Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/MO/St. Louis
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in St. Louis, MO

Studies commonly pay $75 to $4,500 per completed study

1,490 clinical trials are currently recruiting participants within 30 miles of St. Louis. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

1,490studies recruiting
9+research centers nearby
4condition categories
Live from the NIH registry

Studies recruiting near St. Louis right now

Top 25 of 1,490 recruiting studies, sorted by proximity — each links to its official registry page

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
Mercy Infusion Center - Chippewa — St Louis, Missouri (2.6 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

High Grade Glioma, Diffuse Intrinsic Pontine Glioma Phase 2 Interventional 120 participants sought
St. Louis Children's Hospital — St Louis, Missouri (2.6 mi) · Sponsor: Nationwide Children's Hospital
See eligibility & contact on ClinicalTrials.gov (NCT05096481)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Washington University School of Medicine — St Louis, Missouri (2.6 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

PIK3CA Mutation, HER2- Negative Breast Cancer Phase 3 Interventional 540 participants sought
Washington University School of Medicine- Siteman Cancer Center — St Louis, Missouri (2.6 mi) · Sponsor: Relay Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06982521)

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

Solid Tumor, Adult, Metastatic Breast Cancer Phase 1 Interventional 392 participants sought
Washington University School of Medicine — St Louis, Missouri (2.6 mi) · Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)
See eligibility & contact on ClinicalTrials.gov (NCT06625775)

A Phase II Platform Study to Evaluate Treatment With Cemiplimab Monotherapy or Cemiplimab Plus Fianlimab or Other Novel Combinations in Patients With Colorectal Cancer With Minimal Residual Disease Following Definitive Surgery and Chemotherapy (EMPIRE)

Colo-rectal Cancer Phase 2 Interventional 79 participants sought
Missouri Baptist — St Louis, Missouri (2.6 mi) · Sponsor: NSABP Foundation Inc
See eligibility & contact on ClinicalTrials.gov (NCT07058012)

Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

Urothelial Cancer, Bladder Cancer Phase 2, Phase 3 Interventional 630 participants sought
Research Site — St Louis, Missouri (2.6 mi) · Sponsor: Daiichi Sankyo
See eligibility & contact on ClinicalTrials.gov (NCT07129993)

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

Carcinoma, Transitional Cell, Urinary Bladder Neoplasms Phase 3 Interventional 450 participants sought
Washington University School of Medicine — St Louis, Missouri (2.6 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT07218380)

A Study to Evaluate the Efficacy of Cemsidomide + Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma

Multiple Myeloma, Relapsed/Refractory Multiple Myeloma Phase 2 Interventional 100 participants sought
Washington University/Siteman Cancer Center — St Louis, Missouri (2.6 mi) · Sponsor: C4 Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07284758)

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Neovascular Age-related Macular Degeneration Phase 4 Interventional 188 participants sought
Midwest Vision Research Foundation — Chesterfield, Missouri (18.0 mi) · Sponsor: Genentech, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04853251)

First in Human Study to Evaluate AZD9793 in Participants With Advanced or Metastatic Solid Tumours

Hepatocellular Carcinoma Phase 1, Phase 2 Interventional 304 participants sought
Research Site — St Louis, Missouri (2.6 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06795022)

Phase 1a/b Study of ZL-6201 Safety, PK, and Preliminary Efficacy in Sarcoma and Selected Tumors

Solid Tumors, Sarcomas Phase 1 Interventional 180 participants sought
Zai Lab Site 02005 — St Louis, Missouri (2.6 mi) · Sponsor: Zai Lab (Shanghai) Co., Ltd.
See eligibility & contact on ClinicalTrials.gov (NCT07374848)

A Multicenter, Randomized, Vehicle-Controlled, Double-Masked to Open-Label Study to Evaluate the Safety and Efficacy of Lacripep in Subjects With Neurotrophic Keratitis

Neurotrophic Keratitis Phase 2 Interventional 54 participants sought
Ophthalmology Associates — St Louis, Missouri (2.6 mi) · Sponsor: TearSolutions, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07568730)

