Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/VA/Roanoke
Updated September 2026 from ClinicalTrials.gov

Paid Clinical Trials in Roanoke, VA

Studies commonly pay $75 to $4,500 per completed study

191 clinical trials are currently recruiting participants within 30 miles of Roanoke. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

191studies recruiting
4+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Roanoke right now

Top 25 of 191 recruiting studies, sorted by proximity — each links to its official registry page

Study of Tucatinib and Doxil in Participants With Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Metastatic Breast Cancer

Breast Cancer Phase 2 Interventional 36 participants sought
Blue Ridge Cancer Care (Oncology & Hematology Assoc of SW Virginia, Inc) — Salem, Virginia (5.4 mi) · Sponsor: SCRI Development Innovations, LLC
See eligibility & contact on ClinicalTrials.gov (NCT05748834)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
Carilion Children's — Roanoke, Virginia (1.1 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

Malignant Female Reproductive System Neoplasm, Malignant Solid Neoplasm Phase 2 Interventional 70 participants sought
Carilion Roanoke Memorial Hospital — Roanoke, Virginia (1.1 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06126276)

A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)

Non-Small Cell Lung Cancer Phase 2 Interventional 120 participants sought
BRCC/Oncology & Hematology Associates of SW Virginia — Blacksburg, Virginia (25.3 mi) · Sponsor: Regeneron Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT06465329)

BMS-986489 (Atigotatug + Nivolumab) vs Durvalumab in Limited-stage Small-cell Lung Cancer (TIGOS-LS)

Limited Stage Small Cell Lung Cancer Phase 2 Interventional 250 participants sought
Blue Ridge Cancer Center (Oncology & Hematology Associates of Southwest VA) — Salem, Virginia (5.4 mi) · Sponsor: SCRI Development Innovations, LLC
See eligibility & contact on ClinicalTrials.gov (NCT06773910)

A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

Advanced Pancreatic Carcinoma, Metastatic Pancreatic Carcinoma Phase 2 Interventional 40 participants sought
Ohio State University Telemedicine — Roanoke, Virginia (1.1 mi) · Sponsor: Sameek Roychowdhury
See eligibility & contact on ClinicalTrials.gov (NCT06906562)

This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

Metastatic Castration Sensitive Prostate Cancer (mCSPC), Hormone Sensitive Prostate Cancer Phase 3 Interventional 1,000 participants sought
Blue Ridge Cancer Care — Roanoke, Virginia (1.1 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT07028853)

Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes

Prediabetic State, Atherosclerosis Phase 4 Interventional 7,410 participants sought
Salem VA Medical Center, Salem, VA — Salem, Virginia (5.4 mi) · Sponsor: VA Office of Research and Development
See eligibility & contact on ClinicalTrials.gov (NCT02915198)

A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH

NASH - Nonalcoholic Steatohepatitis, MASH - Metabolic Dysfunction-Associated Steatohepatitis Phase 3 Interventional 2,150 participants sought
Akero Clinical Study Site — Roanoke, Virginia (1.1 mi) · Sponsor: Akero Therapeutics, Inc
See eligibility & contact on ClinicalTrials.gov (NCT06528314)

Surabgene Lomparvovec Administered in the Suprachoroidal Space in Adult Participants With Diabetic Retinopathy Without Center-Involved Diabetic Macular Edema

Diabetic Retinopathy Phase 2, Phase 3 Interventional 576 participants sought
Vistar Eye Center - Salem /ID# 282879 — Salem, Virginia (5.4 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT07592273)

Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Mitral Valve Regurgitation N/A Interventional 1,056 participants sought
Carilion Roanoke Memorial Hospital — Roanoke, Virginia (1.1 mi) · Sponsor: Medtronic Cardiovascular
See eligibility & contact on ClinicalTrials.gov (NCT03242642)

ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

Cardiovascular Risk, Acute Myocardial Infarction (AMI) Phase 3 Interventional 10,000 participants sought
VA Medical Center_Salem — Salem, Virginia (5.4 mi) · Sponsor: Novo Nordisk A/S
See eligibility & contact on ClinicalTrials.gov (NCT06118281)

A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants

Hypothyroidism Phase 2, Phase 3 Interventional 2,800 participants sought
Salem VA Medical Center /ID# 262387 — Salem, Virginia (5.4 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT06345339)

Real-World Data Collection of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis When Used in Covered Endovascular Reconstruction of the Aortic Bifurcation (CERAB) to Treat Aortoiliac Occlusive Disease

