Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/CA/Mission Viejo
Updated November 2026 from ClinicalTrials.gov

Paid Clinical Trials in Mission Viejo, CA

Studies commonly pay $75 to $4,500 per completed study

1,416 clinical trials are currently recruiting participants within 30 miles of Mission Viejo. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

1,416studies recruiting
9+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Mission Viejo right now

Top 25 of 1,416 recruiting studies, sorted by proximity — each links to its official registry page

Chemoimmunotherapy and Allogeneic Stem Cell Transplant for NK T-cell Leukemia/Lymphoma

NK-Cell Lymphoma, NK-Cell Leukemia EARLY/Phase 1 Interventional 40 participants sought
Children's Hospital Orange County — Orange, California (16.8 mi) · Sponsor: New York Medical College
See eligibility & contact on ClinicalTrials.gov (NCT03719105)

A Study to Evaluate the Safety of AB-1003 (Previously LION-101) in Subjects With Genetic Confirmation of LGMD2I/R9 (Part1)

Limb Girdle Muscular Dystrophy, Limb-Girdle Muscular Dystrophy Type 2 Phase 1, Phase 2 Interventional 10 participants sought
University of California - Irvine — Irvine, California (10.5 mi) · Sponsor: AskBio Inc
See eligibility & contact on ClinicalTrials.gov (NCT05230459)

Emicizumab for Severe Von Willebrand Disease (VWD) and VWD/Hemophilia A

Von Willebrand Disease, Type 3, Concomitant VWD and Hemophilia Phase 1 Interventional 40 participants sought
The Center for Comprehensive Care and Diagnosis of Inherited Blood Disorders (CIBD) — Orange, California (16.8 mi) · Sponsor: Bleeding and Clotting Disorders Institute Peoria, Illinois
See eligibility & contact on ClinicalTrials.gov (NCT05500807)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Children's Hospital of Orange County — Orange, California (16.8 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

Breast Cancer Phase 3 Interventional 450 participants sought
City of Hope - Lennar Foundation Cancer Center — Irvine, California (10.5 mi) · Sponsor: Hoffmann-La Roche
See eligibility & contact on ClinicalTrials.gov (NCT06790693)

Wearable Device and Behavioral Support for Enhancing Arm Use After Stroke

Chronic Stroke Patients N/A Interventional 32 participants sought
University of California Irvine — Irvine, California (10.5 mi) · Sponsor: University of California, Irvine
See eligibility & contact on ClinicalTrials.gov (NCT07042152)

A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy

Large B-cell Lymphoma, Lymphoma, B-Cell Phase 3 Interventional 400 participants sought
University of California, Irvine — Orange, California (16.8 mi) · Sponsor: Lyell Immunopharma, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07188558)

A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

Sepsis, Acute Kidney Injury Phase 2 Interventional 124 participants sought
Research Site — Newport Beach, California (15.8 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT07215702)

Phase 2 Study to Evaluate EI-001 in Non-segmental Vitiligo Patients

Non-segmental Vitiligo Phase 2 Interventional 45 participants sought
Marvel Clinical Research — Huntington Beach, California (20.1 mi) · Sponsor: Elixiron Immunotherapeutics (Hong Kong) Ltd.
See eligibility & contact on ClinicalTrials.gov (NCT07223229)

A Study to Evaluate Adverse Events, Change in Disease Activity, Tolerability, and How Intravenous ABBV-438 Moves Through the Body in Adult Participants With Multiple Myeloma (MM)

Multiple Myeloma Phase 1 Interventional 127 participants sought
City of Hope - Orange County Lennar Foundation Cancer Center /ID# 279067 — Irvine, California (10.5 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT07409246)

A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated

Diabetic Macular Edema Phase 1, Phase 2 Interventional 49 participants sought
Retina Associates of Southern California — Huntington Beach, California (20.1 mi) · Sponsor: Boehringer Ingelheim
See eligibility & contact on ClinicalTrials.gov (NCT07553429)

Registry of Participants With Generalized Myasthenia Gravis Treated With Alexion C5 Inhibition Therapies (C5ITs)

Generalized Myasthenia Gravis N/A Observational 500 participants sought
Clinical Trial Site — Orange, California (16.8 mi) · Sponsor: Alexion Pharmaceuticals, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04202341)

PyL in Patients With High Risk and Biochemically Recurrent Prostate Cancer

Prostate Cancer Phase 2 Interventional 184 participants sought
Hoag Memorial Hospital Presbyterian — Irvine, California (10.5 mi) · Sponsor: Hoag Memorial Hospital Presbyterian
See eligibility & contact on ClinicalTrials.gov (NCT04700332)

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Neovascular Age-related Macular Degeneration Phase 4 Interventional 188 participants sought
Orange County Retina Med Group — Santa Ana, California (15.4 mi) · Sponsor: Genentech, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04853251)

Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan

Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma Phase 1 Interventional 694 participants sought
City of Hope - Orange County Lennar Foundation Cancer Center /ID# 278589 — Irvine, California (10.5 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT05005403)

Autologous Activated Adipose-derived Stem Cells (RB-ADSC) Injected Directly Into the Brain for Mild to Moderate Alzheimer's Disease

Alzheimer Disease Phase 1 Interventional 18 participants sought
Hoag Memorial Hospital Presbyterian — Newport Beach, California (15.8 mi) · Sponsor: Regeneration Biomedical, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05667649)

Shorter Versus Extended Course of Antibiotic Therapy for Necrotizing Soft Tissue Infections

Necrotizing Soft Tissue Infection N/A Observational 50 participants sought
University of California Irvine Medical Center — Orange, California (16.8 mi) · Sponsor: University of California, Irvine
See eligibility & contact on ClinicalTrials.gov (NCT06002607)

Phytocannabinoids for Reducing Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors

Breast Carcinoma, Chemotherapy-Induced Peripheral Neuropathy Phase 2 Interventional 120 participants sought
City of Hope at Irvine Lennar — Irvine, California (10.5 mi) · Sponsor: City of Hope Medical Center
See eligibility & contact on ClinicalTrials.gov (NCT06731894)

Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC

Prostate Cancer Phase 3 Interventional 940 participants sought
Univ Cali Irvine ALS Neuromuscular — Orange, California (16.8 mi) · Sponsor: Novartis Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT06855277)

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Endometrial Cancer Phase 3 Interventional 600 participants sought
Research Site — Irvine, California (10.5 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06989112)
Actively enrolling

Studies you may be able to join near Mission Viejo

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Mission Viejo

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Orange County Research Center

★ 4.5
25381 Commercentre Dr, Lake Forest, CA 92630
(714) 550-9990
"The care and kindness I received at this medical facility truly deserve to be recognized. From the very first visit, I felt welcomed and genuinely ca…"
— Ines L. Trejos, 5★

Alliance Research Centers

★ 2.0
24012 Calle De La Plata Ste 230, Laguna Hills, CA 92653
(949) 680-3490
"Alliance illegally misrepresents hidden glucose study as only beverage study to underpay 66% plus. Scam, rip off alert! Beverage weight loss study th…"
— Dai Truong, 1★

Avance Clinical Trials

27020 Alicia Pkwy G, Laguna Niguel, CA 92677
(949) 844-0442

Amnova Clinical Research, LLC

★ 5.0
4902 Irvine Center Dr Ste 104, Irvine, CA 92604
(949) 777-5818
"Couldn’t be happier with the care and treatment for my son. Everything from blood draws to communication outside of business hours made me feel at ea…"
— Tara Popov, 5★

Irvine Research Center

Irvine, CA

Irvine Clinical Research

★ 4.6
2515 McCabe Way #350, Irvine, CA 92614
(949) 753-1663
"Really positive experience overall. The staff and coordinators are all so caring and professional throughout the entire process. You can tell they ge…"
— Kevin Tan, 5★

NRC Research Institute

★ 4.7
1010 W Chapman Ave, Orange, CA 92868
(714) 289-1100
"Great women nurses and what not fun place to get paid amazing place helped me restart my life thank you guys here'sy adres 9460 carnation Westminster…"
— Hibrahim Lozano, 5★

ClinDatrix, Inc.

1 Ada Ste 250, Irvine, CA 92618
(949) 428-6600

Kinetic Clinical Research

★ 5.0
215 N State College Blvd A, Anaheim, CA 92806
(657) 230-7120

Clinical trials in Mission Viejo: what's recruiting

The Mission Viejo area currently has 1,416 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Mission Viejo, the most active research areas are:

  • Cancer & Oncology10 studies
  • Heart & Vascular2 studies
  • Diabetes & Metabolism2 studies
  • Liver & Kidney1 studies
  • Brain & Mental Health1 studies

Every listing shows the study phase, the recruiting site and its distance from Mission Viejo, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Mission Viejo

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Mission Viejo participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Mission Viejo pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in Mission Viejo?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Are clinical trials in Mission Viejo safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
How often do new paid studies open in Mission Viejo?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Mission Viejo.

Paid clinical trials near Mission Viejo

Other metros within reach

Irvine, CA1,557 Santa Ana, CA1,979 Corona, CA1,605 Anaheim, CA3,212 Garden Grove, CA3,202 Huntington Beach, CA2,870 Fullerton, CA3,269 Riverside, CA960

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Mission Viejo Bladder Issues Due To Spinal Cord Injury in Mission Viejo All conditions

More of CA

Long Beach3,380 Fullerton3,269 Torrance3,260 Anaheim3,212 Garden Grove3,202 Pomona3,169 Glendale2,968 Los Angeles2,945 Huntington Beach2,870 Santa Clarita2,368 Hayward2,274 Fremont2,265

New paid studies open every week

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