Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/SC/Columbia
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Columbia, SC

Studies commonly pay $75 to $4,500 per completed study

197 clinical trials are currently recruiting participants within 30 miles of Columbia. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

197studies recruiting
9+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Columbia right now

Top 25 of 197 recruiting studies, sorted by proximity — each links to its official registry page

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Prisma Health Richland Hospital — Columbia, South Carolina (7.9 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 1

Narcolepsy Type 1 Phase 3 Interventional 150 participants sought
Alkermes Investigational Site — Columbia, South Carolina (7.9 mi) · Sponsor: Alkermes, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07455383)

Mindful Walking Neural Correlates of Executive Function in SC Older Adults at Risk of Dementias

Older Adults With Elevated Dementia Risk Phase 2 Interventional 54 participants sought
University of South Carolina — Columbia, South Carolina (7.9 mi) · Sponsor: University of South Carolina
See eligibility & contact on ClinicalTrials.gov (NCT07638046)

Implementation Supports for Improving Identification and Delivery of School-based Mental Health Supports for Middle Schools Students

Mental Health Issue N/A Interventional 21,350 participants sought
University of South Carolina — Columbia, South Carolina (7.9 mi) · Sponsor: University of Virginia
See eligibility & contact on ClinicalTrials.gov (NCT06047041)

Evaluating the Effects of Tasimelteon vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD)

Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm Phase 3 Interventional 70 participants sought
Vanda Investigational Site — Columbia, South Carolina (7.9 mi) · Sponsor: Vanda Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT04652882)

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Neovascular Age-related Macular Degeneration Phase 4 Interventional 188 participants sought
Palmetto Retina Center, LLC — West Columbia, South Carolina (10.2 mi) · Sponsor: Genentech, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04853251)

A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8 Phase 3 Interventional 1,875 participants sought
Prisma Health Richland Hospital — Columbia, South Carolina (7.9 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05675410)

A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Idiopathic Hypersomnia (IH)

Idiopathic Hypersomnia Phase 3 Interventional 248 participants sought
Bogan Sleep Consultants, LLC — Columbia, South Carolina (7.9 mi) · Sponsor: Harmony Biosciences Management, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07500090)

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

Malignant Glioma Phase 1, Phase 2 Interventional 132 participants sought
Prisma Health Richland Hospital — Columbia, South Carolina (7.9 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05099003)

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

Heart Failure, Heart Diseases N/A Interventional 850 participants sought
Prisma Health Midlands — Columbia, South Carolina (7.9 mi) · Sponsor: Abbott Medical Devices
See eligibility & contact on ClinicalTrials.gov (NCT06526195)

Beneficial or Fostering Future Struggles (B.F.F.s)? Characterizing the Role of Friends in the Development of 13- to 17-Year-Old Adolescents

Child Maltreatment, Interpersonal Relations N/A Interventional 120 participants sought
University of South Carolina — Columbia, South Carolina (7.9 mi) · Sponsor: University of South Carolina
See eligibility & contact on ClinicalTrials.gov (NCT05893459)

Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

Arrhythmia, Bradycardia N/A Observational 20,000 participants sought
Research site — Columbia, South Carolina (7.9 mi) · Sponsor: Medtronic
See eligibility & contact on ClinicalTrials.gov (NCT00271180)

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

Ganglioneuroblastoma, Nodular, Neuroblastoma Phase 3 Interventional 478 participants sought
Prisma Health Richland Hospital — Columbia, South Carolina (7.9 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06172296)

A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma

Asthma Phase 3 Interventional 231 participants sought
Research Site — Columbia, South Carolina (7.9 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06023589)

A Study of Dulaglutide (LY2189265) 3.0 mg and 4.5 mg in Pediatric Participants With Type 2 Diabetes Mellitus (AWARD-PEDS PLUS)

Type 2 Diabetes Phase 3 Interventional 55 participants sought
Prisma Health Pediatric Endocrinology — Columbia, South Carolina (7.9 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT06739122)

Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

Locally Advanced Lung Non-Small Cell Carcinoma, Stage IIB Lung Cancer AJCC v8 Phase 3 Interventional 474 participants sought
Lexington Medical Center — West Columbia, South Carolina (10.2 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05624996)

