Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/CA/Santa Maria
Updated November 2026 from ClinicalTrials.gov

Paid Clinical Trials in Santa Maria, CA

Studies commonly pay $75 to $4,500 per completed study

92 clinical trials are currently recruiting participants within 30 miles of Santa Maria. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

92studies recruiting
4+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Santa Maria right now

Top 25 of 92 recruiting studies, sorted by proximity — each links to its official registry page

A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.

Breast Cancer Phase 3 Interventional 400 participants sought
Sansum Clinic — Solvang, California (29.1 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT07062965)

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

Castration Levels of Testosterone, Metastatic Prostatic Adenocarcinoma Phase 3 Interventional 1,273 participants sought
Pacific Central Coast Health Center-San Luis Obispo — San Luis Obispo, California (27.1 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03678025)

Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps

Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum N/A Interventional 9,500 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05080673)

Collection and Storage of Tissue and Blood Samples From Patients With Cancer

Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm N/A Observational 5,000 participants sought
PCR Oncology — Arroyo Grande, California (15.3 mi) · Sponsor: National Cancer Institute LAO
See eligibility & contact on ClinicalTrials.gov (NCT02474160)

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
PCR Oncology — Arroyo Grande, California (15.3 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancer

Resectable Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 Phase 3 Interventional 1,100 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06632327)

A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis

Myasthenia Gravis, Generalized Phase 2 Interventional 30 participants sought
Tri Valley Neurology Medical Associates Inc. — Mission Hills, California (17.1 mi) · Sponsor: Vertex Pharmaceuticals Incorporated
See eligibility & contact on ClinicalTrials.gov (NCT07501702)

Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas

Intracranial Meningioma, Recurrent Meningioma Phase 2 Interventional 124 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT02523014)

Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8 Phase 3 Interventional 356 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06958328)

A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis

NASH With Fibrosis, MASH With Fibrosis Phase 3 Interventional 1,650 participants sought
Akero Clinical Study Site — Santa Maria, California (1.4 mi) · Sponsor: Akero Therapeutics, Inc
See eligibility & contact on ClinicalTrials.gov (NCT06215716)

Lifestyle Interventions to Prevent Diabetes in U.S. Home Visiting Programs

Diabetes Mellitus, Gestational Diabetes Mellitus (GDM) N/A Interventional 978 participants sought
California Polytechnic State University — San Luis Obispo, California (27.1 mi) · Sponsor: California Polytechnic State University-San Luis Obispo
See eligibility & contact on ClinicalTrials.gov (NCT06988306)

A Study of Efimosfermin Alfa in Participants With Biopsy-confirmed Cirrhosis (Compensated) Due to MASH

Metabolic Dysfunction-Associated Steatohepatitis, Non-alcoholic Fatty Liver Disease Phase 2 Interventional 42 participants sought
GSK Investigational Site — Santa Maria, California (1.4 mi) · Sponsor: GlaxoSmithKline
See eligibility & contact on ClinicalTrials.gov (NCT06920043)

ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 Phase 3 Interventional 1,524 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06876714)

A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

Prostate Cancer Phase 3 Interventional 700 participants sought
Research Site — San Luis Obispo, California (27.1 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06952803)

Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

Metastatic Malignant Neoplasm in the Liver, Pancreatic Neuroendocrine Tumor Phase 2 Interventional 141 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT05040360)

A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

HER2-positive Gastric Cancer, Gastroesophageal Junction Adenocarcinoma Phase 3 Interventional 840 participants sought
Research Site — Solvang, California (29.1 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06764875)

Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment

Plasma Cell Myeloma Phase 3 Interventional 510 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT05561387)

mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma

Advanced Esophageal Adenocarcinoma, Advanced Gastric Adenocarcinoma Phase 3 Interventional 382 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05677490)

Phase 2 Study of Kylo-11 in ASCVD Patients With Elevated Lp(a)

Lipoprotein Disorder Phase 2 Interventional 204 participants sought
FOMAT - Comprehensive Cardiovascular Care-Santa Maria California — Santa Maria, California (1.4 mi) · Sponsor: Kylonova (Xiamen) Biopharma co., LTD.
See eligibility & contact on ClinicalTrials.gov (NCT07327840)

Comparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage Melanoma

Cutaneous Melanoma Phase 3 Interventional 428 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT07068074)

Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)

Elevated Lp(a), Atherosclerotic Cardiovascular Disease (ASCVD) Phase 3 Interventional 10,450 participants sought
FOMAT Medical Research - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT07157774)

Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

Prostate Cancer (Adenocarcinoma) Phase 3 Interventional 830 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Canadian Cancer Trials Group
See eligibility & contact on ClinicalTrials.gov (NCT06592924)

Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube High Grade Serous Adenocarcinoma Phase 3 Interventional 880 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06580314)

Family Communications After Genetic Testing

Colon Adenocarcinoma, Colorectal Adenocarcinoma N/A Interventional 4,186 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT07143487)
Actively enrolling

Studies you may be able to join near Santa Maria

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Santa Maria

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

A.T. Still University - College for Healthy Communities

★ 4.0
1075 Betteravia Rd Suite 201, Santa Maria, CA 93454
(805) 621-7651
"Very clean and the staff very friendly"
— Mario Espinoza, 5★

Ventura Clinical Trials

★ 4.0
1835 Knoll Dr, Ventura, CA 93003
(805) 339-0549
"ALEX WAS SIMPLY AMAZING...VERY PROFESSIONAL YET CARING AS WELL... EXCELLENT BED SIDE MANNER...VERY COMFORTABLE EXPERIENCE.⛑️"
— Manuel Maez, 5★

Labcorp

★ 2.8
1145 E Clark Ave # B, Santa Maria, CA 93455
(805) 934-4498
"I had some blood drawn here and the staff was very friendly and professional. I made an 8:00 a.m. appointment, got there early, and was done and on m…"
— Stephen Herrick, 5★

PCR Oncology

★ 5.0 (4 reviews)
584 Camino Mercado, Arroyo Grande, CA 93420
(805) 474-9143
"Very homely! Staff and doctors are wonderful!"
— jeny fuentes, 5★

Clinical trials in Santa Maria: what's recruiting

The Santa Maria area currently has 92 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Santa Maria, the most active research areas are:

  • Cancer & Oncology17 studies
  • Liver & Kidney3 studies
  • Diabetes & Metabolism2 studies
  • Immune & Skin1 studies
  • Heart & Vascular1 studies

Every listing shows the study phase, the recruiting site and its distance from Santa Maria, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Santa Maria

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Santa Maria participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Santa Maria pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in Santa Maria?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
How often do new paid studies open in Santa Maria?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Santa Maria.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Santa Maria typically complete one or two studies per year.

Paid clinical trials near Santa Maria

Other metros within reach

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By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Santa Maria Bladder Issues Due To Spinal Cord Injury in Santa Maria All conditions

More of CA

Long Beach3,380 Fullerton3,269 Torrance3,260 Anaheim3,212 Garden Grove3,202 Pomona3,169 Glendale2,968 Los Angeles2,945 Huntington Beach2,870 Santa Clarita2,368 Hayward2,274 Fremont2,265

New paid studies open every week

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