Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/MO/Springfield
Updated October 2026 from ClinicalTrials.gov

Paid Clinical Trials in Springfield, MO

Studies commonly pay $75 to $4,500 per completed study

152 clinical trials are currently recruiting participants within 30 miles of Springfield. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

152studies recruiting
9+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Springfield right now

Top 25 of 152 recruiting studies, sorted by proximity — each links to its official registry page

A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

Non Small Cell Lung Cancer Phase 3 Interventional 768 participants sought
Hulston Cancer Center /ID# 232226 — Springfield, Missouri (1.5 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT04928846)

Study to Evaluate the Maximal Use of Ruxolitinib Cream in Adult and Adolescent Participants With Hidradenitis Suppurativa

Hidradenitis Suppurativa Phase 1 Interventional 24 participants sought
Red River Research Partners — Bolivar, Missouri (29.8 mi) · Sponsor: Incyte Corporation
See eligibility & contact on ClinicalTrials.gov (NCT07049575)

Sacituzumab Govitecan With Bevacizumab Compared to Usual Chemotherapy (Carboplatin, Pegylated Liposomal Doxorubicin and Bevacizumab) for Treating Recurrent Platinum-Sensitive Ovarian Cancer After PARP Inhibitor Maintenance Therapy

Recurrent Platinum-Sensitive Fallopian Tube Endometrioid Adenocarcinoma, Recurrent Platinum-Sensitive Fallopian Tube High Grade Serous Adenocarcinoma Phase 2 Interventional 87 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT07504588)

Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

Metastatic Clear Cell Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma Phase 3 Interventional 364 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT04510597)

Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial

Metastatic Colorectal Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8 Phase 2 Interventional 146 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05673148)

Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8 Phase 3 Interventional 3,680 participants sought
CoxHealth South Hospital — Springfield, Missouri (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06058377)

Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

Renal Pelvis and Ureter Urothelial Carcinoma Phase 2, Phase 3 Interventional 131 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04628767)

ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

Cardiovascular Risk, Acute Myocardial Infarction (AMI) Phase 3 Interventional 10,000 participants sought
Mercy Research — Springfield, Missouri (1.5 mi) · Sponsor: Novo Nordisk A/S
See eligibility & contact on ClinicalTrials.gov (NCT06118281)

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

Lung Non-Small Cell Carcinoma, Lung Non-Small Cell Squamous Carcinoma Phase 3 Interventional 1,210 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04267848)

This Study is a Non-interventional Disease Registry of Adolescent and Adult Patients With Atopic Dermatitis Who Initiate or Switch Any Systemic Treatment

Atopic Dermatitis N/A Observational 1,000 participants sought
Red River Research Partners, Llc- Site Number : 8400054 — Bolivar, Missouri (29.8 mi) · Sponsor: Sanofi
See eligibility & contact on ClinicalTrials.gov (NCT07290803)

Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

Locally Advanced Cervical Adenocarcinoma, Locally Advanced Cervical Adenosquamous Carcinoma Phase 3 Interventional 336 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT07061977)

A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease

Alzheimer's Disease Phase 2 Interventional 407 participants sought
Citizens Memorial Hospital Neurology CLinic — Bolivar, Missouri (29.8 mi) · Sponsor: Novartis Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT07094516)

Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design

Fibromyalgia Phase 3 Interventional 620 participants sought
Clinical Research Site — Springfield, Missouri (1.5 mi) · Sponsor: Axsome Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07398417)

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma, Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7 Phase 2, Phase 3 Interventional 613 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT01810913)

Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

Metastatic Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8 Phase 2 Interventional 240 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05327686)

Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study

Muscle Invasive Bladder Urothelial Carcinoma, Muscle Invasive Renal Pelvis Urothelial Carcinoma Phase 2, Phase 3 Interventional 992 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05987241)

Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia

B Acute Lymphoblastic Leukemia Phase 3 Interventional 303 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT03150693)

Real-world Experience of Catheter Ablation for the Treatment of Arrhythmias

Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation N/A Observational 20,000 participants sought
CoxHealth — Springfield, Missouri (1.5 mi) · Sponsor: Heart Rhythm Clinical and Research Solutions, LLC
See eligibility & contact on ClinicalTrials.gov (NCT04088071)

LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia

Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma N/A Observational 800 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: University of Rochester
See eligibility & contact on ClinicalTrials.gov (NCT06073431)

A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)

Cognitive Dysfunction, Lewy Body Disease Phase 2 Interventional 350 participants sought
Citizens Memorial Hospital District — Bolivar, Missouri (29.8 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT07589595)

A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)

Non-small Cell Lung Cancer Phase 3 Interventional 600 participants sought
Cox Medical Center North ( Site 0133) — Springfield, Missouri (1.5 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06345729)

Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancer

Resectable Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 Phase 3 Interventional 1,100 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06632327)
Actively enrolling

Studies you may be able to join near Springfield

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Springfield

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

QPS Study Campus

★ 3.3
1820 W Mt Vernon St, Springfield, MO 65802
(417) 831-2048
"I recently completed a 9 day confinement there and for the size group we had, I felt like the people working there were very organized and profession…"
— Andrew Dziedzic, 5★

Cancer Research for the Ozarks

★ 5.0
2115 S Fremont Ave Ste 3200, Springfield, MO 65804
(417) 269-4520
"I can state how helpful this group is to the community. Cancer is a horrible, and the kindness and help CRO offers to those in need is a wonderful th…"
— Vince Hamilton, 5★

DelRicht Research of Springfield Clinical Trials

★ 4.9
3238 S National Ave Ste B, Springfield, MO 65807
(417) 590-8383
"Been nothing but a pain. Found on an ad through Facebook. I filled out the form and the robot answering service told me they don't have any trials in…"
— Alice C, 2★

QPS Screening and Recruitment Center

★ 3.5
2025 W Sunshine St Ste L-109, Springfield, MO 65807
(417) 831-2048
"This place is a joke, they will not display all requirements for the study, and they will waste your time,<br>Took my blood multiple times, then had …"
— John Shepard, 1★

Clinvest Research

★ 4.6
909 E Republic Rd Bldg D 200, Springfield, MO 65807
(417) 883-7889
"Very informative and pleasant experience. Looking forward to my study here."
— Chris Mojonnier, 5★

BPVH Clinical Trials

★ 4.7
1255 E Independence St, Springfield, MO 65804
(417) 509-8961
"We participate in any trial that might help our pets and science."
— Gregg Bender, 5★

Lakeland Behavioral Health System - Residential

★ 1.9 (265 reviews)
440 S Market Ave, Springfield, MO 65806
(417) 895-9169
"I don't care what anyone says. This place helped me finally get the help I needed."
— Kenton Coonts, 5★

Sharlin Health Neuroscience Research Center

5508 N Farmer Branch Rd, Ozark, MO 65721
(417) 238-3301

Select Specialty Hospital - Springfield

★ 4.1
1630 E Primrose St, Springfield, MO 65804
(417) 885-4700
"I stayed here for several weeks recovering from surgery. Friendly and accommodating staff. The therapy team was great!"
— Lacey Elmer, 5★

Clinical trials in Springfield: what's recruiting

The Springfield area currently has 152 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Springfield, the most active research areas are:

  • Cancer & Oncology17 studies
  • Liver & Kidney4 studies
  • Heart & Vascular1 studies
  • Immune & Skin1 studies
  • Brain & Mental Health1 studies

Every listing shows the study phase, the recruiting site and its distance from Springfield, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Springfield

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Springfield participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Springfield pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in Springfield?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
How do I join a study in Springfield, MO?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
How often do new paid studies open in Springfield?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Springfield.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Springfield typically complete one or two studies per year.

Paid clinical trials near Springfield

Other metros within reach

Fayetteville, AR126 Columbia, MO249 Overland Park, KS1,029 Olathe, KS1,037 Kansas City, MO1,030 Kansas City, KS1,041 Little Rock, AR509 Tulsa, OK185

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Springfield Bladder Issues Due To Spinal Cord Injury in Springfield All conditions

More of MO

St. Louis1,500 Kansas City1,030 Columbia249

New paid studies open every week

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