Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/ME/Portland
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Portland, ME

Studies commonly pay $75 to $4,500 per completed study

171 clinical trials are currently recruiting participants within 30 miles of Portland. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

171studies recruiting
9+research centers nearby
3condition categories
Live from the NIH registry

Studies recruiting near Portland right now

Top 25 of 171 recruiting studies, sorted by proximity — each links to its official registry page

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm Phase 2 Interventional 2,000 participants sought
MaineHealth Maine Medical Center - Portland — Portland, Maine (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05564390)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Maine Children's Cancer Program — Scarborough, Maine (7.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)

Non-small Cell Lung Cancer (NSCLC) Phase 3 Interventional 614 participants sought
New England Cancer Specialists ( Site 0143) — Westbrook, Maine (5.0 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06170788)

Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8 Phase 3 Interventional 356 participants sought
MaineHealth Maine Medical Center - Portland — Portland, Maine (1.5 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06958328)

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

Malignant Glioma Phase 1, Phase 2 Interventional 132 participants sought
Maine Children's Cancer Program — Scarborough, Maine (7.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05099003)

Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

Malignant Female Reproductive System Neoplasm, Malignant Solid Neoplasm Phase 2 Interventional 70 participants sought
MaineHealth Maine Medical Center- Scarborough — Scarborough, Maine (7.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06126276)

A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer

HER2-positive Breast Cancer, Breast Cancer Phase 2 Interventional 125 participants sought
New England Cancer Specialists — Scarborough, Maine (7.3 mi) · Sponsor: Jazz Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT07102381)

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

Lymphoma, Non-Hodgkin, Multiple Myeloma Phase 2 Interventional 4,200 participants sought
MaineHealth Cancer Care -South Portland — South Portland, Maine (2.9 mi) · Sponsor: American Society of Clinical Oncology
See eligibility & contact on ClinicalTrials.gov (NCT02693535)

Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body

Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene Fusion N/A Observational 150 participants sought
Maine Health — South Portland, Maine (2.9 mi) · Sponsor: Bayer
See eligibility & contact on ClinicalTrials.gov (NCT04142437)

A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

Geographic Atrophy, Macular Degeneration Phase 2 Interventional 274 participants sought
Maine Eye Center — Portland, Maine (1.5 mi) · Sponsor: Janssen Research & Development, LLC
See eligibility & contact on ClinicalTrials.gov (NCT06635148)

Education & Mentorship of Advanced Practice Providers to Increase Community-based Research Within the NCORP Network, COACH-APP Trial

Other N/A Interventional 97 participants sought
MaineHealth Maine Medical Center - Portland — Portland, Maine (1.5 mi) · Sponsor: Wake Forest University Health Sciences
See eligibility & contact on ClinicalTrials.gov (NCT06904391)

Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

Non-small Cell Lung Cancer (NSCLC) Phase 3 Interventional 400 participants sought
Research Site — South Portland, Maine (2.9 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT07291037)

Endurant Stent Graft System vs Excluder Endoprothesis: ADVANCE Trial

Abdominal Aortic Aneurysm, Abdominal Aortic Aneurysm >= 5.5 Centimeters in Male (Disorder) N/A Interventional 600 participants sought
Maine Medical Center — Portland, Maine (1.5 mi) · Sponsor: Medtronic Cardiovascular
See eligibility & contact on ClinicalTrials.gov (NCT05378347)

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8 Phase 3 Interventional 1,209 participants sought
MaineHealth Maine Medical Center - Portland — Portland, Maine (1.5 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05946213)

A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

Locally Advanced Solid Tumors, Metastatic Solid Tumors Phase 1, Phase 2 Interventional 75 participants sought
Maine Medical Center — Scarborough, Maine (7.3 mi) · Sponsor: Turning Point Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04094610)

High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

Head and Neck Squamous Cell Carcinoma, Stage I Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8 Phase 3 Interventional 228 participants sought
MaineHealth Maine Medical Center - Portland — Portland, Maine (1.5 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06992427)

