Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/SC/Greenville
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Greenville, SC

Studies commonly pay $75 to $4,500 per completed study

378 clinical trials are currently recruiting participants within 30 miles of Greenville. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

378studies recruiting
9+research centers nearby
3condition categories
Live from the NIH registry

Studies recruiting near Greenville right now

Top 25 of 378 recruiting studies, sorted by proximity — each links to its official registry page

Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

Diffuse Large B-Cell Lymphoma, Grade 3b Follicular Lymphoma Phase 2 Interventional 396 participants sought
Prisma Health Cancer Institute - Butternut — Greenville, South Carolina (2.0 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT05633615)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
BI-LO Charities Children's Cancer Center — Greenville, South Carolina (2.0 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

Non-Small Cell Lung Cancer Phase 3 Interventional 675 participants sought
Research Site — Greenville, South Carolina (2.0 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06357533)

A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas

Triple Negative Breast Cancer, HER2-negative Breast Cancer Phase 1 Interventional 96 participants sought
Dren Investigational Site — Greenville, South Carolina (2.0 mi) · Sponsor: Dren Bio
See eligibility & contact on ClinicalTrials.gov (NCT06999187)

Phase 2 Study of Inhaled SNG001 in Mechanically Ventilated Patients With Respiratory Viral Infection

Viral Pneumonia Phase 2 Interventional 550 participants sought
AnMed Health Pulmonary and Sleep Medicine — Anderson, South Carolina (28.1 mi) · Sponsor: Synairgen Research Ltd.
See eligibility & contact on ClinicalTrials.gov (NCT06999603)

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
BI-LO Charities Children's Cancer Center — Greenville, South Carolina (2.0 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

Smoldering Plasma Cell Myeloma Phase 3 Interventional 288 participants sought
Prisma Health Cancer Institute - Butternut — Greenville, South Carolina (2.0 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT03937635)

Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention

Percutaneous Coronary Intervention, Peripheral Endovascular Intervention Phase 4 Interventional 6,000 participants sought
AnMed Health Medical Center — Anderson, South Carolina (28.1 mi) · Sponsor: Duke University
See eligibility & contact on ClinicalTrials.gov (NCT06909565)

Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8 Phase 3 Interventional 356 participants sought
Saint Francis Hospital — Greenville, South Carolina (2.0 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06958328)

Trial Comparing the Safety and Efficacy of Two Different Oral VPV Doses With Placebo as Treatment for RV in Participants With COPD

Rhinovirus Infection Phase 2 Interventional 180 participants sought
Velocity Clinical Research - Spartanburg — Spartanburg, South Carolina (25.8 mi) · Sponsor: Altesa Biosciences, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07610395)

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 189 participants sought
Prisma Health Cancer Institute - Butternut — Greenville, South Carolina (2.0 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT02734537)

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm Phase 2 Interventional 2,000 participants sought
Prisma Health Cancer Institute - Butternut — Greenville, South Carolina (2.0 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05564390)

An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants

Systemic Lupus Erythematosus Phase 3 Interventional 100 participants sought
Research Site — Greenville, South Carolina (2.0 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT05835310)

Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Face and Scalp

Actinic Keratosis Phase 3 Interventional 160 participants sought
Palmetto Clinical Trial Services, LLC — Greenville, South Carolina (2.0 mi) · Sponsor: Sun Pharmaceutical Industries, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07144345)

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

Solid Tumors, Hematologic Malignancies Phase 3 Interventional 3,500 participants sought
Saint Francis Health System ( Site 0089) — Greenville, South Carolina (2.0 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT03486873)

Collection of Research Data and Samples From Patients Who Experience Immunotherapy Side Effects

Malignancy N/A Observational 240 participants sought
Saint Francis Hospital — Greenville, South Carolina (2.0 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT04242095)

Study of SLS009 (Formerly GFH009) a Potent Highly Selective CDK9 Inhibitor in Patients With Hematologic Malignancies and High-Risk Newly Diagnosed AML

Hematologic Malignancies Phase 1, Phase 2 Interventional 160 participants sought
Bon Secours St. Francis Cancer Center — Greenville, South Carolina (2.0 mi) · Sponsor: Sellas Life Sciences Group
See eligibility & contact on ClinicalTrials.gov (NCT04588922)

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

Malignant Glioma Phase 1, Phase 2 Interventional 132 participants sought
BI-LO Charities Children's Cancer Center — Greenville, South Carolina (2.0 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05099003)

Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment

Plasma Cell Myeloma Phase 3 Interventional 510 participants sought
Prisma Health Cancer Institute - Butternut — Greenville, South Carolina (2.0 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT05561387)

A Study of ASP1002 in Adults for Treatment of Solid Tumors

Advanced Solid Tumors Phase 1 Interventional 798 participants sought
Prisma Health-Upstate Cancer Institute — Greenville, South Carolina (2.0 mi) · Sponsor: Astellas Pharma Global Development, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05719558)

