Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/MO/Springfield
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Springfield, MO

Studies commonly pay $75 to $4,500 per completed study

150 clinical trials are currently recruiting participants within 30 miles of Springfield. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

150studies recruiting
9+research centers nearby
4condition categories
Live from the NIH registry

Studies recruiting near Springfield right now

Top 25 of 150 recruiting studies, sorted by proximity — each links to its official registry page

Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer

Stage I Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8 Phase 3 Interventional 428 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05646316)

A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

Advanced Pancreatic Carcinoma, Metastatic Pancreatic Carcinoma Phase 2 Interventional 40 participants sought
Ohio State University Telemedicine — Springfield, Missouri (1.5 mi) · Sponsor: Sameek Roychowdhury
See eligibility & contact on ClinicalTrials.gov (NCT06906562)

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Endometrial Cancer Phase 3 Interventional 600 participants sought
Research Site — Springfield, Missouri (1.5 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06989112)

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

Carcinoma, Transitional Cell, Urinary Bladder Neoplasms Phase 3 Interventional 450 participants sought
Oncology Hematology Associates — Springfield, Missouri (1.5 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT07218380)

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

Smoldering Plasma Cell Myeloma Phase 3 Interventional 288 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT03937635)

A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants

Hypothyroidism Phase 2, Phase 3 Interventional 2,800 participants sought
Mercy Research - Springfield /ID# 262385 — Springfield, Missouri (1.5 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT06345339)

Protocol for Collecting, Banking and Distributing Human Tissue Samples: St. Jude Children's Research Hospital Tissue Resources Core Facility

Normal and Diseased Tissue and Body Fluids Samples N/A Observational 100,000 participants sought
Mercy Children's Hospital - Springfield — Springfield, Missouri (1.5 mi) · Sponsor: St. Jude Children's Research Hospital
See eligibility & contact on ClinicalTrials.gov (NCT01354002)

Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment

Plasma Cell Myeloma Phase 3 Interventional 510 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT05561387)

A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.

Epithelial Ovarian Cancer, Fallopian Tube Cancer Phase 2 Interventional 140 participants sought
Cox Medical Center South /ID# 274826 — Springfield, Missouri (1.5 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT06890338)

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 189 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT02734537)

Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

Advanced Endometrial Carcinoma, Recurrent Endometrial Carcinoma Phase 3 Interventional 255 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT07198074)

Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer

Metastatic Colorectal Cancer (CRC) Phase 3 Interventional 600 participants sought
Clinical Study Site — Springfield, Missouri (1.5 mi) · Sponsor: Summit Therapeutics
See eligibility & contact on ClinicalTrials.gov (NCT07228832)

Collection of Research Data and Samples From Patients Who Experience Immunotherapy Side Effects

Malignancy N/A Observational 240 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT04242095)

A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

Obesity, Overweight Phase 3 Interventional 1,100 participants sought
ACCOMPLISH-2 Research Site — Springfield, Missouri (1.5 mi) · Sponsor: Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
See eligibility & contact on ClinicalTrials.gov (NCT07654374)

A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain

Osteoarthritis, Knee, Diabetic Neuropathic Pain Phase 2 Interventional 10,000 participants sought
Clinvest Research LLC — Springfield, Missouri (1.5 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT05986292)

Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier

Pulmonary Nodule, Solitary, Lung Cancer N/A Observational 2,400 participants sought
Mercy Hospital — Springfield, Missouri (1.5 mi) · Sponsor: Veracyte, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06426628)

AZD5335 vs. Mirvetuximab Soravtansine in FRα-high and AZD5335 vs. Chemotherapy in FRα-low Platinum-resistant Ovarian Cancer

Epithelial Ovarian Cancer Phase 3 Interventional 1,100 participants sought
Research Site — Springfield, Missouri (1.5 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT07218809)

Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design

Fibromyalgia Phase 3 Interventional 620 participants sought
Clinical Research Site — Springfield, Missouri (1.5 mi) · Sponsor: Axsome Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07398417)

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma, Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7 Phase 2, Phase 3 Interventional 613 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT01810913)

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8 Phase 3 Interventional 1,209 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05946213)

Prospective Non-Interventional Study Comparing Osimertinib +/- Chemotherapy for EGFR-Mutated NSCLC Patients

Non Small Cell Lung Cancer, Epidermal Growth Factor Receptor Gene Mutation N/A Observational 538 participants sought
Mercy Clinic Springfield Communities — Springfield, Missouri (1.5 mi) · Sponsor: PrECOG, LLC.
See eligibility & contact on ClinicalTrials.gov (NCT06538038)

