Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/MD/Frederick
Updated October 2026 from ClinicalTrials.gov

Paid Clinical Trials in Frederick, MD

Studies commonly pay $75 to $4,500 per completed study

256 clinical trials are currently recruiting participants within 30 miles of Frederick. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

256studies recruiting
9+research centers nearby
6condition categories
Live from the NIH registry

Studies recruiting near Frederick right now

Top 25 of 256 recruiting studies, sorted by proximity — each links to its official registry page

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
Kaiser Permanente-Gaithersburg Medical Center — Gaithersburg, Maryland (23.1 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Ovarian Carcinoma N/A Interventional 1,956 participants sought
WVUH-Berkely Medical Center — Martinsburg, West Virginia (29.4 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT04251052)

Efficacy of Buprenorphine and XR-Naltrexone Combination for Relapse Prevention in Opioid Use Disorder

Opioid-use Disorder Phase 2, Phase 3 Interventional 180 participants sought
Avery Road Treatment Center (ARTC) — Rockville, Maryland (27.9 mi) · Sponsor: New York State Psychiatric Institute
See eligibility & contact on ClinicalTrials.gov (NCT05011266)

A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus

Systemic Lupus Erythematosus Phase 3 Interventional 450 participants sought
Sl0044 50730 — Rockville, Maryland (27.9 mi) · Sponsor: UCB Biopharma SRL
See eligibility & contact on ClinicalTrials.gov (NCT06617325)

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

Smoldering Plasma Cell Myeloma Phase 3 Interventional 288 participants sought
WVUH-Berkely Medical Center — Martinsburg, West Virginia (29.4 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT03937635)

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8 Phase 3 Interventional 1,500 participants sought
Adams Cancer Center — Gettysburg, Pennsylvania (29.1 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05946213)

Clevidipine for the Antihypertensive Treatment of Acute Intracerebral Hemorrhage

Intracerebral Hemorrhage, Stroke N/A Observational 1,018 participants sought
Frederick Memorial Hospital — Frederick, Maryland (1.4 mi) · Sponsor: Zeenat Qureshi Stroke Institute
See eligibility & contact on ClinicalTrials.gov (NCT06402968)

A Study to Assess Adverse Events, Change in Disease Activity, and How Oral Emraclidine Moves Through the Body in Adult Participants With Schizophrenia

Schizophrenia Phase 2 Interventional 268 participants sought
Cbh Health - Gaithersburg /ID# 272932 — Gaithersburg, Maryland (23.1 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT07145918)

A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression

Major Depressive Disorder (MDD) Phase 2 Interventional 300 participants sought
Draig Clinical Site — Gaithersburg, Maryland (23.1 mi) · Sponsor: Draig Therapeutics Ltd
See eligibility & contact on ClinicalTrials.gov (NCT07300969)

Medical Herbs Inhibit Inflammation Directing T Cells to Kill the COVID-19 Virus (COVID)

Covid19 Virus Infection Phase 1, Phase 2 Interventional 100 participants sought
All Natural Medicine Clinic, LLC — Rockville, Maryland (27.9 mi) · Sponsor: All Natural Medicine Clinic, LLC
See eligibility & contact on ClinicalTrials.gov (NCT04790240)

Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

Advanced Endometrial Carcinoma, Recurrent Endometrial Carcinoma Phase 3 Interventional 255 participants sought
WVUH-Berkely Medical Center — Martinsburg, West Virginia (29.4 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT07198074)

Surabgene Lomparvovec Administered in the Suprachoroidal Space in Adult Participants With Diabetic Retinopathy Without Center-Involved Diabetic Macular Edema

Diabetic Retinopathy Phase 2, Phase 3 Interventional 576 participants sought
Mid Atlantic Retina Specialists - Hagerstown /ID# 274725 — Hagerstown, Maryland (21.7 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT07592273)

Collection of Research Data and Samples From Patients Treated With Immunotherapy to Study Its Side Effects

Hematopoietic and Lymphoid Cell Neoplasm, Immune System Disorder N/A Observational 2,240 participants sought
Adams Cancer Center — Gettysburg, Pennsylvania (29.1 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT04242095)

Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

Locally Advanced Lung Non-Small Cell Carcinoma, Stage IIB Lung Cancer AJCC v8 Phase 3 Interventional 474 participants sought
William E Kahlert Regional Cancer Center/Sinai Hospital — Westminster, Maryland (24.4 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05624996)

A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)

Bipolar Disorder Type I With Mania Phase 3 Interventional 450 participants sought
CBH Health — Gaithersburg, Maryland (23.1 mi) · Sponsor: Bristol-Myers Squibb
See eligibility & contact on ClinicalTrials.gov (NCT06929273)

Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)

Pulmonary Disease, Chronic Obstructive Phase 3 Interventional 961 participants sought
GSK Investigational Site — Rockville, Maryland (27.9 mi) · Sponsor: GlaxoSmithKline
See eligibility & contact on ClinicalTrials.gov (NCT06961214)

