Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/CA/Santa Maria
Updated October 2026 from ClinicalTrials.gov

Paid Clinical Trials in Santa Maria, CA

Studies commonly pay $75 to $4,500 per completed study

93 clinical trials are currently recruiting participants within 30 miles of Santa Maria. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

93studies recruiting
4+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Santa Maria right now

Top 25 of 93 recruiting studies, sorted by proximity — each links to its official registry page

RENAISSANCE 2: SPN-817 Phase 2, Double-Blind, Placebo-Controlled Study in Adults With Focal Onset Seizures

Focal Onset Seizures Phase 2 Interventional 216 participants sought
Access Community Clinical Trials — Mission Hills, California (17.1 mi) · Sponsor: Supernus Pharmaceuticals, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06798896)

Effectiveness of the SoundHeal Multi-Sensory Integrative Therapy Among Justice-Involved Youth

Emotional Dysregulation, Therapeutic Alliance N/A Interventional 12 participants sought
San Luis Obispo County Juvenile Hall — San Luis Obispo, California (27.1 mi) · Sponsor: SoundHeal
See eligibility & contact on ClinicalTrials.gov (NCT07364799)

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

Breast Cancer Phase 3 Interventional 3,960 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05879926)

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

Heart Failure Phase 3 Interventional 11,300 participants sought
Research Site — Santa Maria, California (1.4 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06677060)

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

Heart Failure Phase 2 Interventional 620 participants sought
Comprehensive Cardiovascular Care — Santa Maria, California (1.4 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT06991257)

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma Phase 3 Interventional 247 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04269902)

Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

Metastatic Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8 Phase 2 Interventional 240 participants sought
PCR Oncology — Arroyo Grande, California (15.3 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05327686)

Adherence to Different Exercise Interventions

Exercise Adherence N/A Interventional 60 participants sought
California Polytechnic State University — San Luis Obispo, California (27.1 mi) · Sponsor: California Polytechnic State University-San Luis Obispo
See eligibility & contact on ClinicalTrials.gov (NCT06024577)

A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis

NASH With Fibrosis, MASH With Fibrosis Phase 3 Interventional 1,650 participants sought
Akero Clinical Study Site — Santa Maria, California (1.4 mi) · Sponsor: Akero Therapeutics, Inc
See eligibility & contact on ClinicalTrials.gov (NCT06215716)

Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancer

Resectable Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 Phase 3 Interventional 1,100 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06632327)

A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

HER2-positive Gastric Cancer, Gastroesophageal Junction Adenocarcinoma Phase 3 Interventional 840 participants sought
Research Site — Solvang, California (29.1 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06764875)

Symbiotic-GI-16: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer

Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction , or Esophageal Adenocarcinoma, Metastatic Gastric Cancer Phase 2, Phase 3 Interventional 840 participants sought
UCLA Hematology/Oncology - San Luis Obispo — San Luis Obispo, California (27.1 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT07392892)

Sleep Well Firefighters: An App-based Program to Improve Sleep, Cognition, and Behavioral Health in Firefighters

Sleep Health, Stress N/A Interventional 50 participants sought
California Polytechnic University - San Luis Obispo — San Luis Obispo, California (27.1 mi) · Sponsor: California Polytechnic State University-San Luis Obispo
See eligibility & contact on ClinicalTrials.gov (NCT07477184)

Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment

Plasma Cell Myeloma Phase 3 Interventional 510 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT05561387)

Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 Phase 3 Interventional 2,400 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT05929768)

Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer

Miscellaneous Neoplasm, Nos, Non-Neoplastic Condition, Nos N/A Interventional 535 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT07091617)

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

Lung Non-Small Cell Carcinoma, Lung Non-Small Cell Squamous Carcinoma Phase 3 Interventional 1,210 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04267848)

Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas

Intracranial Meningioma, Recurrent Meningioma Phase 2 Interventional 124 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT02523014)

Phase 2 Study of Kylo-11 in ASCVD Patients With Elevated Lp(a)

