Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/PA/Harrisburg
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Harrisburg, PA

Studies commonly pay $75 to $4,500 per completed study

402 clinical trials are currently recruiting participants within 30 miles of Harrisburg. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

402studies recruiting
9+research centers nearby
6condition categories
Live from the NIH registry

Studies recruiting near Harrisburg right now

Top 25 of 402 recruiting studies, sorted by proximity — each links to its official registry page

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
UPMC Pinnacle Harrisburg — Harrisburg, Pennsylvania (0.1 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

Emicizumab for Severe Von Willebrand Disease (VWD) and VWD/Hemophilia A

Von Willebrand Disease, Type 3, Concomitant VWD and Hemophilia Phase 1 Interventional 40 participants sought
Penn State College of Medicine — Hershey, Pennsylvania (12.4 mi) · Sponsor: Bleeding and Clotting Disorders Institute Peoria, Illinois
See eligibility & contact on ClinicalTrials.gov (NCT05500807)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Penn State Children's Hospital — Hershey, Pennsylvania (12.4 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma Phase 3 Interventional 1,200 participants sought
Cancer Care Associates Of York ( Site 0005) — York, Pennsylvania (23.1 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06136559)

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Lymphoma, Large B-Cell, Diffuse Phase 2 Interventional 594 participants sought
Cancer Care Associates Of York ( Site 0174) — York, Pennsylvania (23.1 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06890884)

A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy

Locally Advanced Head and Neck Squamous Cell Carcinoma Phase 3 Interventional 1,145 participants sought
Research Site — York, Pennsylvania (23.1 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06129864)

Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)

Triple-Negative Breast Cancer Phase 3 Interventional 1,530 participants sought
Cancer Care Associates Of York ( Site 9517) — York, Pennsylvania (23.1 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06393374)

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Endometrial Cancer Phase 3 Interventional 600 participants sought
Research Site — Hershey, Pennsylvania (12.4 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06989112)

IGNITE: Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL)

Relapsed/Refractory Primary Central Nervous System Lymphoma Phase 3 Interventional 132 participants sought
Penn State Health Milton S Hershey Medical Center — Hershey, Pennsylvania (12.4 mi) · Sponsor: Ono Pharmaceutical Co., Ltd.
See eligibility & contact on ClinicalTrials.gov (NCT07104032)

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 189 participants sought
UPMC Pinnacle Cancer Center/Community Osteopathic Campus — Harrisburg, Pennsylvania (0.1 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT02734537)

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

Smoldering Plasma Cell Myeloma Phase 3 Interventional 288 participants sought
Penn State Milton S Hershey Medical Center — Hershey, Pennsylvania (12.4 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT03937635)

ENdoluminal LIGHT ActivatED Treatment of Upper Tract Urothelial Cancer (ENLIGHTED) Study

Transitional Cell Cancer of Renal Pelvis and Ureter Phase 3 Interventional 100 participants sought
The Pennsylvania State University (Penn State) Milton S. Hershey Medical Center — Hershey, Pennsylvania (12.4 mi) · Sponsor: Steba Biotech S.A.
See eligibility & contact on ClinicalTrials.gov (NCT04620239)

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm Phase 2 Interventional 2,000 participants sought
Penn State Milton S Hershey Medical Center — Hershey, Pennsylvania (12.4 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05564390)

E-Mindfulness Approaches for Living After Breast Cancer

Breast Cancer, Depression Phase 3 Interventional 402 participants sought
UPMC Pinnacle Cancer Center/Community Osteopathic Campus — Harrisburg, Pennsylvania (0.1 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06748222)

A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)

Amyotrophic Lateral Sclerosis (ALS), Chronic Respiratory Failure Phase 2 Interventional 48 participants sought
Penn State Hershey ALS Clinic — Hershey, Pennsylvania (12.4 mi) · Sponsor: University of Pennsylvania
See eligibility & contact on ClinicalTrials.gov (NCT07071935)

Collection of Research Data and Samples From Patients Who Experience Immunotherapy Side Effects

Malignancy N/A Observational 240 participants sought
Cancer Care Associates of York — York, Pennsylvania (23.1 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT04242095)

Naxitamab Added to Induction for Newly Diagnosed High-Risk Neuroblastoma

Neuroblastoma Phase 2 Interventional 93 participants sought
Penn State Milton S. Hershey Medical Center and Children's Hospital — Hershey, Pennsylvania (12.4 mi) · Sponsor: Giselle Sholler
See eligibility & contact on ClinicalTrials.gov (NCT05489887)

Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention

Percutaneous Coronary Intervention, Peripheral Endovascular Intervention Phase 4 Interventional 6,000 participants sought
Capital Area Research LLC — Camp Hill, Pennsylvania (3.1 mi) · Sponsor: Duke University
See eligibility & contact on ClinicalTrials.gov (NCT06909565)

Limiting Emergence Phenomena After General Anesthesia With Combined LMA and ETT Airway Management Technique

Limit Emergence Phenomena After General Anesthesia N/A Interventional 130 participants sought
Penn State Health - Hershey Medical Center — Hershey, Pennsylvania (12.4 mi) · Sponsor: Milton S. Hershey Medical Center
See eligibility & contact on ClinicalTrials.gov (NCT02708836)

The MIRROR Registry: Minimally Invasive IntRaceRebral HemORrhage Evacuation

Supratentorial Hemorrhage N/A Observational 500 participants sought
Pennsylvania State University — Hershey, Pennsylvania (12.4 mi) · Sponsor: Integra LifeSciences Corporation
See eligibility & contact on ClinicalTrials.gov (NCT04494295)
Actively enrolling

Studies you may be able to join near Harrisburg

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Harrisburg

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Capital Area Research LLC

★ 5.0
875 Poplar Church Rd #330, Camp Hill, PA 17011
(717) 963-8389
"The personalized care you receive here is beyond superb! Staff is easy to talk to, knowledgeable, and always on top of things. Highly recommend!"
— Donna Preas, 5★

Penn State Health Holy Spirit Medical Center

★ 2.4
503 N 21st St, Camp Hill, PA 17011
(717) 763-2100

Hershey Center for Applied Research

★ 4.5
1214 Research Blvd, Hummelstown, PA 17036
(717) 531-8520
"I go here to be seen by my<br>Doctor to get my CPAP perception renewed.<br>The people here are very friendly and helpful.<br>I definitely recommend t…"
— Kenneth Kanode, 5★

Pennsylvania Headache Center - Camp Hill

★ 5.0
205 Grandview Ave #206, Camp Hill, PA 17011
(717) 745-6223
"The PA Headache Center and Dr Peterlin are wonderful. The medical results have been fantastic, the office is well run, and they make being a patient …"
— Kristin Behfar, 5★

Clinical Research Center-Reading

2760 Century Blvd #3, Reading, PA 19610
(610) 375-2466

Center for Vein Restoration | Dr. Tanya Flohr

★ 4.8
2025 Technology Pkwy Ste 304, Mechanicsburg, PA 17050
(443) 219-0624
"Staff is fantastic. Procedures went well. The only problem is the wait time when you get there. It was too long a wait to finally see doctor. Doc…"
— Carole Miller, 5★

Clinicaltrialmd.com

★ 5.0
2014 S Tollgate Rd Ste 207, Bel Air, MD 21015
(410) 670-3076
"Wonderful staff and easy testing. Overall, a good experience!"
— Julia, 5★

Arkview Recovery Center

★ 4.8 (142 reviews)
4950 Wilson Ln, Mechanicsburg, PA 17055
(717) 876-8222
"There's so many people that work here with good intentions but they constantly change the rules instead of talking to individual people causing probl…"
— Lucy, 1★

Penn State Health Milton S. Hershey Medical Center

★ 3.1
500 University Dr, Hershey, PA 17033
(800) 243-1455

Clinical trials in Harrisburg: what's recruiting

The Harrisburg area currently has 402 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Harrisburg, the most active research areas are:

  • Cancer & Oncology14 studies
  • Liver & Kidney2 studies
  • Diabetes & Metabolism1 studies
  • Brain & Mental Health1 studies
  • Lungs & Breathing1 studies

Every listing shows the study phase, the recruiting site and its distance from Harrisburg, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Harrisburg

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Harrisburg participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Are clinical trials in Harrisburg safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
What is the difference between a research center and a hospital study in Harrisburg?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Harrisburg?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Harrisburg.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Harrisburg typically complete one or two studies per year.

Paid clinical trials near Harrisburg

Other metros within reach

York, PA447 Lancaster, PA431 Reading, PA280 Frederick, MD262 Baltimore, MD1,650 Hagerstown, MD114 Washington, DC2,362 Arlington, VA2,331

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Harrisburg Bladder Issues Due To Spinal Cord Injury in Harrisburg All conditions

More of PA

Philadelphia2,177 Pittsburgh1,232 York447 Lancaster431 Reading280 Allentown234 Scranton99 Erie89

New paid studies open every week

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