Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/OH/Columbus
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Columbus, OH

Studies commonly pay $75 to $4,500 per completed study

1,345 clinical trials are currently recruiting participants within 30 miles of Columbus. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

1,345studies recruiting
9+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Columbus right now

Top 25 of 1,345 recruiting studies, sorted by proximity — each links to its official registry page

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

High Grade Glioma, Diffuse Intrinsic Pontine Glioma Phase 2 Interventional 120 participants sought
Nationwide Children's Hospital — Columbus, Ohio (1.9 mi) · Sponsor: Nationwide Children's Hospital
See eligibility & contact on ClinicalTrials.gov (NCT05096481)

PBF-1129 and Nivolumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer

Metastatic Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma Phase 1 Interventional 30 participants sought
Ohio State University Comprehensive Cancer Center — Columbus, Ohio (1.9 mi) · Sponsor: Dwight Owen
See eligibility & contact on ClinicalTrials.gov (NCT05234307)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Nationwide Children's Hospital — Columbus, Ohio (1.9 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

Outreach Project to Connect Underrepresented Populations to Clinical Trials at Ohio State University, CUSP2CT Project Trial

Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm N/A Interventional 208 participants sought
Ohio State University Comprehensive Cancer Center — Columbus, Ohio (1.9 mi) · Sponsor: Ohio State University Comprehensive Cancer Center
See eligibility & contact on ClinicalTrials.gov (NCT06314672)

ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas

Diffuse Intrinsic Pontine Gliomas (DIPG), Progressive DIPG Phase 2 Interventional 60 participants sought
Nationwide Children's Hospital — Columbus, Ohio (1.9 mi) · Sponsor: Nationwide Children's Hospital
See eligibility & contact on ClinicalTrials.gov (NCT06838676)

Studying the Health Perceptions and Social Behaviors of Graduate Students at the Ohio State University for the Development of Effective Oral Nicotine Pouch Addictive Risk Communication

Tobacco-Related Carcinoma N/A Interventional 2,000 participants sought
Ohio State University Comprehensive Cancer Center — Columbus, Ohio (1.9 mi) · Sponsor: Ohio State University Comprehensive Cancer Center
See eligibility & contact on ClinicalTrials.gov (NCT07346092)

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
Ohio State University Comprehensive Cancer Center — Columbus, Ohio (1.9 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

Implementing Scalable, PAtient-centered, Team-based, Technology-enabled Care for Adults With Type 2 Diabetes (iPATH)

Diabetes Mellitus, Type 2 N/A Interventional 119,680 participants sought
The Ohio State University — Columbus, Ohio (1.9 mi) · Sponsor: Stanford University
See eligibility & contact on ClinicalTrials.gov (NCT06251323)

Waveform Capnography Compared to Colorimetric Carbon Dioxide Detection During Tracheal Intubation of Critically Ill Adults

Acute Respiratory Failure N/A Observational 2,092 participants sought
The Ohio State University College of Medicine — Columbus, Ohio (1.9 mi) · Sponsor: Brian Driver
See eligibility & contact on ClinicalTrials.gov (NCT06934876)

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Endometrial Cancer Phase 3 Interventional 600 participants sought
Research Site — Columbus, Ohio (1.9 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06989112)

Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

Acute Myeloid Leukemia (AML) Phase 3 Interventional 1,300 participants sought
Ohio State University — Columbus, Ohio (1.9 mi) · Sponsor: Kura Oncology, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07007312)

Phase 2, Efficacy and Safety Study of ACP-204 in Lewy Body Dementia Psychosis

Lewy Body Dementia Psychosis Phase 2 Interventional 180 participants sought
The Ohio State University, Energy Advancement and Innovation Center — Columbus, Ohio (1.9 mi) · Sponsor: ACADIA Pharmaceuticals Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07029581)

A Study of Buntanetap in Participants With PD

Parkinson's Disease (PD), Deep Brain Stimulation Phase 2, Phase 3 Interventional 500 participants sought
The Ohio State University Wexner Medical Center — Columbus, Ohio (1.9 mi) · Sponsor: Annovis Bio Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07284784)

KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)

Carcinoma, Non-Small-Cell Lung Phase 1, Phase 2 Interventional 450 participants sought
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C ( Site 0015) — Columbus, Ohio (1.9 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT04165070)

BSB-1001 in Patients Undergoing HLA-Matched Allogenic Hematopoietic Stem Cell Transplant for AML, ALL or MDS

AML, Adult Recurrent, ALL, Recurrent, Adult Phase 1, Phase 2 Interventional 38 participants sought
The Ohio State University — Columbus, Ohio (1.9 mi) · Sponsor: BlueSphere Bio, Inc
See eligibility & contact on ClinicalTrials.gov (NCT06704152)

