Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/CA/Santa Cruz
Updated October 2026 from ClinicalTrials.gov

Paid Clinical Trials in Santa Cruz, CA

Studies commonly pay $75 to $4,500 per completed study

163 clinical trials are currently recruiting participants within 30 miles of Santa Cruz. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

163studies recruiting
9+research centers nearby
6condition categories
Live from the NIH registry

Studies recruiting near Santa Cruz right now

Top 25 of 163 recruiting studies, sorted by proximity — each links to its official registry page

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

Breast Cancer Phase 3 Interventional 450 participants sought
Palo Alto Medical Foundation Research Center — Sunnyvale, California (26.9 mi) · Sponsor: Hoffmann-La Roche
See eligibility & contact on ClinicalTrials.gov (NCT06790693)

A Study to Learn About How 20-Valent Pneumococcal Conjugate Vaccine Works in a Real-world Setting

Pneumonia N/A Observational 12,500 participants sought
Kaiser Permanente Santa Clara Medical Center — Santa Clara, California (26.3 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT05452941)

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

Breast Neoplasms, Triple Negative Breast Neoplasms Phase 3 Interventional 2,400 participants sought
El Camino Hospital Cancer Center ( Site 0096) — Mountain View, California (28.3 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06966700)

A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)

Non-Small Cell Lung Cancer (NSCLC) Phase 3 Interventional 750 participants sought
Pacific Cancer Care — Monterey, California (27.3 mi) · Sponsor: Bristol-Myers Squibb
See eligibility & contact on ClinicalTrials.gov (NCT07361510)

Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Mitral Valve Regurgitation N/A Interventional 1,056 participants sought
El Camino Hospital — Mountain View, California (28.3 mi) · Sponsor: Medtronic Cardiovascular
See eligibility & contact on ClinicalTrials.gov (NCT03242642)

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

Breast Cancer Phase 3 Interventional 3,960 participants sought
Palo Alto Medical Foundation-Santa Cruz — Santa Cruz, California (0.4 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05879926)

Surabgene Lomparvovec Administered in the Suprachoroidal Space in Adult Participants With Diabetic Retinopathy Without Center-Involved Diabetic Macular Edema

Diabetic Retinopathy Phase 2, Phase 3 Interventional 576 participants sought
Northern California Retina Vitreous Associates /ID# 282994 — Mountain View, California (28.3 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT07592273)

Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

Metastatic Clear Cell Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma Phase 3 Interventional 364 participants sought
Palo Alto Medical Foundation-Santa Cruz — Santa Cruz, California (0.4 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT04510597)

Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

Renal Pelvis and Ureter Urothelial Carcinoma Phase 2, Phase 3 Interventional 131 participants sought
Palo Alto Medical Foundation-Santa Cruz — Santa Cruz, California (0.4 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04628767)

A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

Major Depressive Disorder Phase 2 Interventional 164 participants sought
Lumos Clinical Research Center — San Jose, California (26.1 mi) · Sponsor: Syndeio Biosciences, Inc
See eligibility & contact on ClinicalTrials.gov (NCT07115329)

A 52-week Study of Rilzabrutinib Efficacy and Safety Compared to Placebo in Adults Diagnosed With IgG4-related Disease

Immunoglobulin G4 Related Disease Phase 3 Interventional 124 participants sought
San Jose Clinical Trials- Site Number : 8400016 — San Jose, California (26.1 mi) · Sponsor: Sanofi
See eligibility & contact on ClinicalTrials.gov (NCT07190196)

A Primary Care Based Intervention to Prevent Childhood Obesity Among Low-income Latino Children

Obesity, Childhood N/A Interventional 576 participants sought
Valley Health Center Sunnyvale — Sunnyvale, California (26.9 mi) · Sponsor: University of California, San Francisco
See eligibility & contact on ClinicalTrials.gov (NCT06398509)

A Randomized, Double-Blind, Placebo-Controlled Trial on Efficacy and Safety of Fluticasone Propionate/Albuterol Sulfate Combination in Participants 12 Years and Older With Asthma

Asthma Phase 3 Interventional 724 participants sought
Teva Investigational Site 12064 — San Jose, California (26.1 mi) · Sponsor: Teva Branded Pharmaceutical Products R&D LLC
See eligibility & contact on ClinicalTrials.gov (NCT06664619)

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

Lymphoma, Non-Hodgkin, Multiple Myeloma Phase 2 Interventional 4,200 participants sought
Sutter Palo Alto Medical Foundation: Santa Cruz — Santa Cruz, California (0.4 mi) · Sponsor: American Society of Clinical Oncology
See eligibility & contact on ClinicalTrials.gov (NCT02693535)

Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed and Have Not Yet Started Treatment (A MyeloMATCH Treatment Trial)

Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm Phase 2 Interventional 335 participants sought
Kaiser Permanente Medical Center - Santa Clara — Santa Clara, California (26.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05554406)

Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study

Muscle Invasive Bladder Urothelial Carcinoma, Muscle Invasive Renal Pelvis Urothelial Carcinoma Phase 2, Phase 3 Interventional 992 participants sought
Kaiser Permanente-Santa Teresa-San Jose — San Jose, California (26.1 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05987241)

SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes

Type 1 Diabetes Phase 2 Interventional 159 participants sought
San Jose Clinical Trials, LLC — San Jose, California (26.1 mi) · Sponsor: SAb Biotherapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07187531)

Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)

Migraine Phase 3 Interventional 1,059 participants sought
Lumos Clinical Research Center /ID# 231267 — San Jose, California (26.1 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT05125302)

Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

Prostate Cancer (Adenocarcinoma) Phase 3 Interventional 830 participants sought
Stanford Cancer Center South Bay — San Jose, California (26.1 mi) · Sponsor: Canadian Cancer Trials Group
See eligibility & contact on ClinicalTrials.gov (NCT06592924)

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

Intestinal Neoplasms, Gastrointestinal Neoplasms Phase 3 Interventional 800 participants sought
Palo Alto Medical Foundation - Sunnyvale Center — Sunnyvale, California (26.9 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT07222800)
Actively enrolling

Studies you may be able to join near Santa Cruz

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Santa Cruz

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Institute for the Biology of Stem Cells (IBSC) at UC Santa Cruz

1156 High St, Santa Cruz, CA 95064
(831) 459-1399

Global Psychedelic Dinner

1115 Mission St, Santa Cruz, CA 95060
(831) 429-6362

Lumos Clinical Research Center

★ 4.9
2516 Samaritan Dr Ste b, San Jose, CA 95124
(408) 402-5424
"This is my first clinical trial experience and I look forward to many more with Lumos. They have the friendliest staff, they made me feel welcome and…"
— Soso Happy, 5★

San Jose Clinical Trials

★ 4.9
2211 Moorpark Ave #275, San Jose, CA 95128
(408) 443-3540
"Very professional and pleasant atmosphere plus informational"
— Zan Cortner, 5★

Department of Microbiology and Environmental Toxicology

Santa Cruz, CA 95064
(831) 459-2190

Gonstead Clinical Studies Society

2230 Ivy Ln, Santa Cruz, CA 95062
(831) 476-1873

Cancer Clinical Trials Office, Stanford Cancer Institute

★ 3.0
800 Welch Rd, Palo Alto, CA 94304
(650) 498-7061
"Do not waitlist here. We've been on waitlist here for over 1.5 yr with nothing to offer. Seek through UCSF or City of Hope."
— Eric Yen, 1★

Central Valley Research

★ 4.9
400 E Orangeburg Ave Ste 5, Modesto, CA 95350
(209) 549-9538

Oakland Clinical

3300 Webster St #1106, Oakland, CA 94609
(510) 817-2000

Clinical trials in Santa Cruz: what's recruiting

The Santa Cruz area currently has 163 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Santa Cruz, the most active research areas are:

  • Cancer & Oncology9 studies
  • Diabetes & Metabolism4 studies
  • Liver & Kidney3 studies
  • Brain & Mental Health2 studies
  • Lungs & Breathing1 studies

Every listing shows the study phase, the recruiting site and its distance from Santa Cruz, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Santa Cruz

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Santa Cruz participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Santa Cruz pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Are clinical trials in Santa Cruz safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Santa Cruz, CA?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
What is the difference between a research center and a hospital study in Santa Cruz?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Santa Cruz typically complete one or two studies per year.

Paid clinical trials near Santa Cruz

Other metros within reach

San Jose, CA1,124 Sunnyvale, CA1,155 Salinas, CA46 Fremont, CA2,257 Hayward, CA2,267 Oakland, CA2,257 San Francisco, CA2,239 Concord, CA1,523

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Santa Cruz Bladder Issues Due To Spinal Cord Injury in Santa Cruz All conditions

More of CA

Long Beach3,380 Fullerton3,270 Torrance3,259 Anaheim3,214 Garden Grove3,204 Pomona3,172 Glendale2,974 Los Angeles2,951 Huntington Beach2,879 Santa Clarita2,378 Hayward2,267 Oakland2,257

New paid studies open every week

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