Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/NC/Charlotte
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Charlotte, NC

Studies commonly pay $75 to $4,500 per completed study

648 clinical trials are currently recruiting participants within 30 miles of Charlotte. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

648studies recruiting
9+research centers nearby
6condition categories
Live from the NIH registry

Studies recruiting near Charlotte right now

Top 25 of 648 recruiting studies, sorted by proximity — each links to its official registry page

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
Novant Health Presbyterian Medical Center — Charlotte, North Carolina (1.5 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Carolinas Medical Center/Levine Cancer Institute — Charlotte, North Carolina (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)

Renal Cell Carcinoma Phase 3 Interventional 904 participants sought
Carolina Oncology Specialists, PA ( Site 9002) — Charlotte, North Carolina (1.5 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT07227402)

A Phase 2A Clinical Trial to Assess the Safety and Tolerability of ERX1000 in Men and Women for the Treatment of Obesity.

Obesity & Overweight Phase 2 Interventional 80 participants sought
Monroe Biomedical Research — Monroe, North Carolina (22.1 mi) · Sponsor: ERX Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT07570758)

Study to Evaluate the REMEDY SPECTRUM GV IM Spacer Nail in the Treatment of Ankle-Related Infections

Periprosthetic Joint Infection Phase 2 Interventional 60 participants sought
OrthoCarolina Research Institute — Charlotte, North Carolina (1.5 mi) · Sponsor: OsteoRemedies, LLC
See eligibility & contact on ClinicalTrials.gov (NCT06428448)

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Endometrial Cancer Phase 3 Interventional 600 participants sought
Research Site — Charlotte, North Carolina (1.5 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06989112)

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

Bladder Carcinoma, Ureter Carcinoma N/A Observational 2,020 participants sought
Carolina Blood and Cancer Care Associates — Rock Hill, South Carolina (22.5 mi) · Sponsor: Guardant Health, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05059444)

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

Carcinoma, Transitional Cell, Urinary Bladder Neoplasms Phase 3 Interventional 450 participants sought
Levine Cancer Institute — Charlotte, North Carolina (1.5 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT07218380)

A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)

Heart Failure Phase 3 Interventional 1,500 participants sought
CON-10318, Charlotte, NC — Charlotte, North Carolina (1.5 mi) · Sponsor: Colorado Prevention Center
See eligibility & contact on ClinicalTrials.gov (NCT06024746)

Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention

Percutaneous Coronary Intervention, Peripheral Endovascular Intervention Phase 4 Interventional 6,000 participants sought
Novant Health Clinical Research/Heart & Vascular Institute — Charlotte, North Carolina (1.5 mi) · Sponsor: Duke University
See eligibility & contact on ClinicalTrials.gov (NCT06909565)

A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension

Uncontrolled Hypertension Phase 2 Interventional 280 participants sought
Retension Clinical Site — Charlotte, North Carolina (1.5 mi) · Sponsor: Retension Pharmaceuticals. Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07142356)

ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves

Aortic Valve Insufficiency, Aortic Valve Stenosis N/A Interventional 200 participants sought
Carolinas Health System — Charlotte, North Carolina (1.5 mi) · Sponsor: Edwards Lifesciences
See eligibility & contact on ClinicalTrials.gov (NCT05172973)

A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma

Multiple Myeloma, Myeloma Phase 1 Interventional 165 participants sought
Atrium Health, Levine Cancer Institute — Charlotte, North Carolina (1.5 mi) · Sponsor: K36 Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05651932)

Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma

Asthma Phase 3 Interventional 440 participants sought
Research Site — Charlotte, North Carolina (1.5 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06307665)

Assoc. of Genomic Polymorphisms With Cancer Cachexia in Subjects With Panc Adenocarcinoma

Pancreas Adenocarcinoma, Cachexia N/A Observational 100 participants sought
Levine Cancer Institute — Charlotte, North Carolina (1.5 mi) · Sponsor: Wake Forest University Health Sciences
See eligibility & contact on ClinicalTrials.gov (NCT05376592)

A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma Phase 3 Interventional 1,200 participants sought
Carolina Oncology Specialists, PA ( Site 0054) — Charlotte, North Carolina (1.5 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06136559)

Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis

Knee Cartilage Defects Phase 3 Interventional 300 participants sought
Atrium Health Mercy — Charlotte, North Carolina (1.5 mi) · Sponsor: Medipost, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07339111)

