Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/OH/Cleveland
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Cleveland, OH

Studies commonly pay $75 to $4,500 per completed study

1,413 clinical trials are currently recruiting participants within 30 miles of Cleveland. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

1,413studies recruiting
9+research centers nearby
6condition categories
Live from the NIH registry

Studies recruiting near Cleveland right now

Top 25 of 1,413 recruiting studies, sorted by proximity — each links to its official registry page

KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)

Carcinoma, Non-Small-Cell Lung Phase 1, Phase 2 Interventional 450 participants sought
Cleveland Clinic Main ( Site 0006) — Cleveland, Ohio (1.8 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT04165070)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Rainbow Babies and Childrens Hospital — Cleveland, Ohio (1.8 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Lymphoma, Large B-Cell, Diffuse Phase 2 Interventional 594 participants sought
University Hospitals of Cleveland ( Site 0155) — Cleveland, Ohio (1.8 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06890884)

A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

Advanced Pancreatic Carcinoma, Metastatic Pancreatic Carcinoma Phase 2 Interventional 40 participants sought
Ohio State University-Telemedicine — Cleveland, Ohio (1.8 mi) · Sponsor: Sameek Roychowdhury
See eligibility & contact on ClinicalTrials.gov (NCT06906562)

GATEWAY: Safety Evaluation of the MiniMed™ NMX8-AID System in Children and Adults Living With Diabetes

Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus N/A Interventional 400 participants sought
University Hospitals Cleveland Medical Center — Cleveland, Ohio (1.8 mi) · Sponsor: Medtronic MiniMed, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07228117)

A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated

Diabetic Macular Edema Phase 1, Phase 2 Interventional 49 participants sought
Cleveland Clinic — Cleveland, Ohio (1.8 mi) · Sponsor: Boehringer Ingelheim
See eligibility & contact on ClinicalTrials.gov (NCT07553429)

A TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND EFFICACY OF SHR-A1904 IN SUBJECTS WITH ADVANCED SOLID TUMORS

Advanced Solid Tumors Phase 1, Phase 2 Interventional 83 participants sought
University Hospitals Cleveland Medical Center — Cleveland, Ohio (1.8 mi) · Sponsor: Jiangsu HengRui Medicine Co., Ltd.
See eligibility & contact on ClinicalTrials.gov (NCT05277168)

Multicenter Clinical Study of the SING-IMT in Patients with Late-stage AMD

Age-Related Macular Degeneration, Geographic Atrophy N/A Interventional 125 participants sought
Cleveland Clinic | Cole Eye Institute — Cleveland, Ohio (1.8 mi) · Sponsor: VisionCare, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05438732)

Impact of the Cionic Neural Sleeve on Mobility in Multiple Sclerosis

Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting N/A Interventional 14 participants sought
Cleveland State University — Cleveland, Ohio (1.8 mi) · Sponsor: Cionic, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05964829)

Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer

Oral Squamous Cell Carcinoma, Oral Cancer Phase 2 Interventional 30 participants sought
Case Comprehensive Cancer Center, Cleveland Clinic Foundation — Cleveland, Ohio (1.8 mi) · Sponsor: Case Comprehensive Cancer Center
See eligibility & contact on ClinicalTrials.gov (NCT06627270)

Study of the Efficacy and Safety of ICP-332 in Participants With Prurigo Nodularis

Prurigo Nodularis (PN) Phase 2 Interventional 135 participants sought
Apex Clinical Research Center — Mayfield Heights, Ohio (11.9 mi) · Sponsor: Beijing InnoCare Pharma Tech Co., Ltd.
See eligibility & contact on ClinicalTrials.gov (NCT07236099)

Study of AZD2389 Safety, Tolerability, and Pharmacodynamics in Adults With Steatotic Liver Disease and Advanced Fibrosis

Liver Fibrosis, Hepatic Cirrhosis Phase 2 Interventional 104 participants sought
Research Site — Westlake, Ohio (12.4 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT07610837)

This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

Metastatic Castration Sensitive Prostate Cancer (mCSPC), Hormone Sensitive Prostate Cancer Phase 3 Interventional 1,000 participants sought
University Hospitals Cleveland Medical Center — Cleveland, Ohio (1.8 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT07028853)

Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease

Liver Cirrhoses, Portal Hypertension Related to Cirrhosis Phase 4 Interventional 70 participants sought
Cleveland Clinic Main Campus — Cleveland, Ohio (1.8 mi) · Sponsor: The Cleveland Clinic
See eligibility & contact on ClinicalTrials.gov (NCT07058155)

