Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/OK/Oklahoma City
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Oklahoma City, OK

Studies commonly pay $75 to $4,500 per completed study

641 clinical trials are currently recruiting participants within 30 miles of Oklahoma City. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

641studies recruiting
9+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Oklahoma City right now

Top 25 of 641 recruiting studies, sorted by proximity — each links to its official registry page

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003)

Ovarian Cancer Recurrent Phase 1, Phase 2 Interventional 460 participants sought
OU Health University of Oklahoma Medical Center ( Site 7000) — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06843447)

Genotype and Phenotype Correlation in Hereditary Thrombotic Thrombocytopenic Purpura (Upshaw-Schulman Syndrome)

Thrombotic Thrombocytopenic Purpura, Congenital Thrombotic Thrombocytopenic Purpura N/A Observational 450 participants sought
University of Oklahoma Health Sciences Center, Department of Medicine, PO Box 26901 — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Insel Gruppe AG, University Hospital Bern
See eligibility & contact on ClinicalTrials.gov (NCT01257269)

Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction, Concentric Hypertrophy N/A Interventional 105 participants sought
Oklahoma Heart Hospital — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Medtronic Cardiac Rhythm and Heart Failure
See eligibility & contact on ClinicalTrials.gov (NCT05839730)

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Endometrial Cancer Phase 3 Interventional 600 participants sought
Research Site — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06989112)

Multi-Center Registry for Peripheral Arterial Disease Interventions and Outcomes

Peripheral Arterial Disease N/A Observational 14,000 participants sought
Oklahoma University Health Science Center — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Baylor Research Institute
See eligibility & contact on ClinicalTrials.gov (NCT01904851)

Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial

Metastatic Castration-Resistant Prostate Carcinoma, Metastatic Prostate Adenocarcinoma Phase 3 Interventional 1,524 participants sought
University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT07200830)

Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment

Plasma Cell Myeloma Phase 3 Interventional 510 participants sought
University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT05561387)

Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)

Triple-Negative Breast Cancer Phase 3 Interventional 1,530 participants sought
Hightower Clinical, LLC ( Site 0085) — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06393374)

Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention

Percutaneous Coronary Intervention, Peripheral Endovascular Intervention Phase 4 Interventional 6,000 participants sought
South Oklahoma Heart Research, LLC — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Duke University
See eligibility & contact on ClinicalTrials.gov (NCT06909565)

The Vanguard Study: Testing a New Way to Screen for Cancer

Bladder Carcinoma, Breast Carcinoma N/A Interventional 24,000 participants sought
University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06995898)

Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Prospective Outcomes Registry

Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease N/A Observational 3,000 participants sought
University of Oklahoma — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Duke University
See eligibility & contact on ClinicalTrials.gov (NCT01915511)

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck Phase 1 Interventional 1,006 participants sought
OU Health University of Oklahoma Medical Center — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Seagen, a wholly owned subsidiary of Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT04389632)

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm Phase 2 Interventional 2,000 participants sought
University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05564390)

Study to Evaluate the Maximal Use of Ruxolitinib Cream in Adult and Adolescent Participants With Hidradenitis Suppurativa

Hidradenitis Suppurativa Phase 1 Interventional 24 participants sought
Unity Clinical Research — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Incyte Corporation
See eligibility & contact on ClinicalTrials.gov (NCT07049575)

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

Malignant Glioma Phase 1, Phase 2 Interventional 132 participants sought
University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05099003)

Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma

Asthma Phase 3 Interventional 440 participants sought
Research Site — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06307665)

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

Advanced/Metastatic Solid Tumors, Colorectal Cancer Phase 1, Phase 2 Interventional 560 participants sought
SSM OKC Hightower Clinical — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Merus B.V.
See eligibility & contact on ClinicalTrials.gov (NCT03526835)

The MIRROR Registry: Minimally Invasive IntRaceRebral HemORrhage Evacuation

Supratentorial Hemorrhage N/A Observational 500 participants sought
University of Oklahoma — Oklahoma City, Oklahoma (0.2 mi) · Sponsor: Integra LifeSciences Corporation
See eligibility & contact on ClinicalTrials.gov (NCT04494295)
Actively enrolling

Studies you may be able to join near Oklahoma City

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Oklahoma City

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Oklahoma Medical Research Foundation

★ 4.6
825 NE 13th St, Oklahoma City, OK 73104
(405) 271-6673
"How did OMRF manage to settle the lawsuit Soliris against Alexion Pharmaceuticals Inc? What were the moral implications? “Own every PNH patient in th…"
— Sonia Owchariw, 1★

Legacy Clinical Trials of Oklahoma City

1211 N Shartel Ave Ste 801, Oklahoma City, OK 73103
(405) 486-0900

Health Research of Oklahoma

★ 5.0
1211 N Shartel Ave #409, Oklahoma City, OK 73103
(405) 702-6770

Cor Clinical Research

1211 N Shartel Ave #802, Oklahoma City, OK 73103
(405) 272-8481

Stanton L Young Biomedical Research Center

★ 4.4
975 NE 10th St, Oklahoma City, OK 73117
(405) 271-4000

Oklahoma City Clinical Research Center

★ 5.0
13700 S Western Ave Ste 200, Oklahoma City, OK 73170
(405) 934-1030
"Superhero origin story waiting to happen!<br><br>Or..... if Ryan Walters ever donates his remains to science..... quite possibly the Apocalypse."
— M Premo, 5★

Unity Clinical Research

★ 4.3
3700 N Classen Blvd #200, Oklahoma City, OK 73118
(405) 606-3900
"The staff at Unity Clinical Research are fast, professional, and know what they are doing! If you are interested in participating in a paid clinical …"
— Mark Christian, 5★

Medical Research International

★ 4.2
5712 S Western Ave, Oklahoma City, OK 73109
(405) 702-4440

Today Clinical Research

1317 SE 44th St Suite F, Oklahoma City, OK 73129
(405) 445-7510

Clinical trials in Oklahoma City: what's recruiting

The Oklahoma City area currently has 641 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Oklahoma City, the most active research areas are:

  • Cancer & Oncology14 studies
  • Heart & Vascular3 studies
  • Lungs & Breathing2 studies
  • Brain & Mental Health1 studies
  • Liver & Kidney1 studies

Every listing shows the study phase, the recruiting site and its distance from Oklahoma City, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Oklahoma City

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Oklahoma City participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Oklahoma City pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in Oklahoma City?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Are clinical trials in Oklahoma City safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Oklahoma City, OK?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.

Paid clinical trials near Oklahoma City

Other metros within reach

Tulsa, OK173 Wichita, KS154 Denton, TX371 Frisco, TX1,808 McKinney, TX446 Plano, TX1,809 Irving, TX1,967 Fort Worth, TX606

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Oklahoma City Bladder Issues Due To Spinal Cord Injury in Oklahoma City All conditions

More of OK

Tulsa173

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