Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/TN/Knoxville
Updated August 2026 from ClinicalTrials.gov

Paid Clinical Trials in Knoxville, TN

Studies commonly pay $75 to $4,500 per completed study

231 clinical trials are currently recruiting participants within 30 miles of Knoxville. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

231studies recruiting
9+research centers nearby
4condition categories
Live from the NIH registry

Studies recruiting near Knoxville right now

Top 25 of 231 recruiting studies, sorted by proximity — each links to its official registry page

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm Phase 2 Interventional 2,000 participants sought
University of Tennessee - Knoxville — Knoxville, Tennessee (1.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05564390)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia Phase 2 Interventional 222 participants sought
East Tennessee Childrens Hospital — Knoxville, Tennessee (1.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06124157)

A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer

Non-Muscle Invasive Bladder Neoplasms Phase 3 Interventional 641 participants sought
University of Tennessee Medical Center — Knoxville, Tennessee (1.7 mi) · Sponsor: Janssen Research & Development, LLC
See eligibility & contact on ClinicalTrials.gov (NCT06319820)

A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)

Non-Small Cell Lung Cancer Phase 2 Interventional 120 participants sought
University of Tennessee Medical Center — Knoxville, Tennessee (1.7 mi) · Sponsor: Regeneron Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT06465329)

A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

Advanced Pancreatic Carcinoma, Metastatic Pancreatic Carcinoma Phase 2 Interventional 40 participants sought
Ohio State University Telemedicine — Knoxville, Tennessee (1.7 mi) · Sponsor: Sameek Roychowdhury
See eligibility & contact on ClinicalTrials.gov (NCT06906562)

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

Malignant Glioma Phase 1, Phase 2 Interventional 132 participants sought
East Tennessee Childrens Hospital — Knoxville, Tennessee (1.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05099003)

Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

Non-Small Cell Lung Cancer Phase 3 Interventional 675 participants sought
Research Site — Knoxville, Tennessee (1.7 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06357533)

AtraUmatic Laparoscopic HerNia Repair Clinical Investigation to Evaluate the Safety and Performance of The ECLIPSIUM System for Mesh Fixation IDE

Hernia N/A Interventional 240 participants sought
University of Tennessee Medical Center — Knoxville, Tennessee (1.7 mi) · Sponsor: Tissium
See eligibility & contact on ClinicalTrials.gov (NCT07277946)

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

Non-Small Cell Lung Cancer (NSCLC) Phase 3 Interventional 750 participants sought
University of Tennessee Medical Center Knoxville — Knoxville, Tennessee (1.7 mi) · Sponsor: Amgen
See eligibility & contact on ClinicalTrials.gov (NCT05920356)

A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine

Menstrual Migraine Phase 3 Interventional 723 participants sought
Alliance for Multispecialty Research, LLC — Knoxville, Tennessee (1.7 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT06641466)

Feasibility, Safety and Efficacy of Nebulized Long-Acting Bronchodilators (Formoterol and Revefenacin) vs. Short-Acting Bronchodilators (Albuterol and Ipratropium) in Hospitalized Patients With AECOPD

COPD Exacerbation Phase 4 Interventional 60 participants sought
University of Tennessee Medical Center — Knoxville, Tennessee (1.7 mi) · Sponsor: University of Tennessee Graduate School of Medicine
See eligibility & contact on ClinicalTrials.gov (NCT04655170)

A Study to Investigate OCS Tapering in Adult Participants With Generalized Myasthenia Gravis Treated With Ravulizumab

Generalized Myasthenia Gravis, gMG Phase 4 Interventional 75 participants sought
Research Site — Knoxville, Tennessee (1.7 mi) · Sponsor: Alexion Pharmaceuticals, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07221838)

Symbiotic-Lung-10: A Study to Learn About PF-08634404 Alone or in Combination in Early-stage or Locally Advanced NSCLC

Carcinoma, Non-Small-Cell Lung Phase 2 Interventional 120 participants sought
University of Tennessee Medical Center — Knoxville, Tennessee (1.7 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT07489066)

Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance

Barrett Esophagus, Barretts Esophagus With Dysplasia N/A Interventional 2,298 participants sought
Gastrointestinal Associates, PC — Knoxville, Tennessee (1.7 mi) · Sponsor: University of Colorado, Denver
See eligibility & contact on ClinicalTrials.gov (NCT05530343)

A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants

Hypothyroidism Phase 2, Phase 3 Interventional 2,800 participants sought
PMG Research of Knoxville /ID# 256854 — Knoxville, Tennessee (1.7 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT06345339)

Lanreotide Versus Placebo Before Surgery to Prevent a Surgical Complication Called a Pancreatic Fistula

Pancreatic Carcinoma, Pancreatic Neoplasm Phase 3 Interventional 274 participants sought
University of Tennessee - Knoxville — Knoxville, Tennessee (1.7 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT06807437)

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MBX 4291 in Adult Participants With Obesity

Obesity Phase 1 Interventional 124 participants sought
MBX Biosciences Investigational Site — Knoxville, Tennessee (1.7 mi) · Sponsor: MBX Biosciences
See eligibility & contact on ClinicalTrials.gov (NCT07142707)

A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

High Grade Osteosarcoma, Localized Osteosarcoma Phase 2, Phase 3 Interventional 1,122 participants sought
East Tennessee Childrens Hospital — Knoxville, Tennessee (1.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05691478)

