Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/NC/Charlotte
Updated October 2026 from ClinicalTrials.gov

Paid Clinical Trials in Charlotte, NC

Studies commonly pay $75 to $4,500 per completed study

666 clinical trials are currently recruiting participants within 30 miles of Charlotte. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

666studies recruiting
9+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Charlotte right now

Top 25 of 666 recruiting studies, sorted by proximity — each links to its official registry page

A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy

Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications Phase 3 Interventional 115 participants sought
Carolinas Medical Center/Levine Children's Hospital (Adults and Pediatrics) — Charlotte, North Carolina (1.5 mi) · Sponsor: Pierre Fabre Medicament
See eligibility & contact on ClinicalTrials.gov (NCT03394365)

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
Novant Health Presbyterian Medical Center — Charlotte, North Carolina (1.5 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC) Phase 1 Interventional 604 participants sought
Carolina BioOncology Institute — Huntersville, North Carolina (14.0 mi) · Sponsor: Revolution Medicines, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06040541)

Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure

Chronic Lymphocytic Leukaemia, Moderate to Severe Cardiac Impairment Phase 4 Interventional 60 participants sought
Research Site — Charlotte, North Carolina (1.5 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06651970)

A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

Advanced Pancreatic Carcinoma, Metastatic Pancreatic Carcinoma Phase 2 Interventional 40 participants sought
Ohio State University-Telemedicine — Charlotte, North Carolina (1.5 mi) · Sponsor: Sameek Roychowdhury
See eligibility & contact on ClinicalTrials.gov (NCT06906562)

A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas

Triple Negative Breast Cancer, HER2-negative Breast Cancer Phase 1 Interventional 96 participants sought
Dren Investigational Site — Huntersville, North Carolina (14.0 mi) · Sponsor: Dren Bio
See eligibility & contact on ClinicalTrials.gov (NCT06999187)

A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis

Colitis, Ulcerative Phase 3 Interventional 882 participants sought
Atrium Health — Charlotte, North Carolina (1.5 mi) · Sponsor: Janssen Research & Development, LLC
See eligibility & contact on ClinicalTrials.gov (NCT07196748)

A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)

Renal Cell Carcinoma Phase 3 Interventional 904 participants sought
Carolina Oncology Specialists, PA ( Site 9002) — Charlotte, North Carolina (1.5 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT07227402)

Registry of Participants With Generalized Myasthenia Gravis Treated With Alexion C5 Inhibition Therapies (C5ITs)

Generalized Myasthenia Gravis N/A Observational 500 participants sought
Clinical Trial Site — Charlotte, North Carolina (1.5 mi) · Sponsor: Alexion Pharmaceuticals, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04202341)

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

Childhood Medulloblastoma Phase 3 Interventional 225 participants sought
Carolinas Medical Center/Levine Cancer Institute — Charlotte, North Carolina (1.5 mi) · Sponsor: Children's Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT05382338)

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

Breast Cancer Phase 3 Interventional 450 participants sought
Novant Health Cancer Institute — Charlotte, North Carolina (1.5 mi) · Sponsor: Hoffmann-La Roche
See eligibility & contact on ClinicalTrials.gov (NCT06790693)

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Lymphoma, Large B-Cell, Diffuse Phase 2 Interventional 594 participants sought
Novant Health Presbyterian Medical Center ( Site 0177) — Charlotte, North Carolina (1.5 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06890884)

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Endometrial Cancer Phase 3 Interventional 600 participants sought
Research Site — Charlotte, North Carolina (1.5 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06989112)

A Study to Evaluate ARV-6723 Alone and With Pembrolizumab in Participants With Advanced Solid Tumors

Advanced Solid Tumor Phase 1, Phase 2 Interventional 499 participants sought
Clinical Trial Site — Huntersville, North Carolina (14.0 mi) · Sponsor: Arvinas Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07749586)

A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus

Systemic Lupus Erythematosus Phase 3 Interventional 450 participants sought
Sl0044 50238 — Charlotte, North Carolina (1.5 mi) · Sponsor: UCB Biopharma SRL
See eligibility & contact on ClinicalTrials.gov (NCT06617325)

RENAISSANCE 2: SPN-817 Phase 2, Double-Blind, Placebo-Controlled Study in Adults With Focal Onset Seizures

Focal Onset Seizures Phase 2 Interventional 216 participants sought
OnSite Clinical Solutions, LLC — Charlotte, North Carolina (1.5 mi) · Sponsor: Supernus Pharmaceuticals, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06798896)

