Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only

Home/SD/Sioux Falls

Updated October 2026 from ClinicalTrials.gov

Paid Clinical Trials in Sioux Falls, SD

Studies commonly pay $75 to $4,500 per completed study

263 clinical trials are currently recruiting participants within 30 miles of Sioux Falls. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

263studies recruiting

4+research centers nearby

3condition categories

Live from the NIH registry

Studies recruiting near Sioux Falls right now

Top 25 of 263 recruiting studies, sorted by proximity — each links to its official registry page

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought

Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota (0.3 mi) · Sponsor: SWOG Cancer Research Network

See eligibility & contact on ClinicalTrials.gov (NCT03851445)

A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

Advanced Pancreatic Carcinoma, Metastatic Pancreatic Carcinoma Phase 2 Interventional 40 participants sought

Ohio State University Telemedicine — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Sameek Roychowdhury

See eligibility & contact on ClinicalTrials.gov (NCT06906562)

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

Breast Neoplasms, Triple Negative Breast Neoplasms Phase 3 Interventional 2,400 participants sought

Avera McKennan Hospital ( Site 0002) — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Merck Sharp & Dohme LLC

See eligibility & contact on ClinicalTrials.gov (NCT06966700)

Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies

Breast Cancer, TNBC - Triple-Negative Breast Cancer N/A Observational 900 participants sought

Sanford - Sioux Falls — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Tempus AI

See eligibility & contact on ClinicalTrials.gov (NCT07211178)

LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis

Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate Phase 2 Interventional 1,431 participants sought

Sanford USD Medical Center — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Eli Lilly and Company

See eligibility & contact on ClinicalTrials.gov (NCT07415044)

Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

Retroperitoneal Sarcoma, Liposarcoma Phase 3 Interventional 250 participants sought

Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota (0.3 mi) · Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

See eligibility & contact on ClinicalTrials.gov (NCT04031677)

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

Biochemically Recurrent Prostate Carcinoma, Metastatic Prostate Carcinoma Phase 3 Interventional 804 participants sought

Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota (0.3 mi) · Sponsor: ECOG-ACRIN Cancer Research Group

See eligibility & contact on ClinicalTrials.gov (NCT04423211)

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8 Phase 3 Interventional 1,500 participants sought

Sanford USD Medical Center - Sioux Falls — Sioux Falls, South Dakota (0.3 mi) · Sponsor: NRG Oncology

See eligibility & contact on ClinicalTrials.gov (NCT05946213)

Investigations of Reproductive Cancers in Women

Uterine Cancer N/A Observational 4,500 participants sought

Avera Research Institute — Sioux Falls, South Dakota (0.3 mi) · Sponsor: PinkDx, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT06527157)

KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)

Malignant Neoplasm Phase 2 Interventional 140 participants sought

Sanford Cancer Center Oncology Clinic ( Site 0038) — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Merck Sharp & Dohme LLC

See eligibility & contact on ClinicalTrials.gov (NCT07252739)

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

Smoldering Plasma Cell Myeloma Phase 3 Interventional 288 participants sought

Avera Cancer Institute — Sioux Falls, South Dakota (0.3 mi) · Sponsor: ECOG-ACRIN Cancer Research Group

See eligibility & contact on ClinicalTrials.gov (NCT03937635)

Collection of Research Data and Samples From Patients Treated With Immunotherapy to Study Its Side Effects

Hematopoietic and Lymphoid Cell Neoplasm, Immune System Disorder N/A Observational 2,240 participants sought

Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Alliance for Clinical Trials in Oncology

See eligibility & contact on ClinicalTrials.gov (NCT04242095)

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Ovarian Carcinoma N/A Interventional 1,956 participants sought

Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota (0.3 mi) · Sponsor: NRG Oncology

See eligibility & contact on ClinicalTrials.gov (NCT04251052)

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

Childhood Medulloblastoma Phase 3 Interventional 225 participants sought

Sanford USD Medical Center - Sioux Falls — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Children's Oncology Group

See eligibility & contact on ClinicalTrials.gov (NCT05382338)

Oral Ifetroban in Patients With Idiopathic Pulmonary Fibrosis (IPF)

Idiopathic Pulmonary Fibrosis Phase 2 Interventional 128 participants sought

Avera Research Institute — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Cumberland Pharmaceuticals

