Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only

Home/SC/Charleston

Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Charleston, SC

Studies commonly pay $75 to $4,500 per completed study

730 clinical trials are currently recruiting participants within 30 miles of Charleston. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

730studies recruiting

2+research centers nearby

5condition categories

Live from the NIH registry

Studies recruiting near Charleston right now

Top 25 of 730 recruiting studies, sorted by proximity — each links to its official registry page

COAST Therapy in Advanced Solid Tumors and Prostate Cancer

Prostate Cancer Recurrent, Solid Tumor, Adult Phase 1, Phase 2 Interventional 76 participants sought

Medical University of South Carolina — Charleston, South Carolina (3.5 mi) · Sponsor: Medical University of South Carolina

See eligibility & contact on ClinicalTrials.gov (NCT05036226)

Switch or Quit R01

Cigarette Smoking, Smoking Behaviors N/A Interventional 225 participants sought

Medical Univeristy of South Carolina — Charleston, South Carolina (3.5 mi) · Sponsor: Medical University of South Carolina

See eligibility & contact on ClinicalTrials.gov (NCT06373679)

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Lymphoma, Large B-Cell, Diffuse Phase 2 Interventional 594 participants sought

Medical University of South Carolina ( Site 0153) — Charleston, South Carolina (3.5 mi) · Sponsor: Merck Sharp & Dohme LLC

See eligibility & contact on ClinicalTrials.gov (NCT06890884)

A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

Advanced Pancreatic Carcinoma, Metastatic Pancreatic Carcinoma Phase 2 Interventional 40 participants sought

Ohio State University-Telemedicine — Charleston, South Carolina (3.5 mi) · Sponsor: Sameek Roychowdhury

See eligibility & contact on ClinicalTrials.gov (NCT06906562)

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought

Ralph H Johnson VA Medical Center — Charleston, South Carolina (3.5 mi) · Sponsor: SWOG Cancer Research Network

See eligibility & contact on ClinicalTrials.gov (NCT03851445)

A Study to Investigate the Safety and Efficacy of MEDI0618 Compared to Placebo in Adult Participants With Episodic Migraine

Migraine Phase 2 Interventional 488 participants sought

Palmetto Primary Care Physicians Division of Gastroenterology - Summerville — Summerville, South Carolina (18.4 mi) · Sponsor: AbbVie

See eligibility & contact on ClinicalTrials.gov (NCT06602479)

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Endometrial Cancer Phase 3 Interventional 600 participants sought

Research Site — Charleston, South Carolina (3.5 mi) · Sponsor: AstraZeneca

See eligibility & contact on ClinicalTrials.gov (NCT06989112)

Real Life Evaluation of the LibAirty Airway Clearance System in Adults With Bronchiectasis (RELACS)

Bronchiectasis Adult N/A Observational 200 participants sought

Medical University of South Carolina — Charleston, South Carolina (3.5 mi) · Sponsor: Synchrony-Medical, Ltd

See eligibility & contact on ClinicalTrials.gov (NCT07135284)

Closed-loop rTMS-EEG During Visuomotor Integration.

Visuomotor Skills, Brain Lesion (General) N/A Interventional 20 participants sought

Medical University of South Carolina — Charleston, South Carolina (3.5 mi) · Sponsor: Medical University of South Carolina

See eligibility & contact on ClinicalTrials.gov (NCT07249801)

A Study of Buntanetap in Participants With PD

Parkinson's Disease (PD), Deep Brain Stimulation Phase 2, Phase 3 Interventional 500 participants sought

Medical University of South Carolina (MUSC) - The Murray Center for Research on Parkinson's Disease — Charleston, South Carolina (3.5 mi) · Sponsor: Annovis Bio Inc.

See eligibility & contact on ClinicalTrials.gov (NCT07284784)

A Safety Study of SEA-CD70 in Patients With Myeloid Malignancies

Myelodysplastic Syndrome, Acute Myeloid Leukemia Phase 1 Interventional 178 participants sought

Hollings Cancer Center — Charleston, South Carolina (3.5 mi) · Sponsor: Seagen, a wholly owned subsidiary of Pfizer

See eligibility & contact on ClinicalTrials.gov (NCT04227847)

CARS: Cannabis and Alcohol Reduction Study

Cannabis Use, Alcohol Use, Unspecified N/A Interventional 52 participants sought

Medical University of South Carolina — Charleston, South Carolina (3.5 mi) · Sponsor: Medical University of South Carolina

See eligibility & contact on ClinicalTrials.gov (NCT05486234)

An Observational Study of Etrasimod in Adult Patients With Moderate to Severe Ulcerative Colitis

Colitis, Ulcerative N/A Observational 300 participants sought

Medical University of South Carolina (MUSC) — Charleston, South Carolina (3.5 mi) · Sponsor: Pfizer

See eligibility & contact on ClinicalTrials.gov (NCT06398626)

E-Mindfulness Approaches for Living After Breast Cancer

Breast Cancer, Depression Phase 3 Interventional 402 participants sought

Medical University of South Carolina — Charleston, South Carolina (3.5 mi) · Sponsor: NRG Oncology

See eligibility & contact on ClinicalTrials.gov (NCT06748222)

