Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/MO/Springfield
Updated October 2026 from ClinicalTrials.gov

Paid Clinical Trials in Springfield, MO

Studies commonly pay $75 to $4,500 per completed study

153 clinical trials are currently recruiting participants within 30 miles of Springfield. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

153studies recruiting
9+research centers nearby
6condition categories
Live from the NIH registry

Studies recruiting near Springfield right now

Top 25 of 153 recruiting studies, sorted by proximity — each links to its official registry page

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

Biochemically Recurrent Prostate Carcinoma, Metastatic Prostate Carcinoma Phase 3 Interventional 804 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT04423211)

A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults

Chronic Idiopathic Constipation (CIC) Phase 3 Interventional 692 participants sought
DelRicht Clinical Research - Springfield — Springfield, Missouri (1.5 mi) · Sponsor: Ardelyx
See eligibility & contact on ClinicalTrials.gov (NCT07382167)

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Ovarian Carcinoma N/A Interventional 1,956 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT04251052)

Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program

Cigarette Smoking-Related Carcinoma Phase 3 Interventional 600 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05008848)

Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

Metastatic Clear Cell Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma Phase 3 Interventional 364 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT04510597)

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma Phase 3 Interventional 247 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04269902)

A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

Overweight, Obesity Phase 2 Interventional 400 participants sought
Clinvest Headlands Llc — Springfield, Missouri (1.5 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT07589608)

ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

Cardiovascular Risk, Acute Myocardial Infarction (AMI) Phase 3 Interventional 10,000 participants sought
Mercy Research — Springfield, Missouri (1.5 mi) · Sponsor: Novo Nordisk A/S
See eligibility & contact on ClinicalTrials.gov (NCT06118281)

Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

Advanced Endometrial Carcinoma, Recurrent Endometrial Carcinoma Phase 3 Interventional 255 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT07198074)

Consolidation of First-Line MRD+ Remission With Cema-cel in Patients With LBCL

Large B-cell Lymphoma Phase 2 Interventional 250 participants sought
Oncology Hematology Associates — Springfield, Missouri (1.5 mi) · Sponsor: Allogene Therapeutics
See eligibility & contact on ClinicalTrials.gov (NCT06500273)

This Study is a Non-interventional Disease Registry of Adolescent and Adult Patients With Atopic Dermatitis Who Initiate or Switch Any Systemic Treatment

Atopic Dermatitis N/A Observational 1,000 participants sought
Red River Research Partners, Llc- Site Number : 8400054 — Bolivar, Missouri (29.8 mi) · Sponsor: Sanofi
See eligibility & contact on ClinicalTrials.gov (NCT07290803)

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer

Colorectal Cancer, Sarcopenia N/A Observational 300 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: Wake Forest University Health Sciences
See eligibility & contact on ClinicalTrials.gov (NCT03998202)

A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease

Alzheimer's Disease Phase 2 Interventional 407 participants sought
Citizens Memorial Hospital Neurology CLinic — Bolivar, Missouri (29.8 mi) · Sponsor: Novartis Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT07094516)

Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design

Fibromyalgia Phase 3 Interventional 620 participants sought
Clinical Research Site — Springfield, Missouri (1.5 mi) · Sponsor: Axsome Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07398417)

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma, Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7 Phase 2, Phase 3 Interventional 613 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT01810913)

Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)

Migraine Phase 3 Interventional 1,059 participants sought
Sharlin Health and Neurology /ID# 229523 — Ozark, Missouri (12.9 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT05125302)

Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study

Muscle Invasive Bladder Urothelial Carcinoma, Muscle Invasive Renal Pelvis Urothelial Carcinoma Phase 2, Phase 3 Interventional 992 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05987241)

A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes

Diabetes Mellitus, Type 2 Phase 2 Interventional 270 participants sought
Headlands Research — Springfield, Missouri (1.5 mi) · Sponsor: Novo Nordisk A/S
See eligibility & contact on ClinicalTrials.gov (NCT07415954)

Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps

Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum N/A Interventional 9,500 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05080673)
Actively enrolling

Studies you may be able to join near Springfield

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Springfield

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

QPS Study Campus

★ 3.3
1820 W Mt Vernon St, Springfield, MO 65802
(417) 831-2048
"I recently completed a 9 day confinement there and for the size group we had, I felt like the people working there were very organized and profession…"
— Andrew Dziedzic, 5★

Cancer Research for the Ozarks

★ 5.0
2115 S Fremont Ave Ste 3200, Springfield, MO 65804
(417) 269-4520
"I can state how helpful this group is to the community. Cancer is a horrible, and the kindness and help CRO offers to those in need is a wonderful th…"
— Vince Hamilton, 5★

DelRicht Research of Springfield Clinical Trials

★ 4.9
3238 S National Ave Ste B, Springfield, MO 65807
(417) 590-8383
"Been nothing but a pain. Found on an ad through Facebook. I filled out the form and the robot answering service told me they don't have any trials in…"
— Alice C, 2★

QPS Screening and Recruitment Center

★ 3.5
2025 W Sunshine St Ste L-109, Springfield, MO 65807
(417) 831-2048
"This place is a joke, they will not display all requirements for the study, and they will waste your time,<br>Took my blood multiple times, then had …"
— John Shepard, 1★

Clinvest Research

★ 4.6
909 E Republic Rd Bldg D 200, Springfield, MO 65807
(417) 883-7889
"Very informative and pleasant experience. Looking forward to my study here."
— Chris Mojonnier, 5★

BPVH Clinical Trials

★ 4.7
1255 E Independence St, Springfield, MO 65804
(417) 509-8961
"We participate in any trial that might help our pets and science."
— Gregg Bender, 5★

Lakeland Behavioral Health System - Residential

★ 1.9 (265 reviews)
440 S Market Ave, Springfield, MO 65806
(417) 895-9169
"I don't care what anyone says. This place helped me finally get the help I needed."
— Kenton Coonts, 5★

Sharlin Health Neuroscience Research Center

5508 N Farmer Branch Rd, Ozark, MO 65721
(417) 238-3301

Select Specialty Hospital - Springfield

★ 4.1
1630 E Primrose St, Springfield, MO 65804
(417) 885-4700
"I stayed here for several weeks recovering from surgery. Friendly and accommodating staff. The therapy team was great!"
— Lacey Elmer, 5★

Clinical trials in Springfield: what's recruiting

The Springfield area currently has 153 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Springfield, the most active research areas are:

  • Cancer & Oncology13 studies
  • Liver & Kidney2 studies
  • Diabetes & Metabolism2 studies
  • Heart & Vascular1 studies
  • Immune & Skin1 studies

Every listing shows the study phase, the recruiting site and its distance from Springfield, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Springfield

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Springfield participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Springfield pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in Springfield?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
How do I join a study in Springfield, MO?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
How often do new paid studies open in Springfield?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Springfield.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Springfield typically complete one or two studies per year.

Paid clinical trials near Springfield

Other metros within reach

Fayetteville, AR125 Columbia, MO247 Overland Park, KS1,027 Olathe, KS1,036 Kansas City, MO1,029 Kansas City, KS1,041 Little Rock, AR505 Tulsa, OK190

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Springfield Bladder Issues Due To Spinal Cord Injury in Springfield All conditions

More of MO

St. Louis1,510 Kansas City1,029 Columbia247

New paid studies open every week

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