Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/MD/Frederick
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Frederick, MD

Studies commonly pay $75 to $4,500 per completed study

262 clinical trials are currently recruiting participants within 30 miles of Frederick. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

262studies recruiting
9+research centers nearby
6condition categories
Live from the NIH registry

Studies recruiting near Frederick right now

Top 25 of 262 recruiting studies, sorted by proximity — each links to its official registry page

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
Kaiser Permanente-Gaithersburg Medical Center — Gaithersburg, Maryland (23.1 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

Quaratusugene Ozeplasmid (Reqorsa) and Osimertinib in Patients With Advanced Lung Cancer Who Progressed on Osimertinib

Carcinoma, Non-Small Cell Lung Phase 1, Phase 2 Interventional 158 participants sought
Maryland Oncology Hematology — Rockville, Maryland (27.9 mi) · Sponsor: Genprex, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04486833)

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Neovascular Age-related Macular Degeneration Phase 4 Interventional 188 participants sought
Cumberland Valley Retina Consultants PC — Hagerstown, Maryland (21.7 mi) · Sponsor: Genentech, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04853251)

Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

Non-Small Cell Lung Cancer Phase 3 Interventional 675 participants sought
Research Site — Leesburg, Virginia (23.4 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06357533)

Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention

Percutaneous Coronary Intervention, Peripheral Endovascular Intervention Phase 4 Interventional 6,000 participants sought
Shady Grove Adventist Hospital — Rockville, Maryland (27.9 mi) · Sponsor: Duke University
See eligibility & contact on ClinicalTrials.gov (NCT06909565)

Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8 Phase 3 Interventional 356 participants sought
Inova Loudoun Hospital — Leesburg, Virginia (23.4 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06958328)

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

Carcinoma, Transitional Cell, Urinary Bladder Neoplasms Phase 3 Interventional 450 participants sought
James M Stockman Cancer Institute — Frederick, Maryland (1.4 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT07218380)

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

Smoldering Plasma Cell Myeloma Phase 3 Interventional 288 participants sought
WVUH-Berkely Medical Center — Martinsburg, West Virginia (29.4 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT03937635)

To Assess the Safety and Efficacy of SP-002 with Vismodegib for the Treatment of Locally Advanced Basal Cell Carcinoma

Basal Cell Carcinoma Phase 2 Interventional 80 participants sought
Research Site — Rockville, Maryland (27.9 mi) · Sponsor: Stamford Pharmaceuticals, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06344052)

Real-world Experience Using Nemolizumab in the Treatment of Moderate-to-Severe Atopic Dermatitis in Adolescents & Adults

Atopic Dermatitis N/A Observational 1,000 participants sought
Galderma Investigational Site 7068 — Rockville, Maryland (27.9 mi) · Sponsor: Galderma R&D
See eligibility & contact on ClinicalTrials.gov (NCT06988605)

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Advanced Non-Small Cell Lung Cancer, Non-Small Cell Lung Cancer Phase 3 Interventional 1,410 participants sought
Maryland Oncology Hematology, P.A. — Germantown, Maryland (19.5 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT07222566)

Collection of Research Data and Samples From Patients Who Experience Immunotherapy Side Effects

Malignancy N/A Observational 240 participants sought
Adams Cancer Center — Gettysburg, Pennsylvania (29.1 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT04242095)

A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

Geographic Atrophy, Macular Degeneration Phase 2 Interventional 274 participants sought
Cumberland Valley Retina Consultants — Hagerstown, Maryland (21.7 mi) · Sponsor: Janssen Research & Development, LLC
See eligibility & contact on ClinicalTrials.gov (NCT06635148)

High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

Head and Neck Squamous Cell Carcinoma, Stage I Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8 Phase 3 Interventional 228 participants sought
WVUH-Berkely Medical Center — Martinsburg, West Virginia (29.4 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06992427)

DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study

Pleuropulmonary Blastoma, Cystic Nephroma N/A Observational 1,500 participants sought
National Cancer Institute - Shady Grove — Rockville, Maryland (27.9 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT01247597)

A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Pediatric Participants With Nonsegmental Vitiligo

NonSegmental Vitiligo Phase 3 Interventional 180 participants sought
Dermatology Associates Pc — Rockville, Maryland (27.9 mi) · Sponsor: Incyte Corporation
See eligibility & contact on ClinicalTrials.gov (NCT06548360)

