Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/MA/Springfield
Updated October 2026 from ClinicalTrials.gov

Paid Clinical Trials in Springfield, MA

Studies commonly pay $75 to $4,500 per completed study

311 clinical trials are currently recruiting participants within 30 miles of Springfield. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

311studies recruiting
9+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Springfield right now

Top 25 of 311 recruiting studies, sorted by proximity — each links to its official registry page

Identify Barriers to Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Newly Diagnosed and Relapsed Acute Leukemia

Acute Leukemia, Newly Diagnosed N/A Observational 1,365 participants sought
Hartford Healthcare Cancer Institute @ Hartford Hospital — Hartford, Connecticut (25.4 mi) · Sponsor: Memorial Sloan Kettering Cancer Center
See eligibility & contact on ClinicalTrials.gov (NCT02677064)

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
Baystate Medical Center — Springfield, Massachusetts (2.8 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

Smoldering Plasma Cell Myeloma Phase 3 Interventional 288 participants sought
Mercy Medical Center — Springfield, Massachusetts (2.8 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT03937635)

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Ovarian Carcinoma N/A Interventional 1,956 participants sought
Baystate Medical Center — Springfield, Massachusetts (2.8 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT04251052)

Assessment of Gait Adaptation Due to an Asymmetric Walking Protocol

Anterior Cruciate Ligament Reconstruction N/A Interventional 40 participants sought
University of Connecticut — Storrs, Connecticut (25.9 mi) · Sponsor: University of Connecticut
See eligibility & contact on ClinicalTrials.gov (NCT05968729)

A Novel Program Using Ride-on Toys to Improve Upper Extremity Function in Children With Hemiplegia

Hemiplegia, Cerebral Palsy N/A Interventional 30 participants sought
Physical Therapy Program, Department of Kinesiology, University of Connecticut — Storrs, Connecticut (25.9 mi) · Sponsor: University of Connecticut
See eligibility & contact on ClinicalTrials.gov (NCT06579027)

Dexmedetomidine Transdermal Systems (DMTS) Treatment for Agitation Associated With Dementia of the Alzheimer's Type

Agitation Phase 2 Interventional 150 participants sought
Elixia MA, LLC — Springfield, Massachusetts (2.8 mi) · Sponsor: Teikoku Pharma USA, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06052254)

A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer, KRAS G12C Lung Cancer Phase 3 Interventional 600 participants sought
Hartford Hospital — Hartford, Connecticut (25.4 mi) · Sponsor: Hoffmann-La Roche
See eligibility & contact on ClinicalTrials.gov (NCT06793215)

A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis

Colitis, Ulcerative Phase 3 Interventional 882 participants sought
Connecticut Children's Medical Center — Hartford, Connecticut (25.4 mi) · Sponsor: Janssen Research & Development, LLC
See eligibility & contact on ClinicalTrials.gov (NCT07196748)

A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults

Chronic Idiopathic Constipation (CIC) Phase 3 Interventional 692 participants sought
Elixia SISU BHR - Sprinfield — Springfield, Massachusetts (2.8 mi) · Sponsor: Ardelyx
See eligibility & contact on ClinicalTrials.gov (NCT07382167)

Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8 Phase 3 Interventional 3,680 participants sought
Smilow Cancer Hospital Care Center at Saint Francis — Hartford, Connecticut (25.4 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06058377)

Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

Neuroblastoma, Ewing Sarcoma Phase 1, Phase 2 Interventional 104 participants sought
Connecticut Children's Hospital — Hartford, Connecticut (25.4 mi) · Sponsor: Milton S. Hershey Medical Center
See eligibility & contact on ClinicalTrials.gov (NCT06541262)

Study to Evaluate Weight Gain as Assessed by Change in BMI Z-score in Pediatric Subjects With Schizophrenia or Bipolar I Disorder

Schizophrenia, Bipolar I Disorder Phase 3 Interventional 220 participants sought
Alkermes Investigator Site — Hartford, Connecticut (25.4 mi) · Sponsor: Alkermes, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05303064)

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

Childhood Medulloblastoma Phase 3 Interventional 225 participants sought
Connecticut Children's Medical Center — Hartford, Connecticut (25.4 mi) · Sponsor: Children's Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT05382338)

An Open-Label ProSpective MultiCENTer Study to Evaluate Safety and Tolerability of Dry Powder Inhaled Treprostinil in PH

Pulmonary Hypertension, Interstitial Lung Disease N/A Observational 80 participants sought
Hartford Hospital — Hartford, Connecticut (25.4 mi) · Sponsor: Liquidia Technologies, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06129240)

Observational Study of Decentralized Urine Optical Interaction Patterns Associated With Environmental Microplastic and Nanoplastic Exposure

Healthy Adult Participants N/A Observational 15 participants sought
Decentralized / At-Home Participation (U.S.) — Hartford, Connecticut (25.4 mi) · Sponsor: Ecotera Health LLC
See eligibility & contact on ClinicalTrials.gov (NCT07775495)

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

Low Grade Astrocytoma, Low Grade Glioma Phase 3 Interventional 170 participants sought
Connecticut Children's Medical Center — Hartford, Connecticut (25.4 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04166409)
Actively enrolling

Studies you may be able to join near Springfield

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Springfield

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Sisu Clincal Research

★ 3.5
95 Frank B Murray St, Springfield, MA 01103
(413) 305-1142
"I called and talked to a very nice Spanish woman. She answered all my questions was very direct very responsive. I’m trying to do the depression and …"
— Nicole Koske, 5★

Baystate Health Clinical Trials Unit

★ 5.0
80 Wason Ave, Springfield, MA 01107
(413) 794-6690

Elixia

★ 5.0
95 Frank B Murray St, Springfield, MA 01103
"Super friendly, had a good experience"
— Nick Bean, 5★

Colaccino Center For Health Sciences

★ 5.0
Springfield, MA 01109

Clinical Research Management Group

★ 5.0
1408 Main St, Agawam, MA 01001
(413) 821-0022

Pioneer Valley Life Sciences

3601 Main St, Springfield, MA 01107
(413) 794-0653

CT Clinical Research

160 West St Ste 1A, Cromwell, CT 06416
(860) 632-0144

Pioneer Behavioral Health

★ 5.0 (135 reviews)
175 Dwight Rd, Longmeadow, MA 01106
(888) 617-3070
"I cannot say enough good things about Pioneer Behavioral Health and the incredible team that helped me when I needed it most. When I first started th…"
— Nick, 5★

Clinical Trials of New England

1234 Hyde Park Ave #205, Hyde Park, MA 02136

Clinical trials in Springfield: what's recruiting

The Springfield area currently has 311 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Springfield, the most active research areas are:

  • Cancer & Oncology11 studies
  • Brain & Mental Health2 studies
  • Immune & Skin1 studies
  • Heart & Vascular1 studies
  • Lungs & Breathing1 studies

Every listing shows the study phase, the recruiting site and its distance from Springfield, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Springfield

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Springfield participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Springfield pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in Springfield?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
What is the difference between a research center and a hospital study in Springfield?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Springfield?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Springfield.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Springfield typically complete one or two studies per year.

Paid clinical trials near Springfield

Other metros within reach

Hartford, CT441 Norwich, CT123 Waterbury, CT1,141 Worcester, MA273 New Haven, CT1,185 Bridgeport, CT1,464 Providence, RI554 Danbury, CT1,174

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Springfield Bladder Issues Due To Spinal Cord Injury in Springfield All conditions

More of MA

Boston2,972 New Bedford515 Worcester273

New paid studies open every week

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