Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only

Home/CA/Santa Maria

Updated September 2026 from ClinicalTrials.gov

Paid Clinical Trials in Santa Maria, CA

Studies commonly pay $75 to $4,500 per completed study

88 clinical trials are currently recruiting participants within 30 miles of Santa Maria. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

88studies recruiting

4+research centers nearby

4condition categories

Live from the NIH registry

Studies recruiting near Santa Maria right now

Top 25 of 88 recruiting studies, sorted by proximity — each links to its official registry page

Sleep Well Firefighters: An App-based Program to Improve Sleep, Cognition, and Behavioral Health in Firefighters

Sleep Health, Stress N/A Interventional 50 participants sought

California Polytechnic University - San Luis Obispo — San Luis Obispo, California (27.1 mi) · Sponsor: California Polytechnic State University-San Luis Obispo

See eligibility & contact on ClinicalTrials.gov (NCT07477184)

Effectiveness of the SoundHeal Multi-Sensory Integrative Therapy Among Justice-Involved Youth

Emotional Dysregulation, Therapeutic Alliance N/A Interventional 12 participants sought

San Luis Obispo County Juvenile Hall — San Luis Obispo, California (27.1 mi) · Sponsor: SoundHeal

See eligibility & contact on ClinicalTrials.gov (NCT07364799)

Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

Metastatic Clear Cell Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma Phase 3 Interventional 364 participants sought

PCR Oncology — Arroyo Grande, California (15.3 mi) · Sponsor: SWOG Cancer Research Network

See eligibility & contact on ClinicalTrials.gov (NCT04510597)

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

Breast Carcinoma, Colorectal Carcinoma N/A Observational 2,000 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Wake Forest University Health Sciences

See eligibility & contact on ClinicalTrials.gov (NCT06418204)

Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancer

Resectable Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 Phase 3 Interventional 1,100 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Alliance for Clinical Trials in Oncology

See eligibility & contact on ClinicalTrials.gov (NCT06632327)

Phase 2 Study of Kylo-11 in ASCVD Patients With Elevated Lp(a)

Lipoprotein Disorder Phase 2 Interventional 204 participants sought

FOMAT - Comprehensive Cardiovascular Care-Santa Maria California — Santa Maria, California (1.4 mi) · Sponsor: Kylonova (Xiamen) Biopharma co., LTD.

See eligibility & contact on ClinicalTrials.gov (NCT07327840)

A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

Endometrial Cancer Phase 3 Interventional 1,123 participants sought

Sansum Clinic (Ridley Tree) ( Site 8007) — Solvang, California (29.1 mi) · Sponsor: Merck Sharp & Dohme LLC

See eligibility & contact on ClinicalTrials.gov (NCT06952504)

Early Intervention to Promote Cardiovascular Health of Mothers and Children

Cardiovascular Health N/A Interventional 6,618 participants sought

California Polytechnic State University — San Luis Obispo, California (27.1 mi) · Sponsor: JHSPH Center for Clinical Trials

See eligibility & contact on ClinicalTrials.gov (NCT06272045)

Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer

Miscellaneous Neoplasm, Nos, Non-Neoplastic Condition, Nos N/A Interventional 535 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Alliance for Clinical Trials in Oncology

See eligibility & contact on ClinicalTrials.gov (NCT07091617)

Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8 Phase 3 Interventional 356 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: NRG Oncology

See eligibility & contact on ClinicalTrials.gov (NCT06958328)

Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors

Colorectal Cancer Stage II, Colorectal Cancer Stage III Phase 3 Interventional 1,057 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: SWOG Cancer Research Network

See eligibility & contact on ClinicalTrials.gov (NCT07018869)

A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis

Myasthenia Gravis, Generalized Phase 2 Interventional 30 participants sought

Tri Valley Neurology Medical Associates Inc. — Mission Hills, California (17.1 mi) · Sponsor: Vertex Pharmaceuticals Incorporated

See eligibility & contact on ClinicalTrials.gov (NCT07501702)

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

Metastatic Malignant Neoplasm in the Lung, Metastatic Osteosarcoma Phase 3 Interventional 62 participants sought

PCR Oncology — Arroyo Grande, California (15.3 mi) · Sponsor: Children's Oncology Group

See eligibility & contact on ClinicalTrials.gov (NCT05235165)

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

Heart Failure Phase 2 Interventional 620 participants sought

Comprehensive Cardiovascular Care — Santa Maria, California (1.4 mi) · Sponsor: Pfizer

See eligibility & contact on ClinicalTrials.gov (NCT06991257)

A Study to Assess Adverse Events and Change in Disease Activity of Multiple Treatment Combinations With Intravenous Mirvetuximab Soravtansine in Adult Participants With Ovarian Cancer

Ovarian Cancer Phase 2 Interventional 400 participants sought

Sansum Clinic - Solvang /ID# 277712 — Solvang, California (29.1 mi) · Sponsor: AbbVie

See eligibility & contact on ClinicalTrials.gov (NCT07059845)

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 189 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: ECOG-ACRIN Cancer Research Group

See eligibility & contact on ClinicalTrials.gov (NCT02734537)

Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer

Urothelial Cancer, Advanced/Metastatic Urothelial Cancer Phase 1, Phase 2 Interventional 132 participants sought

