Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/MA/Springfield
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Springfield, MA

Studies commonly pay $75 to $4,500 per completed study

325 clinical trials are currently recruiting participants within 30 miles of Springfield. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

325studies recruiting
9+research centers nearby
4condition categories
Live from the NIH registry

Studies recruiting near Springfield right now

Top 25 of 325 recruiting studies, sorted by proximity — each links to its official registry page

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
Baystate Medical Center — Springfield, Massachusetts (2.8 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Connecticut Children's Medical Center — Hartford, Connecticut (25.4 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

QuantifyHER: Quantitative Immunofluorescence and/or RT-qPCR for Measuring HER2 in HER2-low Metastatic Breast Cancer

HER2-positive Metastatic Breast Cancer N/A Observational 200 participants sought
Smilow Cancer Hospital at Saint Francis — Hartford, Connecticut (25.4 mi) · Sponsor: Abramson Cancer Center at Penn Medicine
See eligibility & contact on ClinicalTrials.gov (NCT06551116)

A Novel Program Using Ride-on Toys to Improve Upper Extremity Function in Children With Hemiplegia

Hemiplegia, Cerebral Palsy N/A Interventional 30 participants sought
Physical Therapy Program, Department of Kinesiology, University of Connecticut — Storrs, Connecticut (25.9 mi) · Sponsor: University of Connecticut
See eligibility & contact on ClinicalTrials.gov (NCT06579027)

Feasibility and Efficacy Study of the CardioPulmonary Management (CPM) System in Patients With Chronic Heart Failure

Heart Failure N/A Interventional 1,200 participants sought
Baystate Medical Center — Springfield, Massachusetts (2.8 mi) · Sponsor: Analog Device, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05650541)

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

Malignant Glioma Phase 1, Phase 2 Interventional 132 participants sought
Connecticut Children's Medical Center — Hartford, Connecticut (25.4 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05099003)

Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment

Plasma Cell Myeloma Phase 3 Interventional 510 participants sought
Smilow Cancer Hospital Care Center at Saint Francis — Hartford, Connecticut (25.4 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT05561387)

An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)

Cardiovascular Disease and Lipoprotein(a) Phase 3 Interventional 5,700 participants sought
Hartford Hospital — Hartford, Connecticut (25.4 mi) · Sponsor: Novartis Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT07517263)

A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8 Phase 3 Interventional 1,875 participants sought
Smilow Cancer Hospital Care Center at Saint Francis — Hartford, Connecticut (25.4 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05675410)

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

Ganglioneuroblastoma, Nodular, Neuroblastoma Phase 3 Interventional 478 participants sought
Connecticut Children's Medical Center — Hartford, Connecticut (25.4 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06172296)

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 189 participants sought
Mercy Medical Center — Springfield, Massachusetts (2.8 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT02734537)

A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer Phase 2 Interventional 310 participants sought
Site 0263 - Baystate Medical Center — Springfield, Massachusetts (2.8 mi) · Sponsor: K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc
See eligibility & contact on ClinicalTrials.gov (NCT05128825)

Treatment With Endovascular Intervention for STroke Patients With Existing Disability

Stroke, Stroke, Acute N/A Observational 1,060 participants sought
Hartford Health Hospital — Hartford, Connecticut (25.4 mi) · Sponsor: University of Cincinnati
See eligibility & contact on ClinicalTrials.gov (NCT05911568)

Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

Arrhythmia, Bradycardia N/A Observational 20,000 participants sought
Research site — Hartford, Connecticut (25.4 mi) · Sponsor: Medtronic
See eligibility & contact on ClinicalTrials.gov (NCT00271180)

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

Multiple conditions Phase 2 Interventional 150 participants sought
Baystate Medical Center — Springfield, Massachusetts (2.8 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05136196)

Improving Communication Between AYA Oncology Patients and Clinicians: A Patient-Centered Intervention

