Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/TN/Knoxville
Updated November 2026 from ClinicalTrials.gov

Paid Clinical Trials in Knoxville, TN

Studies commonly pay $75 to $4,500 per completed study

236 clinical trials are currently recruiting participants within 30 miles of Knoxville. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

236studies recruiting
9+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Knoxville right now

Top 25 of 236 recruiting studies, sorted by proximity — each links to its official registry page

Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy

B Acute Lymphoblastic Leukemia, B Lymphoblastic Lymphoma Phase 3 Interventional 5,951 participants sought
East Tennessee Childrens Hospital — Knoxville, Tennessee (1.7 mi) · Sponsor: Children's Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT03959085)

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

Childhood Medulloblastoma Phase 3 Interventional 225 participants sought
East Tennessee Childrens Hospital — Knoxville, Tennessee (1.7 mi) · Sponsor: Children's Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT05382338)

A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)

Non-Small Cell Lung Cancer Phase 2 Interventional 120 participants sought
University of Tennessee Medical Center — Knoxville, Tennessee (1.7 mi) · Sponsor: Regeneron Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT06465329)

A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

Advanced Pancreatic Carcinoma, Metastatic Pancreatic Carcinoma Phase 2 Interventional 40 participants sought
Ohio State University Telemedicine — Knoxville, Tennessee (1.7 mi) · Sponsor: Sameek Roychowdhury
See eligibility & contact on ClinicalTrials.gov (NCT06906562)

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

Breast Neoplasms, Triple Negative Breast Neoplasms Phase 3 Interventional 2,400 participants sought
Tennessee Cancer Specialists ( Site 7001) — Knoxville, Tennessee (1.7 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06966700)

A Study to Investigate OCS Tapering in Adult Participants With Generalized Myasthenia Gravis Treated With Ravulizumab

Generalized Myasthenia Gravis, gMG Phase 4 Interventional 75 participants sought
Research Site — Knoxville, Tennessee (1.7 mi) · Sponsor: Alexion Pharmaceuticals, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07221838)

A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults

Chronic Idiopathic Constipation (CIC) Phase 3 Interventional 692 participants sought
New Phase Research & Development - Knoxville — Knoxville, Tennessee (1.7 mi) · Sponsor: Ardelyx
See eligibility & contact on ClinicalTrials.gov (NCT07382167)

A Study to Investigate Subcutaneous Isatuximab in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma

Plasma Cell Myeloma Refractory Phase 2 Interventional 64 participants sought
Tennessee Cancer Specialists - Knoxville - Old Weisgarber Road- Site Number : 8400035 — Knoxville, Tennessee (1.7 mi) · Sponsor: Sanofi
See eligibility & contact on ClinicalTrials.gov (NCT06356571)

DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

Pulmonary Hypertension Due to Lung Diseases and Hypoxia, Pulmonary Hypertension N/A Observational 900 participants sought
StatCare Pulmonary Consultants and Center for Biomedical Research — Knoxville, Tennessee (1.7 mi) · Sponsor: United Therapeutics
See eligibility & contact on ClinicalTrials.gov (NCT06388421)

BMS-986489 (Atigotatug + Nivolumab) vs Durvalumab in Limited-stage Small-cell Lung Cancer (TIGOS-LS)

Limited Stage Small Cell Lung Cancer Phase 2 Interventional 250 participants sought
Tennessee Cancer Specialists — Knoxville, Tennessee (1.7 mi) · Sponsor: SCRI Development Innovations, LLC
See eligibility & contact on ClinicalTrials.gov (NCT06773910)

Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design

Fibromyalgia Phase 3 Interventional 620 participants sought
Clinical Research Site — Knoxville, Tennessee (1.7 mi) · Sponsor: Axsome Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07398417)

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Lymphoma, Large B-Cell, Diffuse Phase 2 Interventional 594 participants sought
Tennessee Cancer Specialists ( Site 7004) — Knoxville, Tennessee (1.7 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06890884)

Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)

Pulmonary Disease, Chronic Obstructive Phase 3 Interventional 961 participants sought
GSK Investigational Site — Knoxville, Tennessee (1.7 mi) · Sponsor: GlaxoSmithKline
See eligibility & contact on ClinicalTrials.gov (NCT06961214)

Clinical Trial Protocol: Alzheimer's Dementia Underlying Encephalopathy

Alzheimer Dementia, Alzheimer Disease N/A Interventional 30 participants sought
Fort Sanders Regional Medical Center — Knoxville, Tennessee (1.7 mi) · Sponsor: Covenant Health, US
See eligibility & contact on ClinicalTrials.gov (NCT07222280)

Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)

Obesity, Overweight Phase 3 Interventional 3,600 participants sought
ACCOMPLISH-1 Research Site — Knoxville, Tennessee (1.7 mi) · Sponsor: Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
See eligibility & contact on ClinicalTrials.gov (NCT07654361)

Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities

Obesity, Overweight Phase 2 Interventional 360 participants sought
New Phase Research & Development /ID# 282131 — Knoxville, Tennessee (1.7 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT07752979)

Feasibility, Safety and Efficacy of Nebulized Long-Acting Bronchodilators (Formoterol and Revefenacin) vs. Short-Acting Bronchodilators (Albuterol and Ipratropium) in Hospitalized Patients With AECOPD

COPD Exacerbation Phase 4 Interventional 60 participants sought
University of Tennessee Medical Center — Knoxville, Tennessee (1.7 mi) · Sponsor: University of Tennessee Graduate School of Medicine
See eligibility & contact on ClinicalTrials.gov (NCT04655170)

