Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/FL/Port St. Lucie
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Port St. Lucie, FL

Studies commonly pay $75 to $4,500 per completed study

106 clinical trials are currently recruiting participants within 30 miles of Port St. Lucie. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

106studies recruiting
9+research centers nearby
6condition categories
Live from the NIH registry

Studies recruiting near Port St. Lucie right now

Top 25 of 106 recruiting studies, sorted by proximity — each links to its official registry page

Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment

Plasma Cell Myeloma Phase 3 Interventional 510 participants sought
Jupiter Medical Center — Jupiter, Florida (29.9 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT05561387)

Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS

COPD, Smoking N/A Interventional 290 participants sought
CDC Research Institute — Port Saint Lucie, Florida (2.5 mi) · Sponsor: Philip Morris Products S.A.
See eligibility & contact on ClinicalTrials.gov (NCT07108166)

A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated

Diabetic Macular Edema Phase 1, Phase 2 Interventional 49 participants sought
East Florida Eye Institute — Stuart, Florida (10.1 mi) · Sponsor: Boehringer Ingelheim
See eligibility & contact on ClinicalTrials.gov (NCT07553429)

Study of AZD2389 Safety, Tolerability, and Pharmacodynamics in Adults With Steatotic Liver Disease and Advanced Fibrosis

Liver Fibrosis, Hepatic Cirrhosis Phase 2 Interventional 104 participants sought
Research Site — Jupiter, Florida (29.9 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT07610837)

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 189 participants sought
Jupiter Medical Center — Jupiter, Florida (29.9 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT02734537)

AZD5335 vs. Mirvetuximab Soravtansine in FRα-high and AZD5335 vs. Chemotherapy in FRα-low Platinum-resistant Ovarian Cancer

Epithelial Ovarian Cancer Phase 3 Interventional 1,100 participants sought
Research Site — Jupiter, Florida (29.9 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT07218809)

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Advanced Non-Small Cell Lung Cancer, Non-Small Cell Lung Cancer Phase 3 Interventional 1,410 participants sought
Hematology Oncology Associates of the Treasure Coast — Port Saint Lucie, Florida (2.5 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT07222566)

A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma

Primary Open Angle Glaucoma Phase 3 Interventional 130 participants sought
New Vision Eye Center /ID# 269955 — Vero Beach, Florida (24.8 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT06822738)

A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease

Alzheimer's Disease Phase 3 Interventional 586 participants sought
Alzheimer's Research and Treatment Center — Stuart, Florida (10.1 mi) · Sponsor: Bristol-Myers Squibb
See eligibility & contact on ClinicalTrials.gov (NCT06976216)

A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)

Leukemia, Myeloid, Acute Phase 3 Interventional 600 participants sought
Jupiter Research — Jupiter, Florida (29.9 mi) · Sponsor: Janssen Research & Development, LLC
See eligibility & contact on ClinicalTrials.gov (NCT06852222)

First-in-human Study of 7MW4911 in GI Cancer

GI Cancers Phase 1, Phase 2 Interventional 200 participants sought
Hematology Oncology Associates of the Treasure Coast — Port Saint Lucie, Florida (2.5 mi) · Sponsor: Mabwell (Shanghai) Bioscience Co., Ltd.
See eligibility & contact on ClinicalTrials.gov (NCT07216560)

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8 Phase 3 Interventional 1,209 participants sought
Jupiter Medical Center — Jupiter, Florida (29.9 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05946213)

A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis Phase 3 Interventional 1,350 participants sought
89bio Clinical Study Site — Jupiter, Florida (29.9 mi) · Sponsor: 89bio, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06318169)

A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease

Alzheimers Disease Phase 3 Interventional 800 participants sought
Alzheimer's Research and Treatment Center — Stuart, Florida (10.1 mi) · Sponsor: Hoffmann-La Roche
See eligibility & contact on ClinicalTrials.gov (NCT07170150)

Efficacy and Safety of IMVT-1402 in Adult Participants With Primary Sjogren's Disease With Moderate to Severe Systemic Disease Activity

Primary Sjögren's Syndrome Phase 2 Interventional 180 participants sought
Site Number - 1021 — Jupiter, Florida (29.9 mi) · Sponsor: Immunovant Sciences GmbH
See eligibility & contact on ClinicalTrials.gov (NCT06979531)

Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease

Diabetic Kidney Disease (DKD) Phase 2 Interventional 270 participants sought
CDC Research Institute — Port Saint Lucie, Florida (2.5 mi) · Sponsor: Regeneron Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT07271186)

BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease

HR+/HER2- Breast Cancer Phase 3 Interventional 1,056 participants sought
Hematology Oncology Associates of the Treasure Coast — Port Saint Lucie, Florida (2.5 mi) · Sponsor: BeOne Medicines
See eligibility & contact on ClinicalTrials.gov (NCT07492641)

A Study of GS-3242 in Combination With Lenacapavir Versus Biktarvy in Virologically Suppressed People With HIV-1

HIV-1-infection Phase 2 Interventional 175 participants sought
Midway Immunology and Research Center — Ft. Pierce, Florida (12.2 mi) · Sponsor: Gilead Sciences
See eligibility & contact on ClinicalTrials.gov (NCT07645287)

Inotuzumab Ozogamicin and Blinatumomab With or Without Ponatinib in Treating Patients With Newly Diagnosed, Recurrent, or Refractory CD22-Positive B-Lineage Acute Lymphoblastic Leukemia

B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative, Recurrent B Acute Lymphoblastic Leukemia Phase 2 Interventional 84 participants sought
Jupiter Medical Center — Jupiter, Florida (29.9 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT03739814)

A Study of S-337395 in Symptomatic Nonhospitalized Adults With Respiratory Syncytial Virus (RSV) Who Are at High Risk of Progression to Severe Disease

Respiratory Syncytial Virus Infections Phase 2 Interventional 192 participants sought
CDC Research Institute, LLC — Port Saint Lucie, Florida (2.5 mi) · Sponsor: Shionogi
See eligibility & contact on ClinicalTrials.gov (NCT07214571)

Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.

