Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/WI/Appleton
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Appleton, WI

Studies commonly pay $75 to $4,500 per completed study

151 clinical trials are currently recruiting participants within 30 miles of Appleton. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

151studies recruiting
2+research centers nearby
3condition categories
Live from the NIH registry

Studies recruiting near Appleton right now

Top 25 of 151 recruiting studies, sorted by proximity — each links to its official registry page

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 189 participants sought
ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT02734537)

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm Phase 2 Interventional 2,000 participants sought
ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05564390)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin (24.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

Advanced Pancreatic Carcinoma, Metastatic Pancreatic Carcinoma Phase 2 Interventional 40 participants sought
Ohio State University Telemedicine — Green Bay, Wisconsin (24.7 mi) · Sponsor: Sameek Roychowdhury
See eligibility & contact on ClinicalTrials.gov (NCT06906562)

Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8 Phase 3 Interventional 356 participants sought
Vince Lombardi Cancer Clinic - Oshkosh — Oshkosh, Wisconsin (19.1 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06958328)

Collection of Research Data and Samples From Patients Who Experience Immunotherapy Side Effects

Malignancy N/A Observational 240 participants sought
Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton — Appleton, Wisconsin (1.7 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT04242095)

Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

Malignant Female Reproductive System Neoplasm, Malignant Solid Neoplasm Phase 2 Interventional 70 participants sought
Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin (24.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06126276)

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

Lymphoma, Non-Hodgkin, Multiple Myeloma Phase 2 Interventional 4,200 participants sought
Vince Lombardi Cancer Clinic - Oshkosh — Oshkosh, Wisconsin (19.1 mi) · Sponsor: American Society of Clinical Oncology
See eligibility & contact on ClinicalTrials.gov (NCT02693535)

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

Smoldering Plasma Cell Myeloma Phase 3 Interventional 288 participants sought
ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT03937635)

Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment

Plasma Cell Myeloma Phase 3 Interventional 510 participants sought
ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT05561387)

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8 Phase 3 Interventional 1,209 participants sought
Vince Lombardi Cancer Clinic - Oshkosh — Oshkosh, Wisconsin (19.1 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05946213)

A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

Anaplastic Kidney Wilms Tumor, Recurrent Kidney Wilms Tumor Phase 2 Interventional 256 participants sought
Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin (24.7 mi) · Sponsor: Children's Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT04322318)

A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

High Grade Osteosarcoma, Localized Osteosarcoma Phase 2, Phase 3 Interventional 1,122 participants sought
Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin (24.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05691478)

Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors

Colorectal Cancer Stage II, Colorectal Cancer Stage III Phase 3 Interventional 1,057 participants sought
ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT07018869)

Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer

Colonic Neoplasms, Neoplasms, Colon Phase 3 Interventional 892 participants sought
GSK Investigational Site — Appleton, Wisconsin (1.7 mi) · Sponsor: GlaxoSmithKline
See eligibility & contact on ClinicalTrials.gov (NCT05855200)

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

Stage I Breast Cancer Phase 3 Interventional 1,670 participants sought
ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT04852887)

High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

Head and Neck Squamous Cell Carcinoma, Stage I Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8 Phase 3 Interventional 228 participants sought
Vince Lombardi Cancer Clinic - Oshkosh — Oshkosh, Wisconsin (19.1 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06992427)

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

Cardiotoxicity, HER2/Neu Positive Phase 3 Interventional 491 participants sought
Bellin Memorial Hospital — Green Bay, Wisconsin (24.7 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03418961)

Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

Classic Follicular Lymphoma, Follicular Lymphoma With Unusual Cytological Features Phase 3 Interventional 600 participants sought
ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06337318)

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)

Macular Degeneration, Age-Related Macular Degeneration Phase 2, Phase 3 Interventional 960 participants sought
Northeast Wisconsin Retina Associates — Appleton, Wisconsin (1.7 mi) · Sponsor: EyeBiotech Ltd.
See eligibility & contact on ClinicalTrials.gov (NCT07496567)

Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)

Acute Myeloid Leukemia Phase 2 Interventional 153 participants sought
ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05554393)

An Evaluation of NGM120 in a Randomized, Double-blind, Placebo-controlled Study in Participants With Colorectal Cancer Who Have Cancer Cachexia.

Colorectal Cancer, CRC (Colorectal Cancer) Phase 2 Interventional 136 participants sought
NGM Clinical Study Site — Appleton, Wisconsin (1.7 mi) · Sponsor: NGM Biopharmaceuticals, Inc
See eligibility & contact on ClinicalTrials.gov (NCT07033026)

Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

Advanced Endometrial Carcinoma, Recurrent Endometrial Carcinoma Phase 3 Interventional 255 participants sought
Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin (24.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT07198074)
Actively enrolling

Studies you may be able to join near Appleton

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Appleton

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

ThedaCare Regional Medical Center-Appleton

★ 3.1
1818 N Meade St, Appleton, WI 54911
(920) 731-4101

NeuroSpine Center Of Wisconsin

★ 4.8
5320 W Michaels Dr, Appleton, WI 54913
(920) 882-8200

Clinical trials in Appleton: what's recruiting

The Appleton area currently has 151 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Appleton, the most active research areas are:

  • Cancer & Oncology20 studies
  • Liver & Kidney2 studies
  • Heart & Vascular2 studies

Every listing shows the study phase, the recruiting site and its distance from Appleton, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Appleton

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Appleton participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Appleton pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
How do I join a study in Appleton, WI?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
How often do new paid studies open in Appleton?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Appleton.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Appleton typically complete one or two studies per year.

Paid clinical trials near Appleton

Other metros within reach

Green Bay, WI148 Milwaukee, WI694 Madison, WI535 Round Lake Beach, IL472 Rockford, IL113 Muskegon, MI60 Aurora, IL614 Chicago, IL2,448

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Appleton Bladder Issues Due To Spinal Cord Injury in Appleton All conditions

More of WI

Milwaukee694 Madison535 Green Bay148

New paid studies open every week

Get an email when a new clinical trial starts recruiting within 30 miles of your ZIP code. No spam — only real studies from the NIH registry.

By subscribing you agree to receive study alert emails. Unsubscribe anytime in one click.

Get free trial alerts