Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/MN/St. Paul
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in St. Paul, MN

Studies commonly pay $75 to $4,500 per completed study

1,092 clinical trials are currently recruiting participants within 30 miles of St. Paul. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

1,092studies recruiting
9+research centers nearby
7condition categories
Live from the NIH registry

Studies recruiting near St. Paul right now

Top 25 of 1,092 recruiting studies, sorted by proximity — each links to its official registry page

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Children's Hospitals and Clinics of Minnesota - Minneapolis — Minneapolis, Minnesota (8.1 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

Open Label, Controlled, Post Marketing, Registry Study of Ribociclib (Ribo) Treatment Adherence and Patient Reported Outcomes in Participants Using ReX Technology Platform

Any Solid Oral Medication N/A Interventional 200 participants sought
Allina — Minneapolis, Minnesota (8.1 mi) · Sponsor: Dosentrx Ltd.
See eligibility & contact on ClinicalTrials.gov (NCT06344416)

A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of Niemann-Pick Type C Disease, GM1 Gangliosidosis or GM2 Gangliosidosis

Niemann-Pick Type C Disease, GM1 Gangliosidosis Phase 3 Interventional 147 participants sought
University of Minnesota Medical School — Minneapolis, Minnesota (8.1 mi) · Sponsor: Azafaros B.V.
See eligibility & contact on ClinicalTrials.gov (NCT07054515)

Study of ALXN1920 in Adult Participants With Primary Membranous Nephropathy (PMN)

Primary Membranous Nephropathy Phase 2 Interventional 30 participants sought
Research Site — Minneapolis, Minnesota (8.1 mi) · Sponsor: Alexion Pharmaceuticals, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07157787)

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

PIK3CA Mutation, HER2- Negative Breast Cancer Phase 3 Interventional 540 participants sought
Minnesota Oncology Hematology, P.A. — Minneapolis, Minnesota (8.1 mi) · Sponsor: Relay Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06982521)

GATEWAY: Safety Evaluation of the MiniMed™ NMX8-AID System in Children and Adults Living With Diabetes

Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus N/A Interventional 400 participants sought
International Diabetes Center — Minneapolis, Minnesota (8.1 mi) · Sponsor: Medtronic MiniMed, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07228117)

A Multicenter, Randomized, Vehicle-Controlled, Double-Masked to Open-Label Study to Evaluate the Safety and Efficacy of Lacripep in Subjects With Neurotrophic Keratitis

Neurotrophic Keratitis Phase 2 Interventional 54 participants sought
Minnesota Eye Consultants — Minneapolis, Minnesota (8.1 mi) · Sponsor: TearSolutions, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07568730)

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Neovascular Age-related Macular Degeneration Phase 4 Interventional 188 participants sought
VitreoRetinal Surgery, PLLC. — Minneapolis, Minnesota (8.1 mi) · Sponsor: Genentech, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04853251)

A Study to Evaluate Safety, Tolerability and Efficacy of AP306 at Fixed Doses in Dialysis Participants With Hyperphosphatemia

Hyperphosphatemia, Chronic Kidney Disease Requiring Chronic Dialysis Phase 2 Interventional 168 participants sought
DaVita Clinical Research Edina — Edina, Minnesota (12.7 mi) · Sponsor: R1 Therapeutics
See eligibility & contact on ClinicalTrials.gov (NCT06712654)

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Endometrial Cancer Phase 3 Interventional 600 participants sought
Research Site — Minneapolis, Minnesota (8.1 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06989112)

A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies

Solid Tumors Phase 2 Interventional 170 participants sought
Local Institution - 0073 — Saint Paul, Minnesota (0.6 mi) · Sponsor: Mirati Therapeutics Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07415031)

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
Regions Hospital — Saint Paul, Minnesota (0.6 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)

Cystic Fibrosis (CF), Cystic Fibrosis-related Diabetes N/A Observational 200 participants sought
University of Minnesota — Minneapolis, Minnesota (8.1 mi) · Sponsor: Jaeb Center for Health Research
See eligibility & contact on ClinicalTrials.gov (NCT06837181)

Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial - Part 2

Intracerebral Hemorrhage Phase 3 Interventional 350 participants sought
M Health Fairview St. John's Hospital — Maplewood, Minnesota (5.3 mi) · Sponsor: Joseph Broderick, MD
See eligibility & contact on ClinicalTrials.gov (NCT07227246)

Exploration of the Utility of Dental-dedicated MRI for Dentistry

Dental Crowding, Dental Occlusion, Traumatic N/A Observational 300 participants sought
Orofacial MRI Center at UMN — Minneapolis, Minnesota (8.1 mi) · Sponsor: University of Minnesota
See eligibility & contact on ClinicalTrials.gov (NCT06948162)

A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)