UCLA Hematology/Oncology - San Luis Obispo — San Luis Obispo, California (27.1 mi) · Sponsor: Pfizer

See eligibility & contact on ClinicalTrials.gov (NCT07421700)

Machine Learning Prediction of Possible Central Line Associated Blood Stream Infections and Rate of Reduction

Central Line Associated Blood Stream Infections (CLABSI) N/A Interventional 17,800 participants sought

Providence Holy Cross Medical Center — Mission Hills, California (17.1 mi) · Sponsor: Swedish Medical Center

See eligibility & contact on ClinicalTrials.gov (NCT07108660)

Testing the Addition of Immunotherapy Before Surgery for Patients With Sarcomatoid Mesothelioma

Pleural Biphasic Mesothelioma, Pleural Sarcomatoid Mesothelioma Phase 2 Interventional 26 participants sought

PCR Oncology — Arroyo Grande, California (15.3 mi) · Sponsor: Alliance for Clinical Trials in Oncology

See eligibility & contact on ClinicalTrials.gov (NCT05647265)

Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

Rectal Cancer Phase 3 Interventional 250 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Canadian Cancer Trials Group

See eligibility & contact on ClinicalTrials.gov (NCT06205485)

S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

Anatomic Stage IV Breast Cancer AJCC v8, Estrogen Receptor Positive N/A Interventional 739 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: SWOG Cancer Research Network

See eligibility & contact on ClinicalTrials.gov (NCT03723928)

Family Communications After Genetic Testing

Colon Adenocarcinoma, Colorectal Adenocarcinoma N/A Interventional 4,186 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Alliance for Clinical Trials in Oncology

See eligibility & contact on ClinicalTrials.gov (NCT07143487)

A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

Heart, Heart Failure With Preserved Ejection Fraction (HFPEF) Phase 1 Interventional 42 participants sought

FOMAT — Santa Maria, California (1.4 mi) · Sponsor: Vasa Therapeutics

See eligibility & contact on ClinicalTrials.gov (NCT07219511)

Evidence-Based Quality Improvement to Reduce VA Primary Care Burnout

Burnout, Burnout Syndrome N/A Interventional 203 participants sought

Santa Maria VA Clinic, VA Greater Los Angeles Healthcare System — Santa Maria, California (1.4 mi) · Sponsor: VA Greater Los Angeles Healthcare System

See eligibility & contact on ClinicalTrials.gov (NCT07031245)

Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps

Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum N/A Interventional 9,500 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: NRG Oncology

See eligibility & contact on ClinicalTrials.gov (NCT05080673)

Actively enrolling

Studies you may be able to join near Santa Maria

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Google-rated

Top-rated research centers in Santa Maria

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

A.T. Still University - College for Healthy Communities

★ 4.0

1075 Betteravia Rd Suite 201, Santa Maria, CA 93454

(805) 621-7651

Website

"Very clean and the staff very friendly"

— Mario Espinoza, 5★

Ventura Clinical Trials

★ 4.0

1835 Knoll Dr, Ventura, CA 93003

(805) 339-0549

Website

"ALEX WAS SIMPLY AMAZING...VERY PROFESSIONAL YET CARING AS WELL... EXCELLENT BED SIDE MANNER...VERY COMFORTABLE EXPERIENCE.⛑️"

— Manuel Maez, 5★

Labcorp

★ 2.8

1145 E Clark Ave # B, Santa Maria, CA 93455

(805) 934-4498

Website

"I had some blood drawn here and the staff was very friendly and professional. I made an 8:00 a.m. appointment, got there early, and was done and on m…"

— Stephen Herrick, 5★

PCR Oncology

★ 5.0 (4 reviews)

584 Camino Mercado, Arroyo Grande, CA 93420

(805) 474-9143

Website

"Very homely! Staff and doctors are wonderful!"

— jeny fuentes, 5★

Clinical trials in Santa Maria: what's recruiting

The Santa Maria area currently has 88 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Santa Maria, the most active research areas are:

Cancer & Oncology15 studies
Heart & Vascular3 studies
Brain & Mental Health2 studies
Liver & Kidney1 studies

Every listing shows the study phase, the recruiting site and its distance from Santa Maria, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Santa Maria

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Santa Maria participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Santa Maria pay?

Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.

Do I need to be sick to join a clinical trial in Santa Maria?

No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.

Is compensation for clinical trials taxable?

In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.

How often do new paid studies open in Santa Maria?

Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Santa Maria.

Can I be in more than one clinical trial at a time?

Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Santa Maria typically complete one or two studies per year.

Paid clinical trials near Santa Maria

Other metros within reach

Santa Barbara, CA101 Oxnard, CA130 Bakersfield, CA65 Thousand Oaks, CA668 Visalia, CA2 Fresno, CA165 Santa Clarita, CA2,384 Salinas, CA46

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Santa Maria Bladder Issues Due To Spinal Cord Injury in Santa Maria All conditions

More of CA

Long Beach3,366 Torrance3,258 Fullerton3,251 Anaheim3,193 Garden Grove3,186 Pomona3,148 Glendale2,964 Los Angeles2,949 Huntington Beach2,867 Santa Clarita2,384 Hayward2,257 Oakland2,248

New paid studies open every week

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