Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/FL/Orlando
Updated September 2026 from ClinicalTrials.gov

Paid Clinical Trials in Orlando, FL

Studies commonly pay $75 to $4,500 per completed study

942 clinical trials are currently recruiting participants within 30 miles of Orlando. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

942studies recruiting
4+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Orlando right now

Top 25 of 942 recruiting studies, sorted by proximity — each links to its official registry page

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

Lymphoma, Non-Hodgkin, Multiple Myeloma Phase 2 Interventional 4,200 participants sought
Florida Cancer Specialists North / Sarah Cannon Research Institute — Orlando, Florida (4.9 mi) · Sponsor: American Society of Clinical Oncology
See eligibility & contact on ClinicalTrials.gov (NCT02693535)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Arnold Palmer Hospital for Children — Orlando, Florida (4.9 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

A Study to Investigate the Safety and Efficacy of MEDI0618 Compared to Placebo in Adult Participants With Episodic Migraine

Migraine Phase 2 Interventional 488 participants sought
Florida Neurology - Lake Mary — Lake Mary, Florida (19.5 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT06602479)

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)

Ulcerative Colitis Phase 2 Interventional 224 participants sought
Clinical Research of Osceola, LLC — Kissimmee, Florida (12.9 mi) · Sponsor: Genentech, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06979336)

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

PIK3CA Mutation, HER2- Negative Breast Cancer Phase 3 Interventional 540 participants sought
AdventHealth — Altamonte Springs, Florida (12.8 mi) · Sponsor: Relay Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06982521)

A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas

Triple Negative Breast Cancer, HER2-negative Breast Cancer Phase 1 Interventional 96 participants sought
Dren Investigational Site — Orlando, Florida (4.9 mi) · Sponsor: Dren Bio
See eligibility & contact on ClinicalTrials.gov (NCT06999187)

A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years

Chronic Migraine Phase 3 Interventional 420 participants sought
Pediatric Neurology & Epilepsy Center Of Central Florida - Winter Park /ID# 275263 — Winter Park, Florida (8.5 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT06810505)

A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

Advanced Pancreatic Carcinoma, Metastatic Pancreatic Carcinoma Phase 2 Interventional 40 participants sought
Ohio State University-Telemedicine — Orlando, Florida (4.9 mi) · Sponsor: Sameek Roychowdhury
See eligibility & contact on ClinicalTrials.gov (NCT06906562)

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Endometrial Cancer Phase 3 Interventional 600 participants sought
Research Site — Orlando, Florida (4.9 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06989112)

A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)

Non-Small Cell Lung Cancer (NSCLC) Phase 3 Interventional 750 participants sought
Clermont Oncology Center — Clermont, Florida (26.9 mi) · Sponsor: Bristol-Myers Squibb
See eligibility & contact on ClinicalTrials.gov (NCT07361510)

LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis

Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate Phase 2 Interventional 1,431 participants sought
AdventHealth Orlando — Orlando, Florida (4.9 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT07415044)

A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)

Amyloid Plaque, Beta-Amyloid Phase 1, Phase 2 Interventional 304 participants sought
Charter Research, LLC — Orlando, Florida (4.9 mi) · Sponsor: AC Immune SA
See eligibility & contact on ClinicalTrials.gov (NCT05462106)

A Study Evaluating the Safety, Pharmacokinetics, and Activity of RO7656594 In Participants With Advanced or Metastatic Prostate Cancer

Advanced Prostate Cancer, Metastatic Prostate Cancer Phase 1 Interventional 210 participants sought
Sarah Cannon Research Institute @ Florida Cancer — Orlando, Florida (4.9 mi) · Sponsor: Genentech, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05800665)

Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

Non-Small Cell Lung Cancer Phase 3 Interventional 675 participants sought
Research Site — Orlando, Florida (4.9 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06357533)

A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations

Cancer, PDAC - Pancreatic Ductal Adenocarcinoma Phase 1 Interventional 448 participants sought
Research Site — Orlando, Florida (4.9 mi) · Sponsor: Alterome Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06835569)

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

Carcinoma, Transitional Cell, Urinary Bladder Neoplasms Phase 3 Interventional 450 participants sought
AdventHealth Orlando — Orlando, Florida (4.9 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT07218380)

Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response

Chronic Low Back Pain N/A Interventional 2,529 participants sought
Orlando VA Healthcare System, Orlando, FL — Orlando, Florida (4.9 mi) · Sponsor: VA Office of Research and Development
See eligibility & contact on ClinicalTrials.gov (NCT04142177)
Actively enrolling

Studies you may be able to join near Orlando

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research studies for chronic kidney disease

This research platform is enrolling Black and African American adults in eligible areas who have been diagnosed with chronic kidney disease. Compensation may be available. The study team confirms eligibility before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Orlando

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Orlando Clinical Research Center

★ 4.6
5055 S Orange Ave, Orlando, FL 32809
(407) 240-7878
"Friendly informative doctors and nurses..."
— Jeffrey Kallas, 5★

Cli research

3885 Oakwater Cir, Orlando, FL 32806

Discovery Clinical Trials

★ 5.0
2863 Delaney St, Orlando, FL 32806
(321) 445-8001

Florida Institute for Clinical Research

★ 4.8
10967 Lake Underhill Rd Ste 117, Orlando, FL 32825
(407) 658-0966
"Was involved in a study there for 2 years. Staff is very professional , friendly, and curtios. Especially Marisa, Geo, and Dr Cruz."
— Alan Porreca, 4★

Clinical trials in Orlando: what's recruiting

The Orlando area currently has 942 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Orlando, the most active research areas are:

  • Cancer & Oncology15 studies
  • Immune & Skin2 studies
  • Brain & Mental Health2 studies
  • Lungs & Breathing2 studies
  • Liver & Kidney1 studies

Every listing shows the study phase, the recruiting site and its distance from Orlando, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Orlando

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Orlando participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Do I need to be sick to join a clinical trial in Orlando?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
How do I join a study in Orlando, FL?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
What is the difference between a research center and a hospital study in Orlando?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Orlando typically complete one or two studies per year.

Paid clinical trials near Orlando

Other metros within reach

Kissimmee, FL927 Deltona, FL953 Winter Haven, FL159 Leesburg, FL143 Lakeland, FL191 Palm Bay, FL72 Ocala, FL135 Spring Hill, FL110

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Orlando Chronic Kidney Disease (HealthMatch) in Orlando Bladder Issues Due To Spinal Cord Injury in Orlando All conditions

More of FL

Fort Lauderdale1,987 Pembroke Pines1,980 Hollywood1,980 Hialeah1,934 Miami1,911 St. Petersburg1,353 Tampa1,335 Deltona953 Kissimmee927 Jacksonville916 Gainesville538

New paid studies open every week

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