Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/NC/Durham
Updated July 2026 from ClinicalTrials.gov

Paid Clinical Trials in Durham, NC

Studies commonly pay $75 to $4,500 per completed study

1,671 clinical trials are currently recruiting participants within 30 miles of Durham. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

1,671studies recruiting
9+research centers nearby
6condition categories
Live from the NIH registry

Studies recruiting near Durham right now

Top 25 of 1,671 recruiting studies, sorted by proximity — each links to its official registry page

QuantifyHER: Quantitative Immunofluorescence and/or RT-qPCR for Measuring HER2 in HER2-low Metastatic Breast Cancer

HER2-positive Metastatic Breast Cancer N/A Observational 200 participants sought
UNC Chapel Hill — Chapel Hill, North Carolina (9.7 mi) · Sponsor: Abramson Cancer Center at Penn Medicine
See eligibility & contact on ClinicalTrials.gov (NCT06551116)

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Neovascular Age-related Macular Degeneration Phase 4 Interventional 188 participants sought
Duke Eye Center — Durham, North Carolina (1.0 mi) · Sponsor: Genentech, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04853251)

Improving Thoracic Surgical Care Using Electronic Patient-Reported Outcomes (ePROS)

Thoracic N/A Interventional 200 participants sought
Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill — Chapel Hill, North Carolina (9.7 mi) · Sponsor: UNC Lineberger Comprehensive Cancer Center
See eligibility & contact on ClinicalTrials.gov (NCT06075316)

ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas

Diffuse Intrinsic Pontine Gliomas (DIPG), Progressive DIPG Phase 2 Interventional 60 participants sought
Duke University Medical Center — Durham, North Carolina (1.0 mi) · Sponsor: Nationwide Children's Hospital
See eligibility & contact on ClinicalTrials.gov (NCT06838676)

Phase 2, Efficacy and Safety Study of ACP-204 in Lewy Body Dementia Psychosis

Lewy Body Dementia Psychosis Phase 2 Interventional 180 participants sought
UNC Hospitals — Chapel Hill, North Carolina (9.7 mi) · Sponsor: ACADIA Pharmaceuticals Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07029581)

REVITALIZE: RCT to Reduce Fatigue in Adults With Ovarian Cancer on PARP Inhibitors

Ovarian Cancer, Advanced Ovarian Carcinoma N/A Interventional 240 participants sought
Duke Cancer Center — Durham, North Carolina (1.0 mi) · Sponsor: Dana-Farber Cancer Institute
See eligibility & contact on ClinicalTrials.gov (NCT06710548)

Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction, Concentric Hypertrophy N/A Interventional 105 participants sought
Duke University — Durham, North Carolina (1.0 mi) · Sponsor: Medtronic Cardiac Rhythm and Heart Failure
See eligibility & contact on ClinicalTrials.gov (NCT05839730)

Clinical Study of a Vaginal Cooling Device for the Treatment of Vulvovaginal Candidiasis (VVC)

Vulvovaginal Candidiasis (VVC), Yeast Vaginitis N/A Interventional 55 participants sought
Unified Women's Clinical Research-Raleigh — Raleigh, North Carolina (20.6 mi) · Sponsor: Coologics, Inc
See eligibility & contact on ClinicalTrials.gov (NCT06983041)

4D Duke Microscope Integrated Optical Coherence Tomography in a Zeiss Artevo 800

Corneal Diseases, Retinal Diseases N/A Interventional 5 participants sought
Duke University Eye Center — Durham, North Carolina (1.0 mi) · Sponsor: Duke University
See eligibility & contact on ClinicalTrials.gov (NCT07024719)

Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitial Lung Disease

Interstitial Lung Disease, Common Variable Immunodeficiency Phase 2 Interventional 38 participants sought
Duke University Health System — Durham, North Carolina (1.0 mi) · Sponsor: Children's Hospital Medical Center, Cincinnati
See eligibility & contact on ClinicalTrials.gov (NCT04925375)

Zenith® Fenestrated+ Clinical Study

Aortic Aneurysm, Abdominal, Juxtarenal Aortic Aneurysm N/A Interventional 105 participants sought
University of North Carolina at Chapel Hill — Chapel Hill, North Carolina (9.7 mi) · Sponsor: Cook Research Incorporated
See eligibility & contact on ClinicalTrials.gov (NCT04875429)