Lipoprotein Disorder Phase 2 Interventional 204 participants sought
FOMAT - Comprehensive Cardiovascular Care-Santa Maria California — Santa Maria, California (1.4 mi) · Sponsor: Kylonova (Xiamen) Biopharma co., LTD.
See eligibility & contact on ClinicalTrials.gov (NCT07327840)

Early Intervention to Promote Cardiovascular Health of Mothers and Children

Cardiovascular Health N/A Interventional 6,618 participants sought
California Polytechnic State University — San Luis Obispo, California (27.1 mi) · Sponsor: JHSPH Center for Clinical Trials
See eligibility & contact on ClinicalTrials.gov (NCT06272045)

A Study to Assess Adverse Events and Change in Disease Activity of Multiple Treatment Combinations With Intravenous Mirvetuximab Soravtansine in Adult Participants With Ovarian Cancer

Ovarian Cancer Phase 2 Interventional 400 participants sought
Sansum Clinic - Solvang /ID# 277712 — Solvang, California (29.1 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT07059845)

Family Communications After Genetic Testing

Colon Adenocarcinoma, Colorectal Adenocarcinoma N/A Interventional 4,186 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT07143487)

APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation

Pancreatic Acinar Cell Carcinoma, Pancreatic Adenosquamous Carcinoma Phase 2 Interventional 152 participants sought
Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04858334)

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

Obesity, Heart Failure Phase 3 Interventional 5,610 participants sought
Fomat Medical Research — Santa Maria, California (1.4 mi) · Sponsor: Novo Nordisk A/S
See eligibility & contact on ClinicalTrials.gov (NCT07567001)
Actively enrolling

Studies you may be able to join near Santa Maria

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Santa Maria

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

A.T. Still University - College for Healthy Communities

★ 4.0
1075 Betteravia Rd Suite 201, Santa Maria, CA 93454
(805) 621-7651
"Very clean and the staff very friendly"
— Mario Espinoza, 5★

Ventura Clinical Trials

★ 4.0
1835 Knoll Dr, Ventura, CA 93003
(805) 339-0549
"ALEX WAS SIMPLY AMAZING...VERY PROFESSIONAL YET CARING AS WELL... EXCELLENT BED SIDE MANNER...VERY COMFORTABLE EXPERIENCE.⛑️"
— Manuel Maez, 5★

Labcorp

★ 2.8
1145 E Clark Ave # B, Santa Maria, CA 93455
(805) 934-4498
"I had some blood drawn here and the staff was very friendly and professional. I made an 8:00 a.m. appointment, got there early, and was done and on m…"
— Stephen Herrick, 5★

PCR Oncology

★ 5.0 (4 reviews)
584 Camino Mercado, Arroyo Grande, CA 93420
(805) 474-9143
"Very homely! Staff and doctors are wonderful!"
— jeny fuentes, 5★

Clinical trials in Santa Maria: what's recruiting

The Santa Maria area currently has 93 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Santa Maria, the most active research areas are:

  • Cancer & Oncology14 studies
  • Heart & Vascular4 studies
  • Liver & Kidney3 studies
  • Brain & Mental Health2 studies
  • Diabetes & Metabolism1 studies

Every listing shows the study phase, the recruiting site and its distance from Santa Maria, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Santa Maria

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Santa Maria participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Santa Maria pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in Santa Maria?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
How often do new paid studies open in Santa Maria?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Santa Maria.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Santa Maria typically complete one or two studies per year.

Paid clinical trials near Santa Maria

Other metros within reach

Santa Barbara, CA103 Oxnard, CA121 Bakersfield, CA68 Thousand Oaks, CA662 Visalia, CA2 Fresno, CA168 Santa Clarita, CA2,378 Salinas, CA46

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Santa Maria Bladder Issues Due To Spinal Cord Injury in Santa Maria All conditions

More of CA

Long Beach3,380 Fullerton3,270 Torrance3,259 Anaheim3,214 Garden Grove3,204 Pomona3,172 Glendale2,974 Los Angeles2,951 Huntington Beach2,879 Santa Clarita2,378 Hayward2,267 Oakland2,257

New paid studies open every week

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