Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/OK/Oklahoma City
Updated November 2026 from ClinicalTrials.gov

Paid Clinical Trials in Oklahoma City, OK

Studies commonly pay $75 to $4,500 per completed study

650 clinical trials are currently recruiting participants within 30 miles of Oklahoma City. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

650studies recruiting
9+research centers nearby
6condition categories
Live from the NIH registry

Studies recruiting near Oklahoma City right now

Top 25 of 650 recruiting studies, sorted by proximity — each links to its official registry page

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

Biochemically Recurrent Prostate Carcinoma, Metastatic Prostate Carcinoma Phase 3 Interventional 804 participants sought
University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT04423211)

Evaluation of a New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT 2

Post Operative Surgical Site Infection Phase 3 Interventional 600 participants sought
University of Oklahoma College of Medicine — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Major Extremity Trauma Research Consortium
See eligibility & contact on ClinicalTrials.gov (NCT04678154)

Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer

Stage I Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8 Phase 3 Interventional 428 participants sought
University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05646316)

A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

Acute Myeloid Leukemia, Mixed Lineage Leukemia Gene Mutation Phase 1 Interventional 420 participants sought
OU Health Stephenson Cancer Center — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Kura Oncology, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05735184)

A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

Advanced Pancreatic Carcinoma, Metastatic Pancreatic Carcinoma Phase 2 Interventional 40 participants sought
Ohio State University-Telemedicine — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Sameek Roychowdhury
See eligibility & contact on ClinicalTrials.gov (NCT06906562)

WISPer: Evaluation of MTX-463 in Participants With Idiopathic Pulmonary Fibrosis (IPF)

Idiopathic Pulmonary Fibrosis Phase 2 Interventional 164 participants sought
WISPer site in Oklahoma City, OK — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Mediar Therapeutics
See eligibility & contact on ClinicalTrials.gov (NCT06967805)

A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas

Triple Negative Breast Cancer, HER2-negative Breast Cancer Phase 1 Interventional 96 participants sought
Dren Investigational Site — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Dren Bio
See eligibility & contact on ClinicalTrials.gov (NCT06999187)

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

HNSCC, ESCC Phase 1 Interventional 150 participants sought
Normunity Investigational Site — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Normunity AccelCo, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07182149)

Genotype and Phenotype Correlation in Hereditary Thrombotic Thrombocytopenic Purpura (Upshaw-Schulman Syndrome)

Thrombotic Thrombocytopenic Purpura, Congenital Thrombotic Thrombocytopenic Purpura N/A Observational 450 participants sought
University of Oklahoma Health Sciences Center, Department of Medicine, PO Box 26901 — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Insel Gruppe AG, University Hospital Bern
See eligibility & contact on ClinicalTrials.gov (NCT01257269)

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

Smoldering Plasma Cell Myeloma Phase 3 Interventional 288 participants sought
Mercy Hospital Oklahoma City — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT03937635)

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Ovarian Carcinoma N/A Interventional 1,956 participants sought
University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT04251052)

A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer

Advanced or Metastatic Colorectal Cancer Phase 1, Phase 2 Interventional 225 participants sought
Stephenson Cancer Center — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Janssen Research & Development, LLC
See eligibility & contact on ClinicalTrials.gov (NCT05379595)

Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction, Concentric Hypertrophy N/A Interventional 105 participants sought
Oklahoma Heart Hospital — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Medtronic Cardiac Rhythm and Heart Failure
See eligibility & contact on ClinicalTrials.gov (NCT05839730)

FT825/ONO-8250, an Off-the-Shelf, HER2 CAR-T, With or Without Monoclonal Antibodies in Advanced Solid Tumors

Advanced Solid Tumor Phase 1 Interventional 351 participants sought
OU Health Stephenson Cancer Center — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Fate Therapeutics
See eligibility & contact on ClinicalTrials.gov (NCT06241456)

Attitudes and Perceptions Attitudes and Smoking Perceptions in the Real Environment -II

