Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/NC/Durham
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Durham, NC

Studies commonly pay $75 to $4,500 per completed study

1,669 clinical trials are currently recruiting participants within 30 miles of Durham. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

1,669studies recruiting
9+research centers nearby
6condition categories
Live from the NIH registry

Studies recruiting near Durham right now

Top 25 of 1,669 recruiting studies, sorted by proximity — each links to its official registry page

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Duke University Medical Center — Durham, North Carolina (1.0 mi) · Sponsor: National Cancer Institute (NCI)

Observation of Environment and Reproductive-Endocrine Effects

Hypogonadism, Hypergonadism N/A Observational 300 participants sought
NIEHS Clinical Research Unit (CRU) — Research Triangle Park, North Carolina (6.1 mi) · Sponsor: National Institute of Environmental Health Sciences (NIEHS)

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Lymphoma, Large B-Cell, Diffuse Phase 2 Interventional 594 participants sought
University of North Carolina Medical Center ( Site 0136) — Chapel Hill, North Carolina (9.7 mi) · Sponsor: Merck Sharp & Dohme LLC

A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated

Diabetic Macular Edema Phase 1, Phase 2 Interventional 49 participants sought
North Carolina Retina Associates — Wake Forest, North Carolina (21.9 mi) · Sponsor: Boehringer Ingelheim

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

High Grade Glioma, Diffuse Intrinsic Pontine Glioma Phase 2 Interventional 120 participants sought
Duke Cancer Center — Durham, North Carolina (1.0 mi) · Sponsor: Nationwide Children's Hospital

A Study to Evaluate the Efficacy of Cemsidomide + Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma

Multiple Myeloma, Relapsed/Refractory Multiple Myeloma Phase 2 Interventional 100 participants sought
UNC Hospitals Adult Oncology Clinics — Chapel Hill, North Carolina (9.7 mi) · Sponsor: C4 Therapeutics, Inc.

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought
Durham VA Medical Center — Durham, North Carolina (1.0 mi) · Sponsor: SWOG Cancer Research Network

A Phase 1, Dose Escalation Trial of RP-A601 in Subjects With PKP2 Variant-Mediated Arrhythmogenic Cardiomyopathy (PKP2-ACM)

PKP2 Arrhythmogenic Cardiomyopathy (PKP2-ACM) Phase 1 Interventional 9 participants sought
Duke University — Durham, North Carolina (1.0 mi) · Sponsor: Rocket Pharmaceuticals Inc.

Study to Evaluate the REMEDY SPECTRUM GV IM Spacer Nail in the Treatment of Ankle-Related Infections

Periprosthetic Joint Infection Phase 2 Interventional 60 participants sought
Duke University Medical Center — Durham, North Carolina (1.0 mi) · Sponsor: OsteoRemedies, LLC

Waveform Capnography Compared to Colorimetric Carbon Dioxide Detection During Tracheal Intubation of Critically Ill Adults

Acute Respiratory Failure N/A Observational 2,092 participants sought
Duke University School of Medicine — Durham, North Carolina (1.0 mi) · Sponsor: Brian Driver

Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

Urothelial Cancer, Bladder Cancer Phase 2, Phase 3 Interventional 630 participants sought
Research Site — Chapel Hill, North Carolina (9.7 mi) · Sponsor: Daiichi Sankyo

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Neovascular Age-related Macular Degeneration Phase 4 Interventional 188 participants sought
Duke Eye Center — Durham, North Carolina (1.0 mi) · Sponsor: Genentech, Inc.

A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)

Thrombocythemia, Essential, Primary Myelofibrosis Phase 3 Interventional 400 participants sought
DUHS Duke Blood Cancer Center ( Site 6005) — Durham, North Carolina (1.0 mi) · Sponsor: Merck Sharp & Dohme LLC

A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

Advanced Pancreatic Carcinoma, Metastatic Pancreatic Carcinoma Phase 2 Interventional 40 participants sought
Ohio State University-Telemedicine — Raleigh, North Carolina (20.6 mi) · Sponsor: Sameek Roychowdhury

Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention

Percutaneous Coronary Intervention, Peripheral Endovascular Intervention Phase 4 Interventional 6,000 participants sought
Duke Cardiology — Morrisville, North Carolina (11.6 mi) · Sponsor: Duke University

Ultrasound Simulation Case-based Workshop Implementation and Impact Assessment

Point-of-care Ultrasound, Simulation Training N/A Interventional 100 participants sought
Duke University Health System — Durham, North Carolina (1.0 mi) · Sponsor: Duke University
Actively enrolling

Studies you may be able to join near Durham

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Research study for heart failure

This study is enrolling adults in eligible areas of the United States who have been diagnosed with heart failure. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Research studies for chronic kidney disease

This research platform is enrolling Black and African American adults in eligible areas who have been diagnosed with chronic kidney disease. Compensation may be available. The study team confirms eligibility before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Google-rated

Top-rated research centers in Durham

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Duke Clinical Research Institute

★ 4.9
300 W Morgan St, Durham, NC 27701
(919) 668-8700
"Great awesome place to work!! Loved it❤"
— Ramona Williams, 5★

Velocity Clinical Research

★ 4.5
300 E Main St Ste 200, Durham, NC 27701
(919) 503-4711
"Dr Cromwell and the entire staff are professional and caring people who made me feel important and valued during this year long trial.<br>I recommend…"
— Bob Kingsbery, 5★

Atlas Clinical Research

555 S Mangum St Suite 100, Durham, NC 27701

Clinical Trials of North Carolina

★ 2.5
811 9th St, Durham, NC 27705
(919) 590-9024
"This is NOT A Clinical trials it is a Dentistry and the phone number on the page do not Work"
— Blue Wallpaper, 1★

Institute for Medical Research, Inc.

508 Fulton St, Durham, NC 27705
(919) 286-0411 ext. 5180

Biomanufacturing Research Institute and Technology Enterprise (BRITE)

★ 4.8
Durham, NC 27701
(919) 530-7013
"Highly qualified trained staff and faculty !"
— Summaira Ahmed, 5★

Duke Clinical Research Training Program

Davison Building, 40 Duke Medicine Cir Box 2734, Durham, NC 27710
(919) 681-4560

Pickett Duke office of Clinical Research

★ 4.3
3024 Pickett Rd, Durham, NC 27705
(919) 613-1200

Rose Research Center

★ 4.3
7240 ACC Blvd, Raleigh, NC 27617
(919) 328-2345
"Very clean facility. They're always telling me that I don't qualify for their studies for whatever reason but I feel like it's because I dropped out …"
— Rita Poole, 4★

Clinical trials in Durham: what's recruiting

The Durham area currently has 1,669 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Durham, the most active research areas are:

  • Cancer & Oncology8 studies
  • Heart & Vascular3 studies
  • Diabetes & Metabolism2 studies
  • Liver & Kidney1 studies
  • Immune & Skin1 studies

Every listing shows the study phase, the recruiting site and its distance from Durham, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Durham

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Durham participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Durham pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
How do I join a study in Durham, NC?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
What is the difference between a research center and a hospital study in Durham?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Durham?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Durham.

Paid clinical trials near Durham

Other metros within reach

By condition

Eligibility and exclusions, condition by condition

More of NC

New paid studies open every week

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