Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/ME/Portland
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Portland, ME

Studies commonly pay $75 to $4,500 per completed study

170 clinical trials are currently recruiting participants within 30 miles of Portland. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

170studies recruiting
9+research centers nearby
4condition categories
Live from the NIH registry

Studies recruiting near Portland right now

Top 25 of 170 recruiting studies, sorted by proximity — each links to its official registry page

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
MaineHealth Cancer Care and IV Therapy - South Portland — South Portland, Maine (2.9 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Neovascular Age-related Macular Degeneration Phase 4 Interventional 188 participants sought
Maine Eye Center — Portland, Maine (1.5 mi) · Sponsor: Genentech, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04853251)

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm Phase 2 Interventional 2,000 participants sought
MaineHealth Maine Medical Center - Portland — Portland, Maine (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05564390)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Maine Children's Cancer Program — Scarborough, Maine (7.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

Malignant Glioma Phase 1, Phase 2 Interventional 132 participants sought
Maine Children's Cancer Program — Scarborough, Maine (7.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05099003)

This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

Non-Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung Phase 3 Interventional 714 participants sought
Maine Medical Center — Portland, Maine (1.5 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT06758401)

ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

Cardiovascular Risk, Acute Myocardial Infarction (AMI) Phase 3 Interventional 10,000 participants sought
Maine Medical Center Bramhall — Portland, Maine (1.5 mi) · Sponsor: Novo Nordisk A/S
See eligibility & contact on ClinicalTrials.gov (NCT06118281)

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

Ganglioneuroblastoma, Nodular, Neuroblastoma Phase 3 Interventional 478 participants sought
Maine Children's Cancer Program — Scarborough, Maine (7.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06172296)

A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

Geographic Atrophy, Macular Degeneration Phase 2 Interventional 274 participants sought
Maine Eye Center — Portland, Maine (1.5 mi) · Sponsor: Janssen Research & Development, LLC
See eligibility & contact on ClinicalTrials.gov (NCT06635148)

Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

Locally Advanced Lung Non-Small Cell Carcinoma, Stage IIB Lung Cancer AJCC v8 Phase 3 Interventional 474 participants sought
MaineHealth Maine Medical Center - Portland — Portland, Maine (1.5 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05624996)

A Study to Investigate Efficacy and Safety of Pegtibatinase Compared With Placebo in Participants ≥12 to ≤65 Years of Age With Classical Homocystinuria (HCU) Due to Cystathionine Beta Synthase Deficiency Receiving Standard of Care Treatment

Homocystinuria Phase 3 Interventional 70 participants sought
Maine Health - Maine Medical Center — Portland, Maine (1.5 mi) · Sponsor: Travere Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06247085)

A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer

Endometrial Cancer Phase 1, Phase 2 Interventional 148 participants sought
Maine Medical Center — Scarborough, Maine (7.3 mi) · Sponsor: Alliance Foundation Trials, LLC.
See eligibility & contact on ClinicalTrials.gov (NCT04486352)

Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLL

Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia Phase 3 Interventional 466 participants sought
MaineHealth Maine Medical Center - Portland — Portland, Maine (1.5 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT07321652)

A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

Basal Ganglia Germinoma, Diabetes Insipidus Phase 2 Interventional 240 participants sought
Maine Children's Cancer Program — Scarborough, Maine (7.3 mi) · Sponsor: Children's Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT06368817)

Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube High Grade Serous Adenocarcinoma Phase 3 Interventional 880 participants sought
MaineHealth Maine Medical Center- Scarborough — Scarborough, Maine (7.3 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06580314)

A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

High Grade Osteosarcoma, Localized Osteosarcoma Phase 2, Phase 3 Interventional 1,122 participants sought
Maine Children's Cancer Program — Scarborough, Maine (7.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05691478)

A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)

Non Small Cell Lung Cancer Phase 3 Interventional 780 participants sought
New England Cancer Specialists ( Site 0095) — Westbrook, Maine (5.0 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06312137)

