Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only

Home/WI/Appleton

Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Appleton, WI

Studies commonly pay $75 to $4,500 per completed study

154 clinical trials are currently recruiting participants within 30 miles of Appleton. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

154studies recruiting

2+research centers nearby

2condition categories

Live from the NIH registry

Studies recruiting near Appleton right now

Top 25 of 154 recruiting studies, sorted by proximity — each links to its official registry page

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought

Ascension Saint Elizabeth Hospital — Appleton, Wisconsin (1.7 mi) · Sponsor: SWOG Cancer Research Network

See eligibility & contact on ClinicalTrials.gov (NCT03851445)

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm Phase 2 Interventional 2,000 participants sought

ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT05564390)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought

Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin (24.7 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT06124157)

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

Ganglioneuroblastoma, Nodular, Neuroblastoma Phase 3 Interventional 478 participants sought

Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin (24.7 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT06172296)

Validating a Clinical Prediction Rule to Guide Manual Therapy and Exercise for Neck Pain Relief

Neck Pain Musculoskeletal, Neck Pain Treatment N/A Interventional 160 participants sought

Emplify by Bellin Health Ashwaubenon — Green Bay, Wisconsin (24.7 mi) · Sponsor: Baylor University

See eligibility & contact on ClinicalTrials.gov (NCT06906107)

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

Bladder Carcinoma, Ureter Carcinoma N/A Observational 2,020 participants sought

ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: Guardant Health, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT05059444)

Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment

Plasma Cell Myeloma Phase 3 Interventional 510 participants sought

ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: SWOG Cancer Research Network

See eligibility & contact on ClinicalTrials.gov (NCT05561387)

Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

Locally Advanced Lung Non-Small Cell Carcinoma, Stage IIB Lung Cancer AJCC v8 Phase 3 Interventional 474 participants sought

Vince Lombardi Cancer Clinic - Oshkosh — Oshkosh, Wisconsin (19.1 mi) · Sponsor: NRG Oncology

See eligibility & contact on ClinicalTrials.gov (NCT05624996)

Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLL

Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia Phase 3 Interventional 466 participants sought

Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin (24.7 mi) · Sponsor: Alliance for Clinical Trials in Oncology

See eligibility & contact on ClinicalTrials.gov (NCT07321652)

A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

High Grade Osteosarcoma, Localized Osteosarcoma Phase 2, Phase 3 Interventional 1,122 participants sought

Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin (24.7 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT05691478)

S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

Anatomic Stage IV Breast Cancer AJCC v8, Estrogen Receptor Positive N/A Interventional 739 participants sought

Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin (24.7 mi) · Sponsor: SWOG Cancer Research Network

See eligibility & contact on ClinicalTrials.gov (NCT03723928)

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

Multiple conditions Phase 3 Interventional 158 participants sought

Vince Lombardi Cancer Clinic - Oshkosh — Oshkosh, Wisconsin (19.1 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT06589804)

Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer

Miscellaneous Neoplasm, Nos, Non-Neoplastic Condition, Nos N/A Interventional 535 participants sought

Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin (24.7 mi) · Sponsor: Alliance for Clinical Trials in Oncology

See eligibility & contact on ClinicalTrials.gov (NCT07091617)

Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

Classic Follicular Lymphoma, Follicular Lymphoma With Unusual Cytological Features Phase 3 Interventional 600 participants sought

ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT06337318)

Prospective Non-Interventional Study Comparing Osimertinib +/- Chemotherapy for EGFR-Mutated NSCLC Patients

Non Small Cell Lung Cancer, Epidermal Growth Factor Receptor Gene Mutation N/A Observational 538 participants sought

ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: PrECOG, LLC.

See eligibility & contact on ClinicalTrials.gov (NCT06538038)

Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube High Grade Serous Adenocarcinoma Phase 3 Interventional 880 participants sought

Vince Lombardi Cancer Clinic - Oshkosh — Oshkosh, Wisconsin (19.1 mi) · Sponsor: NRG Oncology

See eligibility & contact on ClinicalTrials.gov (NCT06580314)

A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

Locally Advanced Solid Tumors, Metastatic Solid Tumors Phase 1, Phase 2 Interventional 500 participants sought

Local Institution - 2145 — Appleton, Wisconsin (1.7 mi) · Sponsor: Turning Point Therapeutics, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT03093116)

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 188 participants sought

ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT04671667)

A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

Anaplastic Kidney Wilms Tumor, Recurrent Kidney Wilms Tumor Phase 2 Interventional 256 participants sought

Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin (24.7 mi) · Sponsor: Children's Oncology Group

See eligibility & contact on ClinicalTrials.gov (NCT04322318)

Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma

Mantle Cell Lymphoma Phase 3 Interventional 421 participants sought

ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: Alliance for Clinical Trials in Oncology

See eligibility & contact on ClinicalTrials.gov (NCT05976763)

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8 Phase 3 Interventional 1,209 participants sought

Vince Lombardi Cancer Clinic - Oshkosh — Oshkosh, Wisconsin (19.1 mi) · Sponsor: NRG Oncology

See eligibility & contact on ClinicalTrials.gov (NCT05946213)

A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)

Relapsing Multiple Sclerosis, Multiple Sclerosis N/A Observational 2,000 participants sought

TG Therapeutics Investigational Trial Site — Neenah, Wisconsin (7.3 mi) · Sponsor: TG Therapeutics, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT06433752)

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma, Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7 Phase 2, Phase 3 Interventional 613 participants sought

Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin (24.7 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT01810913)

Nectero EAST System Clinical Study

Abdominal Aortic Aneurysm Phase 2, Phase 3 Interventional 400 participants sought

Bellin Memorial Hospital — Green Bay, Wisconsin (24.7 mi) · Sponsor: Nectero Medical, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT06001918)

Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations

Locally Advanced Pancreatic Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma Phase 3 Interventional 94 participants sought

Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin (24.7 mi) · Sponsor: SWOG Cancer Research Network

See eligibility & contact on ClinicalTrials.gov (NCT06998940)

Actively enrolling

Studies you may be able to join near Appleton

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Google-rated

Top-rated research centers in Appleton

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

ThedaCare Regional Medical Center-Appleton

★ 3.1

1818 N Meade St, Appleton, WI 54911

(920) 731-4101

Website

NeuroSpine Center Of Wisconsin

★ 4.8

5320 W Michaels Dr, Appleton, WI 54913

(920) 882-8200

Website

Clinical trials in Appleton: what's recruiting

The Appleton area currently has 154 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Appleton, the most active research areas are:

Cancer & Oncology21 studies
Liver & Kidney2 studies

Every listing shows the study phase, the recruiting site and its distance from Appleton, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Appleton

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Appleton participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Appleton pay?

Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.

How do I join a study in Appleton, WI?

Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.

Is compensation for clinical trials taxable?

In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.

How often do new paid studies open in Appleton?

Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Appleton.

Can I be in more than one clinical trial at a time?

Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Appleton typically complete one or two studies per year.

Paid clinical trials near Appleton

Other metros within reach

Green Bay, WI151 Milwaukee, WI688 Madison, WI527 Round Lake Beach, IL466 Rockford, IL114 Muskegon, MI61 Aurora, IL615 Chicago, IL2,445

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Appleton Bladder Issues Due To Spinal Cord Injury in Appleton All conditions

More of WI

Milwaukee688 Madison527 Green Bay151

New paid studies open every week

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