Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only

Home/KY/Louisville

Updated October 2026 from ClinicalTrials.gov

Paid Clinical Trials in Louisville, KY

Studies commonly pay $75 to $4,500 per completed study

559 clinical trials are currently recruiting participants within 30 miles of Louisville. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

559studies recruiting

1+research centers nearby

5condition categories

Live from the NIH registry

Studies recruiting near Louisville right now

Top 25 of 559 recruiting studies, sorted by proximity — each links to its official registry page

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

Smoldering Plasma Cell Myeloma Phase 3 Interventional 288 participants sought

Jewish Hospital — Louisville, Kentucky (8.6 mi) · Sponsor: ECOG-ACRIN Cancer Research Group

See eligibility & contact on ClinicalTrials.gov (NCT03937635)

A Safety Study of SEA-CD70 in Patients With Myeloid Malignancies

Myelodysplastic Syndrome, Acute Myeloid Leukemia Phase 1 Interventional 178 participants sought

Norton Hospitals, Inc — Louisville, Kentucky (8.6 mi) · Sponsor: Seagen, a wholly owned subsidiary of Pfizer

See eligibility & contact on ClinicalTrials.gov (NCT04227847)

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8 Phase 3 Interventional 1,209 participants sought

The James Graham Brown Cancer Center at University of Louisville — Louisville, Kentucky (8.6 mi) · Sponsor: NRG Oncology

See eligibility & contact on ClinicalTrials.gov (NCT05946213)

Treatment of Moderate to Severe Refractory Crohn's Disease

Crohns Disease Phase 1, Phase 2 Interventional 39 participants sought

University of Louisville — Louisville, Kentucky (8.6 mi) · Sponsor: Tr1X, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT06721962)

BMS-986489 (Atigotatug + Nivolumab) vs Durvalumab in Limited-stage Small-cell Lung Cancer (TIGOS-LS)

Limited Stage Small Cell Lung Cancer Phase 2 Interventional 250 participants sought

Baptist Health - Louisville — Louisville, Kentucky (8.6 mi) · Sponsor: SCRI Development Innovations, LLC

See eligibility & contact on ClinicalTrials.gov (NCT06773910)

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

Breast Cancer Phase 3 Interventional 450 participants sought

University of Louisville Hospital — Louisville, Kentucky (8.6 mi) · Sponsor: Hoffmann-La Roche

See eligibility & contact on ClinicalTrials.gov (NCT06790693)

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Lymphoma, Large B-Cell, Diffuse Phase 2 Interventional 594 participants sought

Norton Women's and Children's Hospital-Norton Cancer Institute - St. Matthews ( Site 0185) — Louisville, Kentucky (8.6 mi) · Sponsor: Merck Sharp & Dohme LLC

See eligibility & contact on ClinicalTrials.gov (NCT06890884)

WISPer: Evaluation of MTX-463 in Participants With Idiopathic Pulmonary Fibrosis (IPF)

Idiopathic Pulmonary Fibrosis Phase 2 Interventional 164 participants sought

WISPer Site in Louisville, KY — Louisville, Kentucky (8.6 mi) · Sponsor: Mediar Therapeutics

See eligibility & contact on ClinicalTrials.gov (NCT06967805)

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought

Jewish Hospital — Louisville, Kentucky (8.6 mi) · Sponsor: SWOG Cancer Research Network

See eligibility & contact on ClinicalTrials.gov (NCT03851445)

Complex Adult Deformity Surgery (CADS)

Adult Spinal Deformity, Scoliosis N/A Observational 1,500 participants sought

Norton Leatherman Spine Center — Louisville, Kentucky (8.6 mi) · Sponsor: International Spine Study Group Foundation

See eligibility & contact on ClinicalTrials.gov (NCT04194138)

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

Childhood Medulloblastoma Phase 3 Interventional 225 participants sought

Norton Children's Hospital — Louisville, Kentucky (8.6 mi) · Sponsor: Children's Oncology Group

See eligibility & contact on ClinicalTrials.gov (NCT05382338)

Supporting Resilience Among Re-entered Seniors

Chronic Disease N/A Interventional 8 participants sought

New Legacy Reentry — Louisville, Kentucky (8.6 mi) · Sponsor: University of Louisville

See eligibility & contact on ClinicalTrials.gov (NCT06276452)

A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)

Relapsing Multiple Sclerosis, Multiple Sclerosis N/A Observational 2,000 participants sought

TG Therapeutics Investigational Trial Site — Louisville, Kentucky (8.6 mi) · Sponsor: TG Therapeutics, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT06433752)

RENAISSANCE 2: SPN-817 Phase 2, Double-Blind, Placebo-Controlled Study in Adults With Focal Onset Seizures

Focal Onset Seizures Phase 2 Interventional 216 participants sought

University of Louisville Physicians — Louisville, Kentucky (8.6 mi) · Sponsor: Supernus Pharmaceuticals, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT06798896)

LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis

Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate Phase 2 Interventional 1,431 participants sought

Gastroenterology Health Partners — Louisville, Kentucky (8.6 mi) · Sponsor: Eli Lilly and Company