Phase 2 Study of Inhaled SNG001 in Mechanically Ventilated Patients With Respiratory Viral Infection

Viral Pneumonia Phase 2 Interventional 550 participants sought
University of North Carolina (UNC) — Chapel Hill, North Carolina (9.7 mi) · Sponsor: Synairgen Research Ltd.
See eligibility & contact on ClinicalTrials.gov (NCT06999603)

Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer 2

Bladder Cancer, Recurrent Bladder Cancer N/A Observational 408 participants sought
University of North Carolina — Chapel Hill, North Carolina (9.7 mi) · Sponsor: University of Washington
See eligibility & contact on ClinicalTrials.gov (NCT07225127)

A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy

Geographic Atrophy, Macular Degeneration N/A Observational 500 participants sought
North Carolina Retina Associates — Cary, North Carolina (14.6 mi) · Sponsor: Astellas Pharma Global Development, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06779773)

The Vanguard Study: Testing a New Way to Screen for Cancer

Bladder Carcinoma, Breast Carcinoma N/A Interventional 24,000 participants sought
UNC Lineberger Comprehensive Cancer Center — Chapel Hill, North Carolina (9.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06995898)

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 188 participants sought
UNC Lineberger Comprehensive Cancer Center — Chapel Hill, North Carolina (9.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04671667)

Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

Amyloidosis, Amyloid Cardiomyopathy Phase 3 Interventional 587 participants sought
Duke University Medical Center — Durham, North Carolina (1.0 mi) · Sponsor: Eidos Therapeutics, a BridgeBio company
See eligibility & contact on ClinicalTrials.gov (NCT06563895)
Google-rated

Top-rated research centers in Durham

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Duke Clinical Research Institute

★ 4.9
300 W Morgan St, Durham, NC 27701
(919) 668-8700
"Great awesome place to work!! Loved it❤"
— Ramona Williams, 5★

Velocity Clinical Research

★ 4.5
300 E Main St Ste 200, Durham, NC 27701
(919) 503-4711
"Dr Cromwell and the entire staff are professional and caring people who made me feel important and valued during this year long trial.<br>I recommend…"
— Bob Kingsbery, 5★

Atlas Clinical Research

555 S Mangum St Suite 100, Durham, NC 27701

Clinical Trials of North Carolina

★ 2.5
811 9th St, Durham, NC 27705
(919) 590-9024
"This is NOT A Clinical trials it is a Dentistry and the phone number on the page do not Work"
— Blue Wallpaper, 1★

Institute for Medical Research, Inc.

508 Fulton St, Durham, NC 27705
(919) 286-0411 ext. 5180

Biomanufacturing Research Institute and Technology Enterprise (BRITE)

★ 4.8
Durham, NC 27701
(919) 530-7013
"Highly qualified trained staff and faculty !"
— Summaira Ahmed, 5★

Duke Clinical Research Training Program

Davison Building, 40 Duke Medicine Cir Box 2734, Durham, NC 27710
(919) 681-4560

Pickett Duke office of Clinical Research

★ 4.3
3024 Pickett Rd, Durham, NC 27705
(919) 613-1200

Rose Research Center

★ 4.3
7240 ACC Blvd, Raleigh, NC 27617
(919) 328-2345
"Very clean facility. They're always telling me that I don't qualify for their studies for whatever reason but I feel like it's because I dropped out …"
— Rita Poole, 4★

Clinical trials in Durham: what's recruiting

The Durham area currently has 1,671 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Durham, the most active research areas are:

  • Cancer & Oncology7 studies
  • Heart & Vascular3 studies
  • Liver & Kidney2 studies
  • Diabetes & Metabolism1 studies
  • Immune & Skin1 studies

Every listing shows the study phase, the recruiting site and its distance from Durham, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Durham

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Durham participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Durham pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
How do I join a study in Durham, NC?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
What is the difference between a research center and a hospital study in Durham?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Durham?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Durham.

Paid clinical trials near Durham

Other metros within reach

Cary, NC1,671 Raleigh, NC1,662 Burlington, NC761 Fayetteville, NC115 Greensboro, NC601 High Point, NC602 Winston-Salem, NC602 Roanoke, VA200

More of NC

Cary1,671 Raleigh1,662 Burlington761 Gastonia650 Charlotte648 Concord630 High Point602 Winston-Salem602 Greensboro601 Asheville121 Fayetteville115

New paid studies open every week

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