See eligibility & contact on ClinicalTrials.gov (NCT05571059)

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

Metastatic Breast Cancer, Metastatic Gastric Adenocarcinoma Phase 1, Phase 2 Interventional 768 participants sought

Avera Cancer Institute — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Boehringer Ingelheim

See eligibility & contact on ClinicalTrials.gov (NCT06324357)

A Study of Tarlatamab in Combination With AB248 in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-311)

Extensive Stage Small Cell Lung Cancer Phase 1 Interventional 380 participants sought

Avera Cancer Institute — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Amgen

See eligibility & contact on ClinicalTrials.gov (NCT07037758)

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck Phase 1 Interventional 1,006 participants sought

Sanford Cancer Center — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Seagen, a wholly owned subsidiary of Pfizer

See eligibility & contact on ClinicalTrials.gov (NCT04389632)

Nectero EAST System Clinical Study

Abdominal Aortic Aneurysm Phase 2, Phase 3 Interventional 400 participants sought

North Central Heart - A Division of Avera Heart Hospital — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Nectero Medical, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT06001918)

Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer

Breast Neoplasms, Carcinoma, Ductal, Breast N/A Interventional 725 participants sought

Sanford Health — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Natera, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT07214532)

Observational Study of Decentralized Urine Optical Interaction Patterns Associated With Environmental Microplastic and Nanoplastic Exposure

Healthy Adult Participants N/A Observational 15 participants sought

Decentralized / At-Home Participation (U.S.) — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Ecotera Health LLC

See eligibility & contact on ClinicalTrials.gov (NCT07775495)

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

Solid Tumors, Hematologic Malignancies Phase 3 Interventional 3,500 participants sought

Sanford Cancer Center ( Site 0066) — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Merck Sharp & Dohme LLC

See eligibility & contact on ClinicalTrials.gov (NCT03486873)

A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)

Chronic Graft-Versus-Host Disease (cGVHD) Phase 2 Interventional 48 participants sought

Avera Cancer Institute — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Deciphera Pharmaceuticals, LLC

See eligibility & contact on ClinicalTrials.gov (NCT06619561)

The Minimalist Trial-2

HPV-Related Oropharynx Squamous Cell Carcinoma Phase 2 Interventional 142 participants sought

Sanford Cancer Center — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Washington University School of Medicine

See eligibility & contact on ClinicalTrials.gov (NCT06702033)

Trial of Xaluritamig in Adults With Metastatic Castration-resistant Prostate Cancer

Metastatic Castration-resistant Prostate Cancer (mCRPC) Phase 1 Interventional 40 participants sought

Sanford Oncology Clinic and Pharmacy — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Amgen

See eligibility & contact on ClinicalTrials.gov (NCT07493512)

Actively enrolling

Studies you may be able to join near Sioux Falls

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Google-rated

Top-rated research centers in Sioux Falls

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Avera Research Institute — Sioux Falls

6001 S Sharon Ave, Sioux Falls, SD 57108

(605) 504-3154

Website

Sanford Research

★ 5.0

2301 East 60th St N, Sioux Falls, SD 57104

(605) 312-6300

Website

Sanford Imagenetics

★ 4.1

1321 W 22nd St, Sioux Falls, SD 57105

(605) 404-4000

Website

Circle Clinical Research

(605) 215-1159

Website

Clinical trials in Sioux Falls: what's recruiting

The Sioux Falls area currently has 263 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Sioux Falls, the most active research areas are:

Cancer & Oncology17 studies
Immune & Skin1 studies
Lungs & Breathing1 studies

Every listing shows the study phase, the recruiting site and its distance from Sioux Falls, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Sioux Falls

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Sioux Falls participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Do I need to be sick to join a clinical trial in Sioux Falls?

No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.

Are clinical trials in Sioux Falls safe?

Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.

How do I join a study in Sioux Falls, SD?

Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.

How often do new paid studies open in Sioux Falls?

Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Sioux Falls.

Can I be in more than one clinical trial at a time?

Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Sioux Falls typically complete one or two studies per year.

Paid clinical trials near Sioux Falls

Other metros within reach

Omaha, NE600 Lincoln, NE154 Fargo, ND207 Des Moines, IA229 Minneapolis, MN1,075 St. Paul, MN1,077 Topeka, KS111 Kansas City, KS1,041

New paid studies open every week

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