Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/NC/Durham
Updated November 2026 from ClinicalTrials.gov

Paid Clinical Trials in Durham, NC

Studies commonly pay $75 to $4,500 per completed study

1,696 clinical trials are currently recruiting participants within 30 miles of Durham. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

1,696studies recruiting
9+research centers nearby
6condition categories
Live from the NIH registry

Studies recruiting near Durham right now

Top 25 of 1,696 recruiting studies, sorted by proximity — each links to its official registry page

Nephrotic Syndrome Study Network

Minimal Change Disease (MCD), Membranous Nephropathy N/A Observational 1,200 participants sought
University of North Carolina at Chapel Hill — Chapel Hill, North Carolina (9.7 mi) · Sponsor: University of Michigan
See eligibility & contact on ClinicalTrials.gov (NCT01209000)

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

Lymphoma, Non-Hodgkin, Multiple Myeloma Phase 2 Interventional 4,200 participants sought
Lineberger Comprehensive Cancer Center — Chapel Hill, North Carolina (9.7 mi) · Sponsor: American Society of Clinical Oncology
See eligibility & contact on ClinicalTrials.gov (NCT02693535)

A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy

Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications Phase 3 Interventional 115 participants sought
Duke Cancer Institute (Adults and Pediatrics) — Durham, North Carolina (1.0 mi) · Sponsor: Pierre Fabre Medicament
See eligibility & contact on ClinicalTrials.gov (NCT03394365)

Registry of Participants With Generalized Myasthenia Gravis Treated With Alexion C5 Inhibition Therapies (C5ITs)

Generalized Myasthenia Gravis N/A Observational 500 participants sought
Clinical Trial Site — Durham, North Carolina (1.0 mi) · Sponsor: Alexion Pharmaceuticals, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04202341)

Registry of Patients With AQP4+ NMOSD Treated With Alexion C5 Inhibitor Therapies

Neuromyelitis Optica Spectrum Disorder, NMOSD N/A Observational 200 participants sought
Clinical Trial Site — Chapel Hill, North Carolina (9.7 mi) · Sponsor: Alexion Pharmaceuticals, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05966467)

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC) Phase 1 Interventional 604 participants sought
Duke Cancer Center — Durham, North Carolina (1.0 mi) · Sponsor: Revolution Medicines, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06040541)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Duke University Medical Center — Durham, North Carolina (1.0 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

Observation of Environment and Reproductive-Endocrine Effects

Hypogonadism, Hypergonadism N/A Observational 300 participants sought
NIEHS Clinical Research Unit (CRU) — Research Triangle Park, North Carolina (6.1 mi) · Sponsor: National Institute of Environmental Health Sciences (NIEHS)
See eligibility & contact on ClinicalTrials.gov (NCT06280807)

Cognitive Training and Neuroplasticity in Mild Cognitive Impairment: COGIT-2 Trial

Mild Cognitive Impairment (MCI), Cognitive Training Phase 2 Interventional 240 participants sought
Duke University Medical Center — Durham, North Carolina (1.0 mi) · Sponsor: Columbia University
See eligibility & contact on ClinicalTrials.gov (NCT06601933)

A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

Sepsis, Acute Kidney Injury Phase 2 Interventional 124 participants sought
Research Site — Chapel Hill, North Carolina (9.7 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT07215702)

A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated

Diabetic Macular Edema Phase 1, Phase 2 Interventional 49 participants sought
North Carolina Retina Associates — Wake Forest, North Carolina (21.9 mi) · Sponsor: Boehringer Ingelheim
See eligibility & contact on ClinicalTrials.gov (NCT07553429)

Adult and Juvenile Myositis

Dermatomyositis, Polymyositis N/A Observational 1,200 participants sought
NIEHS Clinical Research Unit (CRU) — Research Triangle Park, North Carolina (6.1 mi) · Sponsor: National Institute of Environmental Health Sciences (NIEHS)
See eligibility & contact on ClinicalTrials.gov (NCT00017914)

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

High Grade Glioma, Diffuse Intrinsic Pontine Glioma Phase 2 Interventional 120 participants sought
Duke Cancer Center — Durham, North Carolina (1.0 mi) · Sponsor: Nationwide Children's Hospital
See eligibility & contact on ClinicalTrials.gov (NCT05096481)

SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Immigrant Families

Substance Abuse, Intimate Partner Violence (IPV) N/A Interventional 400 participants sought
Duke School of Nursing — Durham, North Carolina (1.0 mi) · Sponsor: Duke University
See eligibility & contact on ClinicalTrials.gov (NCT06627764)