Relapsing Multiple Sclerosis Phase 3 Interventional 400 participants sought
Vero Beach Neurology — Vero Beach, Florida (24.8 mi) · Sponsor: Novartis Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT06846281)

A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2

Urothelial Carcinoma Phase 2 Interventional 372 participants sought
Florida Cancer Specialists — Stuart, Florida (10.1 mi) · Sponsor: Seagen, a wholly owned subsidiary of Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT04879329)

A Study to Investigate Cabotegravir Ultra Long-Acting (CAB ULA) Plus Rilpivirine Ultra Long-Acting (RPV ULA) in Adults and Adolescents With HIV Who Are Virologically Suppressed

HIV Infections Phase 3 Interventional 564 participants sought
GSK Investigational Site — Ft. Pierce, Florida (12.2 mi) · Sponsor: ViiV Healthcare
See eligibility & contact on ClinicalTrials.gov (NCT07650916)
Actively enrolling

Studies you may be able to join near Port St. Lucie

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Port St. Lucie

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Florida Research and Innovation Center

★ 5.0
9801 SW Discovery Wy, Port St. Lucie, FL 34987

Health Awareness

★ 4.6
1801 SE Hillmoor Dr, Port St. Lucie, FL 34952
(772) 777-3344
"They are always nice and professional and respect your time."
— Julia Terry, 5★

Midway Immunology Research Center

360 E Midway Rd, Fort Pierce, FL 34982
(772) 595-9830

Soma Medical Center, P.A. Adults - Port Saint Lucie

★ 4.6
1170 SW Bayshore Blvd, Port St. Lucie, FL 34983
(772) 309-0020
"I love this medical center. Every visit gets better and better. Everyone is very knowledgeable and professional. They make you feel very comfortable.…"
— PenningtonSherrod, 5★

Brain Matters Research

★ 5.0
900 SE Salerno Rd, Stuart, FL 34997
(772) 223-7880
"They are great ! 👍 please join to cure alzheimers"
— Roberta Pietz, 5★

Alzheimer's Treatment Centers of America

★ 4.0
266 NW Peacock Blvd Ste 204, Port St. Lucie, FL 34986
(772) 298-4477
"Unprofessional and Disappointing Experience - Avoid at All Costs<br>My recent visit to this clinic was, frankly, a waste of time and incredibly frust…"
— Michael Lavenstein, 1★

Comprehensive Clinical Research

★ 4.9
603 Village Blvd #301, West Palm Beach, FL 33409
(561) 478-3177
"Great place employees are very nice"
— Diane Atkins, 5★

Health Synergy Clinical Research

★ 5.0
308 NW 5th Ave, Okeechobee, FL 34972
(863) 824-7989

Florida Cancer Specialists & Research Institute

★ 4.7 (241 reviews)
301 SE Ocean Blvd Suite 102, Stuart, FL 34994
(772) 287-4061
"dr Leary is wonderful, caring , and informative , she put me at rest as soon as i met her and all i can say is thank you from the bottom of my heart …"
— Harry Elsbury, 5★

Clinical trials in Port St. Lucie: what's recruiting

The Port St. Lucie area currently has 106 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Port St. Lucie, the most active research areas are:

  • Cancer & Oncology12 studies
  • Diabetes & Metabolism3 studies
  • Liver & Kidney3 studies
  • Lungs & Breathing2 studies
  • Brain & Mental Health2 studies

Every listing shows the study phase, the recruiting site and its distance from Port St. Lucie, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Port St. Lucie

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Port St. Lucie participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Port St. Lucie pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
How do I join a study in Port St. Lucie, FL?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
What is the difference between a research center and a hospital study in Port St. Lucie?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Port St. Lucie?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Port St. Lucie.

Paid clinical trials near Port St. Lucie

Other metros within reach

Palm Bay, FL67 Fort Lauderdale, FL1,996 Pembroke Pines, FL1,988 Hollywood, FL1,988 Hialeah, FL1,939 Kissimmee, FL924 Winter Haven, FL159 Miami, FL1,917

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Port St. Lucie Bladder Issues Due To Spinal Cord Injury in Port St. Lucie All conditions

More of FL

Fort Lauderdale1,996 Pembroke Pines1,988 Hollywood1,988 Hialeah1,939 Miami1,917 St. Petersburg1,350 Tampa1,331 Deltona946 Orlando937 Kissimmee924 Jacksonville910 Gainesville540

New paid studies open every week

Get an email when a new clinical trial starts recruiting within 30 miles of your ZIP code. No spam — only real studies from the NIH registry.

By subscribing you agree to receive study alert emails. Unsubscribe anytime in one click.

Get free trial alerts