Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only

Home/KY/Louisville

Updated September 2026 from ClinicalTrials.gov

Paid Clinical Trials in Louisville, KY

Studies commonly pay $75 to $4,500 per completed study

557 clinical trials are currently recruiting participants within 30 miles of Louisville. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

557studies recruiting

1+research centers nearby

5condition categories

Live from the NIH registry

Studies recruiting near Louisville right now

Top 25 of 557 recruiting studies, sorted by proximity — each links to its official registry page

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

Smoldering Plasma Cell Myeloma Phase 3 Interventional 288 participants sought

Jewish Hospital — Louisville, Kentucky (8.6 mi) · Sponsor: ECOG-ACRIN Cancer Research Group

See eligibility & contact on ClinicalTrials.gov (NCT03937635)

A Safety Study of SEA-CD70 in Patients With Myeloid Malignancies

Myelodysplastic Syndrome, Acute Myeloid Leukemia Phase 1 Interventional 178 participants sought

Norton Hospitals, Inc — Louisville, Kentucky (8.6 mi) · Sponsor: Seagen, a wholly owned subsidiary of Pfizer

See eligibility & contact on ClinicalTrials.gov (NCT04227847)

Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma

Endometrial Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma Phase 2 Interventional 81 participants sought

The James Graham Brown Cancer Center at University of Louisville — Louisville, Kentucky (8.6 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT05112601)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought

Norton Children's Hospital — Louisville, Kentucky (8.6 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT06124157)

Treatment of Moderate to Severe Refractory Crohn's Disease

Crohns Disease Phase 1, Phase 2 Interventional 39 participants sought

University of Louisville — Louisville, Kentucky (8.6 mi) · Sponsor: Tr1X, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT06721962)

BMS-986489 (Atigotatug + Nivolumab) vs Durvalumab in Limited-stage Small-cell Lung Cancer (TIGOS-LS)

Limited Stage Small Cell Lung Cancer Phase 2 Interventional 250 participants sought

Baptist Health - Louisville — Louisville, Kentucky (8.6 mi) · Sponsor: SCRI Development Innovations, LLC

See eligibility & contact on ClinicalTrials.gov (NCT06773910)

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Lymphoma, Large B-Cell, Diffuse Phase 2 Interventional 594 participants sought

Norton Women's and Children's Hospital-Norton Cancer Institute - St. Matthews ( Site 0185) — Louisville, Kentucky (8.6 mi) · Sponsor: Merck Sharp & Dohme LLC

See eligibility & contact on ClinicalTrials.gov (NCT06890884)

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought

Jewish Hospital — Louisville, Kentucky (8.6 mi) · Sponsor: SWOG Cancer Research Network

See eligibility & contact on ClinicalTrials.gov (NCT03851445)

Complex Adult Deformity Surgery (CADS)

Adult Spinal Deformity, Scoliosis N/A Observational 1,500 participants sought

Norton Leatherman Spine Center — Louisville, Kentucky (8.6 mi) · Sponsor: International Spine Study Group Foundation

See eligibility & contact on ClinicalTrials.gov (NCT04194138)

Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan

Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma Phase 1 Interventional 694 participants sought

Norton Cancer Institute /ID# 248903 — Louisville, Kentucky (8.6 mi) · Sponsor: AbbVie

See eligibility & contact on ClinicalTrials.gov (NCT05005403)

Supporting Resilience Among Re-entered Seniors

Chronic Disease N/A Interventional 8 participants sought

New Legacy Reentry — Louisville, Kentucky (8.6 mi) · Sponsor: University of Louisville

See eligibility & contact on ClinicalTrials.gov (NCT06276452)

A Study to Investigate the Safety and Efficacy of MEDI0618 Compared to Placebo in Adult Participants With Episodic Migraine

Migraine Phase 2 Interventional 488 participants sought

Norton Neuroscience Institute - Headache Clinic — Louisville, Kentucky (8.6 mi) · Sponsor: AbbVie

See eligibility & contact on ClinicalTrials.gov (NCT06602479)

LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis

Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate Phase 2 Interventional 1,431 participants sought

Gastroenterology Health Partners — Louisville, Kentucky (8.6 mi) · Sponsor: Eli Lilly and Company

See eligibility & contact on ClinicalTrials.gov (NCT07415044)

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

Solid Tumors, Hematologic Malignancies Phase 3 Interventional 3,500 participants sought

James Graham Brown Cancer Center ( Site 0058) — Louisville, Kentucky (8.6 mi) · Sponsor: Merck Sharp & Dohme LLC

See eligibility & contact on ClinicalTrials.gov (NCT03486873)

Harnessing Neuroplasticity to Enhance Functional Recovery During Chronic Recovery From Upper Extremity Nerve Repair

Hand Transplantation, Peripheral Nerve Injuries N/A Interventional 180 participants sought

