Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/MO/Springfield
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Springfield, MO

Studies commonly pay $75 to $4,500 per completed study

155 clinical trials are currently recruiting participants within 30 miles of Springfield. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

155studies recruiting
9+research centers nearby
6condition categories
Live from the NIH registry

Studies recruiting near Springfield right now

Top 25 of 155 recruiting studies, sorted by proximity — each links to its official registry page

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Endometrial Cancer Phase 3 Interventional 600 participants sought
Research Site — Springfield, Missouri (1.5 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06989112)

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

Carcinoma, Transitional Cell, Urinary Bladder Neoplasms Phase 3 Interventional 450 participants sought
Oncology Hematology Associates — Springfield, Missouri (1.5 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT07218380)

Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment

Plasma Cell Myeloma Phase 3 Interventional 510 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT05561387)

Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

Locally Advanced Lung Non-Small Cell Carcinoma, Stage IIB Lung Cancer AJCC v8 Phase 3 Interventional 474 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05624996)

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 189 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT02734537)

Study to Evaluate the Maximal Use of Ruxolitinib Cream in Adult and Adolescent Participants With Hidradenitis Suppurativa

Hidradenitis Suppurativa Phase 1 Interventional 24 participants sought
Red River Research Partners — Bolivar, Missouri (29.8 mi) · Sponsor: Incyte Corporation
See eligibility & contact on ClinicalTrials.gov (NCT07049575)

Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer

Metastatic Colorectal Cancer (CRC) Phase 3 Interventional 600 participants sought
Clinical Study Site — Springfield, Missouri (1.5 mi) · Sponsor: Summit Therapeutics
See eligibility & contact on ClinicalTrials.gov (NCT07228832)

A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine

Menstrual Migraine Phase 3 Interventional 723 participants sought
Clinvest Headlands Llc — Springfield, Missouri (1.5 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT06641466)

Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer

Miscellaneous Neoplasm, Nos, Non-Neoplastic Condition, Nos N/A Interventional 535 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT07091617)

A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).

Alzheimer Disease, Dementia Phase 3 Interventional 550 participants sought
Citizens Memorial Hospital District — Bolivar, Missouri (29.8 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT07602582)

Prospective Non-Interventional Study Comparing Osimertinib +/- Chemotherapy for EGFR-Mutated NSCLC Patients

Non Small Cell Lung Cancer, Epidermal Growth Factor Receptor Gene Mutation N/A Observational 538 participants sought
Mercy Clinic Springfield Communities — Springfield, Missouri (1.5 mi) · Sponsor: PrECOG, LLC.
See eligibility & contact on ClinicalTrials.gov (NCT06538038)

Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube High Grade Serous Adenocarcinoma Phase 3 Interventional 880 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06580314)

A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

Locally Advanced Solid Tumors, Metastatic Solid Tumors Phase 1, Phase 2 Interventional 500 participants sought
Local Institution - 2147 — Bolivar, Missouri (29.8 mi) · Sponsor: Turning Point Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT03093116)

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 188 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04671667)

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study

Muscle Invasive Bladder Urothelial Carcinoma, Stage II Bladder Cancer AJCC v8 Phase 3 Interventional 486 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT07097142)

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma, Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7 Phase 2, Phase 3 Interventional 613 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT01810913)

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8 Phase 3 Interventional 1,209 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05946213)

Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma

Mantle Cell Lymphoma Phase 3 Interventional 421 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05976763)

ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

Cardiovascular Risk, Acute Myocardial Infarction (AMI) Phase 3 Interventional 10,000 participants sought
Mercy Research — Springfield, Missouri (1.5 mi) · Sponsor: Novo Nordisk A/S
See eligibility & contact on ClinicalTrials.gov (NCT06118281)

S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

Anatomic Stage IV Breast Cancer AJCC v8, Estrogen Receptor Positive N/A Interventional 739 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03723928)

A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain

Osteoarthritis, Knee, Diabetic Neuropathic Pain Phase 2 Interventional 10,000 participants sought
Clinvest Research LLC — Springfield, Missouri (1.5 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT05986292)

Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

Advanced Breast Cancer Phase 3 Interventional 788 participants sought
Research Site — Springfield, Missouri (1.5 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06380751)
Actively enrolling

Studies you may be able to join near Springfield

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Springfield

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

QPS Study Campus

★ 3.3
1820 W Mt Vernon St, Springfield, MO 65802
(417) 831-2048
"I recently completed a 9 day confinement there and for the size group we had, I felt like the people working there were very organized and profession…"
— Andrew Dziedzic, 5★

Cancer Research for the Ozarks

★ 5.0
2115 S Fremont Ave Ste 3200, Springfield, MO 65804
(417) 269-4520
"I can state how helpful this group is to the community. Cancer is a horrible, and the kindness and help CRO offers to those in need is a wonderful th…"
— Vince Hamilton, 5★

DelRicht Research of Springfield Clinical Trials

★ 4.9
3238 S National Ave Ste B, Springfield, MO 65807
(417) 590-8383
"Been nothing but a pain. Found on an ad through Facebook. I filled out the form and the robot answering service told me they don't have any trials in…"
— Alice C, 2★

QPS Screening and Recruitment Center

★ 3.5
2025 W Sunshine St Ste L-109, Springfield, MO 65807
(417) 831-2048
"This place is a joke, they will not display all requirements for the study, and they will waste your time,<br>Took my blood multiple times, then had …"
— John Shepard, 1★

Clinvest Research

★ 4.6
909 E Republic Rd Bldg D 200, Springfield, MO 65807
(417) 883-7889
"Very informative and pleasant experience. Looking forward to my study here."
— Chris Mojonnier, 5★

BPVH Clinical Trials

★ 4.7
1255 E Independence St, Springfield, MO 65804
(417) 509-8961
"We participate in any trial that might help our pets and science."
— Gregg Bender, 5★

Lakeland Behavioral Health System - Residential

★ 1.9 (265 reviews)
440 S Market Ave, Springfield, MO 65806
(417) 895-9169
"I don't care what anyone says. This place helped me finally get the help I needed."
— Kenton Coonts, 5★

Sharlin Health Neuroscience Research Center

5508 N Farmer Branch Rd, Ozark, MO 65721
(417) 238-3301

Select Specialty Hospital - Springfield

★ 4.1
1630 E Primrose St, Springfield, MO 65804
(417) 885-4700
"I stayed here for several weeks recovering from surgery. Friendly and accommodating staff. The therapy team was great!"
— Lacey Elmer, 5★

Clinical trials in Springfield: what's recruiting

The Springfield area currently has 155 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Springfield, the most active research areas are:

  • Cancer & Oncology18 studies
  • Liver & Kidney1 studies
  • Brain & Mental Health1 studies
  • Heart & Vascular1 studies
  • Diabetes & Metabolism1 studies

Every listing shows the study phase, the recruiting site and its distance from Springfield, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Springfield

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Springfield participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Springfield pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in Springfield?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
How do I join a study in Springfield, MO?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
How often do new paid studies open in Springfield?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Springfield.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Springfield typically complete one or two studies per year.

Paid clinical trials near Springfield

Other metros within reach

Fayetteville, AR128 Columbia, MO256 Overland Park, KS1,023 Olathe, KS1,030 Kansas City, MO1,024 Kansas City, KS1,035 Little Rock, AR503 Tulsa, OK173

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Springfield Bladder Issues Due To Spinal Cord Injury in Springfield All conditions

More of MO

St. Louis1,476 Kansas City1,024 Columbia256

New paid studies open every week

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