Aortoiliac Occlusive Disease N/A Observational 158 participants sought
Carilion Clinic — Roanoke, Virginia (1.1 mi) · Sponsor: W.L.Gore & Associates
See eligibility & contact on ClinicalTrials.gov (NCT06872905)

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

Solid Tumors, Hematologic Malignancies Phase 3 Interventional 3,500 participants sought
Blue Ridge Cancer Care ( Site 0067) — Roanoke, Virginia (1.1 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT03486873)

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

Low Grade Astrocytoma, Low Grade Glioma Phase 3 Interventional 170 participants sought
Carilion Children's — Roanoke, Virginia (1.1 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04166409)

A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

Metastatic Castration-resistant Prostate Cancer (mCRPC), Prostatic Neoplasms Phase 3 Interventional 1,314 participants sought
Blue Ridge Cancer Care ( Site 0004) — Roanoke, Virginia (1.1 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06136650)

A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients (LiGeR-HN2)

Head and Neck Squamous Cell Carcinoma Phase 3 Interventional 600 participants sought
Site 10 — Blacksburg, Virginia (25.3 mi) · Sponsor: Merus B.V.
See eligibility & contact on ClinicalTrials.gov (NCT06496178)

BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease

HR+/HER2- Breast Cancer Phase 3 Interventional 1,056 participants sought
Oncology and Hematology Associates of Southwest Virginia, Inc (Us Oncology Research) — Blacksburg, Virginia (25.3 mi) · Sponsor: BeOne Medicines
See eligibility & contact on ClinicalTrials.gov (NCT07492641)

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia Phase 1, Phase 2 Interventional 960 participants sought
Carilion Children's — Roanoke, Virginia (1.1 mi) · Sponsor: PedAL BCU, LLC
See eligibility & contact on ClinicalTrials.gov (NCT04726241)

The Role of the Locus Coeruleus in Age-related Distractibility

Aging, Alzheimer Disease N/A Interventional 200 participants sought
Virginia Polytechnic Institute and State University — Blacksburg, Virginia (25.3 mi) · Sponsor: Virginia Polytechnic Institute and State University
See eligibility & contact on ClinicalTrials.gov (NCT05574634)

A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma

Primary Open Angle Glaucoma Phase 3 Interventional 130 participants sought
Vistar Eye Center - Roanoke - South Jefferson Street /ID# 276119 — Roanoke, Virginia (1.1 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT06822738)
Actively enrolling

Studies you may be able to join near Roanoke

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Roanoke

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Fralin Biomedical Research Institute at VTC

★ 4.4
4 Riverside Circle, Roanoke, VA 24016
(540) 526-2500
"Seen promptly and answered questions"
— Julie White, 4★

Carilion Clinic Center for Simulation, Research and Patient Safety

★ 4.9
15 Old Woods Ave, Roanoke, VA 24016
(540) 855-6860
"Attended a pre-joint replacement class here and it was a great experience well worth mine and my wife's time. Excellent presentations, caring and kno…"
— Bill Jennings, 5★

Salem Research Institute Inc

1970 Roanoke Blvd, Salem, VA 24153
(540) 224-1914

Addiction Recovery Research Center

2 Riverside Circle, Roanoke, VA 24016
(540) 315-0205

Clinical trials in Roanoke: what's recruiting

The Roanoke area currently has 191 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Roanoke, the most active research areas are:

  • Cancer & Oncology13 studies
  • Diabetes & Metabolism3 studies
  • Heart & Vascular2 studies
  • Liver & Kidney1 studies
  • Brain & Mental Health1 studies

Every listing shows the study phase, the recruiting site and its distance from Roanoke, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Roanoke

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Roanoke participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Roanoke pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in Roanoke?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Are clinical trials in Roanoke safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
What is the difference between a research center and a hospital study in Roanoke?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.

Paid clinical trials near Roanoke

Other metros within reach

Greensboro, NC589 Winston-Salem, NC590 High Point, NC590 Burlington, NC758 Durham, NC1,684 Cary, NC1,684 Raleigh, NC1,677 Concord, NC635

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Roanoke Bladder Issues Due To Spinal Cord Injury in Roanoke All conditions

More of VA

Arlington2,330 Alexandria2,292 Richmond599 Chesapeake399 Virginia Beach398 Norfolk398 Newport News377 Fredericksburg35

New paid studies open every week

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