Renal Cell Carcinoma Phase 3 Interventional 904 participants sought
Metro-Minnesota Community Clinical Oncology ( Site 0144) — Saint Louis Park, Minnesota (11.9 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT07227402)

Study of the Shockwave Medical SkyRunner Carotid Intravascular Lithotripsy (IVL) System for the Treatment of Calcified Carotid Arteries Prior to Trans-Carotid Stenting (SKYWARD Trans-Carotid IDE [Investigational Device Exemption] Study)

Carotid Artery Calcification, Carotid Artery Diseases N/A Interventional 185 participants sought
Allina Health Minneapolis Heart Institute — Minneapolis, Minnesota (8.1 mi) · Sponsor: Shockwave Medical, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07062471)

Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial

Metastatic Castration-Resistant Prostate Carcinoma, Metastatic Prostate Adenocarcinoma Phase 3 Interventional 1,524 participants sought
Regions Hospital — Saint Paul, Minnesota (0.6 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT07200830)

Lumbar & Sacroiliac Fusion Study Involving Previously Implanted Devices

Fusion of Spine, Sacroiliac; Fusion N/A Interventional 500 participants sought
Nura Precision Pain Management — Edina, Minnesota (12.7 mi) · Sponsor: Spinal Simplicity LLC
See eligibility & contact on ClinicalTrials.gov (NCT07204288)

Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections

Pulmonary Invasive Fungal Infections, Pulmonary Invasive Aspergillosis N/A Observational 400 participants sought
Children's Minnesota — Saint Paul, Minnesota (0.6 mi) · Sponsor: Arkansas Children's Hospital Research Institute
See eligibility & contact on ClinicalTrials.gov (NCT03827694)

BAFFR-targeting CAR T Cells for Patients With Relapsed or Refractory B-NHL

Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma Phase 1 Interventional 36 participants sought
University of Minnesota — Minneapolis, Minnesota (8.1 mi) · Sponsor: PeproMene Bio, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05370430)
Actively enrolling

Studies you may be able to join near St. Paul

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in St. Paul

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Clinical Research Institute

★ 4.9
825 Nicollet Mall #1135, Minneapolis, MN 55402
(612) 333-2200
"The best part of this location is that there is a dedicated bike trail past all the traffic from the western suburbs."
— Jesse Kortes, 4★

Nucleus Network Minneapolis Clinic

★ 4.3
1000 Westgate Dr #149, St Paul, MN 55114
(651) 641-2900
"Absolutely outstanding in every way. A+. Ten stars! The staff was the BEST in America! So amazing I just can’t say enough about ALL of them. So dedic…"
— Jennifer, 5★

Prism Clinical Research

1000 Westgate Dr #149, St Paul, MN 55114

Minnesota Clinical Study Center

★ 4.3
119 14th St NW, New Brighton, MN 55112
(763) 571-4200
"I responded to an advertisement in the Strib about a medical study they were conducting. People on the phone were very polite and briefly explained …"
— sven svenson, 1★

University of Minnesota Clinical Research Unit (CRU)

516 Delaware St SE, Minneapolis, MN 55455

Comprehensive Research Group

★ 4.7
2520 Broadway St NE, Minneapolis, MN 55413
(612) 781-3400
"Super, super nice people that work there. They are very organized in how they do things."
— Lisa Bjorken, 5★

UMN Oral Health Clinical Research Center (OHCRC)

Malcolm Moos Health Sciences Tower, 515 Delaware St SE, Minneapolis, MN 55455

Wilder Foundation

★ 4.4
451 Lexington Pkwy N, St Paul, MN 55104
(651) 280-2000
"I volunteered with the meals on wheels program through Wilder Foundation. I asked for a letter of recommendation and even after many follow up emails…"
— Beth T, 1★

Epidemiology Clinical Research Center

★ 5.0
1100 Washington Ave S, Minneapolis, MN 55415
(612) 626-9199

Clinical trials in St. Paul: what's recruiting

The St. Paul area currently has 1,092 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to St. Paul, the most active research areas are:

  • Cancer & Oncology8 studies
  • Diabetes & Metabolism2 studies
  • Heart & Vascular2 studies
  • Liver & Kidney2 studies
  • Brain & Mental Health1 studies

Every listing shows the study phase, the recruiting site and its distance from St. Paul, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in St. Paul

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

St. Paul participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in St. Paul pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in St. Paul?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Are clinical trials in St. Paul safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How often do new paid studies open in St. Paul?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of St. Paul.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in St. Paul typically complete one or two studies per year.

Paid clinical trials near St. Paul

Other metros within reach

Minneapolis, MN1,090 Cedar Rapids, IA591 Des Moines, IA221 Sioux Falls, SD264 Madison, WI527 Fargo, ND201 Davenport, IA42 Omaha, NE595

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in St. Paul Bladder Issues Due To Spinal Cord Injury in St. Paul All conditions

More of MN

Minneapolis1,090

New paid studies open every week

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