Pegtibatinase as a Treatment for Patients With Classical Homocystinuria (HCU) (Also Known as the COMPOSE Study)

Homocystinuria Phase 1, Phase 2 Interventional 39 participants sought
Travere Investigational Site — Portland, Maine (1.5 mi) · Sponsor: Travere Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT03406611)

A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

Anaplastic Kidney Wilms Tumor, Recurrent Kidney Wilms Tumor Phase 2 Interventional 256 participants sought
Maine Children's Cancer Program — Scarborough, Maine (7.3 mi) · Sponsor: Children's Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT04322318)

Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)

Acute Myeloid Leukemia Phase 2 Interventional 153 participants sought
MaineHealth Maine Medical Center - Portland — Portland, Maine (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05554393)

Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

Advanced Endometrial Carcinoma, Recurrent Endometrial Carcinoma Phase 3 Interventional 255 participants sought
MaineHealth Maine Medical Center- Scarborough — Scarborough, Maine (7.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT07198074)

A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

High Grade Osteosarcoma, Localized Osteosarcoma Phase 2, Phase 3 Interventional 1,122 participants sought
Maine Children's Cancer Program — Scarborough, Maine (7.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05691478)
Actively enrolling

Studies you may be able to join near Portland

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Portland

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

MaineHealth Institute for Research

★ 5.0
81 Research Drive, Scarborough, ME 04074
(207) 396-8100
"They do a lot of great research here and the people are great to work with!"
— Teresa Martel, 5★

MaineHealth Hannaford Center for Safety, Innovation and Simulation

335 Brighton Ave Fl 3, Portland, ME 04102
(207) 662-7060

Compass Mental Health Maine LLC

251 Woodford St, Portland, ME 04103
(207) 773-2828

Portland Gastroenterology Center

★ 4.5
161 Marginal Way, Portland, ME 04101
(207) 773-7964
"Dr Vecchio is wonderful and ive now met 2 of the other providers who seem very nice as well. They seem to actually care and want to find solutions fo…"
— Laurie, 5★

MaineHealth Cancer Care and Blood Disorders - Scarborough

★ 4.5
100 Campus Dr Unit 108, Scarborough, ME 04074
(207) 303-1100
"Amazing Group!<br>I took my sister for her chemotherapy treatment today, and I was so impressed with ALL of the staff. Every person we interacted wit…"
— Liz L, 5★

MaineHealth Cancer Risk and Prevention - Scarborough

100 Campus Dr Suite 121, Scarborough, ME 04074
(207) 396-7785

MaineHealth Bleeding Disorders - Scarborough

100 Campus Dr #107, Scarborough, ME 04074
(844) 504-9680

MaineHealth - Scarborough Campus

★ 3.8
100 Campus Dr, Scarborough, ME 04074
"Dr Febrraro is a wonderful Gynecological Oncologist. I had cancer surgery and couldn't have been more pleased. She has me come for a checkup every 6 …"
— MarieElena Mathena, 5★

CIEE: Council on International Educational Exchange

★ 3.9
600 Southborough Dr Ste 104, South Portland, ME 04106
(207) 553-4000
"I had a great time studying abroad, no complaints with the team at my location. However their main office has the slowest response time I have ever d…"
— Ada S, 2★

Clinical trials in Portland: what's recruiting

The Portland area currently has 171 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Portland, the most active research areas are:

  • Cancer & Oncology18 studies
  • Liver & Kidney2 studies
  • Brain & Mental Health1 studies

Every listing shows the study phase, the recruiting site and its distance from Portland, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Portland

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Portland participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Do I need to be sick to join a clinical trial in Portland?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
How do I join a study in Portland, ME?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
How often do new paid studies open in Portland?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Portland.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Portland typically complete one or two studies per year.

Paid clinical trials near Portland

Other metros within reach

Manchester, NH88 Nashua, NH262 Boston, MA2,960 Worcester, MA273 New Bedford, MA519 Providence, RI558 Springfield, MA317 Norwich, CT123

New paid studies open every week

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