A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

Advanced Pancreatic Carcinoma, Metastatic Pancreatic Carcinoma Phase 2 Interventional 40 participants sought
Ohio State University Comprehensive Cancer Center — Columbus, Ohio (1.9 mi) · Sponsor: Sameek Roychowdhury
See eligibility & contact on ClinicalTrials.gov (NCT06906562)

A Cognitive Training Intervention for Improving Cognitive and Neurological Outcomes in Patients Undergoing Treatment for Relapsed or Refractory Multiple Myeloma or B-cell Non-Hodgkin Lymphoma

Recurrent B-Cell Non-Hodgkin Lymphoma, Recurrent Multiple Myeloma N/A Interventional 90 participants sought
Ohio State University Comprehensive Cancer Center — Columbus, Ohio (1.9 mi) · Sponsor: Ohio State University Comprehensive Cancer Center
See eligibility & contact on ClinicalTrials.gov (NCT07609030)

Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance

Ascending Aortic Aneurysm Enlargement, Ascending Aorta Aneurysm N/A Interventional 610 participants sought
Ohio State University Medical Center — Columbus, Ohio (1.9 mi) · Sponsor: Ottawa Heart Institute Research Corporation
See eligibility & contact on ClinicalTrials.gov (NCT03536312)

A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies

Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL) Phase 1 Interventional 248 participants sought
OSU Wexner Medical Center — Columbus, Ohio (1.9 mi) · Sponsor: Nurix Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04830137)

A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)

Thrombocythemia, Essential, Primary Myelofibrosis Phase 3 Interventional 400 participants sought
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C ( Site 6007) — Columbus, Ohio (1.9 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06351631)
Actively enrolling

Studies you may be able to join near Columbus

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research studies for chronic kidney disease

This research platform is enrolling Black and African American adults in eligible areas who have been diagnosed with chronic kidney disease. Compensation may be available. The study team confirms eligibility before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Columbus

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Ohio Clinical Trials

★ 3.8
1380 Edgehill Rd, Columbus, OH 43212
(614) 754-7679
"I love here! Everyone so kind ♥️"
— Ree Ciers, 5★

Institute for Behavioral Medicine Research

★ 4.7
460 Medical Center Dr, Columbus, OH 43210
(614) 292-5526
"Marvellous excellent spinal surgery stimulater to walk for my paraplagic 42year old son of mine successfully done. Amazing and revolutionarry.<br>H…"
— Dr.suresh Khedekar, 5★

Biomedical Research Tower

★ 4.9
460 W 12th Ave, Columbus, OH 43210
(614) 292-6136

Abigail Wexner Research Institute

★ 4.1
575 Children's Xrd, Columbus, OH 43215
(614) 722-2210
"The nicest employees, i felt welcome!"
— Stafford k. Lipscomb II, 4★

OSU College of Medicine, Office of Research and Discovery

370 W 9th Ave, Columbus, OH 43210

OSU Health Sciences Center for Global Health

376 W 10th Ave Ste 165, Columbus, OH 43210
(614) 292-3684

Pelotonia Research Center

★ 4.8
2255 Kenny Rd, Columbus, OH 43210
(614) 292-4458
"Beautiful research center with lots of cool instruments."
— TimOutdoorAdventure, 5★

OSU Comprehensive Cancer Center

460 W 10th Ave, Columbus, OH 43210
(800) 293-5066

The Research Institute at Nationwide Children’s Hospital

★ 5.0
700 Children's Dr, Columbus, OH 43205
(614) 722-2700
"The research group has been great with our son and helping find out more information about children with all kinds of diseases or medical problems."
— Lexi Aquino, 5★

Clinical trials in Columbus: what's recruiting

The Columbus area currently has 1,345 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Columbus, the most active research areas are:

  • Cancer & Oncology13 studies
  • Brain & Mental Health2 studies
  • Diabetes & Metabolism1 studies
  • Lungs & Breathing1 studies
  • Immune & Skin1 studies

Every listing shows the study phase, the recruiting site and its distance from Columbus, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Columbus

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Columbus participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Are clinical trials in Columbus safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Columbus, OH?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
What is the difference between a research center and a hospital study in Columbus?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Columbus?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Columbus.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Columbus typically complete one or two studies per year.

Paid clinical trials near Columbus

Other metros within reach

Dayton, OH310 Lorain, OH1,309 Huntington, WV57 Cincinnati, OH1,127 Toledo, OH211 Canton, OH304 Akron, OH394 Cleveland, OH1,413

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Columbus Chronic Kidney Disease (HealthMatch) in Columbus Bladder Issues Due To Spinal Cord Injury in Columbus All conditions

More of OH

Cleveland1,413 Lorain1,309 Cincinnati1,127 Akron394 Dayton310 Canton304 Toledo211 Youngstown82

New paid studies open every week

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