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

Breast Cancer Phase 3 Interventional 450 participants sought
Duke Cancer Institute — Durham, North Carolina (1.0 mi) · Sponsor: Hoffmann-La Roche
See eligibility & contact on ClinicalTrials.gov (NCT06790693)

HCMT/MM2401: Ph2 Study of Selinexor + Bispecific Antibody for RRMM

Multiple Myeloma in Relapse, Multiple Myeloma, Refractory Phase 2 Interventional 27 participants sought
Duke University Health System — Durham, North Carolina (1.0 mi) · Sponsor: Duke University
See eligibility & contact on ClinicalTrials.gov (NCT06822972)

WISPer: Evaluation of MTX-463 in Participants With Idiopathic Pulmonary Fibrosis (IPF)

Idiopathic Pulmonary Fibrosis Phase 2 Interventional 164 participants sought
WISPer Site in Durham, NC — Durham, North Carolina (1.0 mi) · Sponsor: Mediar Therapeutics
See eligibility & contact on ClinicalTrials.gov (NCT06967805)

A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy

Large B-cell Lymphoma, Lymphoma, B-Cell Phase 3 Interventional 400 participants sought
Duke Cancer Institute — Durham, North Carolina (1.0 mi) · Sponsor: Lyell Immunopharma, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07188558)

ASCEND: Safety and Tolerability of ION337 for the Treatment of Dravet Syndrome

Dravet Syndrome Phase 1, Phase 2 Interventional 32 participants sought
Duke University Health Systems — Durham, North Carolina (1.0 mi) · Sponsor: Ionis Pharmaceuticals, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07531745)

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
Durham VA Medical Center — Durham, North Carolina (1.0 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT03851445)
Actively enrolling

Studies you may be able to join near Durham

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Durham

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Duke Clinical Research Institute

★ 4.9
300 W Morgan St, Durham, NC 27701
(919) 668-8700
"Great awesome place to work!! Loved it❤"
— Ramona Williams, 5★

Velocity Clinical Research

★ 4.5
300 E Main St Ste 200, Durham, NC 27701
(919) 503-4711
"Dr Cromwell and the entire staff are professional and caring people who made me feel important and valued during this year long trial.<br>I recommend…"
— Bob Kingsbery, 5★

Atlas Clinical Research

555 S Mangum St Suite 100, Durham, NC 27701

Clinical Trials of North Carolina

★ 2.5
811 9th St, Durham, NC 27705
(919) 590-9024
"This is NOT A Clinical trials it is a Dentistry and the phone number on the page do not Work"
— Blue Wallpaper, 1★

Institute for Medical Research, Inc.

508 Fulton St, Durham, NC 27705
(919) 286-0411 ext. 5180

Biomanufacturing Research Institute and Technology Enterprise (BRITE)

★ 4.8
Durham, NC 27701
(919) 530-7013
"Highly qualified trained staff and faculty !"
— Summaira Ahmed, 5★

Duke Clinical Research Training Program

Davison Building, 40 Duke Medicine Cir Box 2734, Durham, NC 27710
(919) 681-4560

Pickett Duke office of Clinical Research

★ 4.3
3024 Pickett Rd, Durham, NC 27705
(919) 613-1200

Rose Research Center

★ 4.3
7240 ACC Blvd, Raleigh, NC 27617
(919) 328-2345
"Very clean facility. They're always telling me that I don't qualify for their studies for whatever reason but I feel like it's because I dropped out …"
— Rita Poole, 4★

Clinical trials in Durham: what's recruiting

The Durham area currently has 1,696 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Durham, the most active research areas are:

  • Cancer & Oncology9 studies
  • Liver & Kidney2 studies
  • Immune & Skin2 studies
  • Diabetes & Metabolism1 studies
  • Brain & Mental Health1 studies

Every listing shows the study phase, the recruiting site and its distance from Durham, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Durham

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Durham participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Durham pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
How do I join a study in Durham, NC?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
What is the difference between a research center and a hospital study in Durham?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Durham?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Durham.

Paid clinical trials near Durham

Other metros within reach

Cary, NC1,696 Raleigh, NC1,687 Burlington, NC747 Fayetteville, NC124 Greensboro, NC597 High Point, NC598 Winston-Salem, NC599 Roanoke, VA192

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Durham Heart Failure in Durham Chronic Kidney Disease (HealthMatch) in Durham Bladder Issues Due To Spinal Cord Injury in Durham All conditions

More of NC

Cary1,696 Raleigh1,687 Burlington747 Charlotte673 Gastonia667 Concord648 Winston-Salem599 High Point598 Greensboro597 Asheville125 Fayetteville124

New paid studies open every week

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