Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/SC/Greenville
Updated October 2026 from ClinicalTrials.gov

Paid Clinical Trials in Greenville, SC

Studies commonly pay $75 to $4,500 per completed study

377 clinical trials are currently recruiting participants within 30 miles of Greenville. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

377studies recruiting
9+research centers nearby
4condition categories
Live from the NIH registry

Studies recruiting near Greenville right now

Top 25 of 377 recruiting studies, sorted by proximity — each links to its official registry page

S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

Anatomic Stage IV Breast Cancer AJCC v8, Estrogen Receptor Positive N/A Interventional 739 participants sought
Prisma Health Cancer Institute - Butternut — Greenville, South Carolina (2.0 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03723928)

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8 Phase 3 Interventional 1,209 participants sought
Gibbs Cancer Center-Pelham — Greer, South Carolina (10.6 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05946213)

A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis

Antineutrophil Cytoplasmic Antibody-associated Vasculitis Phase 4 Interventional 300 participants sought
Carolina Nephrology PA — Spartanburg, South Carolina (25.8 mi) · Sponsor: Amgen
See eligibility & contact on ClinicalTrials.gov (NCT06072482)

Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

Non-Small Cell Lung Cancer Phase 3 Interventional 675 participants sought
Research Site — Greenville, South Carolina (2.0 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06357533)

A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas

Triple Negative Breast Cancer, HER2-negative Breast Cancer Phase 1 Interventional 96 participants sought
Dren Investigational Site — Greenville, South Carolina (2.0 mi) · Sponsor: Dren Bio
See eligibility & contact on ClinicalTrials.gov (NCT06999187)

A Study to Investigate Efficacy, Safety and Tolerability of Barzolvolimab Versus Placebo in Adults With Cold Induced Urticaria and Symptomatic Dermographism Inadequately Controlled by H1-antihistamines (EMBARQ - ColdU and SD)

Chronic Inducible Urticaria, Cold Urticaria Phase 3 Interventional 240 participants sought
Advanced Dermatology and Cosmetic Surgery - Spartanburg — Spartanburg, South Carolina (25.8 mi) · Sponsor: Celldex Therapeutics
See eligibility & contact on ClinicalTrials.gov (NCT07266402)

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
BI-LO Charities Children's Cancer Center — Greenville, South Carolina (2.0 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

Smoldering Plasma Cell Myeloma Phase 3 Interventional 288 participants sought
Prisma Health Cancer Institute - Butternut — Greenville, South Carolina (2.0 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT03937635)

A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

Non Small Cell Lung Cancer Phase 3 Interventional 768 participants sought
St Francis Cancer Center /ID# 243596 — Greenville, South Carolina (2.0 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT04928846)

A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo™ Aspiration System (STRIDE II)

Lower Extremity Acute Limb Ischemia, LE ALI N/A Observational 300 participants sought
Prisma Health Greenville Memorial Hospital — Greenville, South Carolina (2.0 mi) · Sponsor: Penumbra Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06747117)

Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention

Percutaneous Coronary Intervention, Peripheral Endovascular Intervention Phase 4 Interventional 6,000 participants sought
AnMed Health Medical Center — Anderson, South Carolina (28.1 mi) · Sponsor: Duke University
See eligibility & contact on ClinicalTrials.gov (NCT06909565)

BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies

Healthy Phase 3 Interventional 6,000 participants sought
Tribe Clinical Research at Parkside Pediatrics Five Forks — Simpsonville, South Carolina (9.2 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT07160244)

Trial Comparing the Safety and Efficacy of Two Different Oral VPV Doses With Placebo as Treatment for RV in Participants With COPD

Rhinovirus Infection Phase 2 Interventional 180 participants sought
Velocity Clinical Research - Spartanburg — Spartanburg, South Carolina (25.8 mi) · Sponsor: Altesa Biosciences, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07610395)

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

Low Grade Astrocytoma, Low Grade Glioma Phase 3 Interventional 170 participants sought
BI-LO Charities Children's Cancer Center — Greenville, South Carolina (2.0 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04166409)

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

Childhood Medulloblastoma Phase 3 Interventional 225 participants sought
BI-LO Charities Children's Cancer Center — Greenville, South Carolina (2.0 mi) · Sponsor: Children's Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT05382338)

A Phase 3 Study of Revaccination in Subsequent Pregnancies With Bivalent RSV Vaccine and Duration of Protection of a Single Dose

RSV Infection Phase 3 Interventional 550 participants sought
Prisma Health Maternal Fetal Medicine — Greenville, South Carolina (2.0 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT06866405)

STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking

Tobacco Use, Substance Use Disorders N/A Interventional 240 participants sought
Phoenix Center — Greenville, South Carolina (2.0 mi) · Sponsor: Medical University of South Carolina
See eligibility & contact on ClinicalTrials.gov (NCT06922617)

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

Solid Tumors, Hematologic Malignancies Phase 3 Interventional 3,500 participants sought
Saint Francis Health System ( Site 0089) — Greenville, South Carolina (2.0 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT03486873)

Collection of Research Data and Samples From Patients Treated With Immunotherapy to Study Its Side Effects

Hematopoietic and Lymphoid Cell Neoplasm, Immune System Disorder N/A Observational 2,240 participants sought
Saint Francis Hospital — Greenville, South Carolina (2.0 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT04242095)

A Study of ASP1002 in Adults for Treatment of Solid Tumors

Advanced Solid Tumors Phase 1 Interventional 798 participants sought
Prisma Health-Upstate Cancer Institute — Greenville, South Carolina (2.0 mi) · Sponsor: Astellas Pharma Global Development, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05719558)

Evaluating BL-M14D1 in Subjects With Locally Advanced or Metastatic Small Cell Lung Cancer and Neuroendocrine Tumors

Small Cell Lung Cancer Metastatic or Locally Advanced, Neuroendocrine Cancer Phase 1 Interventional 120 participants sought
Prisma Health Cancer Institute — Greenville, South Carolina (2.0 mi) · Sponsor: SystImmune Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07080242)
Actively enrolling

Studies you may be able to join near Greenville

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Greenville

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Tribe Clinical Research

★ 4.9
545 Verdae Blvd Ste B, Greenville, SC 29607
(864) 334-0141
"The staff here makes sure you are well informed and comfortable with the trial that you are participating in. Questions are welcomed and answered In …"
— amy bellis, 5★

Palmetto Clinical Trial Services, LLC

37 Brendan Way, Greenville, SC 29615
(864) 214-1217

The Research Center of the Upstate

★ 5.0
2086 Woodruff Rd, Greenville, SC 29607
(864) 626-3117
"Amazing and knowledgeable staff. Research program much needed in our local community."
— Victor & Rene' Pressley, 5★

Institute for Translational Oncology Research

900 W Faris Rd, Greenville, SC 29605
(864) 455-3600

ADAC Research, PA

★ 3.5
1202 E Butler Rd, Greenville, SC 29607
(864) 627-3800 ext. 221
"They were rude and you have to set a timer your self,and they dropped the cotton swabs in the trash,and still put the creem on with the contaminated …"
— Kippy Sloan, 1★

Prisma Health Cancer Institute–Faris Road

★ 3.4 (17 reviews)
900 W Faris Rd, Greenville, SC 29605
(864) 679-3900
"I’ve left so many messages and never a response until it’s time for chemo. If I do reach a live person, then they transfer me to another voicemail. I…"
— ASG Nesmith, 1★

Brio Primary Care

★ 4.8
2 Bella Grove Dr, Greenville, SC 29607
(864) 603-5600

Prisma Health Cancer Institute–Eastside

★ 4.2 (25 reviews)
65 International Dr, Greenville, SC 29615
(864) 987-7000
"At check in i almost passed out. AMY AND VIRGINA at the front desk came and prevented me from falling. They got me a wheel chair and made sure I was …"
— Adrea Webster, 5★

Infused Greenville, Greenville Ketamine Center

★ 4.8
35 Creekview Ct, Greenville, SC 29615
(864) 438-1300
"Absolutely amazing! The staff was so courteous and sweet, but most of all, and most importantly, medically skilled! From the nurse practitioners to t…"
— April King, 5★

Clinical trials in Greenville: what's recruiting

The Greenville area currently has 377 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Greenville, the most active research areas are:

  • Cancer & Oncology13 studies
  • Heart & Vascular2 studies
  • Lungs & Breathing2 studies
  • Liver & Kidney1 studies

Every listing shows the study phase, the recruiting site and its distance from Greenville, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Greenville

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Greenville participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Greenville pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in Greenville?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
What is the difference between a research center and a hospital study in Greenville?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Greenville?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Greenville.

Paid clinical trials near Greenville

Other metros within reach

Mauldin, SC375 Spartanburg, SC362 Asheville, NC123 Gastonia, NC659 Athens, GA75 Rock Hill, SC603 Hickory, NC91 Augusta, GA185

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Greenville Chronic Kidney Disease (HealthMatch) in Greenville Bladder Issues Due To Spinal Cord Injury in Greenville All conditions

More of SC

Charleston738 Rock Hill603 Mauldin375 Spartanburg362 Columbia191 Myrtle Beach89

New paid studies open every week

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