytoma, Low Grade Glioma Phase 3 Interventional 170 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT04166409)

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Ovarian Carcinoma N/A Interventional 1,956 participants sought

Springfield Clinic — Springfield, Illinois (2.2 mi) · Sponsor: NRG Oncology

See eligibility & contact on ClinicalTrials.gov (NCT04251052)

Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program

Cigarette Smoking-Related Carcinoma Phase 3 Interventional 600 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: Alliance for Clinical Trials in Oncology

See eligibility & contact on ClinicalTrials.gov (NCT05008848)

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma Phase 3 Interventional 247 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT04269902)

ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

Cardiovascular Risk, Acute Myocardial Infarction (AMI) Phase 3 Interventional 10,000 participants sought

Prairie Cardiovascular Consultants, Ltd. — Springfield, Illinois (2.2 mi) · Sponsor: Novo Nordisk A/S

See eligibility & contact on ClinicalTrials.gov (NCT06118281)

Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

Advanced Endometrial Carcinoma, Recurrent Endometrial Carcinoma Phase 3 Interventional 255 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT07198074)

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia Phase 1, Phase 2 Interventional 960 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: PedAL BCU, LLC

See eligibility & contact on ClinicalTrials.gov (NCT04726241)

Efficacy of Simbrinza and Rocklatan vs Cosopt and Latanoprost

Open Angle Glaucoma Phase 4 Interventional 70 participants sought

Prairie Eye Center — Springfield, Illinois (2.2 mi) · Sponsor: Prairie Eye Center

See eligibility & contact on ClinicalTrials.gov (NCT06883123)

Renal Pelvic Denervation Pilot Trial

Uncontrolled Hypertension N/A Interventional 60 participants sought

SIU School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: Verve Medical, Inc

See eligibility & contact on ClinicalTrials.gov (NCT07005050)

A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

High Grade Osteosarcoma, Localized Osteosarcoma Phase 2, Phase 3 Interventional 1,122 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT05691478)

Rural Illinois Lung Cancer Screening Initiative

Lung Cancer N/A Observational 10,000 participants sought

Sowmy Thuppal — Springfield, Illinois (2.2 mi) · Sponsor: Southern Illinois University

See eligibility & contact on ClinicalTrials.gov (NCT06084078)

Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

Classic Follicular Lymphoma, Follicular Lymphoma With Unusual Cytological Features Phase 3 Interventional 600 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT06337318)

A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

Heart Failure Phase 3 Interventional 4,200 participants sought

Springfield Clinic — Springfield, Illinois (2.2 mi) · Sponsor: Boehringer Ingelheim

See eligibility & contact on ClinicalTrials.gov (NCT06935370)

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer

Colorectal Cancer, Sarcopenia N/A Observational 300 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: Wake Forest University Health Sciences

See eligibility & contact on ClinicalTrials.gov (NCT03998202)

Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)

Myelodysplastic Syndrome Phase 2 Interventional 54 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT06577441)

A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)

Metastatic Colorectal Cancer Phase 3 Interventional 1,020 participants sought

Springfield Clinic — Springfield, Illinois (2.2 mi) · Sponsor: EMD Serono Research & Development Institute, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT07549412)

Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors

Malignant Solid Neoplasm N/A Observational 2,062 participants sought

Southern Illinois University School of Medicine — Springfield, Illinois (2.2 mi) · Sponsor: SWOG Cancer Research Network

See eligibility & contact on ClinicalTrials.gov (NCT04871542)

Actively enrolling

Studies you may be able to join near Springfield

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Google-rated

Top-rated research centers in Springfield

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Behavioral Health Center of Illinois

★ 4.0 (15 reviews)

1220 S 7th St, Springfield, IL 62703

(217) 679-5379

Website

"Started off as a 4 star review. After going here for a while to see Brittany it was a mutual decision there wasn't much point to keep going. Brittany…"

— Brett R, 1★

SIU Medicine Smith Alzheimer's Center

★ 5.0

751 N Rutledge St Rm 3100, Springfield, IL 62702

(217) 545-8000

Website

"The activity day at Duncan Park was a wonderful way to engage everyone. The live music was a nice touch as it really encouraged dancing and singing …"

— Daren Perrero, 5★

SIU Medicine Simmons Cancer Institute

★ 4.4

315 W Carpenter St, Springfield, IL 62702

(217) 545-8000

Website

Clinical trials in Springfield: what's recruiting

The Springfield area currently has 188 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Springfield, the most active research areas are:

Cancer & Oncology15 studies
Heart & Vascular4 studies
Immune & Skin1 studies
Liver & Kidney1 studies

Every listing shows the study phase, the recruiting site and its distance from Springfield, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Springfield

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Springfield participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Springfield pay?

Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.

Do I need to be sick to join a clinical trial in Springfield?

No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.

How do I join a study in Springfield, IL?

Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.

How often do new paid studies open in Springfield?

Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Springfield.

Can I be in more than one clinical trial at a time?

Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Springfield typically complete one or two studies per year.

Paid clinical trials near Springfield

Other metros within reach

Peoria, IL217 St. Louis, MO1,510 Champaign, IL173 Davenport, IA47 Joliet, IL515 Aurora, IL615 Naperville, IL2,359 Rockford, IL112

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Springfield Bladder Issues Due To Spinal Cord Injury in Springfield All conditions

More of IL

Chicago2,443 Naperville2,359 Aurora615 Joliet515 Round Lake Beach469 Peoria217 Champaign173 Rockford112

New paid studies open every week

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