Christine Kleinert Institute for Hand & Microsurgery — Louisville, Kentucky (8.6 mi) · Sponsor: University of Missouri-Columbia

See eligibility & contact on ClinicalTrials.gov (NCT03610763)

A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)

Heart Failure Phase 3 Interventional 1,500 participants sought

CON-10086, Louisville, Kentucky — Louisville, Kentucky (8.6 mi) · Sponsor: Colorado Prevention Center

See eligibility & contact on ClinicalTrials.gov (NCT06024746)

A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis

Antineutrophil Cytoplasmic Antibody-associated Vasculitis Phase 4 Interventional 300 participants sought

Lake Cumberland Rheumatology — New Albany, Indiana (12.6 mi) · Sponsor: Amgen

See eligibility & contact on ClinicalTrials.gov (NCT06072482)

A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy

Locally Advanced Head and Neck Squamous Cell Carcinoma Phase 3 Interventional 1,145 participants sought

Research Site — Louisville, Kentucky (8.6 mi) · Sponsor: AstraZeneca

See eligibility & contact on ClinicalTrials.gov (NCT06129864)

Consolidation of First-Line MRD+ Remission With Cema-cel in Patients With LBCL

Large B-cell Lymphoma Phase 2 Interventional 250 participants sought

University of Louisville Health Brown Cancer Center — Louisville, Kentucky (8.6 mi) · Sponsor: Allogene Therapeutics

See eligibility & contact on ClinicalTrials.gov (NCT06500273)

A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus

Systemic Lupus Erythematosus Phase 3 Interventional 450 participants sought

Sl0044 50586 — Louisville, Kentucky (8.6 mi) · Sponsor: UCB Biopharma SRL

See eligibility & contact on ClinicalTrials.gov (NCT06617325)

Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis

Ulcerative Colitis (UC) Phase 1, Phase 2 Interventional 270 participants sought

Xencor Investigative Site — Louisville, Kentucky (8.6 mi) · Sponsor: Xencor, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT06619990)

E-Mindfulness Approaches for Living After Breast Cancer

Breast Cancer, Depression Phase 3 Interventional 402 participants sought

CommonSpirit Saint Joseph Hospital - Bardstown — Bardstown, Kentucky (26.6 mi) · Sponsor: NRG Oncology

See eligibility & contact on ClinicalTrials.gov (NCT06748222)

Stress Hydrocortisone In Pediatric Septic Shock

Septic Shock Phase 3 Interventional 500 participants sought

University of Louisville, Norton Children's Hospital — Louisville, Kentucky (8.6 mi) · Sponsor: Jerry Zimmerman

See eligibility & contact on ClinicalTrials.gov (NCT03401398)

LGG Supplementation in Patients With AUD and ALD

Alcohol Use Disorder, Alcohol-associated Liver Disease Phase 2 Interventional 60 participants sought

University of Louisville Hospital — Louisville, Kentucky (8.6 mi) · Sponsor: University of Louisville

See eligibility & contact on ClinicalTrials.gov (NCT05178069)

Correlation Between Noninvasive Blood Vessel Functionality Parameters and Cerebral Hemodynamics in Neurocritical Care Patients

Brain Injuries, Intracranial Pressure Increase N/A Observational 25 participants sought

University of Louisville Health — Louisville, Kentucky (8.6 mi) · Sponsor: University of Louisville

See eligibility & contact on ClinicalTrials.gov (NCT06511804)

Actively enrolling

Studies you may be able to join near Louisville

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Google-rated

Top-rated research centers in Louisville

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

L-MARC Research Center

★ 4.8

3288 Illinois Ave Unit 101, Louisville, KY 40213

(502) 515-5672

Website

"The most wonderful knowledge staff on the planet and I look forward to my visits. Every visit is smooth and consistent."

— D. L., 5★

Clinical trials in Louisville: what's recruiting

The Louisville area currently has 557 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Louisville, the most active research areas are:

Cancer & Oncology12 studies
Immune & Skin4 studies
Heart & Vascular1 studies
Brain & Mental Health1 studies
Liver & Kidney1 studies

Every listing shows the study phase, the recruiting site and its distance from Louisville, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Louisville

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Louisville participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Louisville pay?

Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.

Are clinical trials in Louisville safe?

Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.

Is compensation for clinical trials taxable?

In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.

How often do new paid studies open in Louisville?

Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Louisville.

Can I be in more than one clinical trial at a time?

Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Louisville typically complete one or two studies per year.

Paid clinical trials near Louisville

Other metros within reach

Lexington, KY477 Cincinnati, OH1,128 Indianapolis, IN921 Evansville, IN68 Dayton, OH308 Nashville, TN1,331 Clarksville, TN8 Murfreesboro, TN79

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Louisville Bladder Issues Due To Spinal Cord Injury in Louisville All conditions

More of KY

Lexington477

New paid studies open every week

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