Pediatric Cancer, Adolescent and Young Adult Cancer N/A Interventional 60 participants sought
Connecticut Children's Medical Center — Hartford, Connecticut (25.4 mi) · Sponsor: Connecticut Children's Medical Center
See eligibility & contact on ClinicalTrials.gov (NCT06982066)

Heated Intraperitoneal Chemotherapy Followed by Niraparib for Ovarian, Primary Peritoneal and Fallopian Tube Cancer

Stage III Ovarian Cancer, Stage IV Ovarian Cancer Phase 3 Interventional 220 participants sought
Hartford Hospital — Hartford, Connecticut (25.4 mi) · Sponsor: GOG Foundation
See eligibility & contact on ClinicalTrials.gov (NCT05659381)

A Study Comparing Personalized Radiation Therapy With Standard Radiation Therapy in People With HPV-Positive Throat Cancer

HPV-Related Squamous Cell Carcinoma Phase 3 Interventional 291 participants sought
Hartford Healthcare (Data Collection Only) — Hartford, Connecticut (25.4 mi) · Sponsor: Memorial Sloan Kettering Cancer Center
See eligibility & contact on ClinicalTrials.gov (NCT06563479)

Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial

Plasma Cell Myeloma, RISS Stage I Plasma Cell Myeloma Phase 3 Interventional 1,450 participants sought
Hartford Hospital — Hartford, Connecticut (25.4 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT04566328)

A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease

Crohn's Disease Phase 3 Interventional 90 participants sought
Connecticut Children's Medical Center — Hartford, Connecticut (25.4 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT05509777)
Actively enrolling

Studies you may be able to join near Springfield

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Springfield

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Sisu Clincal Research

★ 3.5
95 Frank B Murray St, Springfield, MA 01103
(413) 305-1142
"I called and talked to a very nice Spanish woman. She answered all my questions was very direct very responsive. I’m trying to do the depression and …"
— Nicole Koske, 5★

Baystate Health Clinical Trials Unit

★ 5.0
80 Wason Ave, Springfield, MA 01107
(413) 794-6690

Elixia

★ 5.0
95 Frank B Murray St, Springfield, MA 01103
"Super friendly, had a good experience"
— Nick Bean, 5★

Colaccino Center For Health Sciences

★ 5.0
Springfield, MA 01109

Clinical Research Management Group

★ 5.0
1408 Main St, Agawam, MA 01001
(413) 821-0022

Pioneer Valley Life Sciences

3601 Main St, Springfield, MA 01107
(413) 794-0653

CT Clinical Research

160 West St Ste 1A, Cromwell, CT 06416
(860) 632-0144

Pioneer Behavioral Health

★ 5.0 (135 reviews)
175 Dwight Rd, Longmeadow, MA 01106
(888) 617-3070
"I cannot say enough good things about Pioneer Behavioral Health and the incredible team that helped me when I needed it most. When I first started th…"
— Nick, 5★

Clinical Trials of New England

1234 Hyde Park Ave #205, Hyde Park, MA 02136

Clinical trials in Springfield: what's recruiting

The Springfield area currently has 325 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Springfield, the most active research areas are:

  • Cancer & Oncology15 studies
  • Heart & Vascular4 studies
  • Brain & Mental Health1 studies
  • Immune & Skin1 studies

Every listing shows the study phase, the recruiting site and its distance from Springfield, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Springfield

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Springfield participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Springfield pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in Springfield?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
What is the difference between a research center and a hospital study in Springfield?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Springfield?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Springfield.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Springfield typically complete one or two studies per year.

Paid clinical trials near Springfield

Other metros within reach

Hartford, CT447 Norwich, CT122 Waterbury, CT1,145 Worcester, MA269 New Haven, CT1,181 Bridgeport, CT1,454 Providence, RI550 Danbury, CT1,159

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Springfield Bladder Issues Due To Spinal Cord Injury in Springfield All conditions

More of MA

Boston2,944 New Bedford511 Worcester269

New paid studies open every week

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