Education & Mentorship of Advanced Practice Providers to Increase Community-based Research Within the NCORP Network, COACH-APP Trial

Other N/A Interventional 97 participants sought
Prisma Health Cancer Institute - Faris — Greenville, South Carolina (2.0 mi) · Sponsor: Wake Forest University Health Sciences
See eligibility & contact on ClinicalTrials.gov (NCT06904391)

The MIRROR Registry: Minimally Invasive IntRaceRebral HemORrhage Evacuation

Supratentorial Hemorrhage N/A Observational 500 participants sought
Prisma Health - Upstate — Greenville, South Carolina (2.0 mi) · Sponsor: Integra LifeSciences Corporation
See eligibility & contact on ClinicalTrials.gov (NCT04494295)

A Study of the Efficacy and Safety of DMX-200 in Patients With FSGS Who Are Receiving an ARB

FSGS Phase 3 Interventional 286 participants sought
Carolina Nephrology, PA — Spartanburg, South Carolina (25.8 mi) · Sponsor: Dimerix Bioscience Pty Ltd
See eligibility & contact on ClinicalTrials.gov (NCT05183646)

BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies

Healthy Phase 3 Interventional 6,000 participants sought
Tribe Clinical Research at Parkside Pediatrics Five Forks — Simpsonville, South Carolina (9.2 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT07160244)
Actively enrolling

Studies you may be able to join near Greenville

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research studies for chronic kidney disease

This research platform is enrolling Black and African American adults in eligible areas who have been diagnosed with chronic kidney disease. Compensation may be available. The study team confirms eligibility before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Greenville

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Tribe Clinical Research

★ 4.9
545 Verdae Blvd Ste B, Greenville, SC 29607
(864) 334-0141
"The staff here makes sure you are well informed and comfortable with the trial that you are participating in. Questions are welcomed and answered In …"
— amy bellis, 5★

Palmetto Clinical Trial Services, LLC

37 Brendan Way, Greenville, SC 29615
(864) 214-1217

The Research Center of the Upstate

★ 5.0
2086 Woodruff Rd, Greenville, SC 29607
(864) 626-3117
"Amazing and knowledgeable staff. Research program much needed in our local community."
— Victor & Rene' Pressley, 5★

Institute for Translational Oncology Research

900 W Faris Rd, Greenville, SC 29605
(864) 455-3600

ADAC Research, PA

★ 3.5
1202 E Butler Rd, Greenville, SC 29607
(864) 627-3800 ext. 221
"They were rude and you have to set a timer your self,and they dropped the cotton swabs in the trash,and still put the creem on with the contaminated …"
— Kippy Sloan, 1★

Prisma Health Cancer Institute–Faris Road

★ 3.4 (17 reviews)
900 W Faris Rd, Greenville, SC 29605
(864) 679-3900
"I’ve left so many messages and never a response until it’s time for chemo. If I do reach a live person, then they transfer me to another voicemail. I…"
— ASG Nesmith, 1★

Brio Primary Care

★ 4.8
2 Bella Grove Dr, Greenville, SC 29607
(864) 603-5600

Prisma Health Cancer Institute–Eastside

★ 4.2 (25 reviews)
65 International Dr, Greenville, SC 29615
(864) 987-7000
"At check in i almost passed out. AMY AND VIRGINA at the front desk came and prevented me from falling. They got me a wheel chair and made sure I was …"
— Adrea Webster, 5★

Infused Greenville, Greenville Ketamine Center

★ 4.8
35 Creekview Ct, Greenville, SC 29615
(864) 438-1300
"Absolutely amazing! The staff was so courteous and sweet, but most of all, and most importantly, medically skilled! From the nurse practitioners to t…"
— April King, 5★

Clinical trials in Greenville: what's recruiting

The Greenville area currently has 378 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Greenville, the most active research areas are:

  • Cancer & Oncology13 studies
  • Heart & Vascular1 studies
  • Immune & Skin1 studies

Every listing shows the study phase, the recruiting site and its distance from Greenville, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Greenville

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Greenville participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Greenville pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in Greenville?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
What is the difference between a research center and a hospital study in Greenville?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Greenville?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Greenville.

Paid clinical trials near Greenville

Other metros within reach

Mauldin, SC376 Spartanburg, SC363 Asheville, NC122 Gastonia, NC644 Athens, GA74 Rock Hill, SC581 Hickory, NC89 Augusta, GA184

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Greenville Chronic Kidney Disease (HealthMatch) in Greenville Bladder Issues Due To Spinal Cord Injury in Greenville All conditions

More of SC

Charleston730 Rock Hill581 Mauldin376 Spartanburg363 Columbia194 Myrtle Beach88

New paid studies open every week

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