Extracellular Vesicle Treatment for Acute Respiratory Distress Syndrome (ARDS) (EXTINGUISH ARDS)

Acute Respiratory Distress Syndrome, ARDS Phase 3 Interventional 970 participants sought
Direct Biologics Investigational Site — Knoxville, Tennessee (1.7 mi) · Sponsor: Direct Biologics, LLC
See eligibility & contact on ClinicalTrials.gov (NCT05354141)

ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

Cardiovascular Risk, Acute Myocardial Infarction (AMI) Phase 3 Interventional 10,000 participants sought
Knoxville Heart Group — Knoxville, Tennessee (1.7 mi) · Sponsor: Novo Nordisk A/S
See eligibility & contact on ClinicalTrials.gov (NCT06118281)

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

PIK3CA Mutation, HER2- Negative Breast Cancer Phase 3 Interventional 540 participants sought
Tennessee Cancer Specialists — Knoxville, Tennessee (1.7 mi) · Sponsor: Relay Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06982521)

Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

Retroperitoneal Sarcoma, Liposarcoma Phase 3 Interventional 250 participants sought
University of Tennessee - Knoxville — Knoxville, Tennessee (1.7 mi) · Sponsor: European Organisation for Research and Treatment of Cancer - EORTC
See eligibility & contact on ClinicalTrials.gov (NCT04031677)

A Phase 1 Study of 99mTc-p5+14 in Healthy Volunteers and Patients With AL or ATTR Systemic Amyloidosis

Systemic Amyloidosis Phase 1 Interventional 31 participants sought
University of Tennessee Graduate School of Medicine — Knoxville, Tennessee (1.7 mi) · Sponsor: University of Tennessee Graduate School of Medicine
See eligibility & contact on ClinicalTrials.gov (NCT05951816)

A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants

Hypothyroidism Phase 2, Phase 3 Interventional 2,800 participants sought
PMG Research of Knoxville /ID# 256854 — Knoxville, Tennessee (1.7 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT06345339)
Actively enrolling

Studies you may be able to join near Knoxville

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Knoxville

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

AMR Clinical

★ 4.0
1924 Alcoa Hwy, Knoxville, TN 37920
(865) 305-3784

New Phase Research & Development

★ 4.8
6914 Office Pk Cir NW, Knoxville, TN 37909
(865) 200-8364
"Amazing group of people. Kind and friendly! Willing to work with you through any scenario!"
— Trudy Honest, 5★

Accellacare Research of Knoxville

★ 3.3
1200 Merchant Dr, Knoxville, TN 37912
(865) 244-4276
"STOP. This business is a scam. They probe for private info. Make you an appt, then call you 3 hrs before appt and a reason to disqualify you. My fear…"
— Elaine Sharp, 1★

AMR Knoxville / Volunteer Research Group (VRG)

★ 3.3
4th & 5th Floors, North Tower, 1924 Alcoa Hwy, Knoxville, TN 37920
(865) 305-3784
"Participant beware!! I would never do another in-house study with AMR. Their in-house location is in one of the oldest buildings of the UT hospital, …"
— Vivver, 1★

AMR Knoxville / Volunteer Research Group (VRG)

★ 4.6
801 N Weisgarber Rd Ste 100, Knoxville, TN 37909
(865) 305-3784
"I was pre-screened via telephone and told I was eligible for a study. I was told that they needed to determine how to enroll me and would get back to…"
— Kristin Stone, 1★

Alliance for Multispecialty Research

801 N Weisgarber Rd, Knoxville, TN 37909
(615) 591-0211

NOCCR Knoxville

★ 3.6
1924 Alcoa Highway 4th and 5th Floors North Tower, Knoxville, TN 37920
(865) 305-3784
"The nurses here are trash, and the facility is bunk."
— Jarrod Glass, 1★

PMG Research of Knoxville

★ 3.7
1200 Merchant Dr, Knoxville, TN 37912
(865) 244-4276
"I tried calling that place I don't know how many times and I can't get ahold of anyone at the place I have question I need to ask but nobody there wi…"
— MaZe Clan, 1★

University of Tennessee Research Foundation

★ 3.5
UT Tower, 400 W Summit Hill Dr SW Ste 961A, Knoxville, TN 37902
(865) 974-1882
"The answer all by questions correctly"
— Evelyn Robinson, 2★

Clinical trials in Knoxville: what's recruiting

The Knoxville area currently has 236 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Knoxville, the most active research areas are:

  • Cancer & Oncology10 studies
  • Lungs & Breathing4 studies
  • Diabetes & Metabolism3 studies
  • Heart & Vascular2 studies
  • Brain & Mental Health1 studies

Every listing shows the study phase, the recruiting site and its distance from Knoxville, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Knoxville

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Knoxville participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Do I need to be sick to join a clinical trial in Knoxville?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Are clinical trials in Knoxville safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Knoxville, TN?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
How often do new paid studies open in Knoxville?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Knoxville.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Knoxville typically complete one or two studies per year.

Paid clinical trials near Knoxville

Other metros within reach

Asheville, NC125 Chattanooga, TN137 Gainesville, GA147 Greenville, SC383 Mauldin, SC381 Athens, GA71 Lexington, KY479 Atlanta, GA1,715

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Knoxville Bladder Issues Due To Spinal Cord Injury in Knoxville All conditions

More of TN

Nashville1,349 Memphis592 Chattanooga137 Murfreesboro84 Clarksville8

New paid studies open every week

Get an email when a new clinical trial starts recruiting within 30 miles of your ZIP code. No spam — only real studies from the NIH registry.

By subscribing you agree to receive study alert emails. Unsubscribe anytime in one click.

Get free trial alerts