Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/CA/Santa Maria
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Santa Maria, CA

Studies commonly pay $75 to $4,500 per completed study

91 clinical trials are currently recruiting participants within 30 miles of Santa Maria. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

91studies recruiting
4+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Santa Maria right now

Top 25 of 91 recruiting studies, sorted by proximity — each links to its official registry page

A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants

Hypothyroidism Phase 2, Phase 3 Interventional 2,800 participants sought
Facey Medical Foundation /ID# 260863 — Mission Hills, California (17.1 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT06345339)

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 189 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT02734537)

Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8 Phase 3 Interventional 356 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06958328)

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Advanced Non-Small Cell Lung Cancer, Non-Small Cell Lung Cancer Phase 3 Interventional 1,410 participants sought
Sansum Clinic — Solvang, California (29.1 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT07222566)

Collection of Research Data and Samples From Patients Who Experience Immunotherapy Side Effects

Malignancy N/A Observational 240 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT04242095)

Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancer

Resectable Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 Phase 3 Interventional 1,100 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06632327)

Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors

Colorectal Cancer Stage II, Colorectal Cancer Stage III Phase 3 Interventional 1,057 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT07018869)

A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma

Neoplasms, Head and Neck Phase 3 Interventional 864 participants sought
GSK Investigational Site — Solvang, California (29.1 mi) · Sponsor: GlaxoSmithKline
See eligibility & contact on ClinicalTrials.gov (NCT06256588)

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

Stage I Breast Cancer Phase 3 Interventional 1,670 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT04852887)

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

Cardiotoxicity, HER2/Neu Positive Phase 3 Interventional 491 participants sought
City of Hope Mission Hills — Mission Hills, California (17.1 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03418961)

Inotuzumab Ozogamicin and Blinatumomab With or Without Ponatinib in Treating Patients With Newly Diagnosed, Recurrent, or Refractory CD22-Positive B-Lineage Acute Lymphoblastic Leukemia

B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative, Recurrent B Acute Lymphoblastic Leukemia Phase 2 Interventional 84 participants sought
PCR Oncology — Arroyo Grande, California (15.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT03739814)

An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis

Ulcerative Colitis Phase 3 Interventional 980 participants sought
Santa Maria Gastroenterology - FOMAT Medical Research HyperCORE - Site Number: 8400025 — Santa Maria, California (1.4 mi) · Sponsor: Sanofi
See eligibility & contact on ClinicalTrials.gov (NCT07184996)

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

Metastatic Malignant Neoplasm in the Lung, Metastatic Osteosarcoma Phase 3 Interventional 62 participants sought
PCR Oncology — Arroyo Grande, California (15.3 mi) · Sponsor: Children's Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT05235165)

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

Castration Levels of Testosterone, Metastatic Prostatic Adenocarcinoma Phase 3 Interventional 1,273 participants sought
Pacific Central Coast Health Center-San Luis Obispo — San Luis Obispo, California (27.1 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03678025)

A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2

Urothelial Carcinoma Phase 2 Interventional 372 participants sought
UCLA Hematology/Oncology - San Luis Obispo — San Luis Obispo, California (27.1 mi) · Sponsor: Seagen, a wholly owned subsidiary of Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT04879329)

Family Communications After Genetic Testing

Colon Adenocarcinoma, Colorectal Adenocarcinoma N/A Interventional 4,186 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT07143487)

Sleep Well Firefighters: An App-based Program to Improve Sleep, Cognition, and Behavioral Health in Firefighters

Sleep Health, Stress N/A Interventional 50 participants sought
California Polytechnic University - San Luis Obispo — San Luis Obispo, California (27.1 mi) · Sponsor: California Polytechnic State University-San Luis Obispo
See eligibility & contact on ClinicalTrials.gov (NCT07477184)

Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube High Grade Serous Adenocarcinoma Phase 3 Interventional 880 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06580314)

Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

Metastatic Malignant Neoplasm in the Liver, Pancreatic Neuroendocrine Tumor Phase 2 Interventional 141 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT05040360)

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Advanced Malignant Solid Neoplasm, Anatomic Stage III Breast Cancer AJCC v8 Phase 2 Interventional 2,900 participants sought
PCR Oncology — Arroyo Grande, California (15.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05564377)

Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors

Hodgkin Lymphoma, Non-Hodgkin Lymphoma N/A Observational 2,000 participants sought
PCR Oncology — Arroyo Grande, California (15.3 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT06002828)

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

Heart Failure Phase 2 Interventional 620 participants sought
Comprehensive Cardiovascular Care — Santa Maria, California (1.4 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT06991257)

A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis

Myasthenia Gravis, Generalized Phase 2 Interventional 30 participants sought
Tri Valley Neurology Medical Associates Inc. — Mission Hills, California (17.1 mi) · Sponsor: Vertex Pharmaceuticals Incorporated
See eligibility & contact on ClinicalTrials.gov (NCT07501702)

Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

Metastatic Clear Cell Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma Phase 3 Interventional 364 participants sought
PCR Oncology — Arroyo Grande, California (15.3 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT04510597)
Actively enrolling

Studies you may be able to join near Santa Maria

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Santa Maria

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

A.T. Still University - College for Healthy Communities

★ 4.0
1075 Betteravia Rd Suite 201, Santa Maria, CA 93454
(805) 621-7651
"Very clean and the staff very friendly"
— Mario Espinoza, 5★

Ventura Clinical Trials

★ 4.0
1835 Knoll Dr, Ventura, CA 93003
(805) 339-0549
"ALEX WAS SIMPLY AMAZING...VERY PROFESSIONAL YET CARING AS WELL... EXCELLENT BED SIDE MANNER...VERY COMFORTABLE EXPERIENCE.⛑️"
— Manuel Maez, 5★

Labcorp

★ 2.8
1145 E Clark Ave # B, Santa Maria, CA 93455
(805) 934-4498
"I had some blood drawn here and the staff was very friendly and professional. I made an 8:00 a.m. appointment, got there early, and was done and on m…"
— Stephen Herrick, 5★

PCR Oncology

★ 5.0 (4 reviews)
584 Camino Mercado, Arroyo Grande, CA 93420
(805) 474-9143
"Very homely! Staff and doctors are wonderful!"
— jeny fuentes, 5★

Clinical trials in Santa Maria: what's recruiting

The Santa Maria area currently has 91 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Santa Maria, the most active research areas are:

  • Cancer & Oncology17 studies
  • Immune & Skin2 studies
  • Heart & Vascular2 studies
  • Liver & Kidney2 studies
  • Brain & Mental Health1 studies

Every listing shows the study phase, the recruiting site and its distance from Santa Maria, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Santa Maria

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Santa Maria participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Santa Maria pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in Santa Maria?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
How often do new paid studies open in Santa Maria?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Santa Maria.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Santa Maria typically complete one or two studies per year.

Paid clinical trials near Santa Maria

Other metros within reach

Santa Barbara, CA97 Oxnard, CA133 Bakersfield, CA66 Thousand Oaks, CA684 Visalia, CA2 Fresno, CA165 Santa Clarita, CA2,390 Salinas, CA43

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Santa Maria Bladder Issues Due To Spinal Cord Injury in Santa Maria All conditions

More of CA

Long Beach3,361 Torrance3,253 Fullerton3,246 Anaheim3,181 Garden Grove3,176 Pomona3,138 Glendale2,959 Los Angeles2,949 Huntington Beach2,863 Santa Clarita2,390 Hayward2,268 Oakland2,257

New paid studies open every week

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