A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)

Multiple Myeloma, Newly Diagnosed Multiple Myeloma Phase 3 Interventional 520 participants sought
GSK Investigational Site — Portland, Maine (1.5 mi) · Sponsor: GlaxoSmithKline
See eligibility & contact on ClinicalTrials.gov (NCT06679101)

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung Phase 3 Interventional 700 participants sought
New England Cancer Specialists — Westbrook, Maine (5.0 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT06890598)

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

Obesity, Heart Failure Phase 3 Interventional 5,610 participants sought
MaineHealth Cardiology - Biddeford — Biddeford, Maine (15.7 mi) · Sponsor: Novo Nordisk A/S
See eligibility & contact on ClinicalTrials.gov (NCT07567001)

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia Phase 1, Phase 2 Interventional 960 participants sought
Maine Children's Cancer Program — Scarborough, Maine (7.3 mi) · Sponsor: PedAL BCU, LLC
See eligibility & contact on ClinicalTrials.gov (NCT04726241)
Actively enrolling

Studies you may be able to join near Portland

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Portland

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

MaineHealth Institute for Research

★ 5.0
81 Research Drive, Scarborough, ME 04074
(207) 396-8100
"They do a lot of great research here and the people are great to work with!"
— Teresa Martel, 5★

MaineHealth Hannaford Center for Safety, Innovation and Simulation

335 Brighton Ave Fl 3, Portland, ME 04102
(207) 662-7060

Compass Mental Health Maine LLC

251 Woodford St, Portland, ME 04103
(207) 773-2828

Portland Gastroenterology Center

★ 4.5
161 Marginal Way, Portland, ME 04101
(207) 773-7964
"Dr Vecchio is wonderful and ive now met 2 of the other providers who seem very nice as well. They seem to actually care and want to find solutions fo…"
— Laurie, 5★

MaineHealth Cancer Care and Blood Disorders - Scarborough

★ 4.5
100 Campus Dr Unit 108, Scarborough, ME 04074
(207) 303-1100
"Amazing Group!<br>I took my sister for her chemotherapy treatment today, and I was so impressed with ALL of the staff. Every person we interacted wit…"
— Liz L, 5★

MaineHealth Cancer Risk and Prevention - Scarborough

100 Campus Dr Suite 121, Scarborough, ME 04074
(207) 396-7785

MaineHealth Bleeding Disorders - Scarborough

100 Campus Dr #107, Scarborough, ME 04074
(844) 504-9680

MaineHealth - Scarborough Campus

★ 3.8
100 Campus Dr, Scarborough, ME 04074
"Dr Febrraro is a wonderful Gynecological Oncologist. I had cancer surgery and couldn't have been more pleased. She has me come for a checkup every 6 …"
— MarieElena Mathena, 5★

CIEE: Council on International Educational Exchange

★ 3.9
600 Southborough Dr Ste 104, South Portland, ME 04106
(207) 553-4000
"I had a great time studying abroad, no complaints with the team at my location. However their main office has the slowest response time I have ever d…"
— Ada S, 2★

Clinical trials in Portland: what's recruiting

The Portland area currently has 170 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Portland, the most active research areas are:

  • Cancer & Oncology18 studies
  • Heart & Vascular4 studies
  • Liver & Kidney2 studies
  • Diabetes & Metabolism2 studies

Every listing shows the study phase, the recruiting site and its distance from Portland, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Portland

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Portland participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Do I need to be sick to join a clinical trial in Portland?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
How do I join a study in Portland, ME?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
How often do new paid studies open in Portland?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Portland.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Portland typically complete one or two studies per year.

Paid clinical trials near Portland

Other metros within reach

Manchester, NH89 Nashua, NH254 Boston, MA2,944 Worcester, MA269 New Bedford, MA511 Providence, RI550 Springfield, MA325 Norwich, CT122

New paid studies open every week

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