Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/ME/Portland
Updated October 2026 from ClinicalTrials.gov

Paid Clinical Trials in Portland, ME

Studies commonly pay $75 to $4,500 per completed study

164 clinical trials are currently recruiting participants within 30 miles of Portland. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

164studies recruiting
9+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Portland right now

Top 25 of 164 recruiting studies, sorted by proximity — each links to its official registry page

Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)

Non-small Cell Lung Cancer (NSCLC) Phase 3 Interventional 614 participants sought
New England Cancer Specialists ( Site 0143) — Westbrook, Maine (5.0 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06170788)

A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

Endometrial Cancer Phase 3 Interventional 1,123 participants sought
Maine Medical Center - Scarborough Campus ( Site 6042) — Scarborough, Maine (7.3 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06952504)

A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer

HER2-positive Breast Cancer, Breast Cancer Phase 2 Interventional 125 participants sought
New England Cancer Specialists — Scarborough, Maine (7.3 mi) · Sponsor: Jazz Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT07102381)

Surabgene Lomparvovec Administered in the Suprachoroidal Space in Adult Participants With Diabetic Retinopathy Without Center-Involved Diabetic Macular Edema

Diabetic Retinopathy Phase 2, Phase 3 Interventional 576 participants sought
Maine Eye Center - Marginal Way Campus /ID# 275039 — Portland, Maine (1.5 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT07592273)

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

Low Grade Astrocytoma, Low Grade Glioma Phase 3 Interventional 170 participants sought
Maine Children's Cancer Program — Scarborough, Maine (7.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04166409)

A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer

Endometrial Cancer Phase 1, Phase 2 Interventional 148 participants sought
Maine Medical Center — Scarborough, Maine (7.3 mi) · Sponsor: Alliance Foundation Trials, LLC.
See eligibility & contact on ClinicalTrials.gov (NCT04486352)

AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia

Community-acquired Pneumonia Phase 3 Interventional 4,000 participants sought
Maine Medical Centre — Portland, Maine (1.5 mi) · Sponsor: University of Manitoba
See eligibility & contact on ClinicalTrials.gov (NCT05848713)

Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

Malignant Female Reproductive System Neoplasm, Malignant Solid Neoplasm Phase 2 Interventional 70 participants sought
MaineHealth Maine Medical Center- Scarborough — Scarborough, Maine (7.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06126276)

Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

Renal Pelvis and Ureter Urothelial Carcinoma Phase 2, Phase 3 Interventional 131 participants sought
MaineHealth Cancer Care and IV Therapy - South Portland — South Portland, Maine (2.9 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04628767)

ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

Cardiovascular Risk, Acute Myocardial Infarction (AMI) Phase 3 Interventional 10,000 participants sought
Maine Medical Center Bramhall — Portland, Maine (1.5 mi) · Sponsor: Novo Nordisk A/S
See eligibility & contact on ClinicalTrials.gov (NCT06118281)

Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

Non-small Cell Lung Cancer (NSCLC) Phase 3 Interventional 400 participants sought
Research Site — South Portland, Maine (2.9 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT07291037)

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia Phase 1, Phase 2 Interventional 960 participants sought
Maine Children's Cancer Program — Scarborough, Maine (7.3 mi) · Sponsor: PedAL BCU, LLC
See eligibility & contact on ClinicalTrials.gov (NCT04726241)

Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma

Endometrial Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma Phase 2 Interventional 81 participants sought
MaineHealth Maine Medical Center- Scarborough — Scarborough, Maine (7.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05112601)

Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed and Have Not Yet Started Treatment (A MyeloMATCH Treatment Trial)

Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm Phase 2 Interventional 335 participants sought
MaineHealth Maine Medical Center - Portland — Portland, Maine (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05554406)

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

Lung Non-Small Cell Carcinoma, Lung Non-Small Cell Squamous Carcinoma Phase 3 Interventional 1,210 participants sought
MaineHealth Cancer Care and IV Therapy - South Portland — South Portland, Maine (2.9 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04267848)

Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)

Acute Myeloid Leukemia Phase 2 Interventional 93 participants sought
MaineHealth Maine Medical Center - Portland — Portland, Maine (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06672146)

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

Lymphoma, Non-Hodgkin, Multiple Myeloma Phase 2 Interventional 4,200 participants sought
MaineHealth Cancer Care -South Portland — South Portland, Maine (2.9 mi) · Sponsor: American Society of Clinical Oncology
See eligibility & contact on ClinicalTrials.gov (NCT02693535)