Study of AZD2389 Safety, Tolerability, and Pharmacodynamics in Adults With Steatotic Liver Disease and Advanced Fibrosis

Liver Fibrosis, Hepatic Cirrhosis Phase 2 Interventional 104 participants sought
Research Site — St Louis, Missouri (2.6 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT07610837)

A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy

Locally Advanced Head and Neck Squamous Cell Carcinoma Phase 3 Interventional 1,145 participants sought
Research Site — St Louis, Missouri (2.6 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06129864)

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Endometrial Cancer Phase 3 Interventional 600 participants sought
Research Site — St Louis, Missouri (2.6 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06989112)

Medical Management With Endovascular Thrombectomy Versus Medical Management Alone in Patients Presenting Beyond 24 Hours of Last Known Well

Acute Ischemic Stroke N/A Interventional 408 participants sought
Washington University School of Medicine — St Louis, Missouri (2.6 mi) · Sponsor: Amrou Sarraj
See eligibility & contact on ClinicalTrials.gov (NCT07115940)
Actively enrolling

Studies you may be able to join near St. Louis

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in St. Louis

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Clinical Research Training Center CRTC

★ 5.0
4950 Children's Pl, St. Louis, MO 63110
(314) 454-8960

Clinical Research Center

★ 4.3
969 N Mason Rd Ste 240, Creve Coeur, MO 63141
(314) 514-8509
"Great staff ... Doctor T ... BEST ... concerned for their patients. I have been in the various asthma studies over the years. Would recommend C…"
— W Joseph Gallagher, 5★

CRConcierge

1409 Washington Ave Ste 504, St. Louis, MO 63103

American Medical Research Center

★ 3.0
3737 Kingshighway Blvd, St. Louis, MO 63115
(314) 917-1682
"Contributing to research so that we can have new medicine for our disease!"
— Mohammed Nezam, 5★

Center for the Study of Itch

★ 3.0
St. Louis, MO 63110
(314) 362-8171

Saint Louis University Center for Vaccine Development

★ 4.3
1100 S Grand Blvd, St. Louis, MO 63104
(314) 977-6333
"I always find the staff very accommodating from front desk through to nurses/doctor. Have participated 3x in trials/studies. Have been glad to volu…"
— B Dodson, 5★

Center for Clinical Pharmacology

2 Pharmacy Place, St. Louis, MO 63110
(314) 367-8700

WashU Jeffrey T. Fort Neuroscience Research Building (Fort Labs)

★ 4.9
4370 Duncan Ave, St. Louis, MO 63110
(314) 362-3033
"Some of the best minds coming together in a state-of-the-art building."
— Jan Kubanek, 5★

Sundance Clinical Research

★ 4.8
711 Old Ballas Rd #105, St. Louis, MO 63141
(314) 567-3377
"This place is absolutely amazing. Staff is so knowledgeable. Customer care is on point, so professional. I think this is the best medical research ex…"
— Tiff Stockton, 5★

Clinical trials in St. Louis: what's recruiting

The St. Louis area currently has 1,490 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to St. Louis, the most active research areas are:

  • Cancer & Oncology13 studies
  • Heart & Vascular2 studies
  • Liver & Kidney2 studies
  • Immune & Skin1 studies

Every listing shows the study phase, the recruiting site and its distance from St. Louis, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in St. Louis

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

St. Louis participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in St. Louis pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
How do I join a study in St. Louis, MO?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
What is the difference between a research center and a hospital study in St. Louis?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in St. Louis typically complete one or two studies per year.

Paid clinical trials near St. Louis

Other metros within reach

Springfield, IL188 Columbia, MO253 Peoria, IL219 Champaign, IL169 Evansville, IN66 Davenport, IA41 Springfield, MO150 Memphis, TN580

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in St. Louis Bladder Issues Due To Spinal Cord Injury in St. Louis All conditions

More of MO

Kansas City1,018 Columbia253 Springfield150

New paid studies open every week

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