Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/MA/Worcester
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Worcester, MA

Studies commonly pay $75 to $4,500 per completed study

273 clinical trials are currently recruiting participants within 30 miles of Worcester. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

273studies recruiting
9+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Worcester right now

Top 25 of 273 recruiting studies, sorted by proximity — each links to its official registry page

Dexmedetomidine Transdermal Systems (DMTS) Treatment for Agitation Associated With Dementia of the Alzheimer's Type

Agitation Phase 2 Interventional 150 participants sought
Vitalix — Worcester, Massachusetts (0.6 mi) · Sponsor: Teikoku Pharma USA, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06052254)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
UMass Memorial Medical Center - University Campus — Worcester, Massachusetts (0.6 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

Acute Myeloid Leukemia (AML) Phase 3 Interventional 1,300 participants sought
University of Massachusetts — Worcester, Massachusetts (0.6 mi) · Sponsor: Kura Oncology, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07007312)

Phase 2 Study to Evaluate EI-001 in Non-segmental Vitiligo Patients

Non-segmental Vitiligo Phase 2 Interventional 45 participants sought
U Mass Chan Medical School — Worcester, Massachusetts (0.6 mi) · Sponsor: Elixiron Immunotherapeutics (Hong Kong) Ltd.
See eligibility & contact on ClinicalTrials.gov (NCT07223229)

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
UMass Memorial Medical Center - University Campus — Worcester, Massachusetts (0.6 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

Lupus Landmark Study: A Prospective Registry and Biorepository

Systemic Lupus Erythematosus (SLE), Lupus Nephritis N/A Observational 3,500 participants sought
University of Massachusetts Memorial Health — Worcester, Massachusetts (0.6 mi) · Sponsor: Lupus Research Alliance
See eligibility & contact on ClinicalTrials.gov (NCT05934149)

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Endometrial Cancer Phase 3 Interventional 600 participants sought
Research Site — Worcester, Massachusetts (0.6 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06989112)

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

Carcinoma, Transitional Cell, Urinary Bladder Neoplasms Phase 3 Interventional 450 participants sought
University of Massachusetts Medical School — Worcester, Massachusetts (0.6 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT07218380)

ACX-362E [Ibezapolstat] for Oral Treatment of Recurrent Clostridioides Difficile Infection

Clostridium Difficile Infection Recurrence Phase 2 Interventional 20 participants sought
University of Massachusetts Memorial Healthcare — Worcester, Massachusetts (0.6 mi) · Sponsor: Acurx Pharmaceuticals Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07513285)

Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)

Non-small Cell Lung Cancer (NSCLC) Phase 3 Interventional 614 participants sought
University of Massachusetts Chan Medical School-Division of Hematology/Oncology ( Site 0144) — Worcester, Massachusetts (0.6 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06170788)

Evaluating Signs of Safety: A Deaf-Accessible Therapy Toolkit for AUD and Trauma

PTSD, Alcohol; Use, Problem N/A Interventional 144 participants sought
University of Massachusetts Medical School — Worcester, Massachusetts (0.6 mi) · Sponsor: University of Massachusetts, Worcester
See eligibility & contact on ClinicalTrials.gov (NCT06278922)

An Evaluation of the Effect of the Erchonia FX-405 Laser as an Adjunctive Treatment of Periodontitis

Periodontal Diseases, Periodontitis N/A Interventional 70 participants sought
Acton Dental Associates — Acton, Massachusetts (24.2 mi) · Sponsor: Erchonia Corporation
See eligibility & contact on ClinicalTrials.gov (NCT06656325)

Evaluation of the Paramedic Evaluation for Acute COPD Exacerbation

COPD (Chronic Obstructive Pulmonary Disease) N/A Interventional 50 participants sought
University of Massachusetts Chan Medical School — Worcester, Massachusetts (0.6 mi) · Sponsor: University of Massachusetts, Worcester
See eligibility & contact on ClinicalTrials.gov (NCT07072039)

A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

Major Depressive Disorder Phase 2 Interventional 164 participants sought
Vitalix Clinical — Worcester, Massachusetts (0.6 mi) · Sponsor: Syndeio Biosciences, Inc
See eligibility & contact on ClinicalTrials.gov (NCT07115329)

Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer

Colorectal Neoplasms Phase 3 Interventional 300 participants sought
University of Massachusetts — Worcester, Massachusetts (0.6 mi) · Sponsor: Surgimab
See eligibility & contact on ClinicalTrials.gov (NCT03659448)

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm Phase 2 Interventional 2,000 participants sought
UMass Memorial Medical Center - University Campus — Worcester, Massachusetts (0.6 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05564390)

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

Non-Small Cell Lung Cancer (NSCLC) Phase 3 Interventional 750 participants sought
Reliant Medical Group Inc — Worcester, Massachusetts (0.6 mi) · Sponsor: Amgen
See eligibility & contact on ClinicalTrials.gov (NCT05920356)

A Study to Learn About the Study Medicine Called Rimegepant in Adolescents With Frequent Migraine

Migraine Phase 3 Interventional 200 participants sought
New England Regional Headache Center — Worcester, Massachusetts (0.6 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT06616194)

Preliminary Trial of an Avatar Guided Digital Intervention for Emerging Adults

Binge Alcohol Consumption, Suicidal Ideation N/A Interventional 60 participants sought
UMass Memorial Health - University Campus — Worcester, Massachusetts (0.6 mi) · Sponsor: University of Massachusetts, Worcester
See eligibility & contact on ClinicalTrials.gov (NCT07418047)

Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction Phase 3 Interventional 2,000 participants sought
Charles River Medical Associates — Natick, Massachusetts (23.5 mi) · Sponsor: Uppsala University
See eligibility & contact on ClinicalTrials.gov (NCT02901184)
Actively enrolling

Studies you may be able to join near Worcester

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Worcester

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Reliant Medical Group Research Department

640 Lincoln St, Worcester, MA 01605
(508) 595-2195

PracticePoint: Accelerating Medtech Innovation & Empowering Medskill Training

★ 5.0
Gateway Park II, 50 Prescott St, Worcester, MA 01605
(508) 831-4653

Meyers Health Care Institute

385 Grove St, Worcester, MA 01605
(508) 791-7392

Center For Outcomes Research

55 N Lake Ave, Worcester, MA 01655
(508) 856-1336

UMass Cancer Walk

55 N Lake Ave, Worcester, MA 01655
(508) 856-2589

Community Healthlink, Inc.

★ 2.5
72 Jaques Ave, Worcester, MA 01610
(508) 860-1000

Eunice Kennedy Shriver Center

55 N Lake Ave, Worcester, MA 01655
(774) 455-6562

Behavioral Healthcare Services

★ 3.3 (185 reviews)
435 Shrewsbury St, Worcester, MA 01604
(508) 753-5554
"I had a very disappointing experience with Sherrie Urena. I arrived on time for my scheduled appointment, but after waiting over 30 minutes without b…"
— Christina Garoulis, 1★

Clinical Trials of New England

1234 Hyde Park Ave #205, Hyde Park, MA 02136

Clinical trials in Worcester: what's recruiting

The Worcester area currently has 273 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Worcester, the most active research areas are:

  • Cancer & Oncology9 studies
  • Immune & Skin2 studies
  • Brain & Mental Health2 studies
  • Lungs & Breathing1 studies
  • Heart & Vascular1 studies

Every listing shows the study phase, the recruiting site and its distance from Worcester, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Worcester

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Worcester participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Are clinical trials in Worcester safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Worcester, MA?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
What is the difference between a research center and a hospital study in Worcester?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Worcester?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Worcester.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Worcester typically complete one or two studies per year.

Paid clinical trials near Worcester

Other metros within reach

Nashua, NH262 Providence, RI558 Boston, MA2,960 Springfield, MA317 Norwich, CT123 Manchester, NH88 Hartford, CT441 New Bedford, MA519

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Worcester Bladder Issues Due To Spinal Cord Injury in Worcester All conditions

More of MA

Boston2,960 New Bedford519 Springfield317

New paid studies open every week

Get an email when a new clinical trial starts recruiting within 30 miles of your ZIP code. No spam — only real studies from the NIH registry.

By subscribing you agree to receive study alert emails. Unsubscribe anytime in one click.

Get free trial alerts