Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/MA/Worcester
Updated October 2026 from ClinicalTrials.gov

Paid Clinical Trials in Worcester, MA

Studies commonly pay $75 to $4,500 per completed study

273 clinical trials are currently recruiting participants within 30 miles of Worcester. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

273studies recruiting
9+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Worcester right now

Top 25 of 273 recruiting studies, sorted by proximity — each links to its official registry page

Targeting Nociceptors in Hidradenitis Suppurativa

Hidradenitis Suppurativa, Hyperhidrosis N/A Observational 20 participants sought
University of Massachusetts Chan Medical School — Worcester, Massachusetts (0.6 mi) · Sponsor: University of Massachusetts, Worcester
See eligibility & contact on ClinicalTrials.gov (NCT05403710)

Lupus Landmark Study: A Prospective Registry and Biorepository

Systemic Lupus Erythematosus (SLE), Lupus Nephritis N/A Observational 3,500 participants sought
University of Massachusetts Memorial Health — Worcester, Massachusetts (0.6 mi) · Sponsor: Lupus Research Alliance
See eligibility & contact on ClinicalTrials.gov (NCT05934149)

Dexmedetomidine Transdermal Systems (DMTS) Treatment for Agitation Associated With Dementia of the Alzheimer's Type

Agitation Phase 2 Interventional 150 participants sought
Vitalix — Worcester, Massachusetts (0.6 mi) · Sponsor: Teikoku Pharma USA, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06052254)

A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)

Relapsing Multiple Sclerosis, Multiple Sclerosis N/A Observational 2,000 participants sought
TG Therapeutics Investigational Trial Site — Norfolk, Massachusetts (26.8 mi) · Sponsor: TG Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06433752)

Re-Engineered Discharge for Diabetes Care Transitions

Diabetes Mellitus Type 2, Social Determinants of Health (SDOH) N/A Interventional 412 participants sought
UMASS Memorial Healthcare System — Worcester, Massachusetts (0.6 mi) · Sponsor: University of Massachusetts, Worcester
See eligibility & contact on ClinicalTrials.gov (NCT06869057)

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
UMass Memorial Medical Center - University Campus — Worcester, Massachusetts (0.6 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

SELUTION4BTK Trial

Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia Nos of Native Arteries of Extremities N/A Interventional 376 participants sought
University of Massachusetts Medical Center — Worcester, Massachusetts (0.6 mi) · Sponsor: M.A. Med Alliance S.A.
See eligibility & contact on ClinicalTrials.gov (NCT05055297)

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8 Phase 3 Interventional 1,500 participants sought
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional — Milford, Massachusetts (17.4 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05946213)

A Follow-up Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

Immune Thrombocytopenic Purpura (ITP) Phase 3 Interventional 150 participants sought
University of Massachusetts Chan Medical School — Worcester, Massachusetts (0.6 mi) · Sponsor: Takeda
See eligibility & contact on ClinicalTrials.gov (NCT06948318)

A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised

COVID-19 Infection Phase 3 Interventional 300 participants sought
University of Massachusetts Chan Medical School — Worcester, Massachusetts (0.6 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT07013474)

Improving Jail Response to the Overdose Crisis: A Hybrid Trial of Jail ECHO to Improve MOUD Implementation and Public Health Outcomes

Opioid Abuse (Disorder) N/A Interventional 100 participants sought
UMass Chan Medical School — Worcester, Massachusetts (0.6 mi) · Sponsor: University of Massachusetts, Worcester
See eligibility & contact on ClinicalTrials.gov (NCT07637994)

Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

Renal Pelvis and Ureter Urothelial Carcinoma Phase 2, Phase 3 Interventional 131 participants sought
UMass Memorial Medical Center - University Campus — Worcester, Massachusetts (0.6 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04628767)

A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo™ Aspiration System (STRIDE II)

Lower Extremity Acute Limb Ischemia, LE ALI N/A Observational 300 participants sought
UMass Memorial Medical Center — Worcester, Massachusetts (0.6 mi) · Sponsor: Penumbra Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06747117)

A Study to Evaluate the Clinical Outcomes of Efgartigimod PH20 SC in Adults With New-onset Generalized Myasthenia Gravis (gMG)