See eligibility & contact on ClinicalTrials.gov (NCT07415044)

Pediatric Precision Laboratory Advanced Neuroblastoma Therapy

Neuroblastoma Phase 2 Interventional 500 participants sought

Norton Children's Research Institute/Affiliated with University of Louisville School of Medicine — Louisville, Kentucky (8.6 mi) · Sponsor: Giselle Sholler

See eligibility & contact on ClinicalTrials.gov (NCT02559778)

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

Solid Tumors, Hematologic Malignancies Phase 3 Interventional 3,500 participants sought

James Graham Brown Cancer Center ( Site 0058) — Louisville, Kentucky (8.6 mi) · Sponsor: Merck Sharp & Dohme LLC

See eligibility & contact on ClinicalTrials.gov (NCT03486873)

Harnessing Neuroplasticity to Enhance Functional Recovery During Chronic Recovery From Upper Extremity Nerve Repair

Hand Transplantation, Peripheral Nerve Injuries N/A Interventional 180 participants sought

Christine Kleinert Institute for Hand & Microsurgery — Louisville, Kentucky (8.6 mi) · Sponsor: University of Missouri-Columbia

See eligibility & contact on ClinicalTrials.gov (NCT03610763)

Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

Metastatic Breast Cancer Phase 3 Interventional 600 participants sought

Norton Cancer Institute — Louisville, Kentucky (8.6 mi) · Sponsor: LeonaBio

See eligibility & contact on ClinicalTrials.gov (NCT05696626)

A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)

Heart Failure Phase 3 Interventional 1,500 participants sought

CON-10086, Louisville, Kentucky — Louisville, Kentucky (8.6 mi) · Sponsor: Colorado Prevention Center

See eligibility & contact on ClinicalTrials.gov (NCT06024746)

A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis

Antineutrophil Cytoplasmic Antibody-associated Vasculitis Phase 4 Interventional 300 participants sought

Lake Cumberland Rheumatology — New Albany, Indiana (12.6 mi) · Sponsor: Amgen

See eligibility & contact on ClinicalTrials.gov (NCT06072482)

A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy

Locally Advanced Head and Neck Squamous Cell Carcinoma Phase 3 Interventional 1,145 participants sought

Research Site — Louisville, Kentucky (8.6 mi) · Sponsor: AstraZeneca

See eligibility & contact on ClinicalTrials.gov (NCT06129864)

A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus

Systemic Lupus Erythematosus Phase 3 Interventional 450 participants sought

Sl0044 50586 — Louisville, Kentucky (8.6 mi) · Sponsor: UCB Biopharma SRL

See eligibility & contact on ClinicalTrials.gov (NCT06617325)

E-Mindfulness Approaches for Living After Breast Cancer

Breast Cancer, Depression Phase 3 Interventional 402 participants sought

CommonSpirit Saint Joseph Hospital - Bardstown — Bardstown, Kentucky (26.6 mi) · Sponsor: NRG Oncology

See eligibility & contact on ClinicalTrials.gov (NCT06748222)

A Study to Investigate Efficacy, Safety and Tolerability of Barzolvolimab Versus Placebo in Adults With Cold Induced Urticaria and Symptomatic Dermographism Inadequately Controlled by H1-antihistamines (EMBARQ - ColdU and SD)

Chronic Inducible Urticaria, Cold Urticaria Phase 3 Interventional 240 participants sought

Advanced ENT and Allergy, PLLC — Louisville, Kentucky (8.6 mi) · Sponsor: Celldex Therapeutics

See eligibility & contact on ClinicalTrials.gov (NCT07266402)

Actively enrolling

Studies you may be able to join near Louisville

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Google-rated

Top-rated research centers in Louisville

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

L-MARC Research Center

★ 4.8

3288 Illinois Ave Unit 101, Louisville, KY 40213

(502) 515-5672

Website

"The most wonderful knowledge staff on the planet and I look forward to my visits. Every visit is smooth and consistent."

— D. L., 5★

Clinical trials in Louisville: what's recruiting

The Louisville area currently has 559 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Louisville, the most active research areas are:

Cancer & Oncology14 studies
Immune & Skin3 studies
Lungs & Breathing1 studies
Heart & Vascular1 studies
Brain & Mental Health1 studies

Every listing shows the study phase, the recruiting site and its distance from Louisville, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Louisville

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Louisville participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Louisville pay?

Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.

Are clinical trials in Louisville safe?

Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.

Is compensation for clinical trials taxable?

In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.

How often do new paid studies open in Louisville?

Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Louisville.

Can I be in more than one clinical trial at a time?

Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Louisville typically complete one or two studies per year.

Paid clinical trials near Louisville

Other metros within reach

Lexington, KY473 Cincinnati, OH1,131 Indianapolis, IN941 Evansville, IN73 Dayton, OH307 Nashville, TN1,336 Clarksville, TN8 Murfreesboro, TN79

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Louisville Bladder Issues Due To Spinal Cord Injury in Louisville All conditions

More of KY

Lexington473

New paid studies open every week

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