A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)

Psoriasis, Overweight or Obesity Phase 4 Interventional 200 participants sought
Columbia Dermatology & Aesthetics — Columbia, South Carolina (7.9 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT06857942)

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

Cognitive Impairment, Mild, Dementia Phase 4 Interventional 20,000 participants sought
Columbia VA Health Care/Dorn VA Medical Center — Columbia, South Carolina (7.9 mi) · Sponsor: Duke University
See eligibility & contact on ClinicalTrials.gov (NCT04262206)
Actively enrolling

Studies you may be able to join near Columbia

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for severe chronic itching

Enrolling adults aged 18 to 90 who have had chronic itching for six months or longer. Not open to itching caused by atopic dermatitis, psoriasis, chronic kidney disease, notalgia paresthetica or medication, nor to people with an autoimmune condition such as lupus, Crohn's disease, ulcerative colitis or rheumatoid arthritis.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research studies for chronic kidney disease

This research platform is enrolling Black and African American adults in eligible areas who have been diagnosed with chronic kidney disease. Compensation may be available. The study team confirms eligibility before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Columbia

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Velocity Clinical Research

★ 4.0
1655 Bernardin Ave Ste 300, Columbia, SC 29204
(803) 766-2680
"Be sure to get a copy of your contract for study with payment details and a contact number for any medical complications."
— Azilee Billy, 3★

MUSC Research Center - Columbia

2001 Laurel St, Columbia, SC 29204
(803) 255-2927

Biocentric Health Research Center

★ 4.1
160 Medical Cir, West Columbia, SC 29169
(803) 764-2406
"It has been a great experience to work with this company's excellent team. They are very friendly, provide excellent service, and accommodate appoint…"
— Laura C. Bonilla, 5★

Vista Clinical Research

★ 5.0
700 Gervais St Ste 300, Columbia, SC 29201
(803) 251-1160
"ANY CALL BACK NUMBERS>>? Sleep to Heart rate and blood testing sugar testing have eating pyramids .<br>Would like to be paid for Clinical Research"
— jessie parsley, 5★

Carolina Clinical Research Services

712 Richland St # H, Columbia, SC 29201
(803) 988-0080

Columbia Digestive Health Research

2739 Laurel St Ste 2-A, Columbia, SC 29204
(803) 386-8933

South Carolina Clinical Research

1301 Taylor St #5L, Columbia, SC 29201
(803) 988-1438

USC COBRE Center for Targeted Therapeutics (CTT)

Coker Life Sciences Building, 700 Sumter St, Columbia, SC 29208
(803) 777-4689

Lexington Medical Center Park 3

★ 5.0
222 E Medical Ln, West Columbia, SC 29169
"Excellent hospital with great quality doctor and nursing care. The staff is always so very helpful and the facility is very clean."
— Denise Perez, 5★

Clinical trials in Columbia: what's recruiting

The Columbia area currently has 197 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Columbia, the most active research areas are:

  • Heart & Vascular6 studies
  • Cancer & Oncology5 studies
  • Diabetes & Metabolism3 studies
  • Lungs & Breathing2 studies
  • Immune & Skin1 studies

Every listing shows the study phase, the recruiting site and its distance from Columbia, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Columbia

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Columbia participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Do I need to be sick to join a clinical trial in Columbia?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Are clinical trials in Columbia safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Columbia, SC?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Columbia typically complete one or two studies per year.

Paid clinical trials near Columbia

Other metros within reach

Rock Hill, SC585 Charlotte, NC648 Gastonia, NC651 Augusta, GA182 Spartanburg, SC357 Concord, NC627 Charleston, SC733 Mauldin, SC373

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Columbia Severe Chronic Pruritus in Columbia Chronic Kidney Disease (HealthMatch) in Columbia Bladder Issues Due To Spinal Cord Injury in Columbia All conditions

More of SC

Charleston733 Rock Hill585 Greenville373 Mauldin373 Spartanburg357 Myrtle Beach89

New paid studies open every week

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