New Onset Generalized Myasthenia Gravis (gMG) Phase 4 Interventional 30 participants sought
UMass Memorial Medical Center — Worcester, Massachusetts (0.6 mi) · Sponsor: argenx
See eligibility & contact on ClinicalTrials.gov (NCT06909214)

Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)

Non-small Cell Lung Cancer (NSCLC) Phase 3 Interventional 614 participants sought
University of Massachusetts Chan Medical School-Division of Hematology/Oncology ( Site 0144) — Worcester, Massachusetts (0.6 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06170788)

A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH

Metabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis Phase 3 Interventional 1,800 participants sought
89bio Clinical Study Site — Framingham, Massachusetts (20.0 mi) · Sponsor: Hoffmann-La Roche
See eligibility & contact on ClinicalTrials.gov (NCT06419374)

Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

Castration-Resistant Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8 Phase 2 Interventional 474 participants sought
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional — Milford, Massachusetts (17.4 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06632977)

Androgen-responsive POSLUMA-guided Intra-prostatic Boost

Intermediate Risk Prostate Cancer, High Risk Prostate Cancer Phase 2 Interventional 23 participants sought
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Medical Center — Milford, Massachusetts (17.4 mi) · Sponsor: Martin T. King, MD, PhD
See eligibility & contact on ClinicalTrials.gov (NCT07393867)

Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With Alcohol-associated Hepatitis (AH)

Hepatitis Phase 3 Interventional 350 participants sought
UMass Chan Medical School — Worcester, Massachusetts (0.6 mi) · Sponsor: Bausch Health Americas, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07428538)

A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative Colitis

Colitis, Ulcerative Phase 2, Phase 3 Interventional 120 participants sought
University of Massachusetts Chan Medical School — Worcester, Massachusetts (0.6 mi) · Sponsor: Bristol-Myers Squibb
See eligibility & contact on ClinicalTrials.gov (NCT05076175)
Actively enrolling

Studies you may be able to join near Worcester

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Worcester

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Reliant Medical Group Research Department

640 Lincoln St, Worcester, MA 01605
(508) 595-2195

PracticePoint: Accelerating Medtech Innovation & Empowering Medskill Training

★ 5.0
Gateway Park II, 50 Prescott St, Worcester, MA 01605
(508) 831-4653

Meyers Health Care Institute

385 Grove St, Worcester, MA 01605
(508) 791-7392

Center For Outcomes Research

55 N Lake Ave, Worcester, MA 01655
(508) 856-1336

UMass Cancer Walk

55 N Lake Ave, Worcester, MA 01655
(508) 856-2589

Community Healthlink, Inc.

★ 2.5
72 Jaques Ave, Worcester, MA 01610
(508) 860-1000

Eunice Kennedy Shriver Center

55 N Lake Ave, Worcester, MA 01655
(774) 455-6562

Behavioral Healthcare Services

★ 3.3 (185 reviews)
435 Shrewsbury St, Worcester, MA 01604
(508) 753-5554
"I had a very disappointing experience with Sherrie Urena. I arrived on time for my scheduled appointment, but after waiting over 30 minutes without b…"
— Christina Garoulis, 1★

Clinical Trials of New England

1234 Hyde Park Ave #205, Hyde Park, MA 02136

Clinical trials in Worcester: what's recruiting

The Worcester area currently has 273 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Worcester, the most active research areas are:

  • Cancer & Oncology6 studies
  • Liver & Kidney3 studies
  • Immune & Skin2 studies
  • Diabetes & Metabolism2 studies
  • Lungs & Breathing1 studies

Every listing shows the study phase, the recruiting site and its distance from Worcester, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Worcester

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Worcester participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Are clinical trials in Worcester safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Worcester, MA?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
What is the difference between a research center and a hospital study in Worcester?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Worcester?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Worcester.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Worcester typically complete one or two studies per year.

Paid clinical trials near Worcester

Other metros within reach

Nashua, NH266 Providence, RI554 Boston, MA2,972 Springfield, MA311 Norwich, CT123 Manchester, NH85 Hartford, CT441 New Bedford, MA515

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Worcester Bladder Issues Due To Spinal Cord Injury in Worcester All conditions

More of MA

Boston2,972 New Bedford515 Springfield311

New paid studies open every week

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