This Study is a Non-interventional Disease Registry of Adolescent and Adult Patients With Atopic Dermatitis Who Initiate or Switch Any Systemic Treatment

Atopic Dermatitis N/A Observational 1,000 participants sought
Red River Research Partners, Llc- Site Number : 8400054 — Bolivar, Missouri (29.8 mi) · Sponsor: Sanofi
See eligibility & contact on ClinicalTrials.gov (NCT07290803)

Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors

Colorectal Cancer Stage II, Colorectal Cancer Stage III Phase 3 Interventional 1,057 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT07018869)

Inotuzumab Ozogamicin and Blinatumomab With or Without Ponatinib in Treating Patients With Newly Diagnosed, Recurrent, or Refractory CD22-Positive B-Lineage Acute Lymphoblastic Leukemia

B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative, Recurrent B Acute Lymphoblastic Leukemia Phase 2 Interventional 84 participants sought
Mercy Hospital Springfield — Springfield, Missouri (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT03739814)

A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

Obesity, Overweight Phase 2 Interventional 1,481 participants sought
Clinvest Headlands Llc — Springfield, Missouri (1.5 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT06143956)
Actively enrolling

Studies you may be able to join near Springfield

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Springfield

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

QPS Study Campus

★ 3.3
1820 W Mt Vernon St, Springfield, MO 65802
(417) 831-2048
"I recently completed a 9 day confinement there and for the size group we had, I felt like the people working there were very organized and profession…"
— Andrew Dziedzic, 5★

Cancer Research for the Ozarks

★ 5.0
2115 S Fremont Ave Ste 3200, Springfield, MO 65804
(417) 269-4520
"I can state how helpful this group is to the community. Cancer is a horrible, and the kindness and help CRO offers to those in need is a wonderful th…"
— Vince Hamilton, 5★

DelRicht Research of Springfield Clinical Trials

★ 4.9
3238 S National Ave Ste B, Springfield, MO 65807
(417) 590-8383
"Been nothing but a pain. Found on an ad through Facebook. I filled out the form and the robot answering service told me they don't have any trials in…"
— Alice C, 2★

QPS Screening and Recruitment Center

★ 3.5
2025 W Sunshine St Ste L-109, Springfield, MO 65807
(417) 831-2048
"This place is a joke, they will not display all requirements for the study, and they will waste your time,<br>Took my blood multiple times, then had …"
— John Shepard, 1★

Clinvest Research

★ 4.6
909 E Republic Rd Bldg D 200, Springfield, MO 65807
(417) 883-7889
"Very informative and pleasant experience. Looking forward to my study here."
— Chris Mojonnier, 5★

BPVH Clinical Trials

★ 4.7
1255 E Independence St, Springfield, MO 65804
(417) 509-8961
"We participate in any trial that might help our pets and science."
— Gregg Bender, 5★

Lakeland Behavioral Health System - Residential

★ 1.9 (265 reviews)
440 S Market Ave, Springfield, MO 65806
(417) 895-9169
"I don't care what anyone says. This place helped me finally get the help I needed."
— Kenton Coonts, 5★

Sharlin Health Neuroscience Research Center

5508 N Farmer Branch Rd, Ozark, MO 65721
(417) 238-3301

Select Specialty Hospital - Springfield

★ 4.1
1630 E Primrose St, Springfield, MO 65804
(417) 885-4700
"I stayed here for several weeks recovering from surgery. Friendly and accommodating staff. The therapy team was great!"
— Lacey Elmer, 5★

Clinical trials in Springfield: what's recruiting

The Springfield area currently has 150 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Springfield, the most active research areas are:

  • Cancer & Oncology17 studies
  • Diabetes & Metabolism3 studies
  • Immune & Skin2 studies
  • Lungs & Breathing1 studies

Every listing shows the study phase, the recruiting site and its distance from Springfield, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Springfield

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Springfield participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Springfield pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in Springfield?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
How do I join a study in Springfield, MO?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
How often do new paid studies open in Springfield?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Springfield.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Springfield typically complete one or two studies per year.

Paid clinical trials near Springfield

Other metros within reach

Fayetteville, AR126 Columbia, MO253 Overland Park, KS1,017 Olathe, KS1,025 Kansas City, MO1,018 Kansas City, KS1,029 Little Rock, AR505 Tulsa, OK179

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Springfield Bladder Issues Due To Spinal Cord Injury in Springfield All conditions

More of MO

St. Louis1,490 Kansas City1,018 Columbia253

New paid studies open every week

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