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

Carcinoma, Transitional Cell, Urinary Bladder Neoplasms Phase 3 Interventional 450 participants sought
Levine Cancer Institute — Charlotte, North Carolina (1.5 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT07218380)

A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury

Traumatic Brain Injury N/A Observational 2,000 participants sought
Atrium Health - Carolina Medical Center — Charlotte, North Carolina (1.5 mi) · Sponsor: Hoffmann-La Roche
See eligibility & contact on ClinicalTrials.gov (NCT07455136)

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

Smoldering Plasma Cell Myeloma Phase 3 Interventional 288 participants sought
Carolinas Medical Center/Levine Cancer Institute — Charlotte, North Carolina (1.5 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT03937635)

A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)

Heart Failure Phase 3 Interventional 1,500 participants sought
CON-10318, Charlotte, NC — Charlotte, North Carolina (1.5 mi) · Sponsor: Colorado Prevention Center
See eligibility & contact on ClinicalTrials.gov (NCT06024746)
Actively enrolling

Studies you may be able to join near Charlotte

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Charlotte

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Queen City Clinical Research, PLLC

330 Billingsley Rd Ste 206?, Charlotte, NC 28211
(704) 405-3150

New Hope Clinical Research, Inc.

★ 4.2
3101 Latrobe Dr, Charlotte, NC 28211
(980) 209-9784
"They called to screen me and I’m not even depressed. Just lied because I need the money. I’m sure they haven’t called a bunch of others like they cal…"
— Pluto Enterprises LLC, 3★

DJL Clinical Research, PLLC

★ 5.0
431 N Wendover Rd, Charlotte, NC 28211
(704) 247-9179
"Was in a study with DJL Research for 4+ years. An experience I entered with apprehension thinking I'd be treated like a #, and quickly felt like I w…"
— margaret frantz, 5★

New Hope Speciality Clinic

★ 3.5 (19 reviews)
3101 Latrobe Dr, Charlotte, NC 28211
(704) 817-8331
"STAY AWAY! Medication not called in to pharmacy in a timely manner. Phone calls not answered. Phone calls not returned. This facility is just UNPR…"
— Ann Fern, 1★

Carolinas Research Center

★ 5.0
1805 Milton Rd # B, Charlotte, NC 28215
(704) 595-7887

DelRicht Research | Charlotte Clinical Trials

★ 4.8
6719 Fairview Rd Ste A, Charlotte, NC 28210
(704) 644-8469
"The team members are kind and considerate. They will answer questions and provide you with feedback you can share with your primary provider. Super P…"
— Kenya Davis, 5★

Rose Research Center

★ 4.9
8401 Medical Plaza Dr #275, Charlotte, NC 28262
(704) 350-2999
"I had an excellent experience I am definitely team Mary Beth and team rejoice definitely five stars for the ladies"
— Griselda Crawford, 5★

OrthoCarolina Research Institute, Inc.

★ 5.0
2001 Vail Ave #300, Charlotte, NC 28207
(704) 945-7710
"Outstanding experience with doctors, staff, nurses...."
— JamesRichard Smutney, 5★

Catawba Research, LLC

★ 5.0
5200 77 Center Dr #160, Charlotte, NC 28217
(980) 242-3980

Clinical trials in Charlotte: what's recruiting

The Charlotte area currently has 666 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Charlotte, the most active research areas are:

  • Cancer & Oncology15 studies
  • Immune & Skin2 studies
  • Liver & Kidney1 studies
  • Brain & Mental Health1 studies
  • Heart & Vascular1 studies

Every listing shows the study phase, the recruiting site and its distance from Charlotte, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Charlotte

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Charlotte participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Are clinical trials in Charlotte safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Charlotte, NC?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
What is the difference between a research center and a hospital study in Charlotte?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Charlotte?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Charlotte.

Paid clinical trials near Charlotte

Other metros within reach

Concord, NC645 Rock Hill, SC603 Gastonia, NC661 Hickory, NC94 Winston-Salem, NC587 Spartanburg, SC364 High Point, NC586 Columbia, SC190

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Charlotte Chronic Kidney Disease (HealthMatch) in Charlotte Bladder Issues Due To Spinal Cord Injury in Charlotte All conditions

More of NC

Durham1,680 Cary1,680 Raleigh1,672 Burlington743 Gastonia661 Concord645 Winston-Salem587 High Point586 Greensboro585 Fayetteville125 Asheville124

New paid studies open every week

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