Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/CA/Santa Ana
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Santa Ana, CA

Studies commonly pay $75 to $4,500 per completed study

1,945 clinical trials are currently recruiting participants within 30 miles of Santa Ana. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

1,945studies recruiting
9+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Santa Ana right now

Top 25 of 1,945 recruiting studies, sorted by proximity — each links to its official registry page

Congenital Muscle Disease Study of Patient and Family Reported Medical Information

Multiple conditions N/A Observational 4,000 participants sought
Congenital Muscle Disease International Registry (www.cmdir.org) — Lakewood, California (16.6 mi) · Sponsor: Cure CMD
See eligibility & contact on ClinicalTrials.gov (NCT01403402)

Emicizumab for Severe Von Willebrand Disease (VWD) and VWD/Hemophilia A

Von Willebrand Disease, Type 3, Concomitant VWD and Hemophilia Phase 1 Interventional 40 participants sought
The Center for Comprehensive Care and Diagnosis of Inherited Blood Disorders (CIBD) — Orange, California (3.9 mi) · Sponsor: Bleeding and Clotting Disorders Institute Peoria, Illinois
See eligibility & contact on ClinicalTrials.gov (NCT05500807)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Children's Hospital of Orange County — Orange, California (3.9 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Lymphoma, Large B-Cell, Diffuse Phase 2 Interventional 594 participants sought
City of Hope Comprehensive Cancer Center ( Site 0191) — Duarte, California (28.4 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06890884)

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

PIK3CA Mutation, HER2- Negative Breast Cancer Phase 3 Interventional 540 participants sought
City of Hope National Medical Center — Duarte, California (28.4 mi) · Sponsor: Relay Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06982521)

Phase 2 Study to Evaluate EI-001 in Non-segmental Vitiligo Patients

Non-segmental Vitiligo Phase 2 Interventional 45 participants sought
Marvel Clinical Research — Huntington Beach, California (8.6 mi) · Sponsor: Elixiron Immunotherapeutics (Hong Kong) Ltd.
See eligibility & contact on ClinicalTrials.gov (NCT07223229)

A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated

Diabetic Macular Edema Phase 1, Phase 2 Interventional 49 participants sought
Retina Associates of Southern California — Huntington Beach, California (8.6 mi) · Sponsor: Boehringer Ingelheim
See eligibility & contact on ClinicalTrials.gov (NCT07553429)

A Study to Evaluate the Safety of AB-1003 (Previously LION-101) in Subjects With Genetic Confirmation of LGMD2I/R9 (Part1)

Limb Girdle Muscular Dystrophy, Limb-Girdle Muscular Dystrophy Type 2 Phase 1, Phase 2 Interventional 10 participants sought
University of California - Irvine — Irvine, California (5.7 mi) · Sponsor: AskBio Inc
See eligibility & contact on ClinicalTrials.gov (NCT05230459)

Shorter Versus Extended Course of Antibiotic Therapy for Necrotizing Soft Tissue Infections

Necrotizing Soft Tissue Infection N/A Observational 50 participants sought
University of California Irvine Medical Center — Orange, California (3.9 mi) · Sponsor: University of California, Irvine
See eligibility & contact on ClinicalTrials.gov (NCT06002607)

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Endometrial Cancer Phase 3 Interventional 600 participants sought
Research Site — Irvine, California (5.7 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06989112)

A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies

Solid Tumors Phase 2 Interventional 170 participants sought
Southern California Permanente Medical Group — Bellflower, California (16.8 mi) · Sponsor: Mirati Therapeutics Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07415031)

KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)

Carcinoma, Non-Small-Cell Lung Phase 1, Phase 2 Interventional 450 participants sought
City of Hope ( Site 0014) — Duarte, California (28.4 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT04165070)

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Neovascular Age-related Macular Degeneration Phase 4 Interventional 188 participants sought
Orange County Retina Med Group — Santa Ana, California (1.0 mi) · Sponsor: Genentech, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04853251)

A First-in-human (FIH), Phase I Study of PTX-912 in Patients with Locally Advanced/Metastatic Solid Tumors

Advanced Cancer, Solid Tumor Phase 1 Interventional 26 participants sought
City of Hope National Medical Center — Duarte, California (28.4 mi) · Sponsor: Proviva Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06190886)

225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome

Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia Phase 1 Interventional 15 participants sought
City of Hope Medical Center — Duarte, California (28.4 mi) · Sponsor: City of Hope Medical Center
See eligibility & contact on ClinicalTrials.gov (NCT06287944)

Phytocannabinoids for Reducing Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors

Breast Carcinoma, Chemotherapy-Induced Peripheral Neuropathy Phase 2 Interventional 120 participants sought
City of Hope at Irvine Lennar — Irvine, California (5.7 mi) · Sponsor: City of Hope Medical Center
See eligibility & contact on ClinicalTrials.gov (NCT06731894)

A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors

MTAP-deleted Solid Tumors Phase 1, Phase 2 Interventional 450 participants sought
City of Hope - Duarte Cancer Center — Duarte, California (28.4 mi) · Sponsor: Bayer
See eligibility & contact on ClinicalTrials.gov (NCT06914128)

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

Bladder Carcinoma, Ureter Carcinoma N/A Observational 2,020 participants sought
Hoag Memorial Hospital Presbyterian — Newport Beach, California (8.6 mi) · Sponsor: Guardant Health, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05059444)

Multicenter Clinical Study of the SING-IMT in Patients with Late-stage AMD

Age-Related Macular Degeneration, Geographic Atrophy N/A Interventional 125 participants sought
Eye Physicians of Long Beach — Long Beach, California (17.8 mi) · Sponsor: VisionCare, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05438732)

