Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/MA/Worcester
Updated September 2026 from ClinicalTrials.gov

Paid Clinical Trials in Worcester, MA

Studies commonly pay $75 to $4,500 per completed study

270 clinical trials are currently recruiting participants within 30 miles of Worcester. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

270studies recruiting
9+research centers nearby
4condition categories
Live from the NIH registry

Studies recruiting near Worcester right now

Top 25 of 270 recruiting studies, sorted by proximity — each links to its official registry page

Lupus Landmark Study: A Prospective Registry and Biorepository

Systemic Lupus Erythematosus (SLE), Lupus Nephritis N/A Observational 3,500 participants sought
University of Massachusetts Memorial Health — Worcester, Massachusetts (0.6 mi) · Sponsor: Lupus Research Alliance
See eligibility & contact on ClinicalTrials.gov (NCT05934149)

Dexmedetomidine Transdermal Systems (DMTS) Treatment for Agitation Associated With Dementia of the Alzheimer's Type

Agitation Phase 2 Interventional 150 participants sought
Vitalix — Worcester, Massachusetts (0.6 mi) · Sponsor: Teikoku Pharma USA, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06052254)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
UMass Memorial Medical Center - University Campus — Worcester, Massachusetts (0.6 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

Acute Myeloid Leukemia (AML) Phase 3 Interventional 1,300 participants sought
University of Massachusetts — Worcester, Massachusetts (0.6 mi) · Sponsor: Kura Oncology, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07007312)

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
UMass Memorial Medical Center - University Campus — Worcester, Massachusetts (0.6 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative Colitis

Colitis, Ulcerative Phase 2, Phase 3 Interventional 120 participants sought
University of Massachusetts Chan Medical School — Worcester, Massachusetts (0.6 mi) · Sponsor: Bristol-Myers Squibb
See eligibility & contact on ClinicalTrials.gov (NCT05076175)

A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised

COVID-19 Infection Phase 3 Interventional 300 participants sought
University of Massachusetts Chan Medical School — Worcester, Massachusetts (0.6 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT07013474)

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

Carcinoma, Transitional Cell, Urinary Bladder Neoplasms Phase 3 Interventional 450 participants sought
University of Massachusetts Medical School — Worcester, Massachusetts (0.6 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT07218380)

ACX-362E [Ibezapolstat] for Oral Treatment of Recurrent Clostridioides Difficile Infection

Clostridium Difficile Infection Recurrence Phase 2 Interventional 20 participants sought
University of Massachusetts Memorial Healthcare — Worcester, Massachusetts (0.6 mi) · Sponsor: Acurx Pharmaceuticals Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07513285)

A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo™ Aspiration System (STRIDE II)

Lower Extremity Acute Limb Ischemia, LE ALI N/A Observational 300 participants sought
UMass Memorial Medical Center — Worcester, Massachusetts (0.6 mi) · Sponsor: Penumbra Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06747117)

Influences of Long-acting Reversible Contraceptives on Iron Status and Physiological Responses to Extreme Environments in Women

Contraception, Iron Deficiencies N/A Observational 33 participants sought
US Army Research Institute of Environmental Medicine — Natick, Massachusetts (23.5 mi) · Sponsor: United States Army Research Institute of Environmental Medicine
See eligibility & contact on ClinicalTrials.gov (NCT06909695)

PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia

Critical Limb Ischemia, Chronic Limb-Threatening Ischemia N/A Interventional 100 participants sought
UMass Chan Medical School — Worcester, Massachusetts (0.6 mi) · Sponsor: LimFlow, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05313165)

Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)

Non-small Cell Lung Cancer (NSCLC) Phase 3 Interventional 614 participants sought
University of Massachusetts Chan Medical School-Division of Hematology/Oncology ( Site 0144) — Worcester, Massachusetts (0.6 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06170788)

A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

Cystic Fibrosis N/A Observational 400 participants sought
University of Massachusetts Memorial Health Care — Worcester, Massachusetts (0.6 mi) · Sponsor: Nicole Hamblett
See eligibility & contact on ClinicalTrials.gov (NCT06504589)

Evaluation of the Paramedic Evaluation for Acute COPD Exacerbation

COPD (Chronic Obstructive Pulmonary Disease) N/A Interventional 50 participants sought
University of Massachusetts Chan Medical School — Worcester, Massachusetts (0.6 mi) · Sponsor: University of Massachusetts, Worcester
See eligibility & contact on ClinicalTrials.gov (NCT07072039)

A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

Major Depressive Disorder Phase 2 Interventional 164 participants sought
Vitalix Clinical — Worcester, Massachusetts (0.6 mi) · Sponsor: Syndeio Biosciences, Inc
See eligibility & contact on ClinicalTrials.gov (NCT07115329)

Promoting Early Intervention Timing and Attention to Language

MONITOR, COACH N/A Interventional 140 participants sought
University of Massachusetts Medical Center — Worcester, Massachusetts (0.6 mi) · Sponsor: University of California, Los Angeles
See eligibility & contact on ClinicalTrials.gov (NCT05853861)

A Study to Learn About the Study Medicine Called Rimegepant in Adolescents With Frequent Migraine

Migraine Phase 3 Interventional 200 participants sought
New England Regional Headache Center — Worcester, Massachusetts (0.6 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT06616194)
Actively enrolling

Studies you may be able to join near Worcester

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Worcester

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Reliant Medical Group Research Department

640 Lincoln St, Worcester, MA 01605
(508) 595-2195

PracticePoint: Accelerating Medtech Innovation & Empowering Medskill Training

★ 5.0
Gateway Park II, 50 Prescott St, Worcester, MA 01605
(508) 831-4653

Meyers Health Care Institute

385 Grove St, Worcester, MA 01605
(508) 791-7392

Center For Outcomes Research

55 N Lake Ave, Worcester, MA 01655
(508) 856-1336

UMass Cancer Walk

55 N Lake Ave, Worcester, MA 01655
(508) 856-2589

Community Healthlink, Inc.

★ 2.5
72 Jaques Ave, Worcester, MA 01610
(508) 860-1000

Eunice Kennedy Shriver Center

55 N Lake Ave, Worcester, MA 01655
(774) 455-6562

Behavioral Healthcare Services

★ 3.3 (185 reviews)
435 Shrewsbury St, Worcester, MA 01604
(508) 753-5554
"I had a very disappointing experience with Sherrie Urena. I arrived on time for my scheduled appointment, but after waiting over 30 minutes without b…"
— Christina Garoulis, 1★

Clinical Trials of New England

1234 Hyde Park Ave #205, Hyde Park, MA 02136

Clinical trials in Worcester: what's recruiting

The Worcester area currently has 270 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Worcester, the most active research areas are:

  • Cancer & Oncology5 studies
  • Immune & Skin3 studies
  • Lungs & Breathing2 studies
  • Brain & Mental Health2 studies

Every listing shows the study phase, the recruiting site and its distance from Worcester, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Worcester

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Worcester participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Are clinical trials in Worcester safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Worcester, MA?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
What is the difference between a research center and a hospital study in Worcester?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Worcester?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Worcester.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Worcester typically complete one or two studies per year.

Paid clinical trials near Worcester

Other metros within reach

Nashua, NH263 Providence, RI554 Boston, MA2,966 Springfield, MA315 Norwich, CT115 Manchester, NH83 Hartford, CT437 New Bedford, MA517

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Worcester Bladder Issues Due To Spinal Cord Injury in Worcester All conditions

More of MA

Boston2,966 New Bedford517 Springfield315

New paid studies open every week

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