Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/TX/Plano
Updated July 2026 from ClinicalTrials.gov

Paid Clinical Trials in Plano, TX

Studies commonly pay $75 to $4,500 per completed study

1,810 clinical trials are currently recruiting participants within 30 miles of Plano. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

1,810studies recruiting
9+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Plano right now

Top 25 of 1,810 recruiting studies, sorted by proximity — each links to its official registry page

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

PIK3CA Mutation, HER2- Negative Breast Cancer Phase 3 Interventional 540 participants sought
Texas Oncology DFW — Dallas, Texas (18.8 mi) · Sponsor: Relay Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06982521)

AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss

Obesity Phase 3 Interventional 600 participants sought
North Texas Endocrine Center — Dallas, Texas (18.8 mi) · Sponsor: Novo Nordisk A/S
See eligibility & contact on ClinicalTrials.gov (NCT07503210)

Safety and Effectiveness of Minimally Invasive Micro Sclerostomy (MIMS®) to Reduce Intraocular Pressure in Open-Angle Glaucoma Which is Not Controlled Despite Polypharmacy

Primary Open Angle Glaucoma, Open Angle Glaucoma N/A Interventional 129 participants sought
Glaucoma Associates of Texas — Dallas, Texas (18.8 mi) · Sponsor: Sanoculis Ltd
See eligibility & contact on ClinicalTrials.gov (NCT06313749)

AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)

Solid Tumor Cancer, Locally Advanced Phase 1, Phase 2 Interventional 480 participants sought
Avenzo Therapeutics Recruiting Site — Dallas, Texas (18.8 mi) · Sponsor: Avenzo Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07038343)

A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies

Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL) Phase 1 Interventional 248 participants sought
Baylor University Medical Center — Dallas, Texas (18.8 mi) · Sponsor: Nurix Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04830137)

A Phase 2, Baseline-Controlled Study Evaluating the Safety and Efficacy of PTX-022 (Sirolimus) Topical Gel 3.9% in the Treatment of Angiokeratomas (LOTU)

Angiokeratomas Phase 2 Interventional 15 participants sought
Epiphany Dermatology — Southlake, Texas (23.6 mi) · Sponsor: Palvella Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07552077)

Phase 2 Study of Inhaled SNG001 in Mechanically Ventilated Patients With Respiratory Viral Infection

Viral Pneumonia Phase 2 Interventional 550 participants sought
Baylor University Medical Center — Dallas, Texas (18.8 mi) · Sponsor: Synairgen Research Ltd.
See eligibility & contact on ClinicalTrials.gov (NCT06999603)

A Study of OR502, a Monoclonal Antibody Targeting LILRB2, Alone and in Combination With Anticancer Agents

Cancer, Tumor, Solid Phase 1, Phase 2 Interventional 168 participants sought
NEXT Dallas — Irving, Texas (20.0 mi) · Sponsor: OncoResponse, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06090266)

A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy

Geographic Atrophy, Macular Degeneration N/A Observational 500 participants sought
Retina of North Texas — Dallas, Texas (18.8 mi) · Sponsor: Astellas Pharma Global Development, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06779773)

A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Sjogren's Disease

Sjögren, Sjogren Disease Phase 1 Interventional 36 participants sought
Cullinan Investigative Site — Plano, Texas (3.6 mi) · Sponsor: Cullinan Therapeutics Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07041099)

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck Phase 1 Interventional 1,006 participants sought
US Oncology Investigational Product Center (IPC) — Irving, Texas (20.0 mi) · Sponsor: Seagen, a wholly owned subsidiary of Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT04389632)

ENdoluminal LIGHT ActivatED Treatment of Upper Tract Urothelial Cancer (ENLIGHTED) Study

Transitional Cell Cancer of Renal Pelvis and Ureter Phase 3 Interventional 100 participants sought
University of Texas Southwestern — Dallas, Texas (18.8 mi) · Sponsor: Steba Biotech S.A.
See eligibility & contact on ClinicalTrials.gov (NCT04620239)

Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis

Knee Cartilage Defects Phase 3 Interventional 300 participants sought
Zenos Clinical Research — Dallas, Texas (18.8 mi) · Sponsor: Medipost, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07339111)

A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes

Diabetes Mellitus, Type 2 Phase 2 Interventional 270 participants sought
University of Texas Southwestern Medical Center — Dallas, Texas (18.8 mi) · Sponsor: Novo Nordisk A/S
See eligibility & contact on ClinicalTrials.gov (NCT07415954)
Google-rated

Top-rated research centers in Plano

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

ClinRx Research

★ 4.5
6300 Stonewood Dr Ste 102, Plano, TX 75024
(972) 886-8969
"The staff is very professional and friendly. The procedure was very good, and I didn't experience any complications. I recommend ClinRx for any futur…"
— Johnny Thompson, 5★

North Texas Center for Clinical Research

★ 5.0
3880 Parkwood Blvd, Frisco, TX 75034
(214) 618-0220
"Aly, Summer and Keisha are awesome. Very little waiting time and the staff are always there to welcome you with a smile."
— Brett Kozlowski, 5★

ACRC Trials

★ 4.8
5655 W Spring Creek Pkwy Ste 125, Plano, TX 75024
(469) 382-3949
"Was in a study with ACRC and it was great! Thorough explanations for the study, and super friendly coordinator who called periodically to see how th…"
— Kara B, 5★

Future Med Clinical Research

5072 W Plano Pkwy #190, Plano, TX 75093
(972) 312-7285

Clinical Investigations of Texas

★ 5.0
1524 Independence Pkwy M, Plano, TX 75075
(972) 599-1530
"Clinical Investigations is extremely professional and makes patient care a priority. Clinical trials lead to new treatments for those in need!"
— Pam Vincent, 5★

Pillar Clinical Research, Richardson, Texas

★ 4.8
630 N Coit Rd Ste.2200, Richardson, TX 75080
(214) 396-4844
"Berry beautiful place valm the Staff are very admint about about take care of you it was a beautiful experience I love you all. I would definitely re…"
— Vig Dall, 5★

Discovery Clinical Trials - Dallas

★ 4.9
7777 Forest Ln Bldg D, Suite 1200, Dallas, TX 75230
(855) 468-7788
"The office staff are so professional and caring just like family well educated and explained the procedures love being a part of this trial❤️❤️❤️"
— delia anthony, 5★

Callier Clinical Research Center

811 Synergy Park Blvd, Richardson, TX 75080

SGS USA - Richardson

★ 4.4
1801 N Glenville Dr, Richardson, TX 75081
(833) 530-7596
"Their email doesn't work.<br>They hardly answer phone calls.<br>Zelle payment didn't work and I updated my info and spent 5 hours trying to get a hol…"
— Ruth Curiel, 1★

Clinical trials in Plano: what's recruiting

The Plano area currently has 1,810 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Plano, the most active research areas are:

  • Cancer & Oncology9 studies
  • Diabetes & Metabolism2 studies
  • Liver & Kidney2 studies
  • Heart & Vascular2 studies
  • Brain & Mental Health1 studies

Every listing shows the study phase, the recruiting site and its distance from Plano, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Plano

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Plano participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Do I need to be sick to join a clinical trial in Plano?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
How do I join a study in Plano, TX?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
What is the difference between a research center and a hospital study in Plano?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Plano typically complete one or two studies per year.

Paid clinical trials near Plano

Other metros within reach

Frisco, TX1,809 McKinney, TX440 Garland, TX1,816 Dallas, TX1,856 Irving, TX1,967 Mesquite, TX1,758 Denton, TX370 Grand Prairie, TX1,933

More of TX

Houston3,067 Pasadena3,006 Irving1,967 Grand Prairie1,933 Dallas1,856 Arlington1,853 Garland1,816 Frisco1,809 Mesquite1,758 San Antonio1,025 Austin724

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