Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/MD/Frederick
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Frederick, MD

Studies commonly pay $75 to $4,500 per completed study

261 clinical trials are currently recruiting participants within 30 miles of Frederick. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

261studies recruiting
9+research centers nearby
7condition categories
Live from the NIH registry

Studies recruiting near Frederick right now

Top 25 of 261 recruiting studies, sorted by proximity — each links to its official registry page

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
Kaiser Permanente-Gaithersburg Medical Center — Gaithersburg, Maryland (23.1 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Neovascular Age-related Macular Degeneration Phase 4 Interventional 188 participants sought
Cumberland Valley Retina Consultants PC — Hagerstown, Maryland (21.7 mi) · Sponsor: Genentech, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04853251)

Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention

Percutaneous Coronary Intervention, Peripheral Endovascular Intervention Phase 4 Interventional 6,000 participants sought
Shady Grove Adventist Hospital — Rockville, Maryland (27.9 mi) · Sponsor: Duke University
See eligibility & contact on ClinicalTrials.gov (NCT06909565)

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

Carcinoma, Transitional Cell, Urinary Bladder Neoplasms Phase 3 Interventional 450 participants sought
James M Stockman Cancer Institute — Frederick, Maryland (1.4 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT07218380)

Real-world Experience Using Nemolizumab in the Treatment of Moderate-to-Severe Atopic Dermatitis in Adolescents & Adults

Atopic Dermatitis N/A Observational 1,000 participants sought
Galderma Investigational Site 7068 — Rockville, Maryland (27.9 mi) · Sponsor: Galderma R&D
See eligibility & contact on ClinicalTrials.gov (NCT06988605)

A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer Phase 2 Interventional 310 participants sought
Site 0146 - Maryland Oncology Hematology, PA — Rockville, Maryland (27.9 mi) · Sponsor: K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc
See eligibility & contact on ClinicalTrials.gov (NCT05128825)

A Phase III Trial of BNT324 Versus Docetaxel in Metastatic Castration-resistant Prostate Cancer

Metastatic Castration-resistant Prostate Cancer Phase 3 Interventional 736 participants sought
Maryland Oncology Hematology — Rockville, Maryland (27.9 mi) · Sponsor: BioNTech SE
See eligibility & contact on ClinicalTrials.gov (NCT07365995)

A Study to Evaluate Efficacy and Safety of MELT-300 for Procedural Sedation in Subjects Undergoing Cataract Extraction With Lens Replacement (CELR)

Cataract Phase 3 Interventional 528 participants sought
Maryland Vision Institute — Hagerstown, Maryland (21.7 mi) · Sponsor: Melt Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT06383273)

A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

Geographic Atrophy, Macular Degeneration Phase 2 Interventional 274 participants sought
Cumberland Valley Retina Consultants — Hagerstown, Maryland (21.7 mi) · Sponsor: Janssen Research & Development, LLC
See eligibility & contact on ClinicalTrials.gov (NCT06635148)

A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)

Bipolar Disorder Type I With Mania Phase 3 Interventional 450 participants sought
CBH Health — Gaithersburg, Maryland (23.1 mi) · Sponsor: Bristol-Myers Squibb
See eligibility & contact on ClinicalTrials.gov (NCT06929273)

Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

Locally Advanced Lung Non-Small Cell Carcinoma, Stage IIB Lung Cancer AJCC v8 Phase 3 Interventional 474 participants sought
William E Kahlert Regional Cancer Center/Sinai Hospital — Westminster, Maryland (24.4 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05624996)

Syringe Service Based Telemedicine and Social Network Driven HIV Prevention Service Implementation

HIV Infections, Substance Use Disorders N/A Interventional 360 participants sought
Frederick County Health Department, Street Safe Program — Frederick, Maryland (1.4 mi) · Sponsor: Johns Hopkins University
See eligibility & contact on ClinicalTrials.gov (NCT06103370)

Phase 2 Study of ADX-038 in Participants With Geographic Atrophy

Geographic Atrophy Secondary to Age-related Macular Degeneration Phase 2 Interventional 240 participants sought
ADARx Clinical Site — Hagerstown, Maryland (21.7 mi) · Sponsor: ADARx Pharmaceuticals, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06990269)

DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study

Pleuropulmonary Blastoma, Cystic Nephroma N/A Observational 1,500 participants sought
National Cancer Institute - Shady Grove — Rockville, Maryland (27.9 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT01247597)

ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

Cardiovascular Risk, Acute Myocardial Infarction (AMI) Phase 3 Interventional 10,000 participants sought
Adventist HealthCare Shady Grove Medical Center — Rockville, Maryland (27.9 mi) · Sponsor: Novo Nordisk A/S
See eligibility & contact on ClinicalTrials.gov (NCT06118281)

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)

Macular Degeneration, Age-Related Macular Degeneration Phase 2, Phase 3 Interventional 960 participants sought
Cumberland Valley Retina Consultants (Site 007) — Hagerstown, Maryland (21.7 mi) · Sponsor: EyeBiotech Ltd.
See eligibility & contact on ClinicalTrials.gov (NCT07440225)