Evaluating the Safety and Efficacy of Polyethylene Glycol (PEG) Mediated Fusion (PEG Fusion)

Peripheral Nerve Injuries Phase 2 Interventional 40 participants sought
OrthoCarolina — Charlotte, North Carolina (1.5 mi) · Sponsor: Major Extremity Trauma Research Consortium
See eligibility & contact on ClinicalTrials.gov (NCT04789044)

Implementation pRogram to Improve Screening and Management for CKD in Diabetes (Program 1) (IRIS-CKD)

Chronic Kidney Disease(CKD), Type 2 DM N/A Interventional 750 participants sought
Houston Methodist — Houston, North Carolina (20.8 mi) · Sponsor: Duke University
See eligibility & contact on ClinicalTrials.gov (NCT06906627)
Actively enrolling

Studies you may be able to join near Charlotte

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research studies for chronic kidney disease

This research platform is enrolling Black and African American adults in eligible areas who have been diagnosed with chronic kidney disease. Compensation may be available. The study team confirms eligibility before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Charlotte

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Queen City Clinical Research, PLLC

330 Billingsley Rd Ste 206?, Charlotte, NC 28211
(704) 405-3150

New Hope Clinical Research, Inc.

★ 4.2
3101 Latrobe Dr, Charlotte, NC 28211
(980) 209-9784
"They called to screen me and I’m not even depressed. Just lied because I need the money. I’m sure they haven’t called a bunch of others like they cal…"
— Pluto Enterprises LLC, 3★

DJL Clinical Research, PLLC

★ 5.0
431 N Wendover Rd, Charlotte, NC 28211
(704) 247-9179
"Was in a study with DJL Research for 4+ years. An experience I entered with apprehension thinking I'd be treated like a #, and quickly felt like I w…"
— margaret frantz, 5★

New Hope Speciality Clinic

★ 3.5 (19 reviews)
3101 Latrobe Dr, Charlotte, NC 28211
(704) 817-8331
"STAY AWAY! Medication not called in to pharmacy in a timely manner. Phone calls not answered. Phone calls not returned. This facility is just UNPR…"
— Ann Fern, 1★

Carolinas Research Center

★ 5.0
1805 Milton Rd # B, Charlotte, NC 28215
(704) 595-7887

DelRicht Research | Charlotte Clinical Trials

★ 4.8
6719 Fairview Rd Ste A, Charlotte, NC 28210
(704) 644-8469
"The team members are kind and considerate. They will answer questions and provide you with feedback you can share with your primary provider. Super P…"
— Kenya Davis, 5★

Rose Research Center

★ 4.9
8401 Medical Plaza Dr #275, Charlotte, NC 28262
(704) 350-2999
"I had an excellent experience I am definitely team Mary Beth and team rejoice definitely five stars for the ladies"
— Griselda Crawford, 5★

OrthoCarolina Research Institute, Inc.

★ 5.0
2001 Vail Ave #300, Charlotte, NC 28207
(704) 945-7710
"Outstanding experience with doctors, staff, nurses...."
— JamesRichard Smutney, 5★

Catawba Research, LLC

★ 5.0
5200 77 Center Dr #160, Charlotte, NC 28217
(980) 242-3980

Clinical trials in Charlotte: what's recruiting

The Charlotte area currently has 648 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Charlotte, the most active research areas are:

  • Cancer & Oncology11 studies
  • Liver & Kidney3 studies
  • Heart & Vascular3 studies
  • Diabetes & Metabolism2 studies
  • Brain & Mental Health2 studies

Every listing shows the study phase, the recruiting site and its distance from Charlotte, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Charlotte

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Charlotte participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Are clinical trials in Charlotte safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Charlotte, NC?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
What is the difference between a research center and a hospital study in Charlotte?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Charlotte?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Charlotte.

Paid clinical trials near Charlotte

Other metros within reach

Concord, NC627 Rock Hill, SC585 Gastonia, NC651 Hickory, NC89 Winston-Salem, NC597 Spartanburg, SC357 High Point, NC597 Columbia, SC197

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Charlotte Chronic Kidney Disease (HealthMatch) in Charlotte Bladder Issues Due To Spinal Cord Injury in Charlotte All conditions

More of NC

Durham1,679 Cary1,679 Raleigh1,671 Burlington759 Gastonia651 Concord627 High Point597 Winston-Salem597 Greensboro596 Asheville120 Fayetteville119

New paid studies open every week

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