Evaluating Health Outcomes of AI-Based Fitness Wearables and App Programs in Older Adults Living Alone With Cognitive Decline

Older Adults With Cognitive Decline, Older Adults N/A Interventional 64 participants sought
University of Tennessee — Knoxville, Tennessee (1.7 mi) · Sponsor: The University of Tennessee, Knoxville
See eligibility & contact on ClinicalTrials.gov (NCT07207993)

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Advanced Non-Small Cell Lung Cancer, Non-Small Cell Lung Cancer Phase 3 Interventional 1,410 participants sought
Tennessee Cancer Specialists Dowell Springs location — Knoxville, Tennessee (1.7 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT07222566)

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

Atherosclerotic Cardiovascular Disease, Overweight Phase 3 Interventional 12,800 participants sought
Accellacare of Knoxville — Knoxville, Tennessee (1.7 mi) · Sponsor: Amgen
See eligibility & contact on ClinicalTrials.gov (NCT07037433)

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

Heart Failure With Preserved Ejection Fraction, Heart Failure With Mildly Reduced Ejection Fraction Phase 3 Interventional 5,056 participants sought
Cardiovascular Research of Knoxville North Knoxville Medical Center — Powell, Tennessee (6.2 mi) · Sponsor: Amgen
See eligibility & contact on ClinicalTrials.gov (NCT07037459)
Actively enrolling

Studies you may be able to join near Knoxville

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

Research study for alcohol-related liver damage

Enrolling US adults aged 18 to 70 with alcohol-induced liver damage and a history of heavy drinking. Not open to people with a recent stroke, heart attack, dialysis, or who take blood thinners.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Research study for bladder problems after spinal cord injury

This study is enrolling US adults aged 18 to 75 living with chronic involuntary bladder leakage caused by a spinal cord injury, for research including investigational gene therapy approaches. The study team confirms eligibility and any compensation before enrollment.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Knoxville

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

AMR Clinical

★ 4.0
1924 Alcoa Hwy, Knoxville, TN 37920
(865) 305-3784

New Phase Research & Development

★ 4.8
6914 Office Pk Cir NW, Knoxville, TN 37909
(865) 200-8364
"Amazing group of people. Kind and friendly! Willing to work with you through any scenario!"
— Trudy Honest, 5★

Accellacare Research of Knoxville

★ 3.3
1200 Merchant Dr, Knoxville, TN 37912
(865) 244-4276
"STOP. This business is a scam. They probe for private info. Make you an appt, then call you 3 hrs before appt and a reason to disqualify you. My fear…"
— Elaine Sharp, 1★

AMR Knoxville / Volunteer Research Group (VRG)

★ 3.3
4th & 5th Floors, North Tower, 1924 Alcoa Hwy, Knoxville, TN 37920
(865) 305-3784
"Participant beware!! I would never do another in-house study with AMR. Their in-house location is in one of the oldest buildings of the UT hospital, …"
— Vivver, 1★

AMR Knoxville / Volunteer Research Group (VRG)

★ 4.6
801 N Weisgarber Rd Ste 100, Knoxville, TN 37909
(865) 305-3784
"I was pre-screened via telephone and told I was eligible for a study. I was told that they needed to determine how to enroll me and would get back to…"
— Kristin Stone, 1★

Alliance for Multispecialty Research

801 N Weisgarber Rd, Knoxville, TN 37909
(615) 591-0211

NOCCR Knoxville

★ 3.6
1924 Alcoa Highway 4th and 5th Floors North Tower, Knoxville, TN 37920
(865) 305-3784
"The nurses here are trash, and the facility is bunk."
— Jarrod Glass, 1★

PMG Research of Knoxville

★ 3.7
1200 Merchant Dr, Knoxville, TN 37912
(865) 244-4276
"I tried calling that place I don't know how many times and I can't get ahold of anyone at the place I have question I need to ask but nobody there wi…"
— MaZe Clan, 1★

University of Tennessee Research Foundation

★ 3.5
UT Tower, 400 W Summit Hill Dr SW Ste 961A, Knoxville, TN 37902
(865) 974-1882
"The answer all by questions correctly"
— Evelyn Robinson, 2★

Clinical trials in Knoxville: what's recruiting

The Knoxville area currently has 231 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Knoxville, the most active research areas are:

  • Cancer & Oncology13 studies
  • Diabetes & Metabolism4 studies
  • Heart & Vascular2 studies
  • Lungs & Breathing1 studies

Every listing shows the study phase, the recruiting site and its distance from Knoxville, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Knoxville

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Knoxville participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Do I need to be sick to join a clinical trial in Knoxville?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Are clinical trials in Knoxville safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Knoxville, TN?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
How often do new paid studies open in Knoxville?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Knoxville.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Knoxville typically complete one or two studies per year.

Paid clinical trials near Knoxville

Other metros within reach

Asheville, NC122 Chattanooga, TN146 Gainesville, GA157 Greenville, SC378 Mauldin, SC376 Athens, GA74 Lexington, KY472 Atlanta, GA1,710

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Knoxville Bladder Issues Due To Spinal Cord Injury in Knoxville All conditions

More of TN

Nashville1,342 Memphis580 Chattanooga146 Murfreesboro77 Clarksville8

New paid studies open every week

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