Real-world Experience of Catheter Ablation for the Treatment of Arrhythmias

Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation N/A Observational 20,000 participants sought
Maine Medical Center — Portland, Maine (1.5 mi) · Sponsor: Heart Rhythm Clinical and Research Solutions, LLC
See eligibility & contact on ClinicalTrials.gov (NCT04088071)

Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

Metastatic Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8 Phase 2 Interventional 240 participants sought
MaineHealth Maine Medical Center - Portland — Portland, Maine (1.5 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05327686)

A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)

Non-small Cell Lung Cancer Phase 3 Interventional 1,160 participants sought
Research Site — Scarborough, Maine (7.3 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06692738)

A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

Anaplastic Kidney Wilms Tumor, Recurrent Kidney Wilms Tumor Phase 2 Interventional 256 participants sought
Maine Children's Cancer Program — Scarborough, Maine (7.3 mi) · Sponsor: Children's Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT04322318)

A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

High Grade Osteosarcoma, Localized Osteosarcoma Phase 2, Phase 3 Interventional 1,122 participants sought
Maine Children's Cancer Program — Scarborough, Maine (7.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05691478)

Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

Locally Advanced Cervical Adenocarcinoma, Locally Advanced Cervical Adenosquamous Carcinoma Phase 3 Interventional 336 participants sought
MaineHealth Maine Medical Center - Portland — Portland, Maine (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT07061977)
Actively enrolling

Studies you may be able to join near Portland

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Portland

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

MaineHealth Institute for Research

★ 5.0
81 Research Drive, Scarborough, ME 04074
(207) 396-8100
"They do a lot of great research here and the people are great to work with!"
— Teresa Martel, 5★

MaineHealth Hannaford Center for Safety, Innovation and Simulation

335 Brighton Ave Fl 3, Portland, ME 04102
(207) 662-7060

Compass Mental Health Maine LLC

251 Woodford St, Portland, ME 04103
(207) 773-2828

Portland Gastroenterology Center

★ 4.5
161 Marginal Way, Portland, ME 04101
(207) 773-7964
"Dr Vecchio is wonderful and ive now met 2 of the other providers who seem very nice as well. They seem to actually care and want to find solutions fo…"
— Laurie, 5★

MaineHealth Cancer Care and Blood Disorders - Scarborough

★ 4.5
100 Campus Dr Unit 108, Scarborough, ME 04074
(207) 303-1100
"Amazing Group!<br>I took my sister for her chemotherapy treatment today, and I was so impressed with ALL of the staff. Every person we interacted wit…"
— Liz L, 5★

MaineHealth Cancer Risk and Prevention - Scarborough

100 Campus Dr Suite 121, Scarborough, ME 04074
(207) 396-7785

MaineHealth Bleeding Disorders - Scarborough

100 Campus Dr #107, Scarborough, ME 04074
(844) 504-9680

MaineHealth - Scarborough Campus

★ 3.8
100 Campus Dr, Scarborough, ME 04074
"Dr Febrraro is a wonderful Gynecological Oncologist. I had cancer surgery and couldn't have been more pleased. She has me come for a checkup every 6 …"
— MarieElena Mathena, 5★

CIEE: Council on International Educational Exchange

★ 3.9
600 Southborough Dr Ste 104, South Portland, ME 04106
(207) 553-4000
"I had a great time studying abroad, no complaints with the team at my location. However their main office has the slowest response time I have ever d…"
— Ada S, 2★

Clinical trials in Portland: what's recruiting

The Portland area currently has 164 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Portland, the most active research areas are:

  • Cancer & Oncology18 studies
  • Liver & Kidney3 studies
  • Brain & Mental Health1 studies
  • Diabetes & Metabolism1 studies
  • Heart & Vascular1 studies

Every listing shows the study phase, the recruiting site and its distance from Portland, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Portland

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Portland participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Do I need to be sick to join a clinical trial in Portland?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
How do I join a study in Portland, ME?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
How often do new paid studies open in Portland?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Portland.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Portland typically complete one or two studies per year.

Paid clinical trials near Portland

Other metros within reach

Manchester, NH85 Nashua, NH267 Boston, MA2,973 Worcester, MA275 New Bedford, MA519 Providence, RI560 Springfield, MA314 Norwich, CT119

New paid studies open every week

Get an email when a new clinical trial starts recruiting within 30 miles of your ZIP code. No spam — only real studies from the NIH registry.

By subscribing you agree to receive study alert emails. Unsubscribe anytime in one click.

Get free trial alerts