A Study to Assess Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Children From 2 to Less Than 12 Years of Age With Moderate to Severe Atopic Dermatitis

Atopic Dermatitis Phase 3 Interventional 675 participants sought
DermAssociates - Rockville /ID# 266457 — Rockville, Maryland (27.9 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT06461897)

A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)

Psoriasis, Overweight or Obesity Phase 4 Interventional 200 participants sought
Dermatology and Skin Cancer Specialists, LLC — Rockville, Maryland (27.9 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT06857942)

Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

Advanced Endometrial Carcinoma, Recurrent Endometrial Carcinoma Phase 3 Interventional 255 participants sought
WVUH-Berkely Medical Center — Martinsburg, West Virginia (29.4 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT07198074)

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Ovarian Carcinoma N/A Interventional 1,956 participants sought
WVUH-Berkely Medical Center — Martinsburg, West Virginia (29.4 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT04251052)
Actively enrolling

Studies you may be able to join near Frederick

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for severe chronic itching

Enrolling adults aged 18 to 90 who have had chronic itching for six months or longer. Not open to itching caused by atopic dermatitis, psoriasis, chronic kidney disease, notalgia paresthetica or medication, nor to people with an autoimmune condition such as lupus, Crohn's disease, ulcerative colitis or rheumatoid arthritis.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for heart failure

This study is enrolling adults in eligible areas of the United States who have been diagnosed with heart failure. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research studies for chronic kidney disease

This research platform is enrolling Black and African American adults in eligible areas who have been diagnosed with chronic kidney disease. Compensation may be available. The study team confirms eligibility before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Frederick

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Frederick National Laboratory for Cancer Research

★ 4.5
8560 Progress Drive, Frederick, MD 21701
(301) 846-1000

Work NCI Advanced Technology Research Facility

★ 4.9
8560 Progress Drive, Frederick, MD 21701

Concerted Care Group Frederick

★ 4.8 (83 reviews)
92 Thomas Johnson Dr Ste 100, Frederick, MD 21702
(240) 815-7300
"Kelly B the front receptionist is by far the BEST... First off she makes you feel at home when you walk through the door until the moment you walk ou…"
— Melissa Allen, 5★

National Cancer Institute -- Frederick Campus

★ 4.4
1050 Boyles St, Frederick, MD 21702
(800) 422-6237

HIV Dynamics and Replication Program

★ 4.0
1050 Boyles St Bldg 535, Rm 309, Frederick, MD 21702

Community Radiology Associates | Frederick Imaging Center

★ 4.8
67 Thomas Johnson Dr #4, Frederick, MD 21702
(888) 601-0943
"It was great people were very nice<br>And understanding"
— Travis Shane, 5★

IC Health Services, Inc.

★ 4.4 (7 reviews)
15 N Court St #204, Frederick, MD 21701
(240) 698-3678
"I must say, Dr. Chidinma of IC Health Services is amazing. She is caring, open-minded, compassionate, and knowledgeable. She provides the best treatm…"
— Marcus Kometa, 5★

The Center for Holistic Wellness

★ 5.0
6 W 2nd St 1st Floor, Frederick, MD 21701
(240) 739-5081
"The Center for Holistic Wellness providers are very compassionate and caring. I believe Dr. Jedidiah Smith and Mona Theil are truly healers for my mi…"
— Robin Lewis, 5★

Mesa Science Associates Inc.

321 Ballenger Center Dr Ste 125, Frederick, MD 21703
(301) 514-6248

Clinical trials in Frederick: what's recruiting

The Frederick area currently has 261 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Frederick, the most active research areas are:

  • Cancer & Oncology9 studies
  • Heart & Vascular4 studies
  • Immune & Skin3 studies
  • Brain & Mental Health2 studies
  • Liver & Kidney1 studies

Every listing shows the study phase, the recruiting site and its distance from Frederick, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Frederick

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Frederick participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Do I need to be sick to join a clinical trial in Frederick?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Are clinical trials in Frederick safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Frederick, MD?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
How often do new paid studies open in Frederick?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Frederick.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Frederick typically complete one or two studies per year.

Paid clinical trials near Frederick

Other metros within reach

Hagerstown, MD111 Arlington, VA2,342 Washington, DC2,372 Alexandria, VA2,298 Baltimore, MD1,646 York, PA453 Harrisburg, PA405 Fredericksburg, VA33

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Frederick Severe Chronic Pruritus in Frederick Heart Failure in Frederick Chronic Kidney Disease (HealthMatch) in Frederick Bladder Issues Due To Spinal Cord Injury in Frederick All conditions

More of MD

Baltimore1,646 Hagerstown111

New paid studies open every week

Get an email when a new clinical trial starts recruiting within 30 miles of your ZIP code. No spam — only real studies from the NIH registry.

By subscribing you agree to receive study alert emails. Unsubscribe anytime in one click.

Get free trial alerts