Remimazolam vs Propofol in Laser Burn Cases

Burn Scar, Hypertrophic Scarring Phase 4 Interventional 136 participants sought

Medical University of South Carolina — Charleston, South Carolina (3.5 mi) · Sponsor: Medical University of South Carolina

See eligibility & contact on ClinicalTrials.gov (NCT07213544)

Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design

Fibromyalgia Phase 3 Interventional 620 participants sought

Clinical Research Site — Charleston, South Carolina (3.5 mi) · Sponsor: Axsome Therapeutics, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT07398417)

Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Prospective Outcomes Registry

Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease N/A Observational 3,000 participants sought

Medical University of South Carolina — Charleston, South Carolina (3.5 mi) · Sponsor: Duke University

See eligibility & contact on ClinicalTrials.gov (NCT01915511)

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

Smoldering Plasma Cell Myeloma Phase 3 Interventional 288 participants sought

Medical University of South Carolina — Charleston, South Carolina (3.5 mi) · Sponsor: ECOG-ACRIN Cancer Research Group

See eligibility & contact on ClinicalTrials.gov (NCT03937635)

Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD

Posttraumatic Stress Disorder, Alcohol Use Disorder Phase 2 Interventional 200 participants sought

Medical University of South Carolina — Charleston, South Carolina (3.5 mi) · Sponsor: Texas A&M University

See eligibility & contact on ClinicalTrials.gov (NCT05959434)

Impact of Capturing Ictal Events With Ultra-long-term Ambulatory EEG Monitoring With Remote EEG Monitoring System.

Epilepsy, Seizures N/A Interventional 65 participants sought

Medical University of South Carolina — Charleston, South Carolina (3.5 mi) · Sponsor: Epitel, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT06027749)

Prediction Augmented Screening Initiative

Lung Cancer, Lung Cancer Screening N/A Interventional 23,520 participants sought

Ralph H. Johnson VA Medical Center, Charleston, SC — Charleston, South Carolina (3.5 mi) · Sponsor: VA Office of Research and Development

See eligibility & contact on ClinicalTrials.gov (NCT06538636)

Sex Differences in Neurobehavioral Response to THC

Cannabis Use Disorder Phase 2 Interventional 40 participants sought

Medical University of South Carolina — Charleston, South Carolina (3.5 mi) · Sponsor: Medical University of South Carolina

See eligibility & contact on ClinicalTrials.gov (NCT07225777)

Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance

Ascending Aortic Aneurysm Enlargement, Ascending Aorta Aneurysm N/A Interventional 610 participants sought

MUSC Health University Medical Center — Charleston, South Carolina (3.5 mi) · Sponsor: Ottawa Heart Institute Research Corporation

See eligibility & contact on ClinicalTrials.gov (NCT03536312)

Patient Specific Talus Spacer Post Approval Study

Avascular Necrosis of the Talus N/A Observational 50 participants sought

Medical University of South Carolina — Charleston, South Carolina (3.5 mi) · Sponsor: Paragon 28

See eligibility & contact on ClinicalTrials.gov (NCT05364606)

Naxitamab Added to Induction for Newly Diagnosed High-Risk Neuroblastoma

Neuroblastoma Phase 2 Interventional 93 participants sought

Medical University of South Carolina — Charleston, South Carolina (3.5 mi) · Sponsor: Giselle Sholler

See eligibility & contact on ClinicalTrials.gov (NCT05489887)

Actively enrolling

Studies you may be able to join near Charleston

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Google-rated

Top-rated research centers in Charleston

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Clinical Research Center Of The Carolinas

1364 Ashley River Rd, Charleston, SC 29407

(843) 375-8111

Website

Coastal Carolina Research Center

★ 4.4

4920 O'Hear Ave Ste 101, North Charleston, SC 29405

(843) 856-3784

Website

"I feel Coastal Carolina is a valuable asset to the research community in the Charleston area. They are extremely welcoming and professional. Their ex…"

— Pam, 5★

Clinical trials in Charleston: what's recruiting

The Charleston area currently has 730 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Charleston, the most active research areas are:

Cancer & Oncology10 studies
Brain & Mental Health2 studies
Immune & Skin1 studies
Lungs & Breathing1 studies
Heart & Vascular1 studies

Every listing shows the study phase, the recruiting site and its distance from Charleston, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Charleston

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Charleston participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Are clinical trials in Charleston safe?

Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.

How do I join a study in Charleston, SC?

Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.

Is compensation for clinical trials taxable?

In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.

What is the difference between a research center and a hospital study in Charleston?

Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.

Can I be in more than one clinical trial at a time?

Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Charleston typically complete one or two studies per year.

Paid clinical trials near Charleston

Other metros within reach

Myrtle Beach, SC88 Savannah, GA168 Columbia, SC194 Augusta, GA184 Rock Hill, SC581 Fayetteville, NC125 Wilmington, NC111 Charlotte, NC643

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Charleston Bladder Issues Due To Spinal Cord Injury in Charleston All conditions

More of SC

Rock Hill581 Greenville378 Mauldin376 Spartanburg363 Columbia194 Myrtle Beach88

New paid studies open every week

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