Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/FL/Port St. Lucie
Updated November 2026 from ClinicalTrials.gov

Paid Clinical Trials in Port St. Lucie, FL

Studies commonly pay $75 to $4,500 per completed study

110 clinical trials are currently recruiting participants within 30 miles of Port St. Lucie. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

110studies recruiting
9+research centers nearby
6condition categories
Live from the NIH registry

Studies recruiting near Port St. Lucie right now

Top 25 of 110 recruiting studies, sorted by proximity — each links to its official registry page

A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This Condition

Metabolic Dysfunction-Associated SteatoHepatitis (MASH) Phase 2 Interventional 120 participants sought
Health Awareness, inc. — Jupiter, Florida (29.9 mi) · Sponsor: Regeneron Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT05519475)

Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS

COPD, Smoking N/A Interventional 290 participants sought
CDC Research Institute — Port Saint Lucie, Florida (2.5 mi) · Sponsor: Philip Morris Products S.A.
See eligibility & contact on ClinicalTrials.gov (NCT07108166)

Substudy-01: A Study of Long-Acting HIV-1 Treatments Taken by Mouth in People With HIV-1 With Undetectable Virus Levels

HIV-1 Infection Phase 2 Interventional 125 participants sought
Midway Immunology and Research Center — Ft. Pierce, Florida (12.2 mi) · Sponsor: Gilead Sciences
See eligibility & contact on ClinicalTrials.gov (NCT07841990)

A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)

Metabolic Dysfunction-Associated Steatotic Liver Disease Phase 3 Interventional 4,500 participants sought
Health Awareness — Jupiter, Florida (29.9 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT07165028)

A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study)

HIV Infections Phase 2 Interventional 186 participants sought
GSK Investigational Site — Ft. Pierce, Florida (12.2 mi) · Sponsor: ViiV Healthcare
See eligibility & contact on ClinicalTrials.gov (NCT07202546)

FIH Study of RGT-419B Alone and With Endocrine Therapy in HR-Positive, HER2-Negative Advanced/Metastatic Breast Cancer

Breast Cancer Phase 1 Interventional 64 participants sought
Hem-Onc Associates of the Treasure Coast — Port Saint Lucie, Florida (2.5 mi) · Sponsor: Regor Pharmaceuticals Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05304962)

Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

Castration-Resistant Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8 Phase 2 Interventional 474 participants sought
Jupiter Medical Center — Jupiter, Florida (29.9 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06632977)

A Study to Learn About the Effects of the Combination of Elranatamab, Daratumumab and Lenalidomide Compared With Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Who Are Not Candidates for Transplant

Multiple Myeloma Phase 3 Interventional 1,060 participants sought
Jupiter Medical Center/Anderson Family Cancer Institute — Jupiter, Florida (29.9 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT05623020)

A Phase 2 Trial of Dotinurad in Xanthine Oxidase Inhibitor (XOI) Intolerant/Uricase Failure Gout Participants

Gout Phase 2 Interventional 90 participants sought
Health Awareness, Inc. — Jupiter, Florida (29.9 mi) · Sponsor: Crystalys Therapeutics
See eligibility & contact on ClinicalTrials.gov (NCT07535034)

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 626 participants sought
Local Institution - 007-926-D — Stuart, Florida (10.1 mi) · Sponsor: Mirati Therapeutics Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04613596)

A Study to Learn About the Effects of Felzartamab Infusions on Adults With Immunoglobulin A Nephropathy (IgAN)

Immunoglobulin A Nephropathy (IgAN) Phase 3 Interventional 454 participants sought
CDC Research Institute, LLC — Port Saint Lucie, Florida (2.5 mi) · Sponsor: Biogen
See eligibility & contact on ClinicalTrials.gov (NCT06935357)

A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease

Alzheimers Disease Phase 3 Interventional 800 participants sought
Alzheimer's Research and Treatment Center — Stuart, Florida (10.1 mi) · Sponsor: Hoffmann-La Roche
See eligibility & contact on ClinicalTrials.gov (NCT07170150)

A Safety and Efficacy Study of HCB101, Fc-fusion Protein Targeting SIRPα-CD47 Pathway, in Solid or Hematological Tumors

Advanced Solid Tumor, Refractory Non-Hodgkin Lymphoma Phase 1 Interventional 80 participants sought
Hematology-Oncology Associates of the Treasure Coast — Port Saint Lucie, Florida (2.5 mi) · Sponsor: FBD Biologics Limited
See eligibility & contact on ClinicalTrials.gov (NCT05892718)

Efficacy and Safety of IMVT-1402 in Adult Participants With Primary Sjogren's Disease With Moderate to Severe Systemic Disease Activity

Primary Sjögren's Syndrome Phase 2 Interventional 180 participants sought
Site Number - 1021 — Jupiter, Florida (29.9 mi) · Sponsor: Immunovant Sciences GmbH
See eligibility & contact on ClinicalTrials.gov (NCT06979531)

RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain

Pain N/A Observational 4,800 participants sought
Louis J. Raso, MD, PA — Jupiter, Florida (29.9 mi) · Sponsor: Boston Scientific Corporation
See eligibility & contact on ClinicalTrials.gov (NCT01719055)

Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration

Neovascular Age-Related Macular Degeneration (nAMD) Phase 3 Interventional 480 participants sought
East Florida Eye Institute — Stuart, Florida (10.1 mi) · Sponsor: 4D Molecular Therapeutics
See eligibility & contact on ClinicalTrials.gov (NCT07064759)