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

Solid Tumor, Adult, Metastatic Breast Cancer Phase 1 Interventional 392 participants sought
City of Hope Comprehensive Cancer Center — Duarte, California (28.4 mi) · Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)
See eligibility & contact on ClinicalTrials.gov (NCT06625775)

A Study to Evaluate Safety, Tolerability and Efficacy of AP306 at Fixed Doses in Dialysis Participants With Hyperphosphatemia

Hyperphosphatemia, Chronic Kidney Disease Requiring Chronic Dialysis Phase 2 Interventional 168 participants sought
North America Research Institute — San Dimas, California (25.9 mi) · Sponsor: R1 Therapeutics
See eligibility & contact on ClinicalTrials.gov (NCT06712654)

YAG Laser Vitreolysis for Vitreous Floaters

Posterior Vitreous Detachment, Myopic Vitreopathy N/A Interventional 50 participants sought
VMR Institute for Vitreous Macula Retina — Huntington Beach, California (8.6 mi) · Sponsor: VMR Consulting, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06915922)

Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE)

Complex Regional Pain Syndrome Type I Phase 3 Interventional 270 participants sought
Ambros Clinical Trial Site — Tustin, California (3.3 mi) · Sponsor: Ambros Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07210515)
Actively enrolling

Studies you may be able to join near Santa Ana

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research studies for chronic kidney disease

This research platform is enrolling Black and African American adults in eligible areas who have been diagnosed with chronic kidney disease. Compensation may be available. The study team confirms eligibility before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Santa Ana

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Ark Clinical Research

★ 5.0
11160 Warner Ave Ste 311, Fountain Valley, CA 92708
(714) 988-2021
"I love this clinic, everyone that works there is really pleasant, and they make everyone feel comfortable and welcome. I would recommend to any and e…"
— Megan Fillmore, 5★

Sierra Clinical Trials

2010 E 1st St, Santa Ana, CA 92705
(714) 647-1200

NRC Research Institute

★ 4.7
1010 W Chapman Ave, Orange, CA 92868
(714) 289-1100
"Great women nurses and what not fun place to get paid amazing place helped me restart my life thank you guys here'sy adres 9460 carnation Westminster…"
— Hibrahim Lozano, 5★

Velocity Clinical Research

★ 5.0
2621 S Bristol St Ste 303, Santa Ana, CA 92704
(714) 599-8711
"I would like to participate in these clinical studies. I participated in three studies in Mexico at the CECYPE laboratory, and I would like to partic…"
— simon, 5★

Syrentis Clinical Research

★ 4.8
1401 N Tustin Ave #130, Santa Ana, CA 92705
(714) 475-0556
"The Docs and staff at Syrentis Clinical Research are always courteous and professional. They provide a caring environment and communicate all aspect…"
— Glenn Christensen, 5★

Knowledge Research Center

★ 5.0
1010 W La Veta Ave #575, Orange, CA 92868
(657) 247-0087

SDS Clinical Trials

★ 4.8
1535 17th St Ste 101, Santa Ana, CA 92705
(714) 834-1565
"Wonderful caring doctors and staff! They treat their volunteers very well. I like that there are not a lot of other people at the facility when I'm t…"
— Colleen Carmichael, 5★

Wolverine Clinical Trials

★ 5.0
2107 N Broadway Ste 306, Santa Ana, CA 92706
(714) 617-2426
"I had a great experience at this office. Everyone was professional and caring."
— Delia Aponte, 5★

Irvine Clinical Research

★ 4.6
2515 McCabe Way #350, Irvine, CA 92614
(949) 753-1663
"Really positive experience overall. The staff and coordinators are all so caring and professional throughout the entire process. You can tell they ge…"
— Kevin Tan, 5★

Clinical trials in Santa Ana: what's recruiting

The Santa Ana area currently has 1,945 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Santa Ana, the most active research areas are:

  • Cancer & Oncology12 studies
  • Liver & Kidney3 studies
  • Diabetes & Metabolism1 studies
  • Heart & Vascular1 studies
  • Brain & Mental Health1 studies

Every listing shows the study phase, the recruiting site and its distance from Santa Ana, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Santa Ana

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Santa Ana participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Do I need to be sick to join a clinical trial in Santa Ana?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Are clinical trials in Santa Ana safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
What is the difference between a research center and a hospital study in Santa Ana?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Santa Ana?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Santa Ana.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Santa Ana typically complete one or two studies per year.

Paid clinical trials near Santa Ana

Other metros within reach

Garden Grove, CA3,176 Anaheim, CA3,181 Irvine, CA1,532 Huntington Beach, CA2,863 Fullerton, CA3,246 Mission Viejo, CA1,394 Long Beach, CA3,361 Corona, CA1,578

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Santa Ana Chronic Kidney Disease (HealthMatch) in Santa Ana Bladder Issues Due To Spinal Cord Injury in Santa Ana All conditions

More of CA

Long Beach3,361 Torrance3,253 Fullerton3,246 Anaheim3,181 Garden Grove3,176 Pomona3,138 Glendale2,959 Los Angeles2,949 Huntington Beach2,863 Santa Clarita2,390 Hayward2,268 Oakland2,257

New paid studies open every week

Get an email when a new clinical trial starts recruiting within 30 miles of your ZIP code. No spam — only real studies from the NIH registry.

By subscribing you agree to receive study alert emails. Unsubscribe anytime in one click.

Get free trial alerts