A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular Degeneration

Neovascular Age-related Macular Degeneration, nAMD Phase 3 Interventional 304 participants sought
Mid Atlantic Retina Specialists — Hagerstown, Maryland (21.7 mi) · Sponsor: Amgen
See eligibility & contact on ClinicalTrials.gov (NCT07614776)

Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

High Grade Epithelial Ovarian Cancer, High Grade Serous Ovarian Cancer Phase 1, Phase 2 Interventional 952 participants sought
USOR Maryland Oncology Hematology — Rockville, Maryland (27.9 mi) · Sponsor: Genmab
See eligibility & contact on ClinicalTrials.gov (NCT05579366)

Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

Multiple conditions Phase 2 Interventional 98 participants sought
Adams Cancer Center — Gettysburg, Pennsylvania (29.1 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06532279)

A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have Not Taken Biologic Medicines

Psoriatic Arthritis Phase 3 Interventional 1,088 participants sought
Klein & Associates, M.D., P.A. — Hagerstown, Maryland (21.7 mi) · Sponsor: Takeda
See eligibility & contact on ClinicalTrials.gov (NCT06671483)

Relapse Prevention Trial Evaluating KarXT Treatment in Schizophrenia

Schizophrenia Phase 3 Interventional 472 participants sought
Local Institution - 0192 — Gaithersburg, Maryland (23.1 mi) · Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company
See eligibility & contact on ClinicalTrials.gov (NCT07686263)

Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors

Malignant Solid Neoplasm N/A Observational 2,062 participants sought
William E Kahlert Regional Cancer Center/Sinai Hospital — Westminster, Maryland (24.4 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT04871542)

A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

Colorectal Neoplasms Phase 3 Interventional 1,000 participants sought
Frederick Health Hospital - James M Stockman Cancer Institute — Frederick, Maryland (1.4 mi) · Sponsor: Janssen Research & Development, LLC
See eligibility & contact on ClinicalTrials.gov (NCT06662786)
Actively enrolling

Studies you may be able to join near Frederick

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Frederick

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Frederick National Laboratory for Cancer Research

★ 4.5
8560 Progress Drive, Frederick, MD 21701
(301) 846-1000

Work NCI Advanced Technology Research Facility

★ 4.9
8560 Progress Drive, Frederick, MD 21701

Concerted Care Group Frederick

★ 4.8 (83 reviews)
92 Thomas Johnson Dr Ste 100, Frederick, MD 21702
(240) 815-7300
"Kelly B the front receptionist is by far the BEST... First off she makes you feel at home when you walk through the door until the moment you walk ou…"
— Melissa Allen, 5★

National Cancer Institute -- Frederick Campus

★ 4.4
1050 Boyles St, Frederick, MD 21702
(800) 422-6237

HIV Dynamics and Replication Program

★ 4.0
1050 Boyles St Bldg 535, Rm 309, Frederick, MD 21702

Community Radiology Associates | Frederick Imaging Center

★ 4.8
67 Thomas Johnson Dr #4, Frederick, MD 21702
(888) 601-0943
"It was great people were very nice<br>And understanding"
— Travis Shane, 5★

IC Health Services, Inc.

★ 4.4 (7 reviews)
15 N Court St #204, Frederick, MD 21701
(240) 698-3678
"I must say, Dr. Chidinma of IC Health Services is amazing. She is caring, open-minded, compassionate, and knowledgeable. She provides the best treatm…"
— Marcus Kometa, 5★

The Center for Holistic Wellness

★ 5.0
6 W 2nd St 1st Floor, Frederick, MD 21701
(240) 739-5081
"The Center for Holistic Wellness providers are very compassionate and caring. I believe Dr. Jedidiah Smith and Mona Theil are truly healers for my mi…"
— Robin Lewis, 5★

Mesa Science Associates Inc.

321 Ballenger Center Dr Ste 125, Frederick, MD 21703
(301) 514-6248

Clinical trials in Frederick: what's recruiting

The Frederick area currently has 256 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Frederick, the most active research areas are:

  • Cancer & Oncology8 studies
  • Brain & Mental Health4 studies
  • Immune & Skin2 studies
  • Heart & Vascular2 studies
  • Diabetes & Metabolism2 studies

Every listing shows the study phase, the recruiting site and its distance from Frederick, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Frederick

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Frederick participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Do I need to be sick to join a clinical trial in Frederick?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Are clinical trials in Frederick safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Frederick, MD?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
How often do new paid studies open in Frederick?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Frederick.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Frederick typically complete one or two studies per year.

Paid clinical trials near Frederick

Other metros within reach

Hagerstown, MD110 Arlington, VA2,332 Washington, DC2,363 Alexandria, VA2,291 Baltimore, MD1,653 York, PA445 Harrisburg, PA403 Fredericksburg, VA38

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Frederick Severe Chronic Pruritus in Frederick Heart Failure in Frederick Chronic Kidney Disease (HealthMatch) in Frederick Bladder Issues Due To Spinal Cord Injury in Frederick All conditions

More of MD

Baltimore1,653 Hagerstown110

New paid studies open every week

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