A Study of a Thyroid Hormone Receptor Beta Isoform (THRβ) Agonist and an Semicarbazide Sensitive Amine Oxidase (SSAO) Inhibitor, Alone and in Combination, in Adults With Presumed Metabolic Dysfunction-associated Steatohepatitis (MASH)

Metabolic Dysfunction-associated Steatohepatitis Phase 2 Interventional 160 participants sought
Health Awareness, Inc. — Jupiter, Florida (29.9 mi) · Sponsor: Eccogene
See eligibility & contact on ClinicalTrials.gov (NCT07288138)

Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

Intracerebral Hemorrhage, Atrial Fibrillation Phase 3 Interventional 700 participants sought
Cleveland Clinic Tradition Hospital — Port Saint Lucie, Florida (2.5 mi) · Sponsor: Yale University
See eligibility & contact on ClinicalTrials.gov (NCT03907046)

Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

Endometrial Carcinoma, Endometrial Clear Cell Adenocarcinoma Phase 3 Interventional 360 participants sought
Jupiter Medical Center — Jupiter, Florida (29.9 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05256225)

Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment

Plasma Cell Myeloma Phase 3 Interventional 510 participants sought
Jupiter Medical Center — Jupiter, Florida (29.9 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT05561387)

Study of LHP588 in Subjects With P. Gingivalis-Positive Alzheimer's Disease

Alzheimer Disease, Alzheimer Disease Due to P. Gingivalis Phase 2 Interventional 300 participants sought
Alzheimer's Research and Treatment Center - Stuart — Stuart, Florida (10.1 mi) · Sponsor: Lighthouse Pharmaceuticals, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06847321)

REFINE Study: A Study In a Novel Interspinous Fusion Device In Subjects With Low Back Pain

Lumbar Spinal Stenosis N/A Interventional 100 participants sought
The Raso Pain Center — Jupiter, Florida (29.9 mi) · Sponsor: Pacific Research Institute
See eligibility & contact on ClinicalTrials.gov (NCT05504499)
Actively enrolling

Studies you may be able to join near Port St. Lucie

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Port St. Lucie

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Florida Research and Innovation Center

★ 5.0
9801 SW Discovery Wy, Port St. Lucie, FL 34987

Health Awareness

★ 4.6
1801 SE Hillmoor Dr, Port St. Lucie, FL 34952
(772) 777-3344
"They are always nice and professional and respect your time."
— Julia Terry, 5★

Midway Immunology Research Center

360 E Midway Rd, Fort Pierce, FL 34982
(772) 595-9830

Soma Medical Center, P.A. Adults - Port Saint Lucie

★ 4.6
1170 SW Bayshore Blvd, Port St. Lucie, FL 34983
(772) 309-0020
"I love this medical center. Every visit gets better and better. Everyone is very knowledgeable and professional. They make you feel very comfortable.…"
— PenningtonSherrod, 5★

Brain Matters Research

★ 5.0
900 SE Salerno Rd, Stuart, FL 34997
(772) 223-7880
"They are great ! 👍 please join to cure alzheimers"
— Roberta Pietz, 5★

Alzheimer's Treatment Centers of America

★ 4.0
266 NW Peacock Blvd Ste 204, Port St. Lucie, FL 34986
(772) 298-4477
"Unprofessional and Disappointing Experience - Avoid at All Costs<br>My recent visit to this clinic was, frankly, a waste of time and incredibly frust…"
— Michael Lavenstein, 1★

Comprehensive Clinical Research

★ 4.9
603 Village Blvd #301, West Palm Beach, FL 33409
(561) 478-3177
"Great place employees are very nice"
— Diane Atkins, 5★

Health Synergy Clinical Research

★ 5.0
308 NW 5th Ave, Okeechobee, FL 34972
(863) 824-7989

Florida Cancer Specialists & Research Institute

★ 4.7 (241 reviews)
301 SE Ocean Blvd Suite 102, Stuart, FL 34994
(772) 287-4061
"dr Leary is wonderful, caring , and informative , she put me at rest as soon as i met her and all i can say is thank you from the bottom of my heart …"
— Harry Elsbury, 5★

Clinical trials in Port St. Lucie: what's recruiting

The Port St. Lucie area currently has 110 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Port St. Lucie, the most active research areas are:

  • Cancer & Oncology8 studies
  • Diabetes & Metabolism3 studies
  • Liver & Kidney3 studies
  • Brain & Mental Health2 studies
  • Lungs & Breathing1 studies

Every listing shows the study phase, the recruiting site and its distance from Port St. Lucie, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Port St. Lucie

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Port St. Lucie participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Port St. Lucie pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
How do I join a study in Port St. Lucie, FL?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
What is the difference between a research center and a hospital study in Port St. Lucie?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Port St. Lucie?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Port St. Lucie.

Paid clinical trials near Port St. Lucie

Other metros within reach

Palm Bay, FL74 Fort Lauderdale, FL2,010 Pembroke Pines, FL2,009 Hollywood, FL2,009 Hialeah, FL1,960 Kissimmee, FL940 Winter Haven, FL166 Miami, FL1,931

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Port St. Lucie Bladder Issues Due To Spinal Cord Injury in Port St. Lucie All conditions

More of FL

Fort Lauderdale2,010 Pembroke Pines2,009 Hollywood2,009 Hialeah1,960 Miami1,931 St. Petersburg1,357 Tampa1,338 Deltona971 Orlando957 Kissimmee940 Jacksonville920 Gainesville533

New paid studies open every week

Get an email when a new clinical trial starts recruiting within 30 miles of your ZIP code. No spam — only real studies from the NIH registry.

By subscribing you agree to receive study alert emails. Unsubscribe anytime in one click.

Get free trial alerts