A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

Major Depressive Disorder Phase 2 Interventional 164 participants sought
Sunstone Therapies — Rockville, Maryland (27.9 mi) · Sponsor: Syndeio Biosciences, Inc
See eligibility & contact on ClinicalTrials.gov (NCT07115329)

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)

Macular Degeneration, Age-Related Macular Degeneration Phase 2, Phase 3 Interventional 960 participants sought
Cumberland Valley Retina Consultants (Site 007) — Hagerstown, Maryland (21.7 mi) · Sponsor: EyeBiotech Ltd.
See eligibility & contact on ClinicalTrials.gov (NCT07440225)
Actively enrolling

Studies you may be able to join near Frederick

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for severe chronic itching

Enrolling adults aged 18 to 90 who have had chronic itching for six months or longer. Not open to itching caused by atopic dermatitis, psoriasis, chronic kidney disease, notalgia paresthetica or medication, nor to people with an autoimmune condition such as lupus, Crohn's disease, ulcerative colitis or rheumatoid arthritis.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for heart failure

This study is enrolling adults in eligible areas of the United States who have been diagnosed with heart failure. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research studies for chronic kidney disease

This research platform is enrolling Black and African American adults in eligible areas who have been diagnosed with chronic kidney disease. Compensation may be available. The study team confirms eligibility before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Frederick

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Frederick National Laboratory for Cancer Research

★ 4.5
8560 Progress Drive, Frederick, MD 21701
(301) 846-1000

Work NCI Advanced Technology Research Facility

★ 4.9
8560 Progress Drive, Frederick, MD 21701

Concerted Care Group Frederick

★ 4.8 (83 reviews)
92 Thomas Johnson Dr Ste 100, Frederick, MD 21702
(240) 815-7300
"Kelly B the front receptionist is by far the BEST... First off she makes you feel at home when you walk through the door until the moment you walk ou…"
— Melissa Allen, 5★

National Cancer Institute -- Frederick Campus

★ 4.4
1050 Boyles St, Frederick, MD 21702
(800) 422-6237

HIV Dynamics and Replication Program

★ 4.0
1050 Boyles St Bldg 535, Rm 309, Frederick, MD 21702

Community Radiology Associates | Frederick Imaging Center

★ 4.8
67 Thomas Johnson Dr #4, Frederick, MD 21702
(888) 601-0943
"It was great people were very nice<br>And understanding"
— Travis Shane, 5★

IC Health Services, Inc.

★ 4.4 (7 reviews)
15 N Court St #204, Frederick, MD 21701
(240) 698-3678
"I must say, Dr. Chidinma of IC Health Services is amazing. She is caring, open-minded, compassionate, and knowledgeable. She provides the best treatm…"
— Marcus Kometa, 5★

The Center for Holistic Wellness

★ 5.0
6 W 2nd St 1st Floor, Frederick, MD 21701
(240) 739-5081
"The Center for Holistic Wellness providers are very compassionate and caring. I believe Dr. Jedidiah Smith and Mona Theil are truly healers for my mi…"
— Robin Lewis, 5★

Mesa Science Associates Inc.

321 Ballenger Center Dr Ste 125, Frederick, MD 21703
(301) 514-6248

Clinical trials in Frederick: what's recruiting

The Frederick area currently has 262 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Frederick, the most active research areas are:

  • Cancer & Oncology11 studies
  • Heart & Vascular3 studies
  • Brain & Mental Health2 studies
  • Immune & Skin1 studies
  • Liver & Kidney1 studies

Every listing shows the study phase, the recruiting site and its distance from Frederick, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Frederick

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Frederick participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Do I need to be sick to join a clinical trial in Frederick?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Are clinical trials in Frederick safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Frederick, MD?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
How often do new paid studies open in Frederick?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Frederick.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Frederick typically complete one or two studies per year.

Paid clinical trials near Frederick

Other metros within reach

Hagerstown, MD114 Arlington, VA2,331 Washington, DC2,362 Alexandria, VA2,289 Baltimore, MD1,650 York, PA447 Harrisburg, PA402 Fredericksburg, VA33

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Frederick Severe Chronic Pruritus in Frederick Heart Failure in Frederick Chronic Kidney Disease (HealthMatch) in Frederick Bladder Issues Due To Spinal Cord Injury in Frederick All conditions

More of MD

Baltimore1,650 Hagerstown114

New paid studies open every week

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