Cigarillo Flavor N/A Interventional 190 participants sought
TSET Health Promotion Research Center — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: University of Oklahoma
See eligibility & contact on ClinicalTrials.gov (NCT06668350)

Identification and Validation of Blood-Based Biomarkers for Early Detection of Asymptomatic Lung Cancer in High-Risk Heavy Smokers

Lung Cancers N/A Observational 350 participants sought
Site 101 — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Everest Detection, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06816121)

A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis

Colitis, Ulcerative Phase 3 Interventional 882 participants sought
Digestive Disease Specialists Inc — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Janssen Research & Development, LLC
See eligibility & contact on ClinicalTrials.gov (NCT07196748)

A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults

Chronic Idiopathic Constipation (CIC) Phase 3 Interventional 692 participants sought
Tekton Research - Yukon, OK — Yukon, Oklahoma (14.3 mi) · Sponsor: Ardelyx
See eligibility & contact on ClinicalTrials.gov (NCT07382167)

Study to Assess the Effect and Safety of ALV-100 on Maintenance of Weight Loss

Overweight , Obesity, Adults Phase 2 Interventional 220 participants sought
Lynn Health Science Institute — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Alveus Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07837973)

Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers

Recurrent Ovarian Cancer, Recurrent Fallopian Tube Cancer Phase 1, Phase 2 Interventional 890 participants sought
Stephenson Cancer Center — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Regeneron Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT03564340)

Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)

Spinal Muscular Atrophy (SMA) N/A Observational 700 participants sought
Oklahoma University Medical Center — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Novartis Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT04174157)
Actively enrolling

Studies you may be able to join near Oklahoma City

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Oklahoma City

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Oklahoma Medical Research Foundation

★ 4.6
825 NE 13th St, Oklahoma City, OK 73104
(405) 271-6673
"How did OMRF manage to settle the lawsuit Soliris against Alexion Pharmaceuticals Inc? What were the moral implications? “Own every PNH patient in th…"
— Sonia Owchariw, 1★

Legacy Clinical Trials of Oklahoma City

1211 N Shartel Ave Ste 801, Oklahoma City, OK 73103
(405) 486-0900

Health Research of Oklahoma

★ 5.0
1211 N Shartel Ave #409, Oklahoma City, OK 73103
(405) 702-6770

Cor Clinical Research

1211 N Shartel Ave #802, Oklahoma City, OK 73103
(405) 272-8481

Stanton L Young Biomedical Research Center

★ 4.4
975 NE 10th St, Oklahoma City, OK 73117
(405) 271-4000

Oklahoma City Clinical Research Center

★ 5.0
13700 S Western Ave Ste 200, Oklahoma City, OK 73170
(405) 934-1030
"Superhero origin story waiting to happen!<br><br>Or..... if Ryan Walters ever donates his remains to science..... quite possibly the Apocalypse."
— M Premo, 5★

Unity Clinical Research

★ 4.3
3700 N Classen Blvd #200, Oklahoma City, OK 73118
(405) 606-3900
"The staff at Unity Clinical Research are fast, professional, and know what they are doing! If you are interested in participating in a paid clinical …"
— Mark Christian, 5★

Medical Research International

★ 4.2
5712 S Western Ave, Oklahoma City, OK 73109
(405) 702-4440

Today Clinical Research

1317 SE 44th St Suite F, Oklahoma City, OK 73129
(405) 445-7510

Clinical trials in Oklahoma City: what's recruiting

The Oklahoma City area currently has 650 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Oklahoma City, the most active research areas are:

  • Cancer & Oncology14 studies
  • Lungs & Breathing1 studies
  • Heart & Vascular1 studies
  • Brain & Mental Health1 studies
  • Immune & Skin1 studies

Every listing shows the study phase, the recruiting site and its distance from Oklahoma City, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Oklahoma City

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Oklahoma City participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Oklahoma City pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in Oklahoma City?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Are clinical trials in Oklahoma City safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Oklahoma City, OK?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.

Paid clinical trials near Oklahoma City

Other metros within reach

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By condition

Eligibility and exclusions, condition by condition

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More of OK

Tulsa193

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