Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/MA/Springfield
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Springfield, MA

Studies commonly pay $75 to $4,500 per completed study

317 clinical trials are currently recruiting participants within 30 miles of Springfield. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

317studies recruiting
9+research centers nearby
3condition categories
Live from the NIH registry

Studies recruiting near Springfield right now

Top 25 of 317 recruiting studies, sorted by proximity — each links to its official registry page

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
Baystate Medical Center — Springfield, Massachusetts (2.8 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

Smoldering Plasma Cell Myeloma Phase 3 Interventional 288 participants sought
Mercy Medical Center — Springfield, Massachusetts (2.8 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT03937635)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Connecticut Children's Medical Center — Hartford, Connecticut (25.4 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

A Novel Program Using Ride-on Toys to Improve Upper Extremity Function in Children With Hemiplegia

Hemiplegia, Cerebral Palsy N/A Interventional 30 participants sought
Physical Therapy Program, Department of Kinesiology, University of Connecticut — Storrs, Connecticut (25.9 mi) · Sponsor: University of Connecticut
See eligibility & contact on ClinicalTrials.gov (NCT06579027)

Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

Acute Myeloid Leukemia (AML) Phase 3 Interventional 1,300 participants sought
Hartford HealthCare Cancer Institute — Hartford, Connecticut (25.4 mi) · Sponsor: Kura Oncology, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07007312)

Dexmedetomidine Transdermal Systems (DMTS) Treatment for Agitation Associated With Dementia of the Alzheimer's Type

Agitation Phase 2 Interventional 150 participants sought
Elixia MA, LLC — Springfield, Massachusetts (2.8 mi) · Sponsor: Teikoku Pharma USA, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06052254)

A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer, KRAS G12C Lung Cancer Phase 3 Interventional 600 participants sought
Hartford Hospital — Hartford, Connecticut (25.4 mi) · Sponsor: Hoffmann-La Roche
See eligibility & contact on ClinicalTrials.gov (NCT06793215)

Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8 Phase 3 Interventional 356 participants sought
Smilow Cancer Hospital Care Center at Saint Francis — Hartford, Connecticut (25.4 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06958328)

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

Malignant Glioma Phase 1, Phase 2 Interventional 132 participants sought
Connecticut Children's Medical Center — Hartford, Connecticut (25.4 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05099003)

Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment

Plasma Cell Myeloma Phase 3 Interventional 510 participants sought
Smilow Cancer Hospital Care Center at Saint Francis — Hartford, Connecticut (25.4 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT05561387)

Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes

Metastatic Ewing Sarcoma Phase 1 Interventional 15 participants sought
Connecticut Children's Medical Center — Hartford, Connecticut (25.4 mi) · Sponsor: H. Lee Moffitt Cancer Center and Research Institute
See eligibility & contact on ClinicalTrials.gov (NCT07194044)

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

Lymphoma, Non-Hodgkin, Multiple Myeloma Phase 2 Interventional 4,200 participants sought
Hartford Hospital — Hartford, Connecticut (25.4 mi) · Sponsor: American Society of Clinical Oncology
See eligibility & contact on ClinicalTrials.gov (NCT02693535)

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 189 participants sought
Mercy Medical Center — Springfield, Massachusetts (2.8 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT02734537)

Endurant Stent Graft System vs Excluder Endoprothesis: ADVANCE Trial

Abdominal Aortic Aneurysm, Abdominal Aortic Aneurysm >= 5.5 Centimeters in Male (Disorder) N/A Interventional 600 participants sought
Baystate Medical Center — Springfield, Massachusetts (2.8 mi) · Sponsor: Medtronic Cardiovascular
See eligibility & contact on ClinicalTrials.gov (NCT05378347)

Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

Arrhythmia, Bradycardia N/A Observational 20,000 participants sought
Research site — Hartford, Connecticut (25.4 mi) · Sponsor: Medtronic
See eligibility & contact on ClinicalTrials.gov (NCT00271180)

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

Multiple conditions Phase 2 Interventional 150 participants sought
Baystate Medical Center — Springfield, Massachusetts (2.8 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05136196)

QuantifyHER: Quantitative Immunofluorescence and/or RT-qPCR for Measuring HER2 in HER2-low Metastatic Breast Cancer

HER2-positive Metastatic Breast Cancer N/A Observational 200 participants sought
Smilow Cancer Hospital at Saint Francis — Hartford, Connecticut (25.4 mi) · Sponsor: Abramson Cancer Center at Penn Medicine
See eligibility & contact on ClinicalTrials.gov (NCT06551116)

Collection of Research Data and Samples From Patients Who Experience Immunotherapy Side Effects

Malignancy N/A Observational 240 participants sought
Mercy Medical Center — Springfield, Massachusetts (2.8 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT04242095)

A Study Comparing Personalized Radiation Therapy With Standard Radiation Therapy in People With HPV-Positive Throat Cancer

HPV-Related Squamous Cell Carcinoma Phase 3 Interventional 291 participants sought
Hartford Healthcare (Data Collection Only) — Hartford, Connecticut (25.4 mi) · Sponsor: Memorial Sloan Kettering Cancer Center
See eligibility & contact on ClinicalTrials.gov (NCT06563479)
Actively enrolling

Studies you may be able to join near Springfield

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Springfield

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Sisu Clincal Research

★ 3.5
95 Frank B Murray St, Springfield, MA 01103
(413) 305-1142
"I called and talked to a very nice Spanish woman. She answered all my questions was very direct very responsive. I’m trying to do the depression and …"
— Nicole Koske, 5★

Baystate Health Clinical Trials Unit

★ 5.0
80 Wason Ave, Springfield, MA 01107
(413) 794-6690

Elixia

★ 5.0
95 Frank B Murray St, Springfield, MA 01103
"Super friendly, had a good experience"
— Nick Bean, 5★

Colaccino Center For Health Sciences

★ 5.0
Springfield, MA 01109

Clinical Research Management Group

★ 5.0
1408 Main St, Agawam, MA 01001
(413) 821-0022

Pioneer Valley Life Sciences

3601 Main St, Springfield, MA 01107
(413) 794-0653

CT Clinical Research

160 West St Ste 1A, Cromwell, CT 06416
(860) 632-0144

Pioneer Behavioral Health

★ 5.0 (135 reviews)
175 Dwight Rd, Longmeadow, MA 01106
(888) 617-3070
"I cannot say enough good things about Pioneer Behavioral Health and the incredible team that helped me when I needed it most. When I first started th…"
— Nick, 5★

Clinical Trials of New England

1234 Hyde Park Ave #205, Hyde Park, MA 02136

Clinical trials in Springfield: what's recruiting

The Springfield area currently has 317 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Springfield, the most active research areas are:

  • Cancer & Oncology15 studies
  • Diabetes & Metabolism1 studies
  • Heart & Vascular1 studies

Every listing shows the study phase, the recruiting site and its distance from Springfield, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Springfield

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Springfield participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Springfield pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in Springfield?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
What is the difference between a research center and a hospital study in Springfield?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Springfield?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Springfield.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Springfield typically complete one or two studies per year.

Paid clinical trials near Springfield

Other metros within reach

Hartford, CT441 Norwich, CT123 Waterbury, CT1,134 Worcester, MA273 New Haven, CT1,174 Bridgeport, CT1,445 Providence, RI558 Danbury, CT1,147

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Springfield Bladder Issues Due To Spinal Cord Injury in Springfield All conditions

More of MA

Boston2,960 New Bedford519 Worcester273

New paid studies open every week

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