Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/CA/Mission Viejo
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Mission Viejo, CA

Studies commonly pay $75 to $4,500 per completed study

1,394 clinical trials are currently recruiting participants within 30 miles of Mission Viejo. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

1,394studies recruiting
9+research centers nearby
6condition categories
Live from the NIH registry

Studies recruiting near Mission Viejo right now

Top 25 of 1,394 recruiting studies, sorted by proximity — each links to its official registry page

A Study to Evaluate the Safety of AB-1003 (Previously LION-101) in Subjects With Genetic Confirmation of LGMD2I/R9 (Part1)

Limb Girdle Muscular Dystrophy, Limb-Girdle Muscular Dystrophy Type 2 Phase 1, Phase 2 Interventional 10 participants sought
University of California - Irvine — Irvine, California (10.5 mi) · Sponsor: AskBio Inc
See eligibility & contact on ClinicalTrials.gov (NCT05230459)

Emicizumab for Severe Von Willebrand Disease (VWD) and VWD/Hemophilia A

Von Willebrand Disease, Type 3, Concomitant VWD and Hemophilia Phase 1 Interventional 40 participants sought
The Center for Comprehensive Care and Diagnosis of Inherited Blood Disorders (CIBD) — Orange, California (16.8 mi) · Sponsor: Bleeding and Clotting Disorders Institute Peoria, Illinois
See eligibility & contact on ClinicalTrials.gov (NCT05500807)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Children's Hospital of Orange County — Orange, California (16.8 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

Phase 2 Study to Evaluate EI-001 in Non-segmental Vitiligo Patients

Non-segmental Vitiligo Phase 2 Interventional 45 participants sought
Marvel Clinical Research — Huntington Beach, California (20.1 mi) · Sponsor: Elixiron Immunotherapeutics (Hong Kong) Ltd.
See eligibility & contact on ClinicalTrials.gov (NCT07223229)

A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated

Diabetic Macular Edema Phase 1, Phase 2 Interventional 49 participants sought
Retina Associates of Southern California — Huntington Beach, California (20.1 mi) · Sponsor: Boehringer Ingelheim
See eligibility & contact on ClinicalTrials.gov (NCT07553429)

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Neovascular Age-related Macular Degeneration Phase 4 Interventional 188 participants sought
Orange County Retina Med Group — Santa Ana, California (15.4 mi) · Sponsor: Genentech, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04853251)

Shorter Versus Extended Course of Antibiotic Therapy for Necrotizing Soft Tissue Infections

Necrotizing Soft Tissue Infection N/A Observational 50 participants sought
University of California Irvine Medical Center — Orange, California (16.8 mi) · Sponsor: University of California, Irvine
See eligibility & contact on ClinicalTrials.gov (NCT06002607)

Phytocannabinoids for Reducing Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors

Breast Carcinoma, Chemotherapy-Induced Peripheral Neuropathy Phase 2 Interventional 120 participants sought
City of Hope at Irvine Lennar — Irvine, California (10.5 mi) · Sponsor: City of Hope Medical Center
See eligibility & contact on ClinicalTrials.gov (NCT06731894)

YAG Laser Vitreolysis for Vitreous Floaters

Posterior Vitreous Detachment, Myopic Vitreopathy N/A Interventional 50 participants sought
VMR Institute for Vitreous Macula Retina — Huntington Beach, California (20.1 mi) · Sponsor: VMR Consulting, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06915922)

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Endometrial Cancer Phase 3 Interventional 600 participants sought
Research Site — Irvine, California (10.5 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06989112)

Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE)

Complex Regional Pain Syndrome Type I Phase 3 Interventional 270 participants sought
Ambros Clinical Trial Site — Tustin, California (13.6 mi) · Sponsor: Ambros Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07210515)

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

Bladder Carcinoma, Ureter Carcinoma N/A Observational 2,020 participants sought
Hoag Memorial Hospital Presbyterian — Newport Beach, California (15.8 mi) · Sponsor: Guardant Health, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05059444)

Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

Non-Small Cell Lung Cancer Phase 3 Interventional 675 participants sought
Research Site — Newport Beach, California (15.8 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06357533)

A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)

Non-Small Cell Lung Cancer Phase 2 Interventional 120 participants sought
University of California Irvine — Orange, California (16.8 mi) · Sponsor: Regeneron Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT06465329)

Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

Acute Myeloid Leukemia (AML) Phase 3 Interventional 1,300 participants sought
University of California, Irvine — Orange, California (16.8 mi) · Sponsor: Kura Oncology, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07007312)

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

Carcinoma, Transitional Cell, Urinary Bladder Neoplasms Phase 3 Interventional 450 participants sought
Chao Family Comprehensive Cancer Center and Ambulatory Care (CIACC) - Irvine — Irvine, California (10.5 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT07218380)

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
City of Hope at Irvine Lennar — Irvine, California (10.5 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy

Locally Advanced Head and Neck Squamous Cell Carcinoma Phase 3 Interventional 1,145 participants sought
Research Site — Orange, California (16.8 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06129864)

Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

Urothelial Cancer, Bladder Cancer Phase 2, Phase 3 Interventional 630 participants sought
Research Site — Orange, California (16.8 mi) · Sponsor: Daiichi Sankyo
See eligibility & contact on ClinicalTrials.gov (NCT07129993)
Actively enrolling

Studies you may be able to join near Mission Viejo

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Mission Viejo

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Orange County Research Center

★ 4.5
25381 Commercentre Dr, Lake Forest, CA 92630
(714) 550-9990
"The care and kindness I received at this medical facility truly deserve to be recognized. From the very first visit, I felt welcomed and genuinely ca…"
— Ines L. Trejos, 5★

Alliance Research Centers

★ 2.0
24012 Calle De La Plata Ste 230, Laguna Hills, CA 92653
(949) 680-3490
"Alliance illegally misrepresents hidden glucose study as only beverage study to underpay 66% plus. Scam, rip off alert! Beverage weight loss study th…"
— Dai Truong, 1★

Avance Clinical Trials

27020 Alicia Pkwy G, Laguna Niguel, CA 92677
(949) 844-0442

Amnova Clinical Research, LLC

★ 5.0
4902 Irvine Center Dr Ste 104, Irvine, CA 92604
(949) 777-5818
"Couldn’t be happier with the care and treatment for my son. Everything from blood draws to communication outside of business hours made me feel at ea…"
— Tara Popov, 5★

Irvine Research Center

Irvine, CA

Irvine Clinical Research

★ 4.6
2515 McCabe Way #350, Irvine, CA 92614
(949) 753-1663
"Really positive experience overall. The staff and coordinators are all so caring and professional throughout the entire process. You can tell they ge…"
— Kevin Tan, 5★

NRC Research Institute

★ 4.7
1010 W Chapman Ave, Orange, CA 92868
(714) 289-1100
"Great women nurses and what not fun place to get paid amazing place helped me restart my life thank you guys here'sy adres 9460 carnation Westminster…"
— Hibrahim Lozano, 5★

ClinDatrix, Inc.

1 Ada Ste 250, Irvine, CA 92618
(949) 428-6600

Kinetic Clinical Research

★ 5.0
215 N State College Blvd A, Anaheim, CA 92806
(657) 230-7120

Clinical trials in Mission Viejo: what's recruiting

The Mission Viejo area currently has 1,394 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Mission Viejo, the most active research areas are:

  • Cancer & Oncology11 studies
  • Immune & Skin2 studies
  • Diabetes & Metabolism1 studies
  • Heart & Vascular1 studies
  • Liver & Kidney1 studies

Every listing shows the study phase, the recruiting site and its distance from Mission Viejo, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Mission Viejo

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Mission Viejo participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Mission Viejo pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in Mission Viejo?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Are clinical trials in Mission Viejo safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
How often do new paid studies open in Mission Viejo?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Mission Viejo.

Paid clinical trials near Mission Viejo

Other metros within reach

Irvine, CA1,532 Santa Ana, CA1,945 Corona, CA1,578 Anaheim, CA3,181 Garden Grove, CA3,176 Huntington Beach, CA2,863 Fullerton, CA3,246 Riverside, CA946

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Mission Viejo Bladder Issues Due To Spinal Cord Injury in Mission Viejo All conditions

More of CA

Long Beach3,361 Torrance3,253 Fullerton3,246 Anaheim3,181 Garden Grove3,176 Pomona3,138 Glendale2,959 Los Angeles2,949 Huntington Beach2,863 Santa Clarita2,390 Hayward2,268 Oakland2,257

New paid studies open every week

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