Cognitive and Immunologic Profiles of Patients With Olfactory Dysfunction After Smell Training

Smell Loss, Chronic Rhinosinusitis (CRS) N/A Interventional 52 participants sought
The Cleveland Clinic — Cleveland, Ohio (1.8 mi) · Sponsor: The Cleveland Clinic
See eligibility & contact on ClinicalTrials.gov (NCT07681973)

Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections

Pulmonary Invasive Fungal Infections, Pulmonary Invasive Aspergillosis N/A Observational 400 participants sought
Cleveland Clinic — Cleveland, Ohio (1.8 mi) · Sponsor: Arkansas Children's Hospital Research Institute
See eligibility & contact on ClinicalTrials.gov (NCT03827694)

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Neovascular Age-related Macular Degeneration Phase 4 Interventional 188 participants sought
Cleveland Clinic — Cleveland, Ohio (1.8 mi) · Sponsor: Genentech, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04853251)

A Study of Vedolizumab With Tofacitinib in Adults With Ulcerative Colitis (UC)

Ulcerative Colitis Phase 4 Interventional 65 participants sought
Gastro Intestinal Research Institute of Northern Ohio, LLC. — Westlake, Ohio (12.4 mi) · Sponsor: Takeda
See eligibility & contact on ClinicalTrials.gov (NCT06095128)

A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy

Locally Advanced Head and Neck Squamous Cell Carcinoma Phase 3 Interventional 1,145 participants sought
Research Site — Cleveland, Ohio (1.8 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06129864)
Actively enrolling

Studies you may be able to join near Cleveland

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Cleveland

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

C7Research

3762 Pearl Rd, Cleveland, OH 44109
(216) 282-7047

Charak Clinical Research Center

12395 McCracken Rd Ste e, Garfield Heights, OH 44125
(877) 463-9633

Cleveland Clinic N Building - Education Building & Cleveland Clinic Research

★ 4.7
9620 Carnegie Ave N Bldg, Cleveland, OH 44106
(216) 444-3900

Cleveland Clinic - Center For Ophthalmic Bioinformatics

10685 Carnegie Ave, Cleveland, OH 44106
(216) 444-3672

Velocity Clinical Research

★ 4.5
3619 Park E Dr Ste 300, Beachwood, OH 44122
(216) 682-0320

Cleveland AIDS Clinical Trials Unit

★ 5.0
2061 Cornell Rd, Cleveland, OH 44106
(216) 844-4444
"It's an efficient facility staffed by caring people. A drawback is the parking situation..."
— Allan Yheulon, 5★

Clinical Research Solutions - Cleveland, OH

★ 5.0
6900 Pearl Rd #305, Middleburg Heights, OH 44130
(440) 340-9010
"Outstanding staff. I look forward to seeing Cara and Brandon. Great experience!"
— steve allen, 5★

Center for Medical Mycology

★ 5.0
11100 Euclid Ave, Cleveland, OH 44106
(216) 844-8580

Insight Clinical Trials

★ 4.7
4801 Acorn Dr, Independence, OH 44131
(216) 526-1843
"I love the staff very welcoming"
— El-Rico A Dejesus, 5★

Clinical trials in Cleveland: what's recruiting

The Cleveland area currently has 1,413 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Cleveland, the most active research areas are:

  • Cancer & Oncology9 studies
  • Diabetes & Metabolism4 studies
  • Immune & Skin3 studies
  • Liver & Kidney3 studies
  • Heart & Vascular2 studies

Every listing shows the study phase, the recruiting site and its distance from Cleveland, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Cleveland

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Cleveland participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Cleveland pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in Cleveland?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Are clinical trials in Cleveland safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Cleveland, OH?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
What is the difference between a research center and a hospital study in Cleveland?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.

Paid clinical trials near Cleveland

Other metros within reach

Akron, OH394 Lorain, OH1,309 Canton, OH304 Youngstown, OH82 Detroit, MI1,197 Erie, PA89 Toledo, OH211 Columbus, OH1,345

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Cleveland Bladder Issues Due To Spinal Cord Injury in Cleveland All conditions

More of OH

Columbus1,345 Lorain1,309 Cincinnati1,127 Akron394 Dayton310 Canton304 Toledo211 Youngstown82

New paid studies open every week

Get an email when a new clinical trial starts recruiting within 30 miles of your ZIP code. No spam — only real studies from the NIH registry.

By subscribing you agree to receive study alert emails